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Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 24, 10 Issues, 2021
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access

Aims & Scope

Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:

  • Target identification and validation
  • Assay design, development, miniaturization and comparison
  • High throughput/high content/in silico screening and associated technologies
  • Label-free detection technologies and applications
  • Stem cell technologies
  • Biomarkers
  • ADMET/PK/PD methodologies and screening
  • Probe discovery and development, hit to lead optimization
  • Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
  • Chemical library design and chemical diversity
  • Chemo/bio-informatics, data mining
  • Compound management
  • Pharmacognosy
  • Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
  • Natural Product Analytical Studies
  • Bipharmaceutical studies of Natural products
  • Drug repurposing
  • Data management and statistical analysis
  • Laboratory automation, robotics, microfluidics, signal detection technologies
  • Current & Future Institutional Research Profile
  • Technology transfer, legal and licensing issues
  • Patents

In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.

Combinatorial Chemistry & High Throughput Screening

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Volume 24

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Number 10





Review Article

Carbon Nano Tubes: Novel Drug Delivery System in Amelioration of Alzheimer’s Disease

, 24(10): 1528 - 1543

Jayanti Mishra, Bhumika Kumar, Mukesh Pandey, Faheem H. Pottoo, Faizana Fayaz, Firdos Alam Khan and Pravat K. Sahoo*


DOI: 10.2174/1386207323999200918112538


Review Article

Envisioning the Future of Nanomedicines in Management and Treatment of Neurological Disorders

, 24(10): 1544 - 1556

Shobhit Kumar*, Priyanka Singh, Shrestha Sharma, Faheem H. Pottoo, Javed Ali and Sanjula Baboota


DOI: 10.2174/1386207323666201217151132


Research Article

A Potential MRI Agent and an Anticancