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CNS & Neurological Disorders - Drug Targets

Formerly: Current Drug Targets - CNS & Neurological Disorders

Volume 20, 10 Issues, 2021
ISSN: 1996-3181 (Online)
ISSN: 1871-5273 (Print)
This journal supports open access

Aims & Scope

CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.

CNS & Neurological Disorders - Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

CNS & Neurological Disorders - Drug Targets

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Volume 20

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Number 3



Biography   Open Access





Review Article (Mini-Review)

The Role of Statins in the Management of Delirium: Recent Advances

, 20(3): 203 - 215

Junhui Chen, Yuhai Wang, Ximin Hu, Mingchang Li, Kun Xiong, Zhaocai Zhang* and Qianxue Chen*


DOI: 10.2174/1871527319666200720111318


Review Article (Mini-Review)

Targeting Microglial Polarization to Improve TBI Outcomes

, 20(3): 216 - 227

Matti Nathalie, Sai P. Polineni, Christopher N. Chin, Daniela Fawcett, Helene Clervius, Quesada S.L. Maria, Fernandez Legnay, Lucas Rego, Anil K. Mahavadi, Walter J. Jermakowicz, Lee SW-T, Shoji Yokobori and Shyam Gajavelli*


DOI: 10.2174/1871527319666200918145903








Research Article

The Retrotransposition of L1 is Involved in the Reconsolidation of Contextual Fear Memory in Mice

, 20(3): 273 - 284

Wen-Juan Zhang, Yan-Qing Huang, Ao Fu, Kang-Zhi Chen, Song-Ji Li, Qi Zhang, Guang-Jing Zou, Yu Liu, Jing-Zhi Su, Shi-Fen Zhou, Jun-Wen Liu, Fang Li, Fang-Fang Bi* and Chang-Qi Li*


DOI: 10.2174/1871527319666200812225509


CNS & Neurological Disorders - Drug Targets , Volume 20 (2021) - Number 8


This issue is in progress but contains articles that are final and fully citable.

CNS & Neurological Disorders - Drug Targets , Volume 20 (2021) - Number 7


This issue is in progress but contains articles that are final and fully citable.

CNS & Neurological Disorders - Drug Targets , Volume 20 (2021) - Number 6


This issue is in progress but contains articles that are final and fully citable.

CNS & Neurological Disorders - Drug Targets , Volume 20 (2021) - Number 5


This issue is in progress but contains articles that are final and fully citable.

CNS & Neurological Disorders - Drug Targets , Volume 20 (2021) - Number 4


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print


Sex-Related Differences in Polygraphic Parameters in a Population of Patients with Obstructive Sleep Apnea Syndrome


Laura Buratti*, Chiara Rocchi, Viviana Totaro, Serena Broggi, Simona Lattanzi, Giovanna Viticchi, Lorenzo Falsetti and Mauro Silvestrini


DOI: 10.2174/1871527320666211022104140
View Abstract



The Protective Effects of Pioglitazone Against Cognitive Impairment Caused by L-methionine Administration in a Rat Model


Karem H. Alzoubi*, Omar F. Khabour, Mahmoud Alfaqih, Murad Tashtoush, Sayer I. Al-Azzam, Nizar M. Mhaidat and Nasr Alrabadi


DOI: 10.2174/1871527320666210809122523
View Abstract View on PubMed




Lipid Nanocarriers for Neurotherapeutics: Introduction, Challenges, Blood-brain Barrier, and Promises of Delivery Approaches


Mohammed Aslam, Md. Noushad Javed*, Hala Hasan Deeb, Michel Kaisar Nicola, Mohd. Aamir Mirza, Md. Sabir Alam, Md. Habban Akhtar and Aafrin Waziri


DOI: 10.2174/1871527320666210706104240
View Abstract


Persons with Co-existing Neurological Disorders: Risk Analysis, Considerations and Management in COVID-19 Pandemic


Sumit Sharma, Sonali Batra, Saurabh Gupta*, Vivek Kumar Sharma, Md Habibur Rahman and Mohammad Amjad Kamal


DOI: 10.2174/1871527320666210308113457
View Abstract View on PubMed


In Vivo Antidepressant Efficacy of 3-Substituted Thietane-1,1-dioxide Derivative - A Preliminary Study for Novel Anti-Depression Therapy in Neurological Disorders


Irina L. Nikitina, Narasimha M. Beeraka, Gulnara G. Gaisina, Kirill V. Bulygin, Elmira F. Galimova, Shamil N. Galimov, Vladimir N. Nikolenko, Liudmila M. Mikhaleva, Siva G. Somasundaram, Cecil E. Kirkland, Marco Avila-Rodriguez and Gjumrakch Aliev*


