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Current Cancer Drug Targets

Volume 21, 11 Issues, 2021
ISSN: 1873-5576 (Online)
ISSN: 1568-0096 (Print)
This journal supports open access

Aims & Scope

Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes.

Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer.

As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.

Current Cancer Drug Targets

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Volume 21

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Number 7







Review Article

Cross Talk between COVID-19 and Breast Cancer

, 21(7): 575 - 600

Hamendra Singh Parmar*, Aakruti Nayak*, Pramod Kumar Gavel, Hem Chandra Jha, Shivani Bhagwat and Rajesh Sharma


DOI: 10.2174/1568009621666210216102236






Research Article

Oncolytic Adenovirus H101 Synergizes with Radiation in Cervical Cancer Cells

, 21(7): 619 - 630

Yixin Duan, Haixia Bai, Xiang Li , Depu Wang , Ying Wang, Meng Cao, Nana Zhang, Hongwei Chen * and Yili Wang*


DOI: 10.2174/1568009621666210308103541


Articles Ahead of Print

Crosstalk of long non-coding RNAs and EMT: Searching the missing pieces of an incomplete puzzle for lung cancer therapy


Milad Ashrafizadeh, Md Shahinozzaman, Sima Orouei, Vahideh Zarrin, Kiavash Hushmandi, Farid Hashemi, Anuj Kumar, Saeed Samarghandian, Masoud Najafi* and Ali Zarrabi*


DOI: 10.2174/1568009621666210203110305
View Abstract View on PubMed


Drug-Induced Peripheral Neuropathy: Diagnosis and Management


Diala Merheb, Georgette Dib, Maroun Bou Zerdan, Clara El Nakib, Saada Alame and Hazem I. Assi*


DOI: 10.2174/1568009621666210720142542
View Abstract View on PubMed




CDK-associated Cullin 1 Promotes Cell Proliferation and Inhibits Cell Apoptosis in Human Glioblastoma


Xiaohua Zhang, Tianying Zhang, Xiaojuan Han, Zhongying Qiu, Jianghong Cheng, Xingchun Gao and Xingchun Gou*


DOI: 10.2174/1568009621666210602164225
View Abstract View on PubMed


Role of Exosomes in Breast Cancer Management: Evidence-Based Review


Razan B. AlHumaidi, Bahgat Fayed, Suleiman I. Sharif, Ayman Noreddin and Sameh S. M. Soliman*


DOI: 10.2174/1568009621666210601115707
View Abstract View on PubMed


The Clinical Application of Circulating Tumor Cells and DNAs as Prognostic and Predictive Biomarkers in Gastrointestinal Cancer


Sara Memarpour*, Ghazaleh Khalili-Tanha*, Awa Alizadeh Ghannad, Masoud Sharifian Razavi, Mona Joudi, Marjan Joodi, Gordon A. Ferns, Seyed Mahdi Hassanian, Majid Khazaei and Amir Avan*


DOI: 10.2174/1568009621666210311090531
View Abstract View on PubMed


Role of ZEB Family Members in Proliferation, Metastasis, and Chemoresistance of Prostate Cancer Cells: Revealing Signaling Networks


Leyla soleymani, Ali Zarrabi, Farid Hashemi, Fardin Hashemi, Amirhossein Zabolian, Seyed Mohammad Banihashemi, Shirin Sabouhi Moghadam, Kiavash Hushmandi, Saeed Samarghandian, Milad Ashrafizadeh* and Haroon Khan*


DOI: 10.2174/1568009621666210601114631
View Abstract View on PubMed




Abstracts Ahead of Print

Dextran sulfate inhibits cell proliferation and induces apoptosis by regulating EZH2 in gastric carcinoma


Yunning Huang *, Wenjun Wang*, Yuan-Yi Xu*, Jiaxin Guo, Longxing Jiao, Honghong Wang, Mengqi Li and Qi Yang


DOI: 10.2174/1568009621666210922112039
View Abstract



A molecular link between diabetes and breast cancer: Therapeutic potential of repurposing incretin-based therapies for breast cancer


Pooja Jaiswal, Versha Tripathi, Aakruti Nayak, Shreya Kataria, Vladimir Lukashevich, Apurba Das and Hamendra Singh Parmar*


DOI: 10.2174/1568009621666210901101851
View Abstract



Current challenges in targeting tumor desmoplasia to improve the efficacy of immunotherapy


Anna Kasperska*, Jędrzej Borowczak*, Krzysztof Szczerbowski*, Ewa Stec, Navid Ahmadi and Łukasz Szylber


DOI: 10.2174/1568009621666210825101456
View Abstract



DDX39B Predicts Poor Survival and Associated with Clinical Benefit of Anti-PD-L1 Therapy in ccRCC


