Bentham Science Logo
Journal Cover

Track Your Manuscript:


Current Topics in Medicinal Chemistry

Volume 21, 32 Issues, 2021
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Current Topics in Medicinal Chemistry

,

Volume 21

-

Number 15







Review Article

Relevance of Aromatase Inhibitors in Breast Cancer Treatment

, 21(15): 1319 - 1336

Ankita Sood, Damanpreet Kaur Lang, Rajwinder Kaur*, Balraj Saini and Sandeep Arora


DOI: 10.2174/1568026621666210701143445


Review Article



Review Article

Nanotechnology, A Tool for Diagnostics and Treatment of Cancer

, 21(15): 1360 - 1376

Abdul Nasir, Amir Khan, Jiayi Li, Muhammad Naeem, Atif Ali Khan Khalil, Khalid Khan and Muhammad Qasim*


DOI: 10.2174/1568026621666210701144124


Review Article

1,3,4-Oxadiazoles as Potential Pharmacophore for Cytotoxic Potentiality: A Comprehensive Review

, 21(15): 1377 - 1397

Divya Sharma, Salahuddin*, Vikas Sharma, Rajnish Kumar, Sagar Joshi, Sunita Kumari, Shivani Saxena, Avijit Mazumder, Mohammad Shahar Yar and Mohamed Jawed Ahsan


DOI: 10.2174/1568026621666210612031144






Current Topics in Medicinal Chemistry, Volume 21 (2021) - Number 20


This issue is in progress but contains articles that are final and fully citable.

Current Topics in Medicinal Chemistry, Volume 21 (2021) - Number 19


This issue is in progress but contains articles that are final and fully citable.

Current Topics in Medicinal Chemistry, Volume 21 (2021) - Number 18


This issue is in progress but contains articles that are final and fully citable.

Current Topics in Medicinal Chemistry, Volume 21 (2021) - Number 17


This issue is in progress but contains articles that are final and fully citable.

Current Topics in Medicinal Chemistry, Volume 21 (2021) - Number 16


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print





An Update on the Synthesis and Applications of Bis(Naphthoquinones): An Important Class of Molecules against Infectious Diseases and other Conditions


Luana da S. M. Forezi*, Acácio S. de Souza, Carolina G. S. Lima, Amanda A. Borges, Patricia G. Ferreira, Marcela C. P. Barros, Debora O. Futuro, Fernando de C. da Silva and Vitor F. Ferreira*


DOI: 10.2174/1568026621666210727165421
View Abstract View on PubMed


Phenanthrene Dimers: Promising Source of Biologically Active Molecules


Antonino De Natale, Antonino Pollio, Anna De Marco, Giovanni Luongo, Giovanni Di Fabio and Armando Zarrelli*


DOI: 10.2174/1568026621666210813113918
View Abstract View on PubMed



Investigation of the Relationship Among Cortisol, Pro-inflammatory Cytokines, and the Degradation of Tryptophan into Kynurenine in Patients with Major Depression and Suicidal Behavior


Amel Messaoud, Mensi Rym, Douki Wahiba, Fadoua Neffati, Mohamed Fadhel Najjar, Gabriella Gobbi, Mirko Manchia, Flavia Valtorta, Gaha Lotfi* and Stefano Comai*


DOI: 10.2174/1568026621666210909160210
View Abstract View on PubMed




Abstracts Ahead of Print

Bergenin – a biologically active scaffold: Nanotechnological perspectives


Reecha Madaan, Rajeev K. Singla*, Suresh Kumar, Ankit Kumar Dubey, Dinesh Kumar, Pooja Sharma, Rajni Bala, Shailja Singla and Bairong Shen


DOI: 10.2174/1568026621666211015092654
View Abstract


Advances in the Design and Development of PROTAC-mediated HDAC degradation


Daniel Alencar Rodrigues*, Andrew Roe, Darren Griffith and Tríona Ní Chonghaile


DOI: 10.2174/1568026621666211015092047
View Abstract







Computer-Aided Design of Coumarins for Neurodegenerative diseases: Trends of the Last Decade


