Bentham Science Logo

Track Your Manuscript:


Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Volume 21, 18 Issues, 2021
ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)
This journal supports open access

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Articles Ahead of Print


Alpha-Terpineol as Antitumor Candidate in Pre-Clinical Studies


Helber A. Negreiros, Kariely G. de Moura, Maria L.L.B. do Nascimento, Débora C.N. Rodrigues, Paulo M.P. Ferreira, Débora C. Braz, Marlene G. de Farias, Layde S. Corrêia, Ana R.S. Pereira, Lubna K.B. Santos, Juan C.R. Gonçalves, Anderson N. Mendes, Felipe C.C. da Silva, Ana A.C. Melo-Cavalcante and João M. de Castro e Sousa*


DOI: 10.2174/1871520621999210104195820
View Abstract





Antimutagenic, Antiproliferative and Antioxidant Properties of Sea Grape Leaf Extract Fractions (Coccoloba uvifera L.)


Jorge A. Ramos-Hernández, Montserrat Calderón-Santoyo, Armando Burgos-Hernández, Joel S. García- Romo, Arturo Navarro-Ocaña, María G. Burboa-Zazueta, Edgar Sandoval-Petris and Juan A. Ragazzo- Sánchez*


DOI: 10.2174/1871520621999210104201242
View Abstract


Anti-MDR Effects of Quercetin and its Nanoemulsion in Multidrug Resistant Human Leukemia Cells


Maiara Bernardes Marques, Ayane Pontes Machado, Priscila Antiqueira Santos, Michele Carrett-Dias, Gabriela Soares Araújo, Barbara da Silva Alves, Bárbara Santos de Oliveira, Flavio M. R. da Silva Júnior, Cristiana Lima Dora, Andrés Delgado Cañedo, Daza M. V. B. Filgueira, Estela Fernandes e Silva* and Ana Paula de Souza Votto


DOI: 10.2174/1871520621999210104200722
View Abstract



99mTechnetium- or Cy7-Labeled Fab(Tocilizumab) as Potential Multiple Myeloma Imaging Agents


Ximena Camacho*, Carolina Perroni, Camila L. Machado, Camila de Godoi Carneiro, Mara de Souza Junqueira, Daniele Faria, María F. García, Marcelo Fernández, Natalia Oddone, Juan Benech, Carlos A. Buchpiguel, Hugo Cerecetto, Roger Chammas, Eloisa Riva, Pablo Cabral and Juan P. Gambini


DOI: 10.2174/1871520621999210104181238
View Abstract


Platelet-Rich and Platelet-Poor Plasma Might Play Supportive Roles in Cancer Cell Culture: A Replacement for Fetal Bovine Serum?


Mehdi Talebi, Mousa Vatanmakanian, Ali Mirzaei, Yaghoub Barfar, Maryam Hemmatzadeh, Milad A. Nahayati, Kobra Velaei, Asghar Hoseinzade, Behruz Yazdanpanah, Yahya Yahyavi, Ako Azimi, Mina Rahmani and Milad Z. Heydarabad*


DOI: 10.2174/1871520621999210101225912
View Abstract







Antiproliferative Activity and Apoptotic Efficiency of Syzygium cumini Bark Methanolic Extract against EAC Cells In Vivo


Ayesha Siddika, Plabon K. Das, Saharia Y. Asha, Suraiya Aktar, Abu R.M. Tareq, Ayesha Siddika, Abdur Rakib, Farhadul Islam* and Jahan Ara Khanam*


DOI: 10.2174/1871520620666200811122137
View Abstract View on PubMed








HCA587 Protein Vaccine Induces Specific Antitumor Immunity Mediated by CD4+ T-cells Expressing Granzyme B in a Mouse Model of Melanoma


Weiming Yang, Weiheng Zhang, Xiaozhong Wang, Liming Tan, Hua Li, Jiemin Wu, Qiong Wu, Wanlei Sun, Juanjuan Chen* and Yanhui Yin*


DOI: 10.2174/1871520620666200728131951
View Abstract View on PubMed





Design, Synthesis and Biological Evaluation of a Novel Series of Thiadiazole-Based Anticancer Agents as Potent Angiogenesis Inhibitors


Burcugül Altuğ-Tasa, Betül Kaya-Çavuşoğlu*, Ayşe T. Koparal, Gülhan Turan, Ali S. Koparal and Zafer A. Kaplancıklı


