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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Volume 19, 18 Issues, 2019
ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)
This journal supports open access

Ranking and Category

  • 39th of 61 in

    Chemistry, Medicinal

  • 172nd of 229 in

    Oncology

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Aims & Scope

Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.

Each issue contains a series of timely in-depth/mini reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication.

Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.

Anti-Cancer Agents in Medicinal Chemistry

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Volume 19

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Number 8



Biography   Open Access



Review Article



Review Article



Research Article



Research Article

Two Novel Tri-Aryl Derivatives Attenuate the Invasion-Promoting Effects of Stromal Mesenchymal Stem Cells on Breast Cancer

, 19(8): 1002 - 1011

Khadijeh Moradi, Farnaz Barneh, Saeed Irian, Mohsen Amini, Raheleh Moradpoor, Amir Amanzadeh, Samira Choopani, Hamzeh Rahimi, Tayebeh Ghodselahi, Massoud M. Boujar and Mona Salimi*


DOI: 10.2174/1871520619666190212123912


Research Article



Research Article



Research Article



Anti-Cancer Agents in Medicinal Chemistry, Volume 19 (2019) - Number 10


This issue is in progress but contains articles that are final and fully citable.

Anti-Cancer Agents in Medicinal Chemistry, Volume 19 (2019) - Number 9


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print


Three Pt-Pt Complexes with Donor-Acceptor Feature: Anticancer Activity, DNA Binding Studies and Molecular Docking Simulation


Pezhman Ashoo, Reza Yousefi*, S. Masoud Nabavizadeh, Marzieh Dadkhah Aseman, Sareh Paziresh, Atiyeh Ghasemi and Ali Akbar Saboury


DOI: 10.2174/1871520619666190702114211
View Abstract View on PubMed


Berberine as Source of Antiproliferative Hybrid Compounds: In Vitro Antiproliferative Activity and Quantitative Structure-Activity Relationship


Mario Alberto Leyva-Peraltaa, Ramón Enrique Robles-Zepedab, Rodrigo Said Razo-Hernándezc, Laura Patricia Álvarez Berberd, Karen Ochoa Laraa, Eduardo Ruiz-Bustosb and Juan Carlos Gálvez-Ruízb*


DOI: 10.2174/1871520619666190503121820
View Abstract


The Correlation between EGFR and Androgen Receptor Pathways: A Novel Potential Prognostic Marker in Gastric Cancer


Shahrzad S. Fard, Kioomars Saliminejad, Masoud Sotoudeh, Niloofar Soleimanifard, Shaghayegh Kouchaki, Mansour Yazdanbod, Habibollah Mahmoodzadeh, Ardeshir Ghavamzadeh, Reza Malekzadeh, Bahram Chahardouli, Kamran Alimoghaddam* and Seyed H. Ghaffari*


DOI: 10.2174/1871520619666190930142820
View Abstract View on PubMed



STK33-Dependent Transcriptional Regulation of SFTA3 Induces Cisplatin- Resistance in Lung Adenocarcinoma


Kuilong Zhou, Runzhi Dong, Zhiheng Wang, Zhian Tang, Xuezhen Gao, Yaqing Du, Xiaoli Zhang, Xiangying Li and Qingfan Xie*


DOI: 10.2174/1871520619666190507100912
View Abstract View on PubMed





Synthesis and Anticancer Activity of Benzimidazole/Benzoxazole Substituted Triazolotriazines in Hepatocellular Carcinoma


Sakineh Dadashpour, Tuba T. Küçükkılınç, Ayse Ercan, Seyed J. Hosseinimehr, Nima Naderi and Hamid Irannejad*


DOI: 10.2174/1871520619666190808152051
View Abstract View on PubMed


Abstracts Ahead of Print

Recent Advances in Characterizing Natural Products that Regulate Autophagy


Qian Zhao, Cheng Peng, Chuan Zheng, Xiang -Hong He, Wei Huang* and Bo Han*


DOI: 10.2174/1871520619666191015104458
View Abstract


Anticancer Potential of Dietary Natural Products: A Comprehensive Review


Rumana Ahmad*, Mohsin A. Khan, A.N. Srivastava, Anamika Gupta, Aditi Srivastava, Tanvir R. Jafri, Zainab Siddiqui, Sunaina Chaubey, Tahmeena Khan and Arvind K. Srivastava


