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Current Drug Targets

Volume 22, 17 Issues, 2021
ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)
This journal supports open access

Aims & Scope

Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes.

Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication full-length/mini review articles and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

Current Drug Targets

,

Volume 22

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Number 15





Review Article

Inflammatory Bowel Disease in Migrant Populations: Should we Look Even Further Back?

, 22(15): 1706 - 1715

Gionata Fiorino, Maria M. Estevinho, Diogo J.M. Lopes, Filippo Chersi, Mariangela Allocca, Miguel T. Souto, Silvio Danese and Fernando Magro*


DOI: 10.2174/1389450122666210203193817


Review Article

Antiplatelet Effects of Bioactive Compounds Present in Tomato Pomace

, 22(15): 1716 - 1724

Eduardo Fuentes, Andrés Trostchansky*, Lívia M. Reguengo, Mario R.M. Junior and Iván Palomo*


DOI: 10.2174/1389450122999210128180456




Review Article

Implications of microRNAs in the Pathogenesis of Atherosclerosis and Prospects for Therapy

, 22(15): 1738 - 1749

Armita M. Gorabi, Mohsen Ghanbari, Thozhukat Sathyapalan, Tannaz Jamialahmadi and Amirhossein Sahebkar*


DOI: 10.2174/1389450122666210120143450








Current Drug Targets, Volume 22 (2021) - Number 16


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print



Dysregulation of Lysyl Oxidases Expression in Diabetic Nephropathy and Renal Cell Carcinoma


Carolina Añazco*, Sebastián Cerro, Nicolás Pereira, Camila Rojas, Álvaro Torres and Isabel Vidal-Beltrán


DOI: 10.2174/1389450122666210712163702
View Abstract


Lipid Metabolism and Mitochondria: Cross Talk in Cancer


Anubhav Srivastava, Pransu Srivastava, Shashank Mathur, Sabiya Abbas*, Neeraj Rai, Swasti Tiwari, Meenakshi Tiwari and Lokendra Sharma*


DOI: 10.2174/1389450122666210824144907
View Abstract View on PubMed


Thioethers: An Overview


M. İhsan Han and Ş. Güniz Küçükgüzel*


DOI: 10.2174/1389450122666210614121237
View Abstract





Polymer-dendrimer Hybrids as Carriers of Anticancer Agents


Guillermo Leobardo Rodríguez-Acosta, Carlos Hernández-Montalbán, María Fernanda Sabrina Vega-Razo, Irving Osiel Castillo-Rodríguez and Marcos Martínez-García*


DOI: 10.2174/1389450122666210906121803
View Abstract View on PubMed



Abstracts Ahead of Print


A Mechanistic Review on Plant-derived Natural Inhibitors of Human Coronaviruses with Emphasis on SARS-COV-1 and SARS-COV-2


Sai Krishna Guguloth, Lakshmi A R, Radhika Rajendran, Kaushik Rajaram, Thirunavukkarasu Chinnasamy, Jian-Dong Huang, Hongjie Zhang, Sanjib Senapati and Siva Sundara Kumar Durairajan*


DOI: 10.2174/1389450122666211005115313
View Abstract



Promising Protective Effects of Chrysin in Cardiometabolic Diseases


Marjan Talebi, Mohsen Talebi, Tahereh Farkhondeh, Jesus Simal-Gandara, Dalia M. Kopustinskiene, Jurga Bernatoniene, Ali Mohammad Pourbagher-Shahri and Saeed Samarghandian*


DOI: 10.2174/1389450122666211005113234
View Abstract




An Updated Review for the Diabetic Wound Healing Systems


Mehmet Evren Okur, Ece Özcan Bülbül, Gökçe Mutlu, Kalliopi Eleftherıadou, Ioannis D. Karantas, Neslihan Üstündağ Okur* and Panoraia I. Sıafaka*


DOI: 10.2174/1389450122666210914104428
View Abstract



Oral semaglutide in the management of type 2 DM: Clinical status and comparative analysis


Ilora Bandyopadhyay, Sunny Dave, Amita Rai, Madhavan Nampoothiri, Mallikarjuna Rao Chamallamudi and Nitesh Kumar*


DOI: 10.2174/1389450122666210901125420
View Abstract



Published Contents

Editor's Choice

GSK-3 Inhibitors: A New Class of Drugs for Alzheimer’s Disease Treatment

, 2021; 22(15): 1725 - 1737

Dilipkumar Pal, Souvik Mukherjee, In-Ho Song and Satish B. Nimse*


DOI: 10.2174/1389450122666210114095307



Role of Mitochondrial Heat-shock Proteins and Immunophilins in Neuro Degenerative Diseases