DOI: 10.2174/1871520621666201231143535
View Abstract


The Efficacy and Safety of Additional Anti-HER2-Targeting Drugs in the Treatment of HER2-Positive Advanced Breast Cancer: A Meta-Analysis


Nannan Du, Bangsheng Chen, Zefeng Shen, Bin Zhou, Xiaojun Fu, Danyi Mao, Feiyan Mao, Derry M. Ng, Parikshit A. Khadaroo and Lei Yang*


DOI: 10.2174/1871520621666201231142841
View Abstract





Evaluation of Anti-Tumor Potential of Lactobacillus acidophilus ATCC4356 Culture Supernatants in MCF-7 Breast Cancer


Ramazan Behzadi, Ahmad Hormati, Karim Eivaziatashbeik, Sajjad Ahmadpour*, Fatemeh Khodadust, Fatemeh Zaboli, Esmail Fattahi, Rana Jahanban‐Esfahlan and Khaled Seidi


DOI: 10.2174/1871520621666201207085239
View Abstract View on PubMed




Chalcone Scaffolds as Anticancer Drugs: A Review on Molecular Insight in Action of Mechanisms and Anticancer Properties


Shefali Shukla, Anantpreet K. Sood, Kartika Goyal, Ambika Singh, Vaidehi Sharma, Neha Guliya, Shikha Gulati and Sanjay Kumar*


DOI: 10.2174/1871520620999201124212840
View Abstract View on PubMed


Anti-tumor Activity and Underlying Mechanism of Phomoxanthone B in MCF7 Cells


Chuan Chen, Ziyue Zhao, Qian Dong, XueHui Gao, Huibin Xu, Runlei Yang, Jian Chun Qin and Duqiang Luo*


DOI: 10.2174/1871520620999201124215511
View Abstract View on PubMed



Effect of Dasatinib on Genes Related to Mitotic Catastrophe Pathway in Chronic Myeloid Leukemia Cells


Sezgi Kipcak, Buket Ozel, Cigir B. Avci*, Leila S. Takanlou, Maryam S. Takanlou, Cumhur Gunduz and Nur S. Gunel


DOI: 10.2174/1871520620666201106085929
View Abstract View on PubMed













Synthesis, Molecular Docking and Biological Activity Evaluation of Alkoxy Substituted Chalcone Derivatives: Potential Apoptosis Inducing Agent on MCF-7 Cells


Wan M. Khairul*, Fatimah Hashim*, Mas Mohammed, Nurul S.M.N. Shah, Syed A.T.T. Johari, Rafizah Rahamathullah, Adibah I. Daud and Nyuk L. Ma


DOI: 10.2174/1871520620999201110190709
View Abstract View on PubMed





Pharmaceutical Aspects of Green Synthesized Silver Nanoparticles: A Boon to Cancer Treatment


Vijay Mishra*, Pallavi Nayak, Manvendra Singh, Murtaza M. Tambuwala, Alaa A. Aljabali, Dinesh K. Chellappan and Kamal Dua


DOI: 10.2174/1871520620666200918111024
View Abstract View on PubMed




1,3,4-Thiadiazolo (3,2-Α) Pyrimidine-6-Carbonitrile Scaffold as PARP1 Inhibitors.


Elizabeth Eldhose, Kaviarasan Lakshmanan, Praveen T. Krishnamurthy, Kalirajan Rajagopal, Manal Mohammed, Pulla Prudviraj and Gowramma Byran*


DOI: 10.2174/1871520621666201216095018
View Abstract








The Evaluation of Effect of Aurora Kinase Inhibitor CCT137690 in Melanoma and Melanoma Cancer Stem Cell


Fatma Sogutlu*, Cagla Kayabasi, Besra Ozmen Yelken, Aycan Asik, Roya Gasimli, Sezgi Kipcak, Sunde Yılmaz Susluer, Cigir Biray Avci and Cumhur Gunduz


DOI: 10.2174/1871520620666201026155101
View Abstract View on PubMed



Downregulation of GPR4 and TCF7 Promotes Apoptosis and Inhibits Growth and Invasion of Ovarian Cancer Cells


Zhuanli Bai, YinYing Wu, Yanli Yan, Shuheng Bai, Haojing Kang, Wen Ma, Jiangzhou Zhang, Ying Gao, Beina Hui, Hailin Ma, Rong Li, Xiaozhi Zhang and Juan Ren*


DOI: 10.2174/1871520620666201001104928
View Abstract View on PubMed







Anticancer Potential of Doxorubicin in Combination with GreenSynthesized Silver Nanoparticle and its Cytotoxicity Effects on CardioMyoblast Normal Cells