DOI: 10.2174/1871520619666191015103712
View Abstract




Evaluation of Tissue and Serum Expression Levels of Lactate Dehydrogenase Isoenzymes in Patients with Head and Neck Squamous Cell Carcinoma


Nooshin Mohtasham, Hossein Ayatollahi, Nasrollah Saghravanian, Reza Zare, Mohammad-Taghi Shakeri, Amirhossein Sahebkar* and Farnaz Mohajertehran*


DOI: 10.2174/1871520619666191014160818
View Abstract


Synthesis, Anticancer and Antibacterial Activity of Betulinic and Betulonic Acid C-28-Triphenylphosphonium Conjugates with Variable Alkyl Linker Length


Olga V. Tsepaeva, Andrey V. Nemtarev*, Leysan R. Grigor`eva, Taliya I. Salikhova, Svetlana A. Khozyainova, Timur I. Abdullin and Vladimir F. Mironov


DOI: 10.2174/1871520619666191014153554
View Abstract





In Vitro Antitumor Evaluation of Some Hybrid Molecules Containing Coumarin and Quinolinone Moieties


Youstina W. Rizzk*, Ibrahim M. El-Deen, Faten Z. Mohammed, Moustafa S. Abdelhamid and Amgad I.M. Khedr


DOI: 10.2174/1871520619666190930143856
View Abstract


Published Contents

Editor's Choice

2,4-Disubstituted Quinazoline Derivatives Act as Inducers of Tubulin Polymerization: Synthesis and Cytotoxicity

, 2019; 19(8): 1048 - 1057

Ebrahim S. Moghadam, Maryam H. Tehrani, René Csuk, Lucie Fischer, Mohammad Ali Faramarzi, Arezoo Rashidi, Iraj Javadi and Mohsen Amini*


DOI: 10.2174/1871520619666190314125254




Synthesis and In Vitro Evaluation of Tetrahydroquinoline Derivatives as Antiproliferative Compounds of Breast Cancer via Targeting the GPER

, 2019; 19(6): 760 - 771

Oscar J. Zacarías-Lara, David Méndez-Luna, Gustavo Martínez-Ruíz, José R. García-Sanchéz, Manuel J. Fragoso-Vázquez*, Martiniano Bello, Elvia Becerra-Martínez, Juan B. García-Vázquez and José Correa-Basurto*


DOI: 10.2174/1871520618666181119094144



Design, Synthesis and Antiproliferative Evaluation of Novel 1,2,4-Triazole/Schiff Base Hybrids with EGFR and B-RAF Inhibitory Activities

, 2019; 19(5): 697 - 706

Hany A.M. El-Sherief, Bahaa G.M. Youssif*, Ahmed H. Abdelazeem, Mohamed Abdel-Aziz and Hamdy M. Abdel-Rahman*


DOI: 10.2174/1871520619666181224115346



A New Synthetic Spiroketal: Studies on Antitumor Activity on Murine Melanoma Model In Vivo and Mechanism of Action In Vitro

, 2019; 19(4): 567 - 578

Maria P. Fuggetta*, Pietro Spanu*, Fausta Ulgheri, Francesco Deligia, Paola Carta, Alberto Mannu, Veronica Trotta, Rosanna De Cicco, Adriano Barra, Enrica Zona and Franco Morelli*


DOI: 10.2174/1871520619666190131141400



Novel Benzo[B]Furans with Anti-Microtubule Activity Upregulate Expression of Apoptotic Genes and Arrest Leukemia Cells in G2/M Phase

, 2019; 19(3): 375 - 388

Karolina Królewska-Golińska, Marcin J. Cieślak*, Milena Sobczak, Rafał Dolot, Ewa Radzikowska-Cieciura, Mariola Napiórkowska, Iwona Wybrańska and Barbara Nawrot


DOI: 10.2174/1871520619666181122123552



Isolation of a New Sesquiterpene Lactone From Vernonia Zeylanica (L) Less and its Anti-Proliferative Effects in Breast Cancer Cell Lines

, 2019; 19(3): 410 - 424

Anuka S. Mendis*, Ira Thabrew, Meran K. Ediriweera, Sameera R. Samarakoon, Kamani H. Tennekoon, Achyut Adhikari* and Egodage D. de Silva


DOI: 10.2174/1871520619666181128163359




Biological Activity and Physicochemical Properties of Dipeptidyl Nitrile Derivatives Against Pancreatic Ductal Adenocarcinoma Cells

