Central Nervous System Agents in Medicinal Chemistry
Formerly: Current Medicinal Chemistry - Central Nervous System Agents
Volume 22, 3 Issues, 2022
ISSN: 1875-6166 (Online)
ISSN: 1871-5249 (Print)
This journal supports open access
ISSN: 1875-6166 (Online)
ISSN: 1871-5249 (Print)
This journal supports open access
Aims & Scope
Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents.
Containing a series of in-depth/mini reviews, original research articles, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.
Central Nervous System Agents in Medicinal Chemistry
,Volume 21
-Number 3
Biography
Meet Our Regional Editor
, 21(3): 155 - 156Sadayuki Hashioka*
DOI: 10.2174/187152492103211231220535
Research Article
Synthesis, Physicochemical, Computational and Biological Evaluation of Phenylurea Derivatives as CNS Agents
, 21(3): 157 - 164Shweta Verma and Sandeep Singh*
DOI: 10.2174/1871524921666210908145356
Research Article
Protective Effect of Monoisoamyl-2, 3-Dimercaptosuccinic Acid against Manganese-induced Neurotoxicity in Rats
, 21(3): 165 - 171Awanish Mishra*, Anjali Dahia and Amit Jaiswal
DOI: 10.2174/1871524921666210825093134
Research Article
Targeting cAMP-pathway in Regeneration-competent Cells of Nervous Tissue: Potential to Create a Novel Drug for Treatment of Ethanol-induced Neurodegeneration
, 21(3): 172 - 180Gleb Nikolaevich Zyuz’kov*, Larisa Arkad`evna, Tatyana Yur`evna Polykova, Elena Vladislavovna Simanina and Larisa Alexandrovna Stavrova
DOI: 10.2174/1871524921666210907102847
Research Article
Effect of Methadone Maintenance on Expression of BDNF and CREB Genes in Brain VTA of Male Morphine Treated Rats
, 21(3): 181 - 186Marzieh Rezai, Mohammad Reza Hajizadeh, Mehdi Mahmoodi, Seyedeh Atekeh Torabizadeh and Mojgan Noroozi Karimabad*
DOI: 10.2174/1871524922666211223153555
Research Article
Dissimilar Anxiety-like Behavior in Prepubertal and Young Adult Female Rats on Acute Exposure to Aluminium
, 21(3): 187 - 194Trina Sengupta, Sutirtha Ghosh, Archana Gaur T. and Prasunpriya Nayak*
DOI: 10.2174/1871524922666211231095507
Research Article
Pharmacophore Modelling and Virtual Screening Studies for the Discovery of Potential Natural Products Based PDE1B Inhibitor Lead Compounds
, 21(3): 195 - 204Teng Woei Shy and Anand Gaurav*
DOI: 10.2174/1871524922666211231115638
Articles Ahead of Print
Behavioral Pharmacology of Five Uncommon Passiflora Species Indicates Sedative and Anxiolytic-like Potential
Marna Eliana Sakalem*, Ricardo Tabach*, Miriane de Oliveira and Elisaldo Araújo Carlini
DOI: 10.2174/1871524922666220426102650
View Abstract View on PubMed
In silico Study of Acetylcholinesterase and Beta-secretase Inhibitors: Potential Multitarget Anti-Alzheimerâs Agents
Daniel Castro da Costa, Hueldem Ronam Cristo Teixeira, Raí Campos Silva, Isaque Antonio Galindo Francischini, Carlos Henrique Tomich de Paula da Silva and Lorane Izabel da Silva Hage-Melim*
DOI: 10.2174/1871524922666220517110606
View Abstract
Design, Synthesis and Evaluation of Benzimidazole Hybrids to Inhibit Acetylcholinesterase and COX for Treatment of Alzheimer's Disease
Sukhvir Kaur, Richa Minhas, Shivam Mishra, Birpal Kaur, Yogita Bansal* and Gulshan Bansal
DOI: 10.2174/1871524922666220428134001
