Central Nervous System Agents in Medicinal Chemistry
Formerly: Current Medicinal Chemistry - Central Nervous System Agents
Volume 21, 3 Issues, 2021
ISSN: 1875-6166 (Online)
ISSN: 1871-5249 (Print)
This journal supports open access
ISSN: 1875-6166 (Online)
ISSN: 1871-5249 (Print)
This journal supports open access
Aims & Scope
Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents.
Containing a series of in-depth/mini reviews, original research articles, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.
Central Nervous System Agents in Medicinal Chemistry
,Volume 21
-Number 1
Biography Open Access
Meet Our Editorial Board Member
Review Article (Mini-Review)
Neuroendocrine Response to Psychosocial Stressors, Inflammation Mediators and Brain-periphery Pathways of Adaptation
, 21(1): 2 - 19Lionella Palego, Gino Giannaccini and Laura Betti*
DOI: 10.2174/1871524920999201214231243
Neuroendocrine Response to Psychosocial Stressors, Inflammation Mediators and Brain-periphery Pathways of Adaptation
Review Article
The Neuroprotective Properties, Functions, and Roles of Cannabis sativa in Selected Diseases Related to the Nervous System
, 21(1): 20 - 38Onesimus Mahdi, Mohamad T.H. Baharuldin, Nurul Huda M. Nor, Samaila M. Chiroma, Saravanan Jagadeesan and Mohamad A.M. Moklas*
DOI: 10.2174/1871524921666210127110028
The Neuroprotective Properties, Functions, and Roles of Cannabis sativa in Selected Diseases Related to the Nervous System
Research Article
In silico Screening of Pyridoxine Carbamates for Anti-Alzheimer’s Activities
, 21(1): 39 - 52Dnyaneshwar Baswar, Abha Sharma and Awanish Mishra*
DOI: 10.2174/1871524920666201119144535
In silico Screening of Pyridoxine Carbamates for Anti-Alzheimer’s Activities
Research Article
Synthesis and Biological Evaluation of Amino Acid Based Mutual Amide Prodrugs of Phenytoin as Anticonvulsant Agents
, 21(1): 53 - 72Sampada Jangam*, Meenakshi Deodhar and Sagar Wankhede
DOI: 10.2174/1871524920666201109152344
Synthesis and Biological Evaluation of Amino Acid Based Mutual Amide Prodrugs of Phenytoin as Anticonvulsant Agents
Research Article
Evaluation of the Behavioural, Antioxidative and Histomorphological Effects of Folic Acid-supplemented Diet in Dexamethasone-induced Depression in Mice
, 21(1): 73 - 81Joshua Falade*, Adejoke Y. Onaolapo and Olakunle J. Onaolapo
DOI: 10.2174/1871524921666210114125355
Evaluation of the Behavioural, Antioxidative and Histomorphological Effects of Folic Acid-supplemented Diet in Dexamethasone-induced Depression in Mice
Central Nervous System Agents in Medicinal Chemistry , Volume 21 (2021) - Number 2
This issue is in progress but contains articles that are final and fully citable.