, 2019; 19(1): 112 - 120

José C. Quilles Jr, Murillo D.L. Bernardi, Pedro H.J. Batista, Samelyn C.M. Silva, Camila M.R. Rocha, Carlos A. Montanari and Andrei Leitão*


DOI: 10.2174/1871520618666181029141649



Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention

, 2019; 19(1): 38 - 47

Alessandro Colapietro, Andrea Mancini, Anna Maria D'Alessandro and Claudio Festuccia*


DOI: 10.2174/1871520619666181231112453



Open Access Articles


New Strategies for Therapeutic Cancer Vaccines

, 2019; 19(2): 213 - 221

Hanjiao Qin, Jiyao Sheng, Dan Zhang, Xuewen Zhang, Linlin Liu*, Bingjin Li*, Guangquan Li* and Zhuo Zhang




Trichinella spiralis and Tumors: Cause, Coincidence or Treatment?

, 2018; 18(8): 1091 - 1099

Chengshui Liao*, Xiangchao Cheng, Mingyuan Liu*, Xuelin Wang and Pascal Boireau




Astragalin Attenuates UVB Radiation-induced Actinic Keratosis Formation

, 2018; 18(7): 1001 - 1008

Na Li, Kun Zhang, Xin Mu, Qiong Tian, Wenli Liu, Tianyuan Gao, Xiaona Ma* and Jian Zhang*





Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals

, 2016; 16(11): 1385 - 1402

Alessandra Bosutti, Fabrizio Zanconati, Gabriele Grassi, Barbara Dapas, Sabina Passamonti and Bruna Scaggiante




Blood-Brain Barrier and Breast Cancer Resistance Protein: A Limit to the Therapy of CNS Tumors and Neurodegenerative Diseases

, 2016; 16(7): 810 - 815

Anna Lisa Iorio, Martina da Ros, Ornella Fantappiè, Maurizio Lucchesi, Ludovica Facchini, Alessia Stival, Sabrina Becciani, Milena Guidi, Claudio Favre, Maurizio de Martino, Lorenzo Genitori and Iacopo Sardi




The Use of Anthracyclines for Therapy of CNS Tumors

, 2015; 15(6): 721 - 727

Martina da Ros, Anna Lisa Iorio, Maurizio Lucchesi, Alessia Stival, Maurizio de Martino and Iacopo Sardi






Episensitization: Therapeutic Tumor Resensitization by Epigenetic Agents: A Review and Reassessment

, 2014; 14(8): 1121 - 1127

Bryan Oronsky, Neil Oronsky, Susan Knox, Gary Fanger and Jan Scicinski




Preclinical Development of Novel Rac1-GEF Signaling Inhibitors using a Rational Design Approach in Highly Aggressive Breast Cancer Cell Lines

, 2014; 14(6): 840 - 851

Georgina A. Cardama, Maria J. Comin, Leandro Hornos, Nazareno Gonzalez, Lucas Defelipe, Adrian G. Turjanski, Daniel F. Alonso, Daniel E. Gomez and Pablo Lorenzano Menna




β2-Microglobulin-mediated Signaling as a Target for Cancer Therapy

, 2014; 14(3): 343 - 352

Takeo Nomura, Wen-Chin Huang, Haiyen E. Zhau, Sajni Josson, Hiromitsu Mimata and Leland W. K. Chung





Cytotoxicity and Apoptosis Induced by a Plumbagin Derivative in Estrogen Positive MCF-7 Breast Cancer Cells

, 2014; 14(1): 170 - 180

Sunil Sagar, Luke Esau, Basem Moosa, Niveen M. Khashab, Vladimir B. Bajic and Mandeep Kaur





Most Cited Articles

Review Article

Recent development of sulfonyl or sulfonamide hybrids as potential anticancer agents: A key review

, 2018; 18(4): 488-505.

K. P. Rakesh, Shi-Meng Wang, Jing Leng, L. Ravindar, Abdullah M. Asiri, Hadi M. Marwani and Hua-Li Qin*


DOI: 10.2174/1871520617666171103140749




Research Article

Genistein induces alterations of epigenetic modulatory signatures in human cervical cancer cells

, 2018; 18(3): 412-421.

