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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Volume 19, 18 Issues, 2019
ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)
This journal supports open access

Aims & Scope

Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.

Each issue contains a series of timely in-depth/mini reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication.

Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.

Anti-Cancer Agents in Medicinal Chemistry

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Volume 19

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Number 1



Biography   Open Access



Overview   Open Access



Preface   Open Access



Editorial   Open Access



Review Article

Hybrid Magnetic Nanostructures For Cancer Diagnosis And Therapy

, 19(1): 6 - 16

Ioana L. Ardelean, Denisa Ficai*, Maria Sonmez, Ovidiu Oprea, Gheorghe Nechifor, Ecaterina Andronescu, Anton Ficai and Mihail A. Titu


DOI: 10.2174/1871520618666181109112655


Review Article



Review Article



Review Article



Anti-Cancer Agents in Medicinal Chemistry, Volume 19 (2019) - Number 4


This issue is in progress but contains articles that are final and fully citable.

Anti-Cancer Agents in Medicinal Chemistry, Volume 19 (2019) - Number 3


This issue is in progress but contains articles that are final and fully citable.

Anti-Cancer Agents in Medicinal Chemistry, Volume 19 (2019) - Number 2


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print











Abstracts Ahead of Print


STK33-dependent transcriptional regulation of SFTA3 induces Cisplatin-resistance in lung adenocarcinoma


Kuilong Zhou, Runzhi Dong, Zhiheng Wang, Zhian Tang, Xuezhen Gao, Yaqing Du, Xiaoli Zhang, Xiangying Li and Qingfan Xie*


View Abstract


Berberine as Source of Antiproliferative Hybrid Compounds: In vitro Antiproliferative Activity and Quantitative Structure-Activity Relationship


Mario Alberto Leyva-Peraltaa, Ramón Enrique Robles-Zepedab, Rodrigo Said Razo-Hernándezc, Laura Patricia Álvarez Berberd, Karen Ochoa Laraa, Eduardo Ruiz-Bustosb and Juan Carlos Gálvez-Ruízb*


View Abstract


Anti-Tumor Mechanisms of Novel 3-(4-Substituted Benzyl)-5-Isopropil-5-Phenylhydantoin Derivatives on Human Colon Cancer Cell Line


Ana Obradovića, Miloš Matića, Branka Ognjanovića, Nenad Vukovićb, Milena Vukićb, Predrag Djurdjevic, Gordana Ušćumlićd, Bojan Božiće and Biljana Božić Nedeljkoviće*


View Abstract



A cytotoxic natural product from Patrinia villosa Juss


Yangcheng Liu, Wei Liu, Changlan Chen, Zheng Xiang and Hongwei Liu*


View Abstract


Bevacizumab Allows Preservation Of Liver Function and its Regenerative Capacity After Major Hepatectomy


Amparo Valverde, Rubén Ciria, Javier Caballero-Villarras*, Patricia Aguilar-Melero, Gustavo Ferrín, Isidora Ranchal, Clara Linares, Carmen Herencia, Sandra González-Rubio, Manuel de la Mata, Álvaro Naranjo and Javier Briceño


View Abstract



An Inventive Report of Inducing Apoptosis in Non-Small Cell Lung Cancer (NSCLC) Cell Lines by Transfection of MiR-4301


Abbas Jamshidi Avval, Ahmad Majd, Naghmeh Gholipour, Kambiz Akbari Noghabi, Anna Ohradanova-Repic and Ghasem Ahangari*


View Abstract


Prognosis Significance and Positive Correlation of Rab1A and p-S6K/Gli1 Expression in Gastric Cancer


Xinyu Shao, Zhengwu Cheng, Menglin Xu, Jiading Mao, Junfeng Wang* and Chunli Zhou*


View Abstract


Published Contents

Editor's Choice


Biological Activity and Physicochemical Properties of Dipeptidyl Nitrile Derivatives Against Pancreatic Ductal Adenocarcinoma Cells

, 2019; 19(1): 112 - 120

José C. Quilles Jr, Murillo D.L. Bernardi, Pedro H.J. Batista, Samelyn C.M. Silva, Camila M.R. Rocha, Carlos A. Montanari and Andrei Leitão*