Articles Ahead of Print
Withdrawal Notice: Applying Peer Mentoring to Improve Learning Human Anatomy
Vladimir N. Nikolenko, Negoriya A. Rizaeva, Marine V. Oganesyan, Valentina A. Kudryashova, Polina I. Dubrovina, Alexandra A. Dubovets, Anastasia A. Bolotskaya, Kirill V. Bulygin, Cristian Muresanu, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*
DOI: 10.2174/1871524921666210212110151
View Abstract
Abstracts Ahead of Print
Synthesis, Physicochemical, Computational and Biological Evaluation of Phenylurea Derivatives as CNS agents
Sandeep Singh* and Shweta Verma
DOI: 10.2174/1871524921666210908145356
View Abstract
Targeting cAMP-pathway in Regeneration-Competent Cells of Nervous Tissue: Potential to Create a Novel Drug for Treatment of Ethanol-Induced Neurodegeneration
Gleb Nikolaevich Zyuz’kov*, Larisa Arkad`evna, Tatyana Yur`evna Polykova, Elena Vladislavovna Simanina and Larisa Alexandrovna Stavrova
DOI: 10.2174/1871524921666210907102847
View Abstract
Protective effect of Monoisoamyl-2, 3-Dimercaptosuccinic Acid against Manganese-induced Neurotoxicity in rats
Awanish Mishra*, Anjali Dahia and Amit Jaiswal
DOI: 10.2174/1871524921666210825093134
View Abstract
Published Contents
Editor's Choice
α-Substituted Lactams and Acetamides: Ion Channel Modulators that Show Promise in Treating Drug-resistant Epilepsy
, 2020; 20(2): 79 - 87Arcadius V. Krivoshein*
DOI: 10.2174/1871524920666200510005458
Conversion of Benzimidazoles, Imidazothiazoles and Imidazoles into more Potent Central Nervous System Acting Drugs
, 2020; 20(1): 3 - 12Saganuwan A. Saganuwan*
DOI: 10.2174/1871524919666190621160323
Antioxidant Effect of Flavonoids Present in Euterpe oleracea Martius and Neurodegenerative Diseases: A Literature Review
, 2019; 19(2): 75 - 99Nayana Keyla Seabra de Oliveira*, Marcos Rafael Silva Almeida, Franco Márcio Maciel Pontes, Mariana Pegrucci Barcelos, Carlos Henrique Tomich de Paula da Silva, Joaquín María Campos Rosa, Rodrigo Alves Soares Cruz and Lorane Izabel da Silva Hage-Melim*
DOI: 10.2174/1871524919666190502105855
A Novel Non-invasive Effective Method for Potential Treatment of Degenerative Disc Disease: A Hypothesis
, 2019; 19(1): 8 - 14Siva G. Somasundaram, Cristian Muresanu, Pamela Schield, Alfiya Makhmutovа, Elena V. Bovina, Vladimir P. Fisenko, Nusrat F. Hasanov and Gjumrakch Aliev*
DOI: 10.2174/1871524918666181017152053
Classification (Agonist/Antagonist) and Regression “Structure-Activity” Models of Drug Interaction with 5-HT6
, 2018; 18(3): 213 - 221Oleg A. Raevsky, Veniamin Y. Grigorev, Alexander V. Yarkov, Daniel E. Polianczyk, Vadim V. Tarasov, Elena V. Bovina, Elena N. Bryzhakina, John C. Dearden, Marco Avila-Rodriguez and Gjumrakch Aliev*
DOI: 10.2174/1871524918666180827100437
Nitrocatechol Derivatives of Chalcone as Inhibitors of Monoamine Oxidase and Catechol-O-Methyltransferase
, 2018; 18(2): 115 - 127Idalet Engelbrecht, Jacobus P. Petzer and Anel Petzer*
DOI: 10.2174/1871524918666180426125714
Astrocyte`s RAGE: More Than Just a Question of Mood
, 2018; 18(1): 39 - 48Rodrigo E. Gonzalez-Reyes* and Maria G. Rubiano
DOI: 10.2174/1871524916999160505105121
Synthesis, Computational and Pharmacological Evaluation of N-(2-benzoyl- 4-chlorophenyl)-2-(4-(Substituted Phenyl) Piperazin-1-yl) Acetamides as CNS Agents
, 2017; 17(3): 229 - 238Shweta Verma*, Surendra Kumar and Sushil Kumar