View Abstract
Synthesis and CNS Activity of Phenytoin Derivatives
Rahul Chauhan, Shweta Verma* and Alankar Shrivasatava
DOI: 10.2174/1871524922666220429122141
View Abstract View on PubMed
The Inflammatory Effect of Epigenetic Factors and Modifications in Depressive Disorder: A Review
Keming Qi, Yi Yu, Jiangli Guan, Jiayuan Zhang, Wei Lu and Yicong Wei*
DOI: 10.2174/1871524922666220308144518
View Abstract View on PubMed
Therapeutic Potential and Clinical Evidence of Hesperidin as Neuroprotective Agent
Shivangi Joshi, Ashwani K. Dhingra*, Bhawna Chopra, Kumar Guarve and Deepak Bhateja
DOI: 10.2174/1871524922666220404164405
View Abstract View on PubMed
Pyrazole Based Furanone Hybrids as Novel Antimalarial: A Combined Experimental, Pharmacological and Computational Study
Deepika Choudhary, Isha Rani, Jyoti Monga, Rajat Goyal, Asif Husain, Prabha Garg and Sukhbir Lal Khokra*
DOI: 10.2174/1871524922666220301121811
View Abstract View on PubMed
Promising Effects of Naringenin and Melatonin against Hepatic Encephalopathy Impairments Induced by Bile Duct Ligation in Male Rats
Elahe Karami Raviz, Fatemeh Noormand, Ali Sharifzadeh Kermani, Ali Galedari, Khadijeh Esmaeilpour, Marzieh Maneshian, Taj Pari Kalantaripour, Shahriar Dabiri and Majid Asadi- Shekaari*
DOI: 10.2174/1871524922666220314123052
View Abstract View on PubMed
Abstracts Ahead of Print
Formulation Development and in-vitro Evaluation of Escitalopram Fast Dissolving Tablets
Vishal Bhatia, Ashwani K. Dhingra*, Rameshwar Dass, Bhawna Chopra and Kumar Guarve
DOI: 10.2174/1871524922666220624113719
View Abstract
Are Patients with Schizophrenia reporting reliably their Cannabis Use? An African cross-sectional study
Ismail Rammouz*, Mohamed Merzouki, Sara Bouri, Aalouane Rachid, Amine Bout and Saïd Boujraf
DOI: 10.2174/1871524922666220620150033
View Abstract
Novel molecular targets and mechanisms for neuroprotective modulation in neurodegenerative disorders
Aala Azari, Amin Goodarzi, Behrouz Jafarkhani, Mohammad Eghbali, Zohreh Karimi, Seyed Sajad Hosseini Balef and Hamid Irannejad*
DOI: 10.2174/1871524922666220616092132
View Abstract
Phyllanthus emblica L. regulates BDNF/PI3K pathway to modulate glutathione towards mitoprotection and neuroprotection in a rodent model of ischemic stroke
Deepaneeta Sarmah, Geetesh Verma, Aishika Datta, Namrata Vadak, Antra Chaudhary, Kiran Kalia and Pallab Bhattacharya*
DOI: 10.2174/1871524922666220607093400
View Abstract
Erythroxylum cuneatum prevented cellular adaptation in morphine-induced neuroblastoma cells
Noor Azuin Suliman, Mohamad Aris Mohd Moklas*, Che Norma Mat Taib, Mohamad Taufik Hidayat Baharuldin and Samaila Musa Chiroma
DOI: 10.2174/1871524922666220516151121
View Abstract
The effects of vitamin D3 and melatonin combination on pentylenetetrazole-induced seizures in mice
Azam Hosseinzadeh, Ehsanz Dehdashtian, Majid Jafari-Sabet and Saeed Mehrzadi*
DOI: 10.2174/1871524922666220429121253
View Abstract
Biomedical Applications of Polyurethane Hydrogels, Polyurethane Aerogels and Polyurethane-Graphene Nanocomposite Materials
Saganuwan Alhaji Saganuwan*
DOI: 10.2174/1871524922666220429115124
View Abstract
Cholinesterase activity in the eye?