Jinhuan Wei, Jun Lu, Yun Cao, Gaosheng Yao, Yong Huang, Hongwei Zhao, Yihui Pan, Zihao Feng, Zhenhua Chen, Wei Chen, Junhang Luo* and Jiazheng Cao*


DOI: 10.2174/1568009621666210811115054
View Abstract


Metastatic Breast Cancer, Organotropism and Therapeutics: A Review


Ajaz Ahmad Waza*, Najeebul Tarfeen, Sabhiya Majid, Yasmeena Hassan, Rashid Mir, Mohd Younis Rather and Naseer Ue Din Shah


DOI: 10.2174/1568009621666210806094410
View Abstract


Don’t overlook spleen glucose metabolism on [18F]-FDG PET/CT for cancer drug discovery and development


Romain-David Seban, Shwe Synn, Izza Muneer, Laurence Champion, Lawrence H. Schwartz and Laurent Dercle*


DOI: 10.2174/1568009621666210720143826
View Abstract


The Plasticity of Circulating Tumor Cells in Ovarian Cancer During Platinum-containing Chemotherapy


Gening Snezhanna O.*, Dolgova Dinara R., Abakumova Tatyana V., Antoneeva Inna I. and Gening Tatyana P.


DOI: 10.2174/1568009621666210720141229
View Abstract


Published Contents

Editor's Choice


Cholangiocarcinoma Therapeutics: An Update

, 2021; 21(6): 457 - 475

Mai Ly Thi Nguyen, Nguyen Linh Toan, Maria Bozko, Khac Cuong Bui* and Przemyslaw Bozko*


DOI: 10.2174/1568009621666210204152028




PROTACs: Promising Approaches for Epigenetic Strategies to Overcome Drug Resistance

, 2021; 21(4): 306 - 325

Sarah F. Giardina*, Elena Valdambrini, J. David Warren and Francis Barany


DOI: 10.2174/1568009621666210203110857



Novel MicroRNA Binding Site SNPs and the Risk of Clear Cell Renal Cell Carcinoma (ccRCC): A Case-Control Study

, 2021; 21(3): 203 - 212

Irina R. Gilyazova, Narasimha M. Beeraka, Elizaveta A. Klimentova, Kirill V. Bulygin, Vladimir N. Nikolenko, Adel A. Izmailov, Gulshat R. Gilyazova, Valentin N. Pavlov, Elsa K. Khusnutdinova, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1568009620666201120151226



Immunotherapy: A Potential Approach to Targeting Cancer Stem Cells

, 2021; 21(2): 117 - 131

Wenjun Wang, Ling Bai, Dongsheng Xu, Wei Li and Jiuwei Cui*


DOI: 10.2174/1568009620666200504111914



C-Myc Signaling Pathway in Treatment and Prevention of Brain Tumors

, 2021; 21(1): 2 - 20

Milad Ashrafizadeh, Ali Zarabi, Kiavash Hushmandi, Ebrahim Rahmani Moghadam, Farid Hashemi, Salman Daneshi, Fardin Hashemi, Shima Tavakol, Reza Mohammadinejad, Masoud Najafi*, Namrata Dudha and Manoj Garg*


DOI: 10.2174/1568009620666201016121005



Clinical Outcomes and Safety of Patients Treated with NAb-Paclitaxel Plus Gemcitabine in Metastatic Pancreatic Cancer: The NAPA Study

, 2020; 20(11): 887 - 895

Martina Catalano, Giandomenico Roviello*, Raffaele Conca, Alberto D’Angelo, Valeria Emma Palmieri, Benedetta Panella, Roberto Petrioli, Anna Ianza, Stefania Nobili, Enrico Mini and Monica Ramello


DOI: 10.2174/1568009620999200918122426



Selinexor (KPT-330), an Oral Selective Inhibitor of Nuclear Export (SINE) Compound, in Combination with FOLFOX in Patients with Metastatic Colorectal Cancer (mCRC) - Final Results of the Phase I Trial SENTINEL

, 2020; 20(10): 811 - 817

Sven Nilsson, Alexander Stein, Christian Rolfo, Anne L. Kranich, Julia Mann, Konstantinos Papadimitriou, Susann Theile, Stefanie Amberg and Carsten Bokemeyer*


DOI: 10.2174/1568009620666200628105727



Cancer Stem Cells with Overexpression of Neuronal Markers Enhance Chemoresistance and Invasion in Retinoblastoma

, 2020; 20(9): 710 - 719

Sekaran Balaji, Radhakrishnan Santhi, Usha Kim, Veerappan Muthukkaruppan, Chidambaranathan G. Priya and Ayyasamy Vanniarajan*