DOI: 10.2174/1871524917666170321103951
Alpha-7 Nicotinic Receptors in Nervous System Disorders: From Function to Therapeutic Perspectives
, 2017; 17(2): 100 - 108Antonella De Jaco, Laura Bernardini, Jessica Rosati and Ada Maria Tata*
DOI: 10.2174/1871524916666160729111446
Psychomotor Seizure Screening and in vitro Neuroprotection Assay of Hydrazones Derived from 2-Acetyl Thiophene
, 2017; 17(1): 51 - 57Bijo Mathew, Githa E. Mathew, Jerad Suresh, Mohammed Jaseel, D. Usman, P. N. Shiva Subramanyan, Kallivalappil F. Safna and Jobin K. Vilapurathu
DOI: 10.2174/1871524915999151028111728
Open Access Articles
The Efficacy of Melanin Precursor QIAPI 1© Against Age-related Macular Degeneration (AMD): A Case Report
, 2020; 20(3): 218 - 225Arturo S. Herrera, Narasimha M. Beeraka, Luis Fernando T. Solis, Liudmila M. Mikhaleva, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*
The Computational Analysis Conducted on miRNA Target Sites in Association with SNPs at 3’UTR of ADHD-implicated Genes
, 2020; 20(1): 58 - 75Adel Abdi, Mina Zafarpiran and Zeinab S. Farsani*
An Assessment of the Effects of Azodicarbonamide-containing Diet on Neurobehaviour, Brain Antioxidant Status and Membrane Lipid Peroxidation Status in Rats
, 2020; 20(1): 49 - 57Anthony T. Olofinnade, Adegboyega Adeyeba, Adejoke Y. Onaolapo and Olakunle J. Onaolapo*
Conversion of Benzimidazoles, Imidazothiazoles and Imidazoles into more Potent Central Nervous System Acting Drugs
, 2020; 20(1): 3 - 12Saganuwan A. Saganuwan*
The Role of Melanin to Dissociate Oxygen from Water to Treat Retinopathy of Prematurity
, 2019; 19(3): 215 - 222Arturo S. Herrera, María del Carmen A. Esparza, Paola E.S. Arias, Ghulam M. Ashraf, Osama F. Mosa, Vladimir P. Fisenko, Susanna S. Sologova, Samira A. Dostdar, Alexander V. Sokolov, Elena V. Bovina, Vladimir N. Chubarev, Vadim V. Tarasov, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*
A Novel Highly Selective Cannabinoid CB2 Agonist Reduces in vitro Growth and TGF-beta Release of Human Glial Cell Tumors
, 2019; 19(3): 206 - 214Chiara Cioni, Maristella Tassi, Giuseppe Marotta, Claudia Mugnaini, Federico Corelli* and Pasquale Annunziata*
Design, Synthesis and Biological Activity of Some 4, 5-Disubstituted-2, 4- Dihydro-3H-1, 2, 4- Triazole-3-Thione Derivatives
, 2019; 19(3): 197 - 205Krishan Kumar Verma*, Umesh Kumar Singh and Jainendra Jain
Noradrenergic Regulation of Hippocampus-Dependent Memory
, 2019; 19(3): 187 - 196Peter V. Nguyen and Steven A. Connor*
Berberine: A Plant-derived Alkaloid with Therapeutic Potential to Combat Alzheimer’s disease
, 2019; 19(3): 154 - 170Anurag K. Singh, Santosh K. Singh, Manmath K. Nandi, Gaurav Mishra, Anand Maurya, Arati Rai, Gopal K. Rai, Rajendra Awasthi*, Bhupesh Sharma and Giriraj T. Kulkarni
Antioxidant Effect of Flavonoids Present in Euterpe oleracea Martius and Neurodegenerative Diseases: A Literature Review
, 2019; 19(2): 75 - 99Nayana Keyla Seabra de Oliveira*, Marcos Rafael Silva Almeida, Franco Márcio Maciel Pontes, Mariana Pegrucci Barcelos, Carlos Henrique Tomich de Paula da Silva, Joaquín María Campos Rosa, Rodrigo Alves Soares Cruz and Lorane Izabel da Silva Hage-Melim*
Evaluation of Selected Natural Compounds as Dual Inhibitors of Catechol-O-Methyltransferase and Monoamine Oxidase
, 2019; 19(2): 133 - 145Idalet Engelbrecht, Jacobus P. Petzer and Anél Petzer*