DOI: 10.2174/1871520618666181029141649



Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention

, 2019; 19(1): 38 - 47

Alessandro Colapietro, Andrea Mancini, Anna Maria D'Alessandro and Claudio Festuccia*


DOI: 10.2174/1871520619666181231112453



Biomarkers in Non-Small Cell Lung Cancer: Perspectives of Individualized Targeted Therapy

, 2018; 18(15): 2070 - 2077

Mateus N. Aoki*, Marla K. Amarante, Carlos E.C. de Oliveira and Maria A.E. Watanabe


DOI: 10.2174/1871520618666180827102101





Association of Phytol with Toxic and Cytotoxic Activities in an Antitumoral Perspective: A Meta-Analysis and Systemic Review

, 2018; 18(13): 1828 - 1837

Marcus V.O.B. Alencar, Muhammad T. Islam*, Eunus S. Ali, José V.O. Santos, Márcia F.C.J. Paz, João M.C. Sousa, Sandra M.M.M. Dantas, Siddhartha K. Mishra* and Ana A.C.M. Cavalcante


DOI: 10.2174/1871520618666180821113830



One-Pot Synthesis of Triazolo-Heterolignans: Biological Evaluation and Molecular Docking Studies as Tubulin Inhibitors

, 2018; 18(12): 1702 - 1710

Chada Raji Reddy*, Muppidi Subbarao, Jonnalagadda Vijaykumar, Surender Singh Jadav, Nilesh Sasane, Reddi Rani Valleti, Bhukya Supriya and Ramesh Ummanni*


DOI: 10.2174/1871520618666180718104647



Selection of a GPER1 Ligand via Ligand-based Virtual Screening Coupled to Molecular Dynamics Simulations and Its Anti-proliferative Effects on Breast Cancer Cells

, 2018; 18(11): 1629 - 1638

Alberto Martínez-Muñoz, Berenice Prestegui-Martel, David Méndez-Luna, Manuel J. Fragoso-Vázquez*, José Rubén García-Sánchez, Martiniano Bello, Marlet Martínez-Archundia, Alma Chávez-Blanco, Alfonso Dueñas-González, Irene Mendoza-Lujambio, José Trujillo-Ferrara and José Correa-Basurto*


DOI: 10.2174/1871520618666180510121431




Open Access Articles

New Strategies for Therapeutic Cancer Vaccines

, 2019; 19(2): 213 - 221

Hanjiao Qin, Jiyao Sheng, Dan Zhang, Xuewen Zhang, Linlin Liu*, Bingjin Li*, Guangquan Li* and Zhuo Zhang




Nicotinamide Overcomes Doxorubicin Resistance of Breast Cancer Cells through Deregulating SIRT1/Akt Pathway

, 2019; 19: 1 - 10 (E-Pub Ahead of Print)

Yingze Wei, Yan Guo, Jianyun Zhou, Kui Dai, Qiang Xu and Xiaoxia Jin*




Trichinella spiralis and Tumors: Cause, Coincidence or Treatment?

, 2018; 18(8): 1091 - 1099

Chengshui Liao*, Xiangchao Cheng, Mingyuan Liu*, Xuelin Wang and Pascal Boireau




Astragalin Attenuates UVB Radiation-induced Actinic Keratosis Formation

, 2018; 18(7): 1001 - 1008

Na Li, Kun Zhang, Xin Mu, Qiong Tian, Wenli Liu, Tianyuan Gao, Xiaona Ma* and Jian Zhang*





Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals

, 2016; 16(11): 1385 - 1402

Alessandra Bosutti, Fabrizio Zanconati, Gabriele Grassi, Barbara Dapas, Sabina Passamonti and Bruna Scaggiante




Blood-Brain Barrier and Breast Cancer Resistance Protein: A Limit to the Therapy of CNS Tumors and Neurodegenerative Diseases

, 2016; 16(7): 810 - 815

Anna Lisa Iorio, Martina da Ros, Ornella Fantappiè, Maurizio Lucchesi, Ludovica Facchini, Alessia Stival, Sabrina Becciani, Milena Guidi, Claudio Favre, Maurizio de Martino, Lorenzo Genitori and Iacopo Sardi