Estela Guardado Yordi, Lourdes Santana, Eugenio Uriarte, Fernanda Borges and Maria J. Matos*


DOI: 10.2174/1568026621666211011101429
View Abstract


QSAR Studies to Predict Activity of HSP90 Inhibitors


Vaishali M. Patil*, Neeraj Masand, Satya P. Gupta and Brian S. J. Blagg


DOI: 10.2174/1568026621666211011095858
View Abstract



Published Contents

Editor's Choice


Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*


DOI: 10.2174/1568026618666180821145215




A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*


DOI: 10.2174/1568026618666180516123229




Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610






Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao


DOI: 10.2174/1568026618666180410151518



Open Access Articles

An Overview of Ovarian Cancer: Molecular Processes Involved and Development of Target-based Chemotherapeutics

, 2021; 21(4): 329 - 346

Basheerulla Shaik, Tabassum Zafar, Krishnan Balasubramanian and Satya P. Gupta*





Beyond DNA-targeting in Cancer Chemotherapy. Emerging Frontiers - A Review

, 2021; 21(1): 28 - 47

Simon N. Mbugua, Lydia W. Njenga, Ruth A. Odhiambo, Shem O. Wandiga and Martin O. Onani*




Peptide Receptor Radionuclide Therapy: Looking Back, Looking Forward

, 2020; 20(32): 2959 - 2969

Danny Feijtel, Marion de Jong and Julie Nonnekens*




Learning the Edit Costs of Graph Edit Distance Applied to Ligand-Based Virtual Screening

, 2020; 20(18): 1582 - 1592

Carlos Garcia-Hernandez, Alberto Fernández* and Francesc Serratosa




Telomere-related Markers for Cancer

, 2020; 20(6): 410 - 432

Xiaotian Yuan*, Mingkai Dai and Dawei Xu*






Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19(18): 1621 - 1649

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*




Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

, 2019; 19(16): 1399 - 1417

Chenyi Liao, Mathilde P. de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May* and Jianing Li*




Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity

, 2019; 19(11): 957 - 969

Ana Yisel Caballero-Alfonso, Maykel Cruz-Monteagudo, Eduardo Tejera, Emilio Benfenati, Fernanda Borges, M. Natália D.S. Cordeiro, Vinicio Armijos-Jaramillo and Yunierkis Perez-Castillo*





Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*




Mechanical Properties of Composite Hydrogels for Tissue Engineering

, 2018; 18(14): 1214 - 1223

Ramon Rial, J.F. Armando Soltero, Pedro V. Verdes, Zhen Liu and Juan M. Ruso*






Most Cited Articles


Review Article

Molecular hybridization as a tool for designing multitarget drug candidates for complex diseases

, 2019; 19(19): 1694-1711.

Viktoriya Ivasiv, Claudia Albertini, Ana E. Gonçalves, Michele Rossi and Maria L. Bolognesi*


DOI: 10.2174/1568026619666190619115735




Review Article

Biological signatures of alzheimer’s disease

, 2020; 20(9): 770-781.

Poornima Sharma, Anjali Sharma, Faizana Fayaz, Sharad Wakode* and Faheem H. Pottoo


DOI: 10.2174/1568026620666200228095553


Review Article

Biological activities of artemisinin derivatives beyond malaria

, 2019; 19(3): 205-222.

Xiaoyan Liu, Jianguo Cao, Guozheng Huang*, Qingjie Zhao* and Jingshan Shen


DOI: 10.2174/1568026619666190122144217


Review Article

Discovery and development of anti-HIV therapeutic agents: Progress towards improved HIV medication

, 2019; 19(18): 1621-1649.

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*


DOI: 10.2174/1568026619666190712204603


Review Article

Mycobacterial tuberculosis Enzyme Targets and their Inhibitors

, 2019; 19(5): 337-355.