Brain and Quantum Dots: Benefits of Nanotechnology for Healthy and Diseased Brain
, 2018; 18(3): 193 - 205Yuri N. Utkin*
Schiff Bases of Benzothiazol-2-ylamine and Thiazolo[5,4-b] pyridin-2-ylamine as Anticonvulsants: Synthesis, Characterization and Toxicity Profiling*
, 2016; 16(3): 240 - 248Rashmi Shukla, Ajeet P. Singh, Pankaj K. Sonar, Mudita Mishra and Shailendra K. Saraf*
Opening New Scenarios for Human MAO Inhibitors
, 2016; 16(2): 98 - 104Celeste De Monte, Melissa D'Ascenzio, Paolo Guglielmi, Veronica Mancini and Simone Carradori
Most Cited Articles
Perspective
Unraveling the structural requirements of chalcone chemistry towards monoamine oxidase inhibition
, 2019; 19(1): 6-7.Bijo Mathew
DOI: 10.2174/1871524919666190131160122
Review Article
Acrylamide induced toxicity and the propensity of phytochemicals in amelioration: A review
, 2019; 19(2): 100-113.Shinomol George Kunnel*, Sunitha Subramanya, Pankaj Satapathy, Ishtapran Sahoo and Farhan Zameer*
DOI: 10.2174/1871524919666190207160236
Review Article
Berberine: A plant-derived alkaloid with therapeutic potential to combat Alzheimer’s disease
, 2019; 19(3): 154-170.Anurag K. Singh, Santosh K. Singh, Manmath K. Nandi, Gaurav Mishra, Anand Maurya, Arati Rai, Gopal K. Rai, Rajendra Awasthi*, Bhupesh Sharma and Giriraj T. Kulkarni
DOI: 10.2174/1871524919666190820160053
Review Article
Antioxidant effect of flavonoids present in euterpe oleracea martius and neurodegenerative diseases: A literature review
, 2019; 19(2): 75-99.Nayana Keyla Seabra de Oliveira*, Marcos Rafael Silva Almeida, Franco Márcio Maciel Pontes, Mariana Pegrucci Barcelos, Carlos Henrique Tomich de Paula da Silva, Joaquín María Campos Rosa, Rodrigo Alves Soares Cruz and Lorane Izabel da Silva Hage-Melim*
DOI: 10.2174/1871524919666190502105855
Review Article
Aging affects nicotinic acetylcholine receptors in brain
, 2019; 19(2): 119-124.Yuri N. Utkin*
DOI: 10.2174/1871524919666190320102834
Research Article
Development and characterization of nasal delivery of selegiline hydrochloride loaded nanolipid carriers for the management of parkinson’s disease
, 2019; 19(1): 46-56.Neeraj Mishra*, Sawarni Sharma, Rahul Deshmukh, Anoop Kumar and Ruchika Sharma
DOI: 10.2174/1871524919666181126124846
Research Article
Behavioral evaluation of the effects of aqueous and ethanol extracts of suaeda vermiculata forssk on rats
, 2020; 20(2): 122-127.Hamdoon A. Mohammed*
DOI: 10.2174/1871524920666200319142536
Research Article
Evaluation of selected natural compounds as dual inhibitors of catechol-o-methyltransferase and monoamine oxidase
, 2019; 19(2): 133-145.Idalet Engelbrecht, Jacobus P. Petzer and Anél Petzer*
DOI: 10.2174/1871524919666190619090852
Research Article
Bacopa monnieri supplements offset paraquat-induced behavioral phenotype and brain oxidative pathways in mice
, 2019; 19(1): 57-66.Gokul Krishna*, Ravikumar Hosamani and Muralidhara
DOI: 10.2174/1871524919666190115125900
Research Article
A novel highly selective cannabinoid CB2 agonist reduces in vitro growth and TGF-beta release of human glial cell tumors
, 2019; 19(3): 206-214.Chiara Cioni, Maristella Tassi, Giuseppe Marotta, Claudia Mugnaini, Federico Corelli* and Pasquale Annunziata*
DOI: 10.2174/1871524919666190923154351
Research Article
An evaluation of the effects of pyridoxal phosphate in chlorpromazineinduced parkinsonism using mice
