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CNS & Neurological Disorders - Drug Targets

Formerly: Current Drug Targets - CNS & Neurological Disorders

Volume 21, 10 Issues, 2022
ISSN: 1996-3181 (Online)
ISSN: 1871-5273 (Print)
This journal supports open access

Aims & Scope

CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.

CNS & Neurological Disorders - Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

CNS & Neurological Disorders - Drug Targets


Volume 21


Number 9

Mini-Review Article

Mini-Review Article

Immunotherapeutics for AD: A Work in Progress

, 21(9): 752 - 765

Anuja Sharma, Jaspreet Singh Anand and Yatender Kumar *

DOI: 10.2174/1871527320666210903101522

Review Article

Role of Vitamins in Neurodegenerative Diseases: A Review

, 21(9): 766 - 773

Ravi Ranjan Kumar, Lovekesh Singh, Amandeep Thakur, Shamsher Singh and Bhupinder Kumar*

DOI: 10.2174/1871527320666211119122150

Review Article

An Overview of Acute Flaccid Myelitis

, 21(9): 774 - 794

Aseem Setia, Jasween Bhatia and Sankha Bhattacharya*

DOI: 10.2174/1871527320666211125101424

Review Article

A Critical Analysis of Quercetin as the Attractive Target for the Treatment of Parkinson's Disease

, 21(9): 795 - 817

Ozlem Bahadır Acıkara, Gökçe Şeker Karatoprak, Çiğdem Yücel, Esra Küpeli Akkol*, Eduardo Sobarzo-Sánchez, Maryam Khayatkashani, Mohammad Amjad Kamal and Hamid Reza Khayat Kashani*

DOI: 10.2174/1871527320666211206122407

CNS & Neurological Disorders - Drug Targets, Volume 21 (2022) - Number 10

This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Importance of Pharmacophore in Designing Anticonvulsant Agents

Amol Kale*, Rajendra Kakde, Smita Pawar, Vishal Jagtap and Rahul Dorgude

DOI: 10.2174/1871527321666220401115529
View Abstract View on PubMed

Notopterygium incisum Root Extract (NRE) Alleviates Epileptiform Symptoms in PTZ-Induced Acute Seizure Mice

Lijun Zhou, Yaping Gao, Hongyuan Lu, Wenwu Liu, Xiangbo Xu, Bo Xing, Xu Liang, Nan Wang, Xiaowen Jiang and Qingchun Zhao*

DOI: 10.2174/1871527321666220406111745
View Abstract View on PubMed

Oxytocin Effect in Adult Patients With Autism: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zahra Kiani, Tahereh Farkhondeh, Hamed Aramjoo, Michael Aschner, Hossein Beydokhti, Aliakbar Esmaeili, Morteza Arab-Zozani* and Saeed Samarghandian*

DOI: 10.2174/1871527321666220517112612
View Abstract View on PubMed

Natural Products as Bioactive Agents in the Prevention of Dementia

Hamid Ullah, Abrar Hussain, Muhammad Asif, Faheem Nawaz and Mahmood Rasool*

DOI: 10.2174/1871527321666220422085835
View Abstract View on PubMed

Abstracts Ahead of Print

Bis-iodine-labeled Curcumin as a Potential CT Imaging Agent for β-amyloid Plaques in the Brain

Yaqian Dai, Liduo Peng, Xiaoyan Tian, Xingwang Wu, Yuanhong Xu*, Taoshan Jiang* and Jinping Qiao*

DOI: 10.2174/1871527321666220707091435
View Abstract

Emerging Promise of Phytochemicals in Ameliorating Neurological Disorders.

Megala Jayaraman*, Parijat Dutta, Sabari Krishnan, Khyati Arora, Diveyaa Sivakumar and Hanumanth Rao Balaji Raghavendran

DOI: 10.2174/1871527321666220701153926
View Abstract

Clinical Onset of Action of Incobotulinum Toxin A Preparation.