Jafar Saeidi, Samaneh Dolatabadi, Mahboubeh B. Esfahani, Masood Saiedi, Mahnaz Mohtashami, Kiana Mokhtari and Ahmad Ghasemi*


DOI: 10.2174/1871520621666201207093913
View Abstract


Synthetic Spirocyclohexadienones as New Anti-Migratory Compounds in Triple Negative Breast Cancer Cell Migration


Wanessa F. Altei, Bianca C. Pachane, Lucimara J. Martins, Ralph C. Gomes, Ricardo N. Santos, Daniara C. Fernandes, Heloisa S. Selistre-de-Araújo, Fernando Coelho * and Adriano D. Andricopulo*


DOI: 10.2174/1871520621666201207092836
View Abstract



Resveratrol as an Enhancer of Apoptosis in Cancer: A Mechanistic Review


Milad Ashrafizadeh, Shahram Taeb, Hamed Haghi-Aminjan, Shima Afrashi, Kave Moloudi, Ahmed E. Musa, Masoud Najafi* and Bagher Farhood


DOI: 10.2174/1871520620666201020160348
View Abstract View on PubMed


Improving Cytotoxicity Against Breast Cancer Cells by Using Mixed-Ligand Ruthenium(II) Complexes of 2,2'-Bipyridine, Amino Acid, and Nitric Oxide Derivatives as Potential Anticancer Agents


Ana P.S. Gaspari, Roberto Santana da Silva*, Zumira A. Carneiro, Marcelo Rodrigues de Carvalho, Ivone Carvalho, Laena Pernomian, Lucimara P. Ferreira, Loyanne C.B. Ramos, Gabriel Aguiar de Souza and André L.B. Formiga


DOI: 10.2174/0929867327666201020155105
View Abstract View on PubMed




Protective Effect of Resveratrol against Glioblastoma: A Review


Milad Ashrafizadeh, Reza Mohammadinejad, Tahereh Farkhondeh and Saeed Samarghandian*


DOI: 10.2174/1871520620666200929151139
View Abstract View on PubMed


Synergistic Combination of Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid and Natural Flavonoid Curcumin Exhibits Anticancer and Antibacterial Activity


Ergül M. Altundağ *, Kübra Toprak, Gizem Şanlıtürk, Mümtaz Güran, Cahit Özbilenler, Namık R. Kerküklü, Ayşe M. Yılmaz and Ahmet S. Yalçın


DOI: 10.2174/1871520620666201006141317
View Abstract View on PubMed


Trigonella foenum-graecum Seeds Oil Attenuated Inflammation and Angiogenesis in vivo through Down-Regulation of TNF-α


Muhammad Asif*, Hafiz Muhammad Yousaf, Mohammed Saleem, Malik Saadullah, Tahir Ali Chohan, Muhammad Usman Shamas, Hafiza Sidra Yaseen, Muhammad Umair Yousaf and Maria Yaseen


DOI: 10.2174/1871520620666201005100132
View Abstract View on PubMed


Viburnum nervosum Leaf Extract Mediated Green Synthesis of Silver Nanoparticles: A Viable Approach to Increase the Efficacy of an Anticancer Drug


Irfana Zahoor, Farhat Jan, Ujjawal Sharma, Kiran K. Sahu, Amita Sharma, Shalini Pareek, Divya Shrivastava and Prakash S. Bisen*


DOI: 10.2174/1871520620999201001201230
View Abstract View on PubMed



Synthesis of 1H-1,2,3-Triazole-Linked Quinoline-Isatin Molecular Hybrids as Anti- Breast Cancer and Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Agents


Paul Awolade, Nosipho Cele, Oluwakemi Ebenezer, Nagaraju Kerru, Lalitha Gummidi, Liang Gu, Gabriella Palma, Mandeep Kaur and Parvesh Singh*


DOI: 10.2174/1871520620666200929153138
View Abstract View on PubMed


Synthesis and Evaluation of Cytotoxic Activity of Certain Benzo[h]chromene Derivatives


Samir M. Awad, Mosaad S. Mohamed, Marwa Abd El-Fattah Khodair and Rania H. Abd El-Hameed*


DOI: 10.2174/1871520620666200925103742
View Abstract View on PubMed











A Study on the Effect and Mechanism of Xiaoaiping (XAP) Injection and S-1 Combination Therapy in Inhibiting the Invasion and Metastasis of Human GC Cells