Sandra Carolina Durán-Cristiano*
DOI: 10.2174/1871524922666220414093730
View Abstract
Published Contents
Editor's Choice
Influence of Inosine on Cerebral Hemodynamics in Space Motion Sickness in Experimental Animals
, 2021; 21(2): 93 - 103Asie N. Useinova , Vitalii B. Kaliberdenko , Igor D. Sapegin , Shanmugaraj Kulanthaivel *, Michael V. Shterenshis , Maria I. Dmitriyevskaya and Keerthanaa Balasundaram
DOI: 10.2174/1871524921666210428111827
α-Substituted Lactams and Acetamides: Ion Channel Modulators that Show Promise in Treating Drug-resistant Epilepsy
, 2020; 20(2): 79 - 87Arcadius V. Krivoshein*
DOI: 10.2174/1871524920666200510005458
Conversion of Benzimidazoles, Imidazothiazoles and Imidazoles into more Potent Central Nervous System Acting Drugs
, 2020; 20(1): 3 - 12Saganuwan A. Saganuwan*
DOI: 10.2174/1871524919666190621160323
Antioxidant Effect of Flavonoids Present in Euterpe oleracea Martius and Neurodegenerative Diseases: A Literature Review
, 2019; 19(2): 75 - 99Nayana Keyla Seabra de Oliveira*, Marcos Rafael Silva Almeida, Franco Márcio Maciel Pontes, Mariana Pegrucci Barcelos, Carlos Henrique Tomich de Paula da Silva, Joaquín María Campos Rosa, Rodrigo Alves Soares Cruz and Lorane Izabel da Silva Hage-Melim*
DOI: 10.2174/1871524919666190502105855
A Novel Non-invasive Effective Method for Potential Treatment of Degenerative Disc Disease: A Hypothesis
, 2019; 19(1): 8 - 14Siva G. Somasundaram, Cristian Muresanu, Pamela Schield, Alfiya Makhmutovа, Elena V. Bovina, Vladimir P. Fisenko, Nusrat F. Hasanov and Gjumrakch Aliev*
DOI: 10.2174/1871524918666181017152053
Classification (Agonist/Antagonist) and Regression “Structure-Activity” Models of Drug Interaction with 5-HT6
, 2018; 18(3): 213 - 221Oleg A. Raevsky, Veniamin Y. Grigorev, Alexander V. Yarkov, Daniel E. Polianczyk, Vadim V. Tarasov, Elena V. Bovina, Elena N. Bryzhakina, John C. Dearden, Marco Avila-Rodriguez and Gjumrakch Aliev*
DOI: 10.2174/1871524918666180827100437
Nitrocatechol Derivatives of Chalcone as Inhibitors of Monoamine Oxidase and Catechol-O-Methyltransferase
, 2018; 18(2): 115 - 127Idalet Engelbrecht, Jacobus P. Petzer and Anel Petzer*
DOI: 10.2174/1871524918666180426125714
Astrocyte`s RAGE: More Than Just a Question of Mood
, 2018; 18(1): 39 - 48Rodrigo E. Gonzalez-Reyes* and Maria G. Rubiano
DOI: 10.2174/1871524916999160505105121
Synthesis, Computational and Pharmacological Evaluation of N-(2-benzoyl- 4-chlorophenyl)-2-(4-(Substituted Phenyl) Piperazin-1-yl) Acetamides as CNS Agents
, 2017; 17(3): 229 - 238Shweta Verma*, Surendra Kumar and Sushil Kumar
DOI: 10.2174/1871524917666170321103951
Alpha-7 Nicotinic Receptors in Nervous System Disorders: From Function to Therapeutic Perspectives
, 2017; 17(2): 100 - 108Antonella De Jaco, Laura Bernardini, Jessica Rosati and Ada Maria Tata*
DOI: 10.2174/1871524916666160729111446
Open Access Articles
The Efficacy of Melanin Precursor QIAPI 1© Against Age-related Macular Degeneration (AMD): A Case Report
, 2020; 20(3): 218 - 225Arturo S. Herrera, Narasimha M. Beeraka, Luis Fernando T. Solis, Liudmila M. Mikhaleva, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*