, 2021; 22(14): 1596 - 1617

Cristina Daneri-Becerra, Sol M. Ciucci, Gisela Mazaira and Mario D. Galigniana*


DOI: 10.2174/1389450121999201230204320





New Framework for the Discovery of PRC2 Inhibitors: Epigenetic Drugs

, 2021; 22(11): 1198 - 1206

Danishuddin, Naidu Subbarao*, Mohd Khan, Sultan Alouffi and Shahper Khan*


DOI: 10.2174/1389450122666210215111744




The Emergence of Immune-checkpoint Inhibitors in Colorectal Cancer Therapy

, 2021; 22(9): 1021 - 1033

Michele Ghidini*, Nicola Fusco, Massimiliano Salati, Shelize Khakoo, Gianluca Tomasello, Fausto Petrelli, Dario Trapani and Angelica Petrillo


DOI: 10.2174/1389450122666210204204415




MiRNA, a New Treatment Strategy for Pulmonary Fibrosis

, 2021; 22(7): 793 - 802

Yanhong Liu, Hongguang Nie*, Yan Ding, Yapeng Hou, Kejun Mao and Yong Cui


DOI: 10.2174/1874609813666200928141822



Progress in Detection of Insomnia Sleep Disorder: A Comprehensive Review

, 2021; 22(6): 672 - 684

Md Belal Bin Heyat, Faijan Akhtar, M.A. Ansari, Asif Khan, Fahed Alkahtani, Haroon Khan* and Dakun Lai*


DOI: 10.2174/1389450121666201027125828



Open Access Articles

Characteristic of Cyclodextrins: Their Role and Use in the Pharmaceutical Technology

, 2020; 21(14): 1495 - 1510

Malwina Lachowicz*, Andrzej Stańczak and Michał Kołodziejczyk




Recognition of Plasminogen Activator Inhibitor Type 1 as the Primary Regulator of Fibrinolysis

, 2019; 20(16): 1695 - 1701

Tetsumei Urano*, Yuko Suzuki, Takayuki Iwaki, Hideto Sano, Naoki Honkura and Francis J. Castellino




Current Understanding of Group A Streptococcal Biofilms

, 2019; 20(9): 982 - 993

Heema K.N. Vyas, Emma-Jayne Proctor, Jason McArthur, Jody Gorman and Martina Sanderson-Smith*








Opportunities of Bacterial Cellulose to Treat Epithelial Tissues

, 2019; 20(8): 808 - 822

Irene Anton-Sales, Uwe Beekmann, Anna Laromaine*, Anna Roig* and Dana Kralisch





Blood Eosinophils as Biomarkers to Drive Treatment Choices in Asthma and COPD

, 2018; 19(16): 1882 - 1896

Konstantinos Kostikas, Caterina Brindicci and Francesco Patalano*




Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm

, 2018; 19(11): 1265 - 1275

Koichi Yoshimura*, Noriyasu Morikage, Shizuka Nishino-Fujimoto, Akira Furutani, Bungo Shirasawa and Kimikazu Hamano





TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook

, 2017; 18(9): 1095 - 1103

Naif Mohammad Alhawiti, Saeed Al Mahri, Mohammad Azhar Aziz, Shuja Shafi Malik and Sameer Mohammad*







Most Cited Articles



Review Article

Cyclin-dependent kinase 2 in cellular senescence and cancer. A structural and functional review

, 2019; 20(7): 716-726.

Priscylla Andrade Volkart, Gabriela Bitencourt-Ferreira, André Arigony Souto* and Walter Filgueira de Azevedo *


DOI: 10.2174/1389450120666181204165344


Review Article

Celecoxib in cancer therapy and prevention - review

, 2019; 20(3): 302-315.

Natalia Tołoczko-Iwaniuk , Dorota Dziemiańczyk-Pakieła, Beata Klaudia Nowaszewska, Katarzyna Celińska-Janowicz and Wojciech Miltyk*


DOI: 10.2174/1389450119666180803121737



Review Article

High mobility group box-1 (HMGB1): A potential target in therapeutics

, 2019; 20(14): 1474-1485.

Eyaldeva C. Vijayakumar, Lokesh Kumar Bhatt* and Kedar S. Prabhavalkar


DOI: 10.2174/1389450120666190618125100



Review Article

A survey for predicting enzyme family classes using machine learning methods

, 2019; 20(5): 540-550.

