Most Popular Articles

Anti-Cancer Agents in Medicinal Chemistry

Recent Developments on 1,2,4-Triazole Nucleus in Anticancer Compounds: A Review, 16(4): (2016)

Ramandeep Kaur, Ashish Ranjan Dwivedi, Bhupinder Kumar and Vinod Kumar

DOI: 10.2174/1871520615666150819121106

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Breast Cancer: Current Molecular Therapeutic Targets and New Players, 17(2): (2017)

Siddavaram Nagini

DOI: 10.2174/1871520616666160502122724

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Current Cancer Drug Targets

Clinical Trials with Oncolytic Measles Virus: Current Status and Future Prospects, 18(2): (2018)

Pavlos Msaouel, Mateusz Opyrchal, Angela Dispenzieri, Kah Whye Peng, Mark J. Federspiel, Stephen J. Russell and Evanthia Galanis*

DOI: 10.2174/1568009617666170222125035

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Mechanisms for the Inhibition of Colon Cancer Cells by Sulforaphane through Epigenetic Modulation of MicroRNA-21 and Human Telomerase Reverse Transcriptase (hTERT) Down-regulation, 18(1): (2018)

Samantha L. Martin, Rishabh Kala and Trygve O. Tollefsbol*

DOI: 10.2174/1568009617666170206104032

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Current Drug Targets

Cytochrome P450 Structure, Function and Clinical Significance: A Review, 19(1): (2018)

Palrasu Manikandan and Siddavaram Nagini*

DOI: 10.2174/1389450118666170125144557

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Current Medicinal Chemistry

Absolute Configuration Determination by Quantum Mechanical Calculation of Chiroptical Spectra: Basics and Applications to Fungal Metabolites, 25(2): (2018)

Stefano Superchi*, Patrizia Scafato, Marcin Gorecki and Gennaro Pescitelli*

DOI: 10.2174/0929867324666170310112009

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Structure, Function, Involvement in Diseases and Targeting of 14-3-3 Proteins: An Update, 25(1): (2018)

Ylenia Cau, Daniela Valensin, Mattia Mori, Sara Draghi and Maurizio Botta*

DOI: 10.2174/0929867324666170426095015

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Immune Checkpoint Inhibitors and Cardiac Toxicity: An Emerging issue, 25(11): (2018)

Gilda Varricchi*, Giancarlo Marone, Valentina Mercurio, Maria Rosaria Galdiero, Domenico Bonaduce and Carlo G. Tocchetti*

DOI: 10.2174/0929867324666170407125017

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Hydroxypyridinone Derivatives: A Fascinating Class of Chelators with Therapeutic Applications - An Update, 25(1): (2018)

Sílvia Chaves, Luca Piemontese, Asha Hiremathad and M. Amélia Santos*

DOI: 10.2174/0929867324666170330092304

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Bioactive Metabolites from Pathogenic and Endophytic Fungi of Forest Trees, 25(2): (2018)

Marco Masi, Lucia Maddau, Benedetto Teodoro Linaldeddu, Bruno Scanu , Antonio Evidente and Alessio Cimmino*

DOI: 10.2174/0929867324666170314145159

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Gut-brain Axis: Role of Lipids in the Regulation of Inflammation, Pain and CNS Diseases, 25(32): (2018)

Roberto Russo*, Claudia Cristiano, Carmen Avagliano, Carmen De Caro, Giovanna La Rana, Giuseppina Mattace Raso, Roberto Berni Canani, Rosaria Meli and Antonio Calignano

DOI: 10.2174/0929867324666170216113756

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Current Molecular Medicine

The Role of the PERK/eIF2 alpha/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress, 16(6): (2016)

W. Rozpedek, D. Pytel, B. Mucha, H. Leszczynska, J.A. Diehl and I. Majsterek

DOI: 10.2174/1566524016666160523143937

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Current Neuropharmacology

Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets, 14(7): (2016)

Ji-chun Zhang, Wei Yao and Kenji Hashimoto

DOI: 10.2174/1570159X14666160119094646

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Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine, 15(1): (2017)