DOI: 10.2174/1568009620666200504112711



Open Access Articles

Re-Sensitizing Tumor Cells to Cancer Drugs with Epigenetic Regulators

, 2021; 21(4): 353 - 359

Stefanie Rauscher, Richard Greil and Roland Geisberger*




Tumor Penetrating Peptide-Functionalized Tenascin-C Antibody for Glioblastoma Targeting

, 2021; 21(1): 70 - 79

Prakash Lingasamy, Anett-Hildegard Laarmann and Tambet Teesalu *




Selinexor (KPT-330), an Oral Selective Inhibitor of Nuclear Export (SINE) Compound, in Combination with FOLFOX in Patients with Metastatic Colorectal Cancer (mCRC) - Final Results of the Phase I Trial SENTINEL

, 2020; 20(10): 811 - 817

Sven Nilsson, Alexander Stein, Christian Rolfo, Anne L. Kranich, Julia Mann, Konstantinos Papadimitriou, Susann Theile, Stefanie Amberg and Carsten Bokemeyer*




The Roles of Alternative Splicing in Tumor-immune Cell Interactions

, 2020; 20(10): 729 - 740

Yue Wang, Honglei Zhang*, Baowei Jiao*, Jianyun Nie*, Xiyin Li, Wenhuan Wang and Hairui Wang





Linc01638 Promotes Tumorigenesis in HER2+ Breast Cancer

, 2019; 19(1): 74 - 80

Peng Liu, Hailin Tang, Jiali Wu, Xingsheng Qiu, Yanan Kong, Lijuan Zhang, Xinhua Xie* and Xiangsheng Xiao*




Role of MicroRNAs in Treatment Response in Prostate Cancer

, 2018; 18(10): 929 - 944

Anshuli Razdan, Paul de Souza* and Tara Laurine Roberts




Noxa: Role in Cancer Pathogenesis and Treatment

, 2018; 18(10): 914 - 928

Rami Z. Morsi, Rouba Hage-Sleiman, Hadile Kobeissy and Ghassan Dbaibo*








Platycodin D Induces Tumor Growth Arrest by Activating FOXO3a Expression in Prostate Cancer in vitro and in vivo

, 2014; 14(9): 860 - 871

Rui Zhou, Zongliang Lu, Kai Liu, Jing Guo, Jie Liu, Yong Zhou, Jian Yang, Mantian Mi and Hongxia Xu




Pleiotropic Role of HSF1 in Neoplastic Transformation

, 2014; 14(2): 144 - 155

Natalia Vydra, Agnieszka Toma and Wieslawa Widlak






Most Cited Articles

Review Article

Polyploid giant cancer cells (PGCCs): The evil roots of cancer

, 2019; 19(5): 360-367.

Junsong Chen, Na Niu, Jing Zhang, Lisha Qi , Weiwei Shen , Krishna Vanaja Donkena, Zhenqing Feng and Jinsong Liu *


DOI: 10.2174/1568009618666180703154233


Review Article

Resveratrol as an adjuvant for normal tissues protection and tumor sensitization

, 2020; 20(2): 130-145.

Keywan Mortezaee, Masoud Najafi*, Bagher Farhood*, Amirhossein Ahmadi*, Dheyauldeen Shabeeb and Ahmed E. Musa


DOI: 10.2174/1568009619666191019143539


Review Article

Old and new approaches to target the hsp90 chaperone

, 2020; 20(4): 253-270.

Jackee Sanchez, Trever R. Carter, Mark S. Cohen* and Brian S.J. Blagg


DOI: 10.2174/1568009619666191202101330


Review Article

The RNA binding protein hur: A promising drug target for anticancer therapy

, 2019; 19(5): 382-399.

Mingxia Wu, Christy W.S. Tong, Wei Yan, Kenneth K.W. To* and William C.S. Cho*


DOI: 10.2174/1568009618666181031145953


Review Article

HSF1 as a cancer biomarker and therapeutic target

, 2019; 19(7): 515-524.

Richard L. Carpenter* and Yesim Gokmen-Polar


DOI: 10.2174/1568009618666181018162117


Review Article

Mesoporous silica nanoparticles as a prospective and promising approach for drug delivery and biomedical applications

, 2019; 19(4): 285-295.

Xiaohui Pu, Jia Li, Peng Qiao, Mengmeng Li, Haiyan Wang, Lanlan Zong*, Qi Yuan and Shaofeng Duan*


DOI: 10.2174/1568009619666181206114904


Review Article

Glycolysis inhibition as a strategy for hepatocellular carcinoma treatment?

, 2019; 19(1): 26-40.

A.P. Alves, A.C. Mamede, M.G. Alves, P.F. Oliveira, S.M. Rocha, M.F. Botelho and C.J. Maia*


DOI: 10.2174/1568009618666180430144441


Review Article

COVID-19 pandemic: Experiences in China and implications for its prevention and treatment worldwide

, 2020; 20(6): 410-416.