Riccardo Marvulli*, Maurizio Ranieri, Laura Belinda Rizzo, Francesco Marra, Giancar lo Ianieri and Marisa Megna

DOI: 10.2174/1871527321666220630154404
View Abstract

Published Contents

Editor's Choice

Cellular Senescence and ApoE4: Their Repercussions in Alzheimer’s Disease

, 2021; 20(9): 778 - 785

Angeles C. Tecalco-Cruz*, Jesús Zepeda-Cervantes, Lilia López-Canovas, Josué Oriando Ramírez-Jarquín, José Pedraza-Chaverrí and Alfredo Briones-Herrera

DOI: 10.2174/1871527320666210628102721

Cellular and Molecular Mechanisms of Dementia: Decoding the Causal link of Diabetes Mellitus in Alzheimer’s Disease

, 2021; 20(7): 602 - 612

Mahmood Rasool*, Arif Malik, Sulayman Waquar, Ahmad Zaheer, Muhammad Asif, Zafar Iqbal, Kalamegam Gauthaman*, Mohammad Amjad Kamal and Peter Natesan Pushparaj*

DOI: 10.2174/1871527320666210212114116

Neurological Manifestations of COVID-19 and the Importance of Magnetic Resonance Imaging

, 2021; 20(5): 390 - 391

Rubens J. Gagliardi*, Renan Domingues, Cristine Cukier, Maria F. Mendes, Vivian D.B. Gagliardi and Francisco T.M. de Oliveira

DOI: 10.2174/1871527320666210122093458

The Role of Statins in the Management of Delirium: Recent Advances

, 2021; 20(3): 203 - 215

Junhui Chen, Yuhai Wang, Ximin Hu, Mingchang Li, Kun Xiong, Zhaocai Zhang* and Qianxue Chen*

DOI: 10.2174/1871527319666200720111318

Nanoparticles Based Intranasal Delivery of Drug to Treat Alzheimer’s Disease: A Recent Update

, 2020; 19(9): 648 - 662

Manisha Pandey*, Hira Choudhury*, Rohit Kumar Verma, Viney Chawla, Subrat Kumar Bhattamisra, Bapi Gorain, Maria Abdul Ghafoor Raja and Muhammad Wahab Amjad

DOI: 10.2174/1871527319999200819095620

Open Access Articles

Molecular and Biochemical Pathways Encompassing Diabetes Mellitus and Dementia

, 2022; 21(7): 542 - 556

Tapan Behl*, Arpita Arora, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al-Harrasi, Simona Bungau and Ebrahim Mostafavi*

L-Ala-L-Gln Suppresses Hypoxic Phenotype and Fibrogenic Activity of Rat Perineurial Fibroblasts

, 2022; 21: 1 - 13 (E-Pub Ahead of Print)

Nilabh Ghosh, Catherine Bregere, Pia Bustos and Raphael Guzman*

Effectiveness and Safety Profile of Ginkgo biloba Standardized Extract (EGb761®) in Patients with Amnestic Mild Cognitive Impairment

, 2021; 20(4): 378 - 384

Ovidiu Băjenaru, Gabriel Prada, Florina Antochi, Cătălin Jianu, Cătălina Tudose, Adina Cuciureanu, Any A. Docu, Valérie Perrot, Madalina Avram and Cristina Tiu*

Management of Impulse Control Disorders with Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease

, 2020; 19(8): 611 - 617

Deborah Amstutz, Steffen Paschen, Martin Lenard Lachenmayer, Marie Elise Maradan-Gachet, Günther Deuschl, Paul Krack and Ines Debove*

When Sick Brain and Hopelessness Meet: Some Aspects of Suicidality in the Neurological Patient

, 2020; 19(4): 257 - 263

Alessandra Costanza*, Andrea Amerio, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Isabella Berardelli, Maurizio Pompili and Mario Amore

Fire Needle Acupuncture Regulates Wnt/ERK Multiple Pathways to Promote Neural Stem Cells to Differentiate into Neurons in Rats with Spinal Cord Injury