Jiu-Xin Tan, Hao Lv, Fang Wang, Fu-Ying Dao, Wei Chen* and Hui Ding*


DOI: 10.2174/1389450119666181002143355


Review Article

Opportunities of bacterial cellulose to treat epithelial tissues

, 2019; 20(8): 808-822.

Irene Anton-Sales, Uwe Beekmann, Anna Laromaine*, Anna Roig* and Dana Kralisch


DOI: 10.2174/1389450120666181129092144



Review Article

CDK9 as an appealing target for therapeutic interventions

, 2019; 20(4): 453-464.

Shirin Eyvazi, Mohammad Saeid Hejazi, Homan Kahroba, Mozghan Abasi, Reza Eghdam Zamiri and Vahideh Tarhriz*


DOI: 10.2174/1389450119666181026152221


Review Article

Exosomes in therapy: Engineering, pharmacokinetics and future applications

, 2019; 20(1): 87-95.

Claudia Arenaccio, Chiara Chiozzini, Flavia Ferrantelli, Patrizia Leone, Eleonora Olivetta and Maurizio Federico*


DOI: 10.2174/1389450119666180521100409


Review Article

Bioinformatics approaches for anti-cancer drug discovery

, 2020; 21(1): 3-17.

Kening Li, Yuxin Du, Lu Li and Dong-Qing Wei*


DOI: 10.2174/1389450120666190923162203


Review Article

Inhibition of RAGE axis signaling: A pharmacological challenge

, 2019; 20(3): 340-346.

Armando Rojas*, Miguel Morales, Ileana Gonzalez and Paulina Araya


DOI: 10.2174/1389450119666180820105956




Most Accessed Articles


CD47 Functionalization of Nanoparticles as a Poly(ethylene glycol) Alternative: A Novel Approach to Improve Drug Delivery

, 2021; 22(15): 1750-1759.

Noushin R. Vandchali, Fatemeh Moadab, Eskandar Taghizadeh, Amir Tajbakhsh and Seyed M. Gheibihayat*


DOI: 10.2174/1389450122666210204203514



Inflammatory Bowel Disease in Migrant Populations: Should we Look Even Further Back?

, 2021; 22(15): 1706-1715.

Gionata Fiorino, Maria M. Estevinho, Diogo J.M. Lopes, Filippo Chersi, Mariangela Allocca, Miguel T. Souto, Silvio Danese and Fernando Magro*


DOI: 10.2174/1389450122666210203193817


Implications of microRNAs in the Pathogenesis of Atherosclerosis and Prospects for Therapy

, 2021; 22(15): 1738-1749.

Armita M. Gorabi, Mohsen Ghanbari, Thozhukat Sathyapalan, Tannaz Jamialahmadi and Amirhossein Sahebkar*


DOI: 10.2174/1389450122666210120143450



Antiplatelet Effects of Bioactive Compounds Present in Tomato Pomace

, 2021; 22(15): 1716-1724.

Eduardo Fuentes, Andrés Trostchansky*, Lívia M. Reguengo, Mario R.M. Junior and Iván Palomo*


DOI: 10.2174/1389450122999210128180456






Role of Mitochondrial Heat-shock Proteins and Immunophilins in Neuro Degenerative Diseases

, 2021; 22(14): 1596-1617.

Cristina Daneri-Becerra, Sol M. Ciucci, Gisela Mazaira and Mario D. Galigniana*


DOI: 10.2174/1389450121999201230204320


Aging of Brain Related with Mitochondrial Dysfunctions

, 2021; 22(14): 1668-1687.

Vipin Dhote*, Prem Samundre, Aditya Ganeshpurkar and Aman Upaganlawar


DOI: 10.2174/1389450121999201209202247



Current Perspectives of Healthy Mitochondrial Function for Healthy Neurons

, 2021; 22(14): 1688-1703.

Muthuraman Arunachalam*, Muthusamy Ramesh*, Venkataratinakumar Thiagarajan, Sumeet K. Singla, Seema Mudhol and Serva P. Muthukumar


DOI: 10.2174/1389450122666210222163528




Editor-in-Chief

graphic
Francis J. Castellino
(14643 citations)
Dean Emeritus, College of Science,
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
(USA)
View Full Editorial Board

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Journal History

Current Drug Targets Journal was launched in 2000. Dr. Francis J. Castellino serves as the Editor-in-Chief of the journal.

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