, 2020; 20(1): 13-25.Anthony T. Olofinnade, Tolulope M. Onaolapo, Samad Oladimeji, Adetunji M. Fatoki, Covenant I. Balogun, Adejoke Y. Onaolapo* and Olakunle J. Onaolapo
DOI: 10.2174/1871524920666200120142508
Research Article
Design, synthesis and biological activity of some 4, 5-disubstituted-2, 4-dihydro-3h-1, 2, 4-triazole-3-thione derivatives
, 2019; 19(3): 197-205.Krishan Kumar Verma*, Umesh Kumar Singh and Jainendra Jain
DOI: 10.2174/1871524919666190722144424
Letter
Cholinesterase inhibitory activities of selected halogenated thiophene chalcones
, 2019; 19(1): 67-71.Della G.T. Parambi, Fakhrya Aljoufi, Vikneswaran Murugaiyah, Githa E. Mathew, Sanal Dev, Balasubramanain Lakshminarayanan, Omnia M. Hendawy and Bijo Mathew*
DOI: 10.2174/1871524918666181119114016
Review Article
A link between brain insulin resistance and cognitive dysfunctions: Targeting ca<sup>2+</sup>/camp signalling
, 2020; 20(2): 103-109.Leandro B. Bergantin*
DOI: 10.2174/1871524920666200129121232
Review Article
Noradrenergic regulation of hippocampus-dependent memory
, 2019; 19(3): 187-196.Peter V. Nguyen and Steven A. Connor*
DOI: 10.2174/1871524919666190719163632
Most Accessed Articles
Effects on the Post-translational Modification of H3K4Me3, H3K9ac, H3K9Me2, H3K27Me3, and H3K36Me2 Levels in Cerebral Cortex, Hypothalamus and Pons of Rats after a Systemic Administration of Cannabidiol: A Preliminary Study
, 2021; 21(2): 142-147.José Carlos Pastrana-Trejo, Fátima Duarte-Aké, Rosa Us-Camas, Clelia De-la-Peña, Linda Parker, Roger G. Pertwee and Eric Murillo-Rodríguez*
DOI: 10.2174/1871524920666200924114524
Concentration-Dependent Effects of Dietary L-Ascorbic Acid Fortification in the Brains of Healthy Mice
, 2021; 21(2): 104-113.Anthony T. Olofinnade, Adejoke Y. Onaolapo* and Olakunle J. Onaolapo
DOI: 10.2174/1871524921666210315130023
Influence of Inosine on Cerebral Hemodynamics in Space Motion Sickness in Experimental Animals
, 2021; 21(2): 93-103.Asie N. Useinova , Vitalii Kaliberdenko , Igor D. Sapegin , Shanmugaraj Kulanthaivel *, Michael V. Shterenshis , Maria I. Dmitriyevskaya and Keerthanaa Balasundaram
DOI: 10.2174/1871524921666210428111827
Neuroendocrine Response to Psychosocial Stressors, Inflammation Mediators and Brain-periphery Pathways of Adaptation
, 2021; 21(1): 2-19.Lionella Palego, Gino Giannaccini and Laura Betti*
DOI: 10.2174/1871524920999201214231243
The Neuroprotective Properties, Functions, and Roles of Cannabis sativa in Selected Diseases Related to the Nervous System
, 2021; 21(1): 20-38.Onesimus Mahdi, Mohamad T.H. Baharuldin, Nurul Huda M. Nor, Samaila M. Chiroma, Saravanan Jagadeesan and Mohamad A.M. Moklas*
DOI: 10.2174/1871524921666210127110028
Synthesis and Biological Evaluation of Amino Acid Based Mutual Amide Prodrugs of Phenytoin as Anticonvulsant Agents
, 2021; 21(1): 53-72.Sampada Jangam*, Meenakshi Deodhar and Sagar Wankhede
DOI: 10.2174/1871524920666201109152344
Evaluation of the Behavioural, Antioxidative and Histomorphological Effects of Folic Acid-supplemented Diet in Dexamethasone-induced Depression in Mice
, 2021; 21(1): 73-81.Joshua Falade*, Adejoke Y. Onaolapo and Olakunle J. Onaolapo
DOI: 10.2174/1871524921666210114125355
In silico Screening of Pyridoxine Carbamates for Anti-Alzheimer’s Activities
, 2021; 21(1): 39-52.Dnyaneshwar Baswar, Abha Sharma and Awanish Mishra*