Peiyu Wen*, Haibo Wang, Tengyang Ni, Xiaojun Dai, Zewen Chu, Shuang Ma, Liangliang Xiang, Zhen Zhou, Yayun Qian, Masataka Sunagawa and Yanqing Liu


DOI: 10.2174/1871520620666200918100422
View Abstract View on PubMed



Transcriptionomic Study on Apoptosis of SKOV-3 Cells Induced by Phycoerythrin from Gracilaria lemaneiformis


Jun Ying*, Zhouhao Tang, Guanan Zhao, Xia Li, Ruowang Pan, Shuangxiang Lin, Yang Lou, Wanping Wang, Peizhen Li, Qiyu Bao and Chunxia Yan


DOI: 10.2174/1871520620666200908102621
View Abstract View on PubMed



A New Series of Antileukemic Agents: Design, Synthesis, In Vitro and In Silico Evaluation of Thiazole-Based ABL1 Kinase Inhibitors


Ebru Zeytün, Mehlika D. Altıntop*, Belgin Sever, Ahmet Özdemir, Doha E. Ellakwa, Zeynep Ocak, Halil I. Ciftci, Masami Otsuka, Mikako Fujita and Mohamed O. Radwan


DOI: 10.2174/1871520620666200824100408
View Abstract View on PubMed


Identification of 3-Bromo-1-Ethyl-1H-Indole as a Potent Anticancer Agent with Promising Inhibitory Effects on GST Isozymes


Can Yılmaz, Sevki Arslan*, Dogukan Mutlu, Metin Konus, Abdussamet Kayhan, Aslıhan KurtKızıldoğan, Çiğdem Otur, Omriye Ozok and Arif Kivrak


DOI: 10.2174/1871520620666200918111940
View Abstract View on PubMed


Fluorinated-NHC Transition Metal Complexes: Leading Characters as Potential Anticancer Metallodrugs


Ernesto Rufino-Felipe, Raúl Colorado-Peralta, Viviana Reyes-Márquez , Hugo Valdés and David Morales-Morales*


DOI: 10.2174/1871520620666200908103452
View Abstract View on PubMed





The Chemosensitizing Role of Metformin in Anti-cancer Therapy


Zhimin Tang, Nan Tang, Shanshan Jiang, Yangjinming Bai, Chenxi Guan, Wansi Zhang, Shipan Fan, Yonghong Huang, Hui Lin and Ying Ying*


DOI: 10.2174/1871520620666200918102642
View Abstract View on PubMed


New Formulation and Evaluation of Camptothecin Encapsulated and/or Dispersed Suppository


Sofiane Fatmi*, Lamia Taouzinet, Malika Lahiani-Skiba, Mohamed Skiba and Mokrane Iguer-Ouada


DOI: 10.2174/1871520620666200903150635
View Abstract View on PubMed


Antiproliferative and Genotoxic Action of an Underexploited Organoteluran Derivative on Sarcoma 180 Cells


Maria L.L. Barreto do Nascimento, Antonielly Campinho dos Reis, José V.O. Santos, Helber A. Negreiros, Felipe C. Carneiro da Silva, Paulo M.P. Ferreira, Juan C.R. Gonçalves, Dalton Dittz, Débora C. Braz, Adriana M.V. Nunes, Rodrigo L.O.R. Cunha, Ana A.C. MeloCavalcante and João Marcelo de Castro e Sousa*


DOI: 10.2174/1871520620666200918110152
View Abstract View on PubMed






Novel Dihydropyrimidinone-Derived Selenoesters as Potential Cytotoxic Agents to Human Hepatocellular Carcinoma: Molecular docking and DNA Fragmentation


Jean C. Benassi, Flavio A.R. Barbosa, Valdelúcia M.A.S. Grinevicius, Fabiana Ourique, Daniela Coelho, Karina B. Felipe, Antônio L. Braga, Danilo W. Filho and Rozangela C. Pedrosa*


DOI: 10.2174/1871520620666200728124640
View Abstract View on PubMed


On the Cytotoxicity of Chiral Ruthenium Complexes Containing Sulfur Amino Acids Against Breast Tumor Cells (MDA-231 and MCF-7)


Celisnolia M. Leite, João Honorato de Araujo-Neto*, Rodrigo S. Corrêa, Legna Colina-Vegas, Diego Martínez-Otero, Paulo R. Martins, Cristiane G. Silva and Alzir A. Batista