Most Cited Articles
Perspective
Unraveling the structural requirements of chalcone chemistry towards monoamine oxidase inhibition
, 2019; 19(1): 6-7.Bijo Mathew
DOI: 10.2174/1871524919666190131160122
Review Article
Acrylamide induced toxicity and the propensity of phytochemicals in amelioration: A review
, 2019; 19(2): 100-113.Shinomol George Kunnel*, Sunitha Subramanya, Pankaj Satapathy, Ishtapran Sahoo and Farhan Zameer*
DOI: 10.2174/1871524919666190207160236
Review Article
Berberine: A plant-derived alkaloid with therapeutic potential to combat Alzheimer’s disease
, 2019; 19(3): 154-170.Anurag K. Singh, Santosh K. Singh, Manmath K. Nandi, Gaurav Mishra, Anand Maurya, Arati Rai, Gopal K. Rai, Rajendra Awasthi*, Bhupesh Sharma and Giriraj T. Kulkarni
DOI: 10.2174/1871524919666190820160053
Review Article
Antioxidant effect of flavonoids present in euterpe oleracea martius and neurodegenerative diseases: A literature review
, 2019; 19(2): 75-99.Nayana Keyla Seabra de Oliveira*, Marcos Rafael Silva Almeida, Franco Márcio Maciel Pontes, Mariana Pegrucci Barcelos, Carlos Henrique Tomich de Paula da Silva, Joaquín María Campos Rosa, Rodrigo Alves Soares Cruz and Lorane Izabel da Silva Hage-Melim*
DOI: 10.2174/1871524919666190502105855
Research Article
Development and characterization of nasal delivery of selegiline hydrochloride loaded nanolipid carriers for the management of parkinson’s disease
, 2019; 19(1): 46-56.Neeraj Mishra*, Sawarni Sharma, Rahul Deshmukh, Anoop Kumar and Ruchika Sharma
DOI: 10.2174/1871524919666181126124846
Research Article
Evaluation of selected natural compounds as dual inhibitors of catechol-o-methyltransferase and monoamine oxidase
, 2019; 19(2): 133-145.Idalet Engelbrecht, Jacobus P. Petzer and Anél Petzer*
DOI: 10.2174/1871524919666190619090852
Review Article
Aging affects nicotinic acetylcholine receptors in brain
, 2019; 19(2): 119-124.Yuri N. Utkin*
DOI: 10.2174/1871524919666190320102834
Research Article
Behavioral evaluation of the effects of aqueous and ethanol extracts of suaeda vermiculata forssk on rats
, 2020; 20(2): 122-127.Hamdoon A. Mohammed*
DOI: 10.2174/1871524920666200319142536
Research Article
An evaluation of the effects of pyridoxal phosphate in chlorpromazineinduced parkinsonism using mice
, 2020; 20(1): 13-25.Anthony T. Olofinnade, Tolulope M. Onaolapo, Samad Oladimeji, Adetunji M. Fatoki, Covenant I. Balogun, Adejoke Y. Onaolapo* and Olakunle J. Onaolapo
DOI: 10.2174/1871524920666200120142508
Research Article
Bacopa monnieri supplements offset paraquat-induced behavioral phenotype and brain oxidative pathways in mice
, 2019; 19(1): 57-66.Gokul Krishna*, Ravikumar Hosamani and Muralidhara
DOI: 10.2174/1871524919666190115125900
Research Article
A novel highly selective cannabinoid CB2 agonist reduces in vitro growth and TGF-beta release of human glial cell tumors
, 2019; 19(3): 206-214.Chiara Cioni, Maristella Tassi, Giuseppe Marotta, Claudia Mugnaini, Federico Corelli* and Pasquale Annunziata*