DOI: 10.2174/1871527320666210301115028
View Abstract View on PubMed


Role of Calcium Homeostasis in Ischemic Stroke: A Review


Abhilash Ludhiadch, Rashmi Sharma, Aishwarya Muriki and Anjana Munshi*


DOI: 10.2174/1871527320666210212141232
View Abstract View on PubMed


Abstracts Ahead of Print




Comparing the efficacy and safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for sedation in colonoscopy patients: A double-blinded randomized clinical trial


Reza Aminnejad, Ahmad Hormati*, Hamed Shafiee, Faezeh Alemi, Maryam Hormati, Mohammad Saeidi, Sajjad Ahmadpour, Seyed Mahdi Sabouri and Mohammad Aghaali


DOI: 10.2174/1871527320666211006141406
View Abstract


Role of SCN2A c.56G/A Gene Polymorphism in Egyptian Children with Genetic Epilepsy with Febrile Seizure Plus


Naglaa Fathy Barseem*, Essam Shawky A. E. H. Khattab, Dalia Saber Saad and Sameh Abdulla Abd Elnaby


DOI: 10.2174/1871527320666211004123731
View Abstract


Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease


Bhuvaneswari Siwaraman *, Vijaykumar R., Bala Aakash Velmurugan and Ramalakshmi Natarajan


DOI: 10.2174/1871527320666210928160159
View Abstract


Pharmacotherapeutic Potential of Garlic in Age-Related Neurological Disorders


Ramin Ahangar-Sirous, Mohadeseh Poudineh, Arina Ansari, Ali Nili, Seyyed Mohammad Matin Alavi Dana, Zahra Nasiri, Zahra Sadat Hosseini, Dariush Karami, Melika Mokhtari and Niloofar Deravi*


DOI: 10.2174/1871527320666210927101257
View Abstract



Effective Connectivity Between the Orbitofrontal Cortex and the Precuneus Differentiates Major Psychiatric Disorders: Results from a Transdiagnostic Spectral DCM Study


Sevdalina Kandilarova, Drozdstoy Stoyanov*, Katrin Aryutova, Rossitsa Paunova, Mladen Mantarkov, Ivo Mitrev, Anna Todeva-Radneva and Karsten Specht


DOI: 10.2174/1871527320666210917142815
View Abstract


Approaches for ear-targeted delivery systems in neurosensory disorders to avoid chronic hearing loss mediated neurological diseases


Rishabh Verma, Preeti Vyas, Jasmeet Kaur, Md. Noushad Javed, Mohammad Sarafroz, Makhmur Ahmad, Sadaf Jamal Gilani and Mohamad Taleuzzaman*


DOI: 10.2174/1871527320666210903102704
View Abstract


Published Contents

Editor's Choice


Nanoparticles Based Intranasal Delivery of Drug to Treat Alzheimer’s Disease: A Recent Update

, 2020; 19(9): 648 - 662

Manisha Pandey*, Hira Choudhury*, Rohit Kumar Verma, Viney Chawla, Subrat Kumar Bhattamisra, Bapi Gorain, Maria Abdul Ghafoor Raja and Muhammad Wahab Amjad


DOI: 10.2174/1871527319999200819095620





The MMP-2/TIMP-2 System in Alzheimer Disease

, 2020; 19(6): 402 - 416

Hongyue Wang, Longjian Huang, Lei Wu, Jiaqi Lan, Xinhong Feng, Pingping Li* and Ying Peng*


DOI: 10.2174/1871527319666200812223007



The locus of Action of CGRPergic Monoclonal Antibodies Against Migraine: Peripheral Over Central Mechanisms

, 2020; 19(5): 344 - 359

Abimael González-Hernández, Bruno A. Marichal-Cancino, Enrique García-Boll and Carlos M. Villalón*


DOI: 10.2174/1871527319666200618144637




Interlink Between Insulin Resistance and Neurodegeneration with an Update on Current Therapeutic Approaches

, 2020; 19(3): 174 - 183

Subrat Kumar Bhattamisra*, Lee Yuen Shin, Hanis Izzati Binti Mohd Saad, Vikram Rao, Mayuren Candasamy, Manisha Pandey and Hira Choudhury


DOI: 10.2174/1871527319666200518102130





Open Access Articles

Restless Leg Syndrome in Patients with Liver Cirrhosis! Its Frequency, Severity, and Correlation