Anil Kumar Saxena* and Anamika Singh


DOI: 10.2174/1568026619666190219105722


Review Article

STAT3: A potential drug target for tumor and inflammation

, 2019; 19(15): 1305-1317.

Yang Sheng Hu, Xu Han and Xin Hua Liu*


DOI: 10.2174/1568026619666190620145052





Review Article

Virtual screening techniques in drug discovery: Review and recent applications

, 2019; 19(19): 1751-1767.

Sheisi F.L. da Silva Rocha, Carolina G. Olanda, Harold H. Fokoue and Carlos M.R. Sant'Anna*


DOI: 10.2174/1568026619666190816101948


Review Article

Zinc-depend ent deacetylase (HDAC) inhibitors with different zinc binding groups

, 2019; 19(3): 223-241.

Yan Li, Fang Wang, Xiaoxue Chen, Jie Wang, Yonglong Zhao, Yongjun Li and Bin He*


DOI: 10.2174/1568026619666190122144949




Most Accessed Articles








Contrasting Roles of the Galectin-3 in the Schizophrenia Onset, Clinical Presentation, and Somatic Comorbidity

, 2021; 21(16): 1471-1487.

Milica M. Borovcanin*, Gordana D. Radosavljevic, Jelena Pantic, Jelena Milovanovic, Natasa R. Mijailovic, Aleksandar N. Arsenijevic and Nebojsa N. Arsenijevic


DOI: 10.2174/1568026621666210611162420


The Recent Development of Tetrahydro-Quinoline/Isoquinoline Based Compounds as Anticancer Agents

, 2021; 21(17): 1587-1622.

Pratik Yadav, Ashish Kumar, Ismail Althagafi, Vishal Nemaysh, Reeta Rai* and Ramendra Pratap*


DOI: 10.2174/1568026621666210526164208


A Review on Natural Sources Derived Protein Nanoparticles as Anticancer Agents

, 2021; 21(12): 1014-1026.

Tanima Bhattacharya, Samka P. Maishu, Rokeya Akter, Md. H. Rahman*, Muhammad F. Akhtar, Ammara Saleem, May Bin-Jumah, Mohamed Kamel, Mervat A. Abdel-Latif and Mohamed M. Abdel-Daim*


DOI: 10.2174/1568026621666210412151700



NGS-based mtDNA Profiling Could Reveal Genetic Alterations in Schizophrenia

, 2021; 21(11): 938-948.

Elena Mihailova Ivanova*, Snezhina Mihailova Kandilarova, Tzvetelin Ivanov Lukanov, Elissaveta Jordanova Naumova, Katerina Valentinova Akabalieva and Vihra Krumova Milanova


DOI: 10.2174/1568026621666210521155500


Review on Pharmacological and Phytochemical Prospects of Traditional Medicinal Plant: Persicaria hydropiper (Smartweed)

, 2021; 21(12): 1027-1036.

Abdul Nasir, Atif A.K. Khalil*, Muhammad Z. Bhatti, Ashfaq Ur Rehman, Jiayi Li and Zahida Parveen


DOI: 10.2174/1568026621666210303145045


Cellular Bioenergetic and Metabolic Changes in Patients with Autism Spectrum Disorder

, 2021; 21(11): 985-994.

Maria Gevezova, Danail Minchev, Iliana Pacheva, Yordan Sbirkov, Ralitsa Yordanova, Elena Timova, Vasil Kotetarov, Ivan Ivanov and Victoria Sarafian*


DOI: 10.2174/1568026621666210521142131





Editor-in-Chief

graphic
Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX
(USA)
Biography
View Full Editorial Board

COPE Compliant

Cope Logo

Journal History

Current Topics in Medicinal Chemistry was introduced in 2001 with the assistance of Dr. Allen B. Reitz, who served as the editor-in-chief from 2001 to 2020. Currently, Dr. Jia Zhou is the Editor-in-Chief of the journal.

Related Journals

Related eBooks

eBooks Catalog