, 2019; 18(3): 245 - 255

Jiachun Xu, Suli Cheng, Zhaohua Jiao, Zhiheng Zhao, Zhimin Cai, Nan Su, Baohong Liu, Zhen Zhou* and Yan Li*

Oleanolic Acid Ameliorates Aβ25-35 Injection-induced Memory Deficit in Alzheimer’s Disease Model Rats by Maintaining Synaptic Plasticity

, 2018; 17(5): 389 - 399

Kai Wang, Weiming Sun, Linlin Zhang, Wei Guo, Jiachun Xu, Shuang Liu, Zhen Zhou and Yulian Zhang*

Physiological and Morphological Principles Underpinning Recruitment of the Cerebellar Reserve

, 2018; 17(3): 184 - 192

Shinji Kakei*, Takahiro Ishikawa, Jongho Lee, Takeru Honda and Donna S. Hoffman

Demonstration of Biological and Immunological Equivalence of a Generic Glatiramer Acetate

, 2017; 16(6): 714 - 723

Josephine D`Alessandro, Kevin Garofalo, Ganlin Zhao, Christopher Honan, Jay Duffner, Ishan Capila, Ian Fier, Ganesh Kaundinya, Daniel Kantor and Tanmoy Ganguly*

Nanomaterials for Neurology: State-of-the-Art

, 2016; 15(10): 1306 - 1324

María Fernanda Veloz-Castillo, Rachel M. West, Jessica Cordero-Arreola, Oscar Arias-Carrión and Miguel A. Méndez-Rojas

The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders

, 2016; 15(5): 564 - 577

Yuko Okamoto, Makoto Ishitobi, Yuji Wada and Hirotaka Kosaka

The Effects of Testosterone Supplementation on Cognitive Functioning in Older Men.

, 2016; 15(3): 337 - 343

Eka J. Wahjoepramono, Prita R. Asih, Vilia Aniwiyanti, Kevin Taddei, Satvinder S. Dhaliwal, Stephanie J. Fuller, Jonathan Foster, Malcolm Carruthers, Giuseppe Verdile, Hamid R Sohrabi and Ralph N. Martins

Most Cited Articles

Review Article

Nf-κb as a key mediator of brain inflammation in Alzheimer’s disease

, 2019; 18(1): 3-10.

Chul Ju Hwang, Dong-Young Choi, Mi Hee Park and Jin Tae Hong*

DOI: 10.2174/1871527316666170807130011

Research Article

Ethyl acetohydroxamate incorporated chalcones: Unveiling a novel class of chalcones for multitarget monoamine oxidase-b inhibitors against alzheimer’s disease

, 2019; 18(8): 643-654.

Reeta, Seung Cheol Baek, Jae Pil Lee, T.M. Rangarajan*, Ayushee, Rishi Pal Singh, Manjula Singh, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Hoon Kim* and Bijo Mathew*

DOI: 10.2174/1871527318666190906101326

Review Article

Epigenetics in neurodegenerative diseases: The role of histone deacetylases

, 2019; 18(1): 11-18.

Sorabh Sharma, K.C. Sarathlal and Rajeev Taliyan*

DOI: 10.2174/1871527317666181004155136

Letter Article

When sick brain and hopelessness meet: Some aspects of suicidality in the neurological patient

, 2020; 19(4): 257-263.

Alessandra Costanza*, Andrea Amerio, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Isabella Berardelli, Maurizio Pompili and Mario Amore

DOI: 10.2174/1871527319666200611130804

Review Article

Perspective design of chalcones for the management of cns disorders: A mini-review

, 2019; 18(6): 432-445.

Bijo Mathew*, Della Grace Thomas Parambi, Vishnu Sankar Sivasankarapillai, Md. Sahab Uddin, Jerad Suresh, Githa Elizabeth Mathew, Monu Joy, Akash Marathakam and Sheeba Varghese Gupta

DOI: 10.2174/1871527318666190610111246

Research Article

The role of annexin A1 and formyl peptide receptor 2/3 signaling in chronic corticosterone-induced depression-like behaviors and impairment in hippocampal-dependent memory

, 2020; 19(1): 27-43.