Eric S. Wohleb, Danielle Gerhard, Alex Thomas and Ronald S. Duman

DOI: 10.2174/1570159X14666160309114549

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CNS & Neurological Disorders - Drug Targets

Inflammatory Mechanisms and Oxidative Stress as Key Factors Responsible for Progression of Neurodegeneration: Role of Brain Innate Immune System, 15(3): (2016)

Jerzy Leszek, George E. Barreto, Kazimierz Gąsiorowski, Euphrosyni Koutsouraki, Marco Ávila-Rodrigues and Gjumrakch Aliev

DOI: 10.2174/1871527315666160202125914

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Current Pharmaceutical Design

Oxidative Stress and Parkinson's Disease: New Hopes in Treatment with Herbal Antioxidants, 22(2): (2016)

Amir Sarrafchi, Mahmoud Bahmani, Hedayatollah Shirzad and Mahmoud Rafieian-Kopaei

DOI: 10.2174/1381612822666151112151653

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Inflammatory Process in Alzheimer's and Parkinson's Diseases: Central Role of Cytokines, 22(5): (2016)

Qamre Alam, Mohammad Zubair Alam, Gohar Mushtaq, Ghazi A. Damanhouri, Mahmood Rasool, Mohammad Amjad Kamal and Absarul Haque

DOI: 10.2174/1381612822666151125000300

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Air Pollution Exposure and Blood Pressure: An Updated Review of the Literature, 22(1): (2016)

Paolo Giorgini, Paolo Di Giosia, Davide Grassi, Melvyn Rubenfire, Robert D. Brook and Claudio Ferri

DOI: 10.2174/1381612822666151109111712

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Current Topics in Medicinal Chemistry

Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry, 16(11): (2016)

Minghao Feng, Bingqing Tang, Steven H. Liang and Xuefeng Jiang

DOI: 10.2174/1568026615666150915111741

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An Unprecedented Revolution in Medicinal Chemistry Driven by the Progress of Biological Science, 17(21): (2017)

Kuo-Chen Chou*

DOI: 10.2174/1568026617666170414145508

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Letters in Drug Design & Discovery

Synthesis of Mannich Bases by Two Different Methods and Evaluation of their Acetylcholine Esterase and Carbonic Anhydrase Inhibitory Activities, 14(5): (2017)

Halise I. Gul*, Alkan Demirtas, Gokbay Ucar, Parham Taslimi and İlhami Gulcin

DOI: 10.2174/1570180814666161128120612

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Medicinal Chemistry

iPGK-PseAAC: Identify Lysine Phosphoglycerylation Sites in Proteins by Incorporating Four Different Tiers of Amino Acid Pairwise Coupling Information into the General PseAAC, 13(6): (2017)

Li-Ming Liu, Yan Xu and Kuo-Chen Chou

DOI: 10.2174/1573406413666170515120507

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Medicinal Chemistry

iPreny-PseAAC: Identify C-terminal Cysteine Prenylation Sites in Proteins by Incorporating Two Tiers of Sequence Couplings into PseAAC, 13(6): (2017)

Yan Xu, Zu Wang, Chunhui Li and Kuo-Chen Chou

DOI: 10.2174/1573406413666170419150052

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iRNA-2methyl: Identify RNA 2'-O-methylation Sites by Incorporating Sequence-Coupled Effects into General PseKNC and Ensemble Classifier, 13(8): (2017)

Wang-Ren Qiu*, Shi-Yu Jiang , Bi-Qian Sun, Xuan Xiao*, Xiang Cheng and Kuo-Chen Chou*

DOI: 10.2174/1573406413666170623082245

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Mini-Reviews in Medicinal Chemistry

The Role Oxidative Stress in the Pathogenesis of Eye Diseases: Current Status and a Dual Role of Physical Activity, 16(3): (2016)

Joanna Kruk, Katarzyna Kubasik-Kladna and Hassan Y. Aboul-Enein

DOI: 10.2174/1389557516666151120114605

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New Progress in Azole Compounds as Antimicrobial Agents, 17(2): (2017)

Hui-Zhen Zhang, Lin-Ling Gan, Hui Wang and Cheng-He Zhou

DOI: 10.2174/1389557516666160630120725

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