, 2021; 20(5): 465 - 472

Iftikhar Haider Naqvi*, Jawad Ahmed, Maliha Salim, Muhammad Ubaid, Farheen Malik, Razna Afzal, Muhammad Moinuddin Ashrafi and Muhammad Arbaz Arshad Khan




Effectiveness and Safety Profile of Ginkgo biloba Standardized Extract (EGb761® ) in Patients with Amnestic Mild Cognitive Impairment

, 2021; 20(4): 378 - 384

Ovidiu Băjenaru*, Gabriel Prada, Florina Antochi, Cătălin Jianu, Cătălina Tudose, Adina Cuciureanu, Any Axelerad Docu, Valérie Perrot, Madalina Avram and Cristina Tiu




Management of Impulse Control Disorders with Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease

, 2020; 19(8): 611 - 617

Deborah Amstutz, Steffen Paschen, Martin Lenard Lachenmayer, Marie Elise Maradan-Gachet, Günther Deuschl, Paul Krack and Ines Debove*




Low Serum Levels of Fibroblast Growth Factor 2 in Gunn Rats: A Hyperbilirubinemia Animal Model of Schizophrenic Symptoms

, 2020; 19(7): 503 - 508

Maiko Hayashida*, Sadayuki Hashioka*, Kenji Hayashida, Shoko Miura, Keiko Tsuchie, Tomoko Araki, Muneto Izuhara, Misako Kanayama, Koji Otsuki, Michiharu Nagahama, Muhammad Alim Jaya, Ryosuke Arauchi, Rei Wake, Arata Oh-Nishi, Jun Horiguchi, Tsuyoshi Miyaoka, Masatoshi Inagaki and Eishin Morita




When Sick Brain and Hopelessness Meet: Some Aspects of Suicidality in the Neurological Patient

, 2020; 19(4): 257 - 263

Alessandra Costanza*, Andrea Amerio, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Isabella Berardelli, Maurizio Pompili and Mario Amore





Fire Needle Acupuncture Regulates Wnt/ERK Multiple Pathways to Promote Neural Stem Cells to Differentiate into Neurons in Rats with Spinal Cord Injury

, 2019; 18(3): 245 - 255

Jiachun Xu, Suli Cheng, Zhaohua Jiao, Zhiheng Zhao, Zhimin Cai, Nan Su, Baohong Liu, Zhen Zhou* and Yan Li*




Oleanolic Acid Ameliorates Aβ25-35 Injection-induced Memory Deficit in Alzheimer’s Disease Model Rats by Maintaining Synaptic Plasticity

, 2018; 17(5): 389 - 399

Kai Wang, Weiming Sun, Linlin Zhang, Wei Guo, Jiachun Xu, Shuang Liu, Zhen Zhou and Yulian Zhang*




Physiological and Morphological Principles Underpinning Recruitment of the Cerebellar Reserve

, 2018; 17(3): 184 - 192

Shinji Kakei*, Takahiro Ishikawa, Jongho Lee, Takeru Honda and Donna S. Hoffman




Demonstration of Biological and Immunological Equivalence of a Generic Glatiramer Acetate

, 2017; 16(6): 714 - 723

Josephine D`Alessandro, Kevin Garofalo, Ganlin Zhao, Christopher Honan, Jay Duffner, Ishan Capila, Ian Fier, Ganesh Kaundinya, Daniel Kantor and Tanmoy Ganguly*




Nanomaterials for Neurology: State-of-the-Art

, 2016; 15(10): 1306 - 1324

María Fernanda Veloz-Castillo, Rachel M. West, Jessica Cordero-Arreola, Oscar Arias-Carrión and Miguel A. Méndez-Rojas




The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders

, 2016; 15(5): 564 - 577

Yuko Okamoto, Makoto Ishitobi, Yuji Wada and Hirotaka Kosaka





The Effects of Testosterone Supplementation on Cognitive Functioning in Older Men.

, 2016; 15(3): 337 - 343

Eka J. Wahjoepramono, Prita R. Asih, Vilia Aniwiyanti, Kevin Taddei, Satvinder S. Dhaliwal, Stephanie J. Fuller, Jonathan Foster, Malcolm Carruthers, Giuseppe Verdile, Hamid R Sohrabi and Ralph N. Martins




Ouabain-Induced Signaling and Cell Survival in SK-N-SH Neuroblastoma Cells Differentiated by Retinoic Acid

, 2015; 14(10): 1343 - 1349

Evgeny E. Akkuratov, Jian Wu, David Sowa, Zahoor A. Shah and Lijun Liu





Most Cited Articles

Review Article

Nf-κb as a key mediator of brain inflammation in Alzheimer’s disease

, 2019; 18(1): 3-10.