DOI: 10.2174/1871524919666190923154351
Review Article
Noradrenergic regulation of hippocampus-dependent memory
, 2019; 19(3): 187-196.Peter V. Nguyen and Steven A. Connor*
DOI: 10.2174/1871524919666190719163632
Research Article
Design, synthesis and biological activity of some 4, 5-disubstituted-2, 4-dihydro-3h-1, 2, 4-triazole-3-thione derivatives
, 2019; 19(3): 197-205.Krishan Kumar Verma*, Umesh Kumar Singh and Jainendra Jain
DOI: 10.2174/1871524919666190722144424
Letter
Cholinesterase inhibitory activities of selected halogenated thiophene chalcones
, 2019; 19(1): 67-71.Della G.T. Parambi, Fakhrya Aljoufi, Vikneswaran Murugaiyah, Githa E. Mathew, Sanal Dev, Balasubramanain Lakshminarayanan, Omnia M. Hendawy and Bijo Mathew*
DOI: 10.2174/1871524918666181119114016
Review Article
A link between brain insulin resistance and cognitive dysfunctions: Targeting ca<sup>2+</sup>/camp signalling
, 2020; 20(2): 103-109.Leandro B. Bergantin*
DOI: 10.2174/1871524920666200129121232
Most Accessed Articles
Influence of Inosine on Cerebral Hemodynamics in Space Motion Sickness in Experimental Animals
, 2021; 21(2): 93-103.Asie N. Useinova , Vitalii B. Kaliberdenko , Igor D. Sapegin , Shanmugaraj Kulanthaivel *, Michael V. Shterenshis , Maria I. Dmitriyevskaya and Keerthanaa Balasundaram
DOI: 10.2174/1871524921666210428111827
Concentration-dependent Effects of Dietary L-Ascorbic Acid Fortification in the Brains of Healthy Mice
, 2021; 21(2): 104-113.Anthony T. Olofinnade, Adejoke Y. Onaolapo* and Olakunle J. Onaolapo
DOI: 10.2174/1871524921666210315130023
Effects on the Post-translational Modification of H3K4Me3, H3K9ac, H3K9Me2, H3K27Me3, and H3K36Me2 Levels in Cerebral Cortex, Hypothalamus and Pons of Rats after a Systemic Administration of Cannabidiol: A Preliminary Study
, 2021; 21(2): 142-147.José Carlos Pastrana-Trejo, Fátima Duarte-Aké, Rosa Us-Camas, Clelia De-la-Peña, Linda Parker, Roger G. Pertwee and Eric Murillo-Rodríguez*
DOI: 10.2174/1871524920666200924114524
Statistical Review of the Suicide Attempts Rates Committed on Polish Railway Tracks between the Years 2013-2016
, 2021; 21(2): 85-92.Marta Makara-Studzinska, Adam Czabański, Katarzyna Gronowska, Jerzy Leszek, Elizaveta V. Mikhaylenko, Marco F. Avila-Rodriguez, Cristian Muresanu, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*
DOI: 10.2174/1871524921666210204220621
Protective Effect of Capparis spinosa Extract against Focal Cerebral Ischemia-reperfusion Injury in Rats
, 2021; 21(2): 148-153.Hassan Rakhshandeh, Samira Asgharzade, Mohammad Bagher Khorrami and Fatemeh Forouzanfar *
DOI: 10.2174/1871524921666210625112356
Anti-depressant, Anxiolytic, and the Muscle Relaxant Activity of Hydroalcoholic Extract of Cissampelos pareira Linn. Leaves
, 2021; 21(2): 114-124.Mohammad Asif*, Jayesh Dwivedi and Sandeep Yadav
DOI: 10.2174/1871524921666210505101704
Anti-convulsive Effect of Thiamine and Melatonin Combination in Mice: Involvement of Oxidative Stress
, 2021; 21(2): 125-129.Ehsan Dehdashtian, Azam Hosseinzadeh, Karim Hemati, Mohammad Yahya Karimi, Iman Fatemi and Saeed Mehrzadi*