DOI: 10.2174/1871524920666201119144535
Statistical Review of the Suicide Attempts Rates Committed on Polish Railway Tracks between the Years 2013-2016
, 2021; 21(2): 85-92.Marta Makara-Studzinska, Adam Czabański, Katarzyna Gronowska, Jerzy Leszek, Elizaveta V. Mikhaylenko, Marco F. Avila-Rodriguez, Cristian Muresanu, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*
DOI: 10.2174/1871524921666210204220621
Synthesis, Molecular Docking, and Biological Evaluation of Some Novel 2- (5-Substituted 1,3,4-oxadiazole-2-yl)-1,3-benzothiazole Derivatives as Anticonvulsant Agents
, 2021; 21(2): 130-141.Sukhbir Lal Khokra*, Simranjeet Kaur, Sahil Banwala, Karan Wadhwa and Asif Husain
DOI: 10.2174/1871524921666210607153407
Anti-convulsive Effect of Thiamine and Melatonin Combination in Mice: Involvement of Oxidative Stress
, 2021; 21(2): 125-129.Ehsan Dehdashtian, Azam Hosseinzadeh, Karim Hemati, Mohammad Yahya Karimi, Iman Fatemi and Saeed Mehrzadi*
DOI: 10.2174/1871524921666210623161212
Anti-depressant, Anxiolytic, and the Muscle Relaxant Activity of Hydroalcoholic Extract of Cissampelos pareira Linn. Leaves
, 2021; 21(2): 114-124.Mohammad Asif*, Jayesh Dwivedi and Sandeep Yadav
DOI: 10.2174/1871524921666210505101704
Protective Effect of Capparis spinosa Extract against Focal Cerebral Ischemia- reperfusion Injury in Rats
, 2021; 21(2): 148-153.Hassan Rakhshandeh, Samira Asgharzade, Mohammad Bagher Khorrami and Fatemeh Forouzanfar *
DOI: 10.2174/1871524921666210625112356
The Efficacy of Melanin Precursor QIAPI 1© Against Age-related Macular Degeneration (AMD): A Case Report
, 2020; 20(3): 218-225.Arturo S. Herrera, Narasimha M. Beeraka, Luis Fernando T. Solis, Liudmila M. Mikhaleva, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*
DOI: 10.2174/1871524920666201109152951
Old Drugs with New Tricks: Paradigm in Drug Development Pipeline for Alzheimer’s Disease
, 2020; 20(3): 157-176.Tanay Dalvi, Bhaskar Dewangan, Rudradip Das, Jyoti Rani, Suchita D. Shinde, Nazmina Vhora, Alok Jain and Bichismita Sahu*
DOI: 10.2174/1871524920666201021164805
Editor-in-Chief
Ramon Cacabelos
International Center of Neuroscience and Genomic Medicine
EuroEspes Biomedical Research Center
Corunna
(Spain)
Biography
International Center of Neuroscience and Genomic Medicine
EuroEspes Biomedical Research Center
Corunna
Biography
Biography of Ramon Cacabelos
Dr. Ramón Cacabelos is Professor and Chairman of Genomic Medicine at Continental
University Medical School, Peru, and President of the International Center of
Neuroscience and Genomic Medicine, Corunna, Spain. He received his M.D. from
Oviedo University, Ph.D. from Santiago University, and D.M.Sci. (Psychiatry) from
Osaka University Medical School, Japan. After a decade at the Department of
Psychiatry in Osaka, he returned to Spain and focused his research activity on the
genomics and pharmacogenomics of CNS disorders. He has published over 700 papers
and 29 books and is Editor-in-Chief of the first World Guide for Drug Use and
Pharmacogenomics and President of the World Association of Genomic Medicine.
COPE Compliant
About the Journal
For Authors
For Librarians & Readers
Quick Links
Journal History
Current Medicinal Chemistry - Central Nervous System Agents was launched in 2001 and later renamed in 2006 as Central Nervous System Agents in Medicinal Chemistry.
Webmaster Contact: info@benthamscience.net