Chul Ju Hwang, Dong-Young Choi, Mi Hee Park and Jin Tae Hong*


DOI: 10.2174/1871527316666170807130011


Research Article

Ethyl acetohydroxamate incorporated chalcones: Unveiling a novel class of chalcones for multitarget monoamine oxidase-b inhibitors against alzheimer’s disease

, 2019; 18(8): 643-654.

Reeta, Seung Cheol Baek, Jae Pil Lee, T.M. Rangarajan*, Ayushee, Rishi Pal Singh, Manjula Singh, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Hoon Kim* and Bijo Mathew*


DOI: 10.2174/1871527318666190906101326



Review Article

Epigenetics in neurodegenerative diseases: The role of histone deacetylases

, 2019; 18(1): 11-18.

Sorabh Sharma, K.C. Sarathlal and Rajeev Taliyan*


DOI: 10.2174/1871527317666181004155136


Review Article

Perspective design of chalcones for the management of cns disorders: A mini-review

, 2019; 18(6): 432-445.

Bijo Mathew*, Della Grace Thomas Parambi, Vishnu Sankar Sivasankarapillai, Md. Sahab Uddin, Jerad Suresh, Githa Elizabeth Mathew, Monu Joy, Akash Marathakam and Sheeba Varghese Gupta


DOI: 10.2174/1871527318666190610111246


Letter Article

When sick brain and hopelessness meet: Some aspects of suicidality in the neurological patient

, 2020; 19(4): 257-263.

Alessandra Costanza*, Andrea Amerio, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Isabella Berardelli, Maurizio Pompili and Mario Amore


DOI: 10.2174/1871527319666200611130804



Research Article

Xuesaitong may protect against ischemic stroke by modulating microglial phenotypes and inhibiting neuronal cell apoptosis via the STAT3 signaling pathway

, 2019; 18(2): 115-123.

Fangfang Li , Haiping Zhao, Ziping Han, Rongliang Wang, Zhen Tao, Zhibin Fan, Sijia Zhang, Guangwen Li, Zhigang Chen* and Yumin Luo*


DOI: 10.2174/1871527317666181114140340


Review Article

Neuro-psychiatric alterations in patients with diabetic foot syndrome

, 2019; 18(8): 598-608.

Emmanuel Navarro-Flores, Pilar Pérez-Ros, Francisco Miguel Martínez-Arnau, Iván Julían-Rochina and Omar Cauli*


DOI: 10.2174/1871527318666191002094406


Research Article

The role of annexin A1 and formyl peptide receptor 2/3 signaling in chronic corticosterone-induced depression-like behaviors and impairment in hippocampal-dependent memory

, 2020; 19(1): 27-43.

Alessio Filippo Peritore, Rosalia Crupi, Maria Scuto, Enrico Gugliandolo, Rosalba Siracusa, Daniela Impellizzeri, Marika Cordaro, Ramona D’amico, Roberta Fusco, Rosanna Di Paola and Salvatore Cuzzocrea*


DOI: 10.2174/1871527319666200107094732


Research Article

Cordycepin exerts neuroprotective effects via an anti-apoptotic mechanism based on the mitochondrial pathway in a rotenone-induced parkinsonism rat model

, 2019; 18(8): 609-620.

Xin Jiang, Pei-Chen Tang, Qin Chen, Xin Zhang, Yi-Yun Fan, Bo-Cheng Yu, Xin-Xia Gu, Ying Sun, Xiao-Qun Ge* and Xiao-Ling Zhang*


DOI: 10.2174/1871527318666190905152138


Clinical Trial

Ultramicronized palmitoylethanolamide (Um-PEA) as add-on treatment in fibromyalgia syndrome (FMS): Retrospective observational study on 407 patients

, 2019; 18(4): 326-333.

Vittorio Schweiger*, Alvise Martini, Paola Bellamoli, Katia Donadello, Carlo Schievano, Giovanna D. Balzo, Piercarlo Sarzi-Puttini, Massimo Parolini and Enrico Polati


DOI: 10.2174/1871527318666190227205359



Systemic Review Article

Efficacy of celecoxib adjunct treatment on bipolar disorder: Systematic review and meta-analysis

, 2019; 18(1): 19-28.

Daniela V. Bavaresco, Tamy Colonetti, Antônio J. Grande, Francesc Colom, Samira S. Valvassori, João Quevedo and Maria I. da Rosa*


DOI: 10.2174/1871527317666181105162347


Research Article

Exosomal miR-214-5p released from glioblastoma cells modulates inflammatory response of microglia after lipopolysaccharide stimulation through targeting CXCR5

, 2019; 18(1): 78-87.