The Use of Anthracyclines for Therapy of CNS Tumors

, 2015; 15(6): 721 - 727

Martina da Ros, Anna Lisa Iorio, Maurizio Lucchesi, Alessia Stival, Maurizio de Martino and Iacopo Sardi






Episensitization: Therapeutic Tumor Resensitization by Epigenetic Agents: A Review and Reassessment

, 2014; 14(8): 1121 - 1127

Bryan Oronsky, Neil Oronsky, Susan Knox, Gary Fanger and Jan Scicinski




Preclinical Development of Novel Rac1-GEF Signaling Inhibitors using a Rational Design Approach in Highly Aggressive Breast Cancer Cell Lines

, 2014; 14(6): 840 - 851

Georgina A. Cardama, Maria J. Comin, Leandro Hornos, Nazareno Gonzalez, Lucas Defelipe, Adrian G. Turjanski, Daniel F. Alonso, Daniel E. Gomez and Pablo Lorenzano Menna




β2-Microglobulin-mediated Signaling as a Target for Cancer Therapy

, 2014; 14(3): 343 - 352

Takeo Nomura, Wen-Chin Huang, Haiyen E. Zhau, Sajni Josson, Hiromitsu Mimata and Leland W. K. Chung





Cytotoxicity and Apoptosis Induced by a Plumbagin Derivative in Estrogen Positive MCF-7 Breast Cancer Cells

, 2014; 14(1): 170 - 180

Sunil Sagar, Luke Esau, Basem Moosa, Niveen M. Khashab, Vladimir B. Bajic and Mandeep Kaur





Most Cited Articles


Review Article

Recent development of sulfonyl or sulfonamide hybrids as potential anticancer agents: A key review

, 2018; 18(4): 488-505.

K. P. Rakesh, Shi-Meng Wang, Jing Leng, L. Ravindar, Abdullah M. Asiri, Hadi M. Marwani and Hua-Li Qin*


DOI: 10.2174/1871520617666171103140749


Research Article

Effects of plasma activated medium on head and neck fadu cancerous cells: Comparison of 3D and 2D response

, 2018; 18(6): 776-783.

Julie Chauvin, Florian Judee, Nofel Merbahi* and Patricia Vicendo


DOI: 10.2174/1871520617666170801111055


Research Article

Structure-based design: Synthesis, X-ray crystallography, and biological evaluation of N-substituted-4-hydroxy-2-quinolone-3-carboxamides as potential cytotoxic agents

, 2018; 18(2): 263-276.

Dima A. Sabbah*, Bayan Hishmah, Kamal Sweidan, Sanaa Bardaweel, Murad AlDamen, Haizhen A. Zhong, Reema Abu Khalaf, Ameerah (Hasan Ibrahim), Tariq Al-Qirim, Ghassan Abu Sheikha and Mohammad S. Mubarak


DOI: 10.2174/1871520617666170911171152


Research Article

Design and discovery of novel quinoxaline derivatives as dual DNA intercalators and topoisomerase II inhibitors

, 2018; 18(2): 195-209.

Ibrahim H. Eissa, Abeer M. El-Naggar*, Nour E.A. Abd El-Sattar and Ahmed S.A. Youssef


DOI: 10.2174/1871520617666170710182405



Research Article

Apoptosis caused by triterpenes and phytosterols and antioxidant activity of an enriched flavonoid extract from passiflora mucronata

, 2018; 18(10): 1405-1416.

Isabel C.V. da Silva, Goran N. Kaluđerović, Pollyana F. de Oliveira, Denise O. Guimarães, Carla H. Quaresma, Andrea Porzel, Michelle F. Muzitano, Ludger A. Wessjohann and Ivana C.R. Leal*


DOI: 10.2174/1871520618666180315090949


Review Article

Critical microRNAs in lung cancer: Recent advances and potential applications

, 2018; 18(14): 1991-2005.

Habib Zarredar, Khalil Ansarin, Behzad Baradaran, Najibeh Shekari, Shirin Eyvazi , Fateme Safari and Safar Farajnia*


DOI: 10.2174/1871520618666180808125459



Research Article

How does plasma activated media treatment differ from direct cold plasma treatment?

, 2018; 18(6): 805-814.