DOI: 10.2174/1871520620666200824114816
View Abstract View on PubMed




Rotundic Acid Regulates the Effects of Let-7f-5p on Caco2 Cell Proliferation


Yuan Feng, Xinran Liu, Yueqing Han, Mantian Chen, Lin Zhang, Yuling Hu, Liya Chen, Gang Chen and Ning Li*


DOI: 10.2174/1871520620999200730165829
View Abstract View on PubMed


Apoptotic Effects of N-(2-hydroxyphenyl)-2-propylpentanamide on U87-MG and U-2 OS Cells and Antiangiogenic Properties


Paola Castillo-Juárez, Sebastián C. Sanchez, Alma D. Chávez-Blanco*, Humberto Mendoza-Figueroa and José Correa-Basurto


DOI: 10.2174/1871520620666200728125356
View Abstract View on PubMed


Fused and Substituted Pyrimidine Derivatives as Profound Anti-cancer Agents


Nahid Abbas*, Gurubasavaraja S.P. Matada, Prasad S. Dhiwar, Shilpa Patel and Giles Devasahayam


DOI: 10.2174/1871520620666200721104431
View Abstract View on PubMed


FOXM1-Dependent Transcriptional Regulation of EZH2 Induces Proliferation and Progression in Prostate Cancer


Juan-Hua Tian, Li-Jun Mu, Mei-Yu Wang, Jin Zeng, Qing-Zhi Long, Bing Guan, Wen Wang, Yu Mei Jiang, Xiao-Jing Bai and Yue-Feng Du*


DOI: 10.2174/1871520620666200731161810
View Abstract View on PubMed








Synthesis and in vitro Cytotoxicity Evaluation of Phenanthrene Linked 2,4- Thiazolidinediones as Potential Anticancer Agents


Upasana Yadav, Yogesh Vanjari, Kritika Laxmikeshav, Ramya Tokala, Praveen Kumar Niggula, Manoj Kumar, Venu Talla, Ahmed Kamal and Nagula Shankaraiah*


DOI: 10.2174/1871520620666200714142931
View Abstract View on PubMed



New Hybrid Scaffolds Based on Carbazole-Chalcones as Potent Anticancer Agents


Faisal Rashid, Sumera Zaib, Aliya Ibrar, Syeda Abida Ejaz, Aamer Saeed, Jamshed Iqbal and Imtiaz Khan*


DOI: 10.2174/1871520620666200721110732
View Abstract View on PubMed




Prospective Anti-cancer Agents: A Recent Update on Drug Repurposing


Anjali S. Sabale, Unnati M. Patel, Ankita A. Gorhe, Vinayak R. Bodhankar, Mahesh N. Shinde, Gaurav A. Sonawane, Hitesh S. Raotole, Rohit Y. Pande and Abhijeet D. Kulkarni*


DOI: 10.2174/1871520620666200728123729
View Abstract


Discovery of a Highly Potent and Novel Gambogic Acid Derivative as an Anticancer Drug Candidate


Huiping Ling, Hong Li, Meijun Chen, Baolong Lai, Haiming Zhou, Hui Gao, Jiangye Zhang, Yan Huang and Yiwen Tao*


DOI: 10.2174/1871520620666200408080040
View Abstract View on PubMed





Isoquinolines: Important Cores in Many Marketed and Clinical Drugs


Chunying Luo, Maxwell Ampomah-Wireko, Huanhuan Wang, Chunli Wu*, Qing Wang, Hui Zhang and Yaquan Cao


DOI: 10.2174/1871520620666200424132248
View Abstract View on PubMed


STK33-Dependent Transcriptional Regulation of SFTA3 Induces Cisplatin- Resistance in Lung Adenocarcinoma


Kuilong Zhou, Runzhi Dong, Zhiheng Wang, Zhian Tang, Xuezhen Gao, Yaqing Du, Xiaoli Zhang, Xiangying Li and Qingfan Xie*


DOI: 10.2174/1871520619666190507100912
View Abstract View on PubMed






Editor-in-Chief

Simone Carradori
Department of Pharmacy
“G. d’Annunzio” University of Chieti-Pescara
Chieti
(Italy)
Biography
View Full Editorial Board

COPE Compliant

Journal History

Current Medicinal Chemistry - Anti-Cancer Agents was launched in 2001 and later renamed in 2006 as Anti-Cancer Agents in Medicinal Chemistry.

Related Journals

Related eBooks

eBooks Catalog