Jian-kai Yang*, Hong-jiang Liu, Yuanyu Wang, Chen Li, Ji-peng Yang, Liang Yang, Xue-jiao Qi, Yin-long Zhao, Xue-fang Shi, Jing-chen Li, Guo-zhu Sun and Bao-hua Jiao


DOI: 10.2174/1871527317666181105112009



Most Accessed Articles




Herbal Drug Interaction: Mechanistic Details Through the Pharmacokinetic Portfolio

, 2021; 20(8): 677-686.

Salman Ahmed, Haroon Khan*, Hamed Mirzaei, Muhammad Mohtasheemul Hasan, Mohamed Eddouks and Maria Daglia


DOI: 10.2174/1871527319666201008151710



Autophagic Dysfunction in Dementia: Scope for the Development of Potential Remedies

, 2021; 20(8): 704-722.

Bhumika Kumar, Mukesh Pandey, Ashwini Kumar Mishra, Anjali Sharma, Faizana Fayaz and Faheem Hyder Pottoo*


DOI: 10.2174/1871527319666201209112256


Neuroblastoma and Stem Cell Therapy: An Updated Review

, 2021; 20(7): 625-643.

Manoj Kumar Gupta, Suresh Mallepalli, Amooru G Damu and Ramakrishna Vadde*


DOI: 10.2174/1871527319666201102100911


Modifiable Risk Factors Associated with Alzheimer’s Disease with Special Reference to Sleep Disturbance

, 2021; 20(7): 594-601.

Pallavi Singh Chauhan, Meerambika Mishra, Bhupendra Koul, Mayank Sharma and Dhananjay Yadav*


DOI: 10.2174/1871527320666210319111852


A Review on Hematopoietic Stem Cell Treatment for Epilepsy

, 2021; 20(7): 644-656.

Mohan Krishna Ghanta, Neha Merchant and VKS Lakkakula Bhaskar*


DOI: 10.2174/1871527320666210218085816


Experimental Rodent Models of Vascular Dementia: A Systematic Review

, 2021; 20(7): 657-672.

Nidhi Tiwari, Jyoti Upadhyay, Mohd Nazam Ansari*, Syed Shadab Raza, Wasim Ahmad and Mohammad Azam Ansari


DOI: 10.2174/1871527319666210108123438


Melatonin and Sleep Disturbances in Alzheimer’s Disease

, 2021; 20(8): 736-754.

A. H. M. Safayet Ullah Prodhan , Cinzia Cavestro, Mohammad Amjad Kamal and Mohammad Asiful Islam*


DOI: 10.2174/1871527320666210804155617


Cellular and Molecular Mechanisms of Dementia: Decoding the Causal link of Diabetes Mellitus in Alzheimer’s Disease

, 2021; 20(7): 602-612.

Mahmood Rasool*, Arif Malik, Sulayman Waquar, Ahmad Zaheer, Muhammad Asif, Zafar Iqbal, Kalamegam Gauthaman*, Mohammad Amjad Kamal and Peter Natesan Pushparaj*


DOI: 10.2174/1871527320666210212114116


Sleep Disorders Research From 1945 to 2020: A Bibliometric Analysis

, 2021; 20(7): 574-593.

Waseem Hassan*, Mehreen Zafar, Hamsa Noreen, Amina Ara, Antonia Eliene Duarte, Jean Paul Kamdem, Mohammad Amjad Kamal and Joao Batista Teixeira da Rocha


DOI: 10.2174/1871527320666210218085341


Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis

, 2021; 20(2): 112-124.

Lina Zhao, Yanxia Gao, Shigong Guo, Xin Lu, Shiyuan Yu, Zeng Zheng Ge, Hua Dong Zhu and Yi Li*


DOI: 10.2174/1871527319999201117122158


Functional Neuroproteomics: An Imperative Approach for Unravelling Protein Implicated Complexities of Brain

, 2021; 20(7): 613-624.

Ibraheem Husain*, Wasim Ahmad*, Abuzer Ali, Laiba Anwar, Sheikh Md Nuruddin, Kamran Ashraf and Mohammad Amjad Kamal


DOI: 10.2174/1871527320666210202121624




Editor-in-Chief

graphic
Edoardo Spina
Department of Clinical and Experimental Medicine
University of Messina
Policlinico Universitario
Via Consolare Valeria
Messina
(Italy)
Biography
View Full Editorial Board

COPE Compliant

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Journal History

Current Drug Targets - CNS & Neurological Disorders was launched in 2002 and later renamed in 2006 as CNS & Neurological Disorders - Drug Targets.

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