Madhumitha Kedhari Sundaram, Mohammad Zeeshan Ansari, Abdullah Al Mutery, Maryam Ashraf, Reem Nasab, Sheethal Rai, Naushad Rais and Arif Hussain*


DOI: 10.2174/1871520617666170918142114


Research Article

Design and discovery of novel quinoxaline derivatives as dual DNA intercalators and topoisomerase II inhibitors

, 2018; 18(2): 195-209.

Ibrahim H. Eissa, Abeer M. El-Naggar*, Nour E.A. Abd El-Sattar and Ahmed S.A. Youssef


DOI: 10.2174/1871520617666170710182405


Research Article

Effects of plasma activated medium on head and neck fadu cancerous cells: Comparison of 3D and 2D response

, 2018; 18(6): 776-783.

Julie Chauvin, Florian Judee, Nofel Merbahi* and Patricia Vicendo


DOI: 10.2174/1871520617666170801111055



General Research Article

Ros-scavenging and anti-tyrosinase properties of crocetin on B16F10 murine melanoma cells

, 2018; 18(7): 1064-1069.

Seyed H. Hashemi-Shahri, Alireza Golshan, Seyed A. Mohajeri, Javad Baharara, Elaheh Amini, Farzaneh Salek, Amirhossein Sahebkar and Zahra Tayarani-Najaran*


DOI: 10.2174/1871520618666171213143455



Review Article

Critical microRNAs in lung cancer: Recent advances and potential applications

, 2018; 18(14): 1991-2005.

Habib Zarredar, Khalil Ansarin, Behzad Baradaran, Najibeh Shekari, Shirin Eyvazi , Fateme Safari and Safar Farajnia*


DOI: 10.2174/1871520618666180808125459


Research Article

Cold physical plasma-treated buffered saline solution as effective agent against pancreatic cancer cells

, 2018; 18(6): 824-831.

Sander Bekeschus*, André Käding, Tim Schröder, Kristian Wende, Christine Hackbarth, Kim R. Liedtke, Julia van der Linde, Thomas von Woedtke, Claus-Dieter Heidecke and Lars-Ivo Partecke


DOI: 10.2174/1871520618666180507130243


Research Article

Structure-based design: Synthesis, X-ray crystallography, and biological evaluation of N-substituted-4-hydroxy-2-quinolone-3-carboxamides as potential cytotoxic agents

, 2018; 18(2): 263-276.

Dima A. Sabbah*, Bayan Hishmah, Kamal Sweidan, Sanaa Bardaweel, Murad AlDamen, Haizhen A. Zhong, Reema Abu Khalaf, Ameerah (Hasan Ibrahim), Tariq Al-Qirim, Ghassan Abu Sheikha and Mohammad S. Mubarak


DOI: 10.2174/1871520617666170911171152


General Review Article

Coumarin derivatives as anticancer agents for lung cancer therapy: A review

, 2018; 18(7): 964-984.

Manvendra Kumar, Ramit Singla, Jyoti Dandriyal and Vikas Jaitak*


DOI: 10.2174/1871520618666171229185926


Review Article

Role of azoles in cancer prevention and treatment: Present and future perspectives

, 2018; 18(1): 46-56.

Khurshid Ahmad, Mohd Kalim A. Khan, Mohammad Hassan Baig*, Mohd Imran and Girish Kumar Gupta*


DOI: 10.2174/1871520616666161221112042


Review Article

Tumor-targeting peptides: Ligands for molecular imaging and therapy

, 2018; 18(1): 74-86.

Ning Zhao, Yeshan Qin, Hongguang Liu* and Zhen Cheng*


DOI: 10.2174/1871520617666170419143459



Most Accessed Articles



Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments

, 2019; 19(4): 463-472.

Evgenii S. Mozhaitsev, Alexandra L. Zakharenko, Evgeniy V. Suslov*, Dina V. Korchagina, Olga D. Zakharova, Inna A. Vasil'eva, Arina A. Chepanova, Ellena Black, Jinal Patel, Raina Chand, Jóhannes Reynisson, Ivanhoe K.H. Leung, Konstantin P. Volcho, Nariman F. Salakhutdinov and Olga I. Lavrik


DOI: 10.2174/1871520619666181207094243











Editor-in-Chief

Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
ICCF-CNRS UMR 6296
Université Clermont Auvergne
Clermont-Ferrand
France

Biography View Full Editorial Board

Journal History

Current Medicinal Chemistry - Anti-Cancer Agents was launched in 2001 and later renamed in 2006 as Anti-Cancer Agents in Medicinal Chemistry.

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