Pankaj Attri*, Ji Hoon Park, Anser Ali and Eun Ha Choi


DOI: 10.2174/1871520618666180406121734


General Research Article

Ros-scavenging and anti-tyrosinase properties of crocetin on B16F10 murine melanoma cells

, 2018; 18(7): 1064-1069.

Seyed H. Hashemi-Shahri, Alireza Golshan, Seyed A. Mohajeri, Javad Baharara, Elaheh Amini, Farzaneh Salek, Amirhossein Sahebkar and Zahra Tayarani-Najaran*


DOI: 10.2174/1871520618666171213143455


Research Article

Cold physical plasma-treated buffered saline solution as effective agent against pancreatic cancer cells

, 2018; 18(6): 824-831.

Sander Bekeschus*, André Käding, Tim Schröder, Kristian Wende, Christine Hackbarth, Kim R. Liedtke, Julia van der Linde, Thomas von Woedtke, Claus-Dieter Heidecke and Lars-Ivo Partecke


DOI: 10.2174/1871520618666180507130243


Review Article

An overview of natural plant products in the treatment of hepatocellular carcinoma

, 2018; 18(13): 1838-1859.

Divya Rawat, Somi Shrivastava, Rayees A Naik, Saurabh K. Chhonker, Aditi Mehrotra and Raj K. Koiri*


DOI: 10.2174/1871520618666180604085612


General Review Article

Coumarin derivatives as anticancer agents for lung cancer therapy: A review

, 2018; 18(7): 964-984.

Manvendra Kumar, Ramit Singla, Jyoti Dandriyal and Vikas Jaitak*


DOI: 10.2174/1871520618666171229185926




Most Accessed Articles




Potential Pharmacological Inhibitors of Pim Kinase Under Clinical Trials

, 2018; 18(8): 1100-1114.

Gomathi P. Jeyapal, Moola J.N. Chandrasekar*, Rajendiran Krishnasamy, Jubie Selvaraj, Manal Mohammad and Moola J. Nanjan


DOI: 10.2174/1871520618666180131113519


Determination of the Apoptotic Effect and Molecular Docking of Benzamide Derivative XT5 in K562 Cells

, 2018; 18(11): 1521-1530.

Tulin Ozkan*, Yalda Hekmatshoar*, Tugba Ertan-Bolelli, Andry N. Hidayat, Meral Beksac, Esin Aki-Yalcin, Ismail Yalcin and Asuman Sunguroglu


DOI: 10.2174/1871520618666171229222534


Synthesis and Evaluation of a New Series of Arylidene Indanones as Potential Anticancer Agents

, 2018; 18(10): 1394-1404.

Ahmet Özdemir*, Sevtem Gökbulut, Belgin Sever, Gülşen A. Çiftçi and Mehlika D. Altıntop


DOI: 10.2174/1871520618666171206111923


The Role of Heat Shock Proteins in Cisplatin Resistance

, 2018; 18(15): 2093-2109.

Zdzisław Krawczyk, Agnieszka Gogler-Pigłowska, Damian R. Sojka and Dorota Scieglinska*


DOI: 10.2174/1871520618666180817114952


Cancer Nanotechnology-An Excursion on Drug Delivery Systems

, 2018; 18(15): 2078-2092.

Mala Sharma, Chitranshu Pandey, Neha Sharma, Mohammad A. Kamal, Usman Sayeed and Salman Akhtar*


DOI: 10.2174/1871520618666180720164015


BRCA1 as Target for Breast Cancer Prevention and Therapy

, 2015; 15(1): 4-14.

Alberto P.G. Romagnolo, Donato F. Romagnolo and Ornella I. Selmin


DOI: 10.2174/1871520614666141020153543


Biomarkers in Non-Small Cell Lung Cancer: Perspectives of Individualized Targeted Therapy

, 2018; 18(15): 2070-2077.

Mateus N. Aoki*, Marla K. Amarante, Carlos E.C. de Oliveira and Maria A.E. Watanabe


DOI: 10.2174/1871520618666180827102101




Editor-in-Chief

Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
ICCF-CNRS UMR 6296
Université Clermont Auvergne
Clermont-Ferrand
France

Journal History

Current Medicinal Chemistry - Anti-Cancer Agents was launched in 2001 and later renamed in 2006 as Anti-Cancer Agents in Medicinal Chemistry.

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