Alessio Filippo Peritore, Rosalia Crupi, Maria Scuto, Enrico Gugliandolo, Rosalba Siracusa, Daniela Impellizzeri, Marika Cordaro, Ramona D’amico, Roberta Fusco, Rosanna Di Paola and Salvatore Cuzzocrea*

DOI: 10.2174/1871527319666200107094732

Research Article

Xuesaitong may protect against ischemic stroke by modulating microglial phenotypes and inhibiting neuronal cell apoptosis via the STAT3 signaling pathway

, 2019; 18(2): 115-123.

Fangfang Li , Haiping Zhao, Ziping Han, Rongliang Wang, Zhen Tao, Zhibin Fan, Sijia Zhang, Guangwen Li, Zhigang Chen* and Yumin Luo*

DOI: 10.2174/1871527317666181114140340

Review Article

Neuro-psychiatric alterations in patients with diabetic foot syndrome

, 2019; 18(8): 598-608.

Emmanuel Navarro-Flores, Pilar Pérez-Ros, Francisco Miguel Martínez-Arnau, Iván Julían-Rochina and Omar Cauli*

DOI: 10.2174/1871527318666191002094406

Research Article

Cordycepin exerts neuroprotective effects via an anti-apoptotic mechanism based on the mitochondrial pathway in a rotenone-induced parkinsonism rat model

, 2019; 18(8): 609-620.

Xin Jiang, Pei-Chen Tang, Qin Chen, Xin Zhang, Yi-Yun Fan, Bo-Cheng Yu, Xin-Xia Gu, Ying Sun, Xiao-Qun Ge* and Xiao-Ling Zhang*

DOI: 10.2174/1871527318666190905152138

General Research Article

Neuroprotection of rotenone-induced parkinsonism by ursolic acid in pd mouse model

, 2020; 19(7): 527-540.

Walia Zahra, Sachchida Nand Rai, Hareram Birla, Saumitra Sen Singh, Aaina Singh Rathore, Hagera Dilnashin, Richa Singh, Chetan Keswani, Rakesh K. Singh and Surya Pratap Singh*

DOI: 10.2174/1871527319666200812224457

Clinical Trial

Ultramicronized palmitoylethanolamide (Um-PEA) as add-on treatment in fibromyalgia syndrome (FMS): Retrospective observational study on 407 patients

, 2019; 18(4): 326-333.

Vittorio Schweiger*, Alvise Martini, Paola Bellamoli, Katia Donadello, Carlo Schievano, Giovanna D. Balzo, Piercarlo Sarzi-Puttini, Massimo Parolini and Enrico Polati

DOI: 10.2174/1871527318666190227205359

Most Accessed Articles

Therapeutic Potential of Biochanin-A Against Isoproterenol-Induced Myocardial Infarction in Rats

, 2020; 18(1): 31-36.

Govindasami, Sangeethadevi; Uddandrao, Veera Venkata Sathibabu; Raveendran, Nivedha; Sasikumar, Vadivukkarasi

DOI: 10.2174/1871525718666200206114304

Antiobesity Effect of Biochanin-A: Effect on Trace Element Metabolism in High Fat Diet-Induced Obesity in Rats

, 2020; 18(1): 21-30.

Rathinasamy, Jansy Isabella Rani Antony; Uddandrao, Veera Venkata Sathibabu; Raveendran, Nivedha; Sasikumar, Vadivukkarasi

DOI: 10.2174/1871524920666200207101920

Stevia as a Natural Sweetener: A Review

, 2020; 18(2): 94-103.

Arumugam, Balakrishnan; Subramaniam, Arunambiga; Alagaraj, Praveena

DOI: 10.2174/1871525718666200207105436


Edoardo Spina
Department of Clinical and Experimental Medicine
University of Messina
Policlinico Universitario
Via Consolare Valeria
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