DOI: 10.2174/1871524921666210623161212
Synthesis, Molecular Docking, and Biological Evaluation of Some Novel 2- (5-Substituted 1,3,4-oxadiazole-2-yl)-1,3-benzothiazole Derivatives as Anticonvulsant Agents
, 2021; 21(2): 130-141.Sukhbir Lal Khokra*, Simranjeet Kaur, Sahil Banwala, Karan Wadhwa and Asif Husain
DOI: 10.2174/1871524921666210607153407
The Neuroprotective Properties, Functions, and Roles of Cannabis sativa in Selected Diseases Related to the Nervous System
, 2021; 21(1): 20-38.Onesimus Mahdi, Mohamad T.H. Baharuldin, Nurul Huda M. Nor, Samaila M. Chiroma, Saravanan Jagadeesan and Mohamad A.M. Moklas*
DOI: 10.2174/1871524921666210127110028
Neuroendocrine Response to Psychosocial Stressors, Inflammation Mediators and Brain-periphery Pathways of Adaptation
, 2021; 21(1): 2-19.Lionella Palego, Gino Giannaccini and Laura Betti*
DOI: 10.2174/1871524920999201214231243
Evaluation of the Behavioural, Antioxidative and Histomorphological Effects of Folic Acid-supplemented Diet in Dexamethasone-induced Depression in Mice
, 2021; 21(1): 73-81.Joshua Falade*, Adejoke Y. Onaolapo and Olakunle J. Onaolapo
DOI: 10.2174/1871524921666210114125355
In silico Screening of Pyridoxine Carbamates for Anti-Alzheimer’s Activities
, 2021; 21(1): 39-52.Dnyaneshwar Baswar, Abha Sharma and Awanish Mishra*
DOI: 10.2174/1871524920666201119144535
Synthesis and Biological Evaluation of Amino Acid Based Mutual Amide Prodrugs of Phenytoin as Anticonvulsant Agents
, 2021; 21(1): 53-72.Sampada Jangam*, Meenakshi Deodhar and Sagar Wankhede
DOI: 10.2174/1871524920666201109152344
Conversion of Benzimidazoles, Imidazothiazoles and Imidazoles into more Potent Central Nervous System Acting Drugs
, 2020; 20(1): 3-12.Saganuwan A. Saganuwan*
DOI: 10.2174/1871524919666190621160323
The Efficacy of Melanin Precursor QIAPI 1© Against Age-related Macular Degeneration (AMD): A Case Report
, 2020; 20(3): 218-225.Arturo S. Herrera, Narasimha M. Beeraka, Luis Fernando T. Solis, Liudmila M. Mikhaleva, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*
DOI: 10.2174/1871524920666201109152951
Editor-in-Chief
Ramon Cacabelos
International Center of Neuroscience and Genomic Medicine
EuroEspes Biomedical Research Center
Corunna
(Spain)
Biography
International Center of Neuroscience and Genomic Medicine
EuroEspes Biomedical Research Center
Corunna
Biography
Biography of Ramon Cacabelos
Dr. Ramón Cacabelos is Professor of Genomic Medicine and President of the EuroEspes Biomedical Research Center, Corunna, Spain. He received his M.D. from Oviedo University, Ph.D. from Santiago University, and D.M.Sci. (Psychiatry) from Osaka University Medical School, Osaka, Japan. After a decade at the Department of Psychiatry in Osaka, he returned to Spain and focused his research activity on the genomics and pharmacogenomics of neurodegenerative disorders. He has published over 600 papers and 24 books, is Editor-in-Chief of the first World Guide for Drug Use and Pharmacogenomics, and is President of the World Association of Genomic Medicine.
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