Ning-Ning Liu*, Jing-Cong Tan, Jingquan Li, Shenghui Li*, Yong Cai* and Hui Wang*


DOI: 10.2174/1568009620666200414151419



Research Article

Interactions of vascular endothelial growth factor and p53 with mir-195 in thyroid carcinoma: Possible therapeutic targets in aggressive thyroid cancers

, 2019; 19(7): 561-570.

Hamidreza Maroof , Soussan Irani , Armin Arianna, Jelena Vider, Vinod Gopalan and Alfred King-yin Lam *


DOI: 10.2174/1568009618666180628154727



Review Article

Epigenetics in metastatic breast cancer: Its regulation and implications in diagnosis, prognosis and therapeutics

, 2019; 19(2): 82-100.

Yuan Seng Wu, Zhong Yang Lee , Lay-Hong Chuah, Chun Wai Mai and Siew Ching Ngai*


DOI: 10.2174/1568009618666180430130248


Research Article

c-Myc inhibitor 10074-G5 induces murine and human hematopoietic stem and progenitor cell expansion and HDR modulator Rad51 expression

, 2019; 19(6): 479-494.

Merve Aksoz, Esra Albayrak, Galip Servet Aslan, Raife Dilek Turan, Lamia Yazgi Alyazici, Pınar Siyah, Emre Can Tuysuz, Serli Canikyan, Dogacan Yucel, Neslihan Meric, Zafer Gulbas, Fikrettin Sahin and Fatih Kocabas*


DOI: 10.2174/1568009618666180905100608



Review Article

Challenges and opportunities from basic cancer biology for nanomedicine for targeted drug delivery

, 2019; 19(4): 257-276.

Xiaodong Xie, Yingying Zhang, Fengqiao Li, Tingting Lv, Ziying Li, Haijun Chen, Lee Jia* and Yu Gao*


DOI: 10.2174/1568009618666180628160211



Most Accessed Articles




Cholangiocarcinoma Therapeutics: An Update

, 2021; 21(6): 457-475.

Mai Ly Thi Nguyen, Nguyen Linh Toan, Maria Bozko, Khac Cuong Bui* and Przemyslaw Bozko*


DOI: 10.2174/1568009621666210204152028


The Efficacy of Vitamin K, A Member Of Naphthoquinones in the Treatment of Cancer: A Systematic Review and Meta-Analysis

, 2021; 21(6): 495-513.

Dariimaa Ganbat, Bat-Erdene Jugder, Lkhamaa Ganbat, Miki Tomoeda, Erdenetsogt Dungubat, Yoshihisa Takahashi, Ichiro Mori, Takayuki Shiomi and Yasuhiko Tomita*


DOI: 10.2174/1568009621999210120182834






Effects of Iron Chelation in Osteosarcoma

, 2021; 21(5): 443-455.

Maura Argenziano, Alessandra Di Paola, Chiara Tortora, Daniela Di Pinto, Elvira Pota, Martina Di Martino, Silverio Perrotta, Francesca Rossi* and Francesca Punzo


DOI: 10.2174/1568009620666201230090531


The Mad2-Binding Protein p31comet as a Potential Target for Human Cancer Therapy

, 2021; 21(5): 401-415.

Ana C. Henriques, Patrícia M. A. Silva, Bruno Sarmento and Hassan Bousbaa*


DOI: 10.2174/1568009621666210129095726



Association of Polymorphism in Survivin Gene and the Risk of Liver Cancer Resulting from Hepatitis C Virus Among Egyptian Patients

, 2021; 21(6): 536-543.

Amal A. Mohamed, Aymen S. Yassin, Basma S. Gomaa, Hossam Darwish, Rasha S. Mohamed, Sahar Makled, Ahmed Ramdan, Sherief Abd-Elsalam* and Marwa M. Raafat


DOI: 10.2174/1568009621666210302090917



Oncolytic Adenovirus H101 Synergizes with Radiation in Cervical Cancer Cells

, 2021; 21(7): 619-630.

Yixin Duan, Haixia Bai, Xiang Li , Depu Wang , Ying Wang, Meng Cao, Nana Zhang, Hongwei Chen * and Yili Wang*


DOI: 10.2174/1568009621666210308103541




Editor-in-Chief

graphic
Ruiwen Zhang
Center for Drug Discovery
University of Houston
3455 Cullen Blvd.
Houston, TX 77204
(USA)
View Full Editorial Board

COPE Compliant

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Journal History

Current Cancer Drug Targets was launched in 2001. Dr. Ruiwen Zhang serves as the Editor-in-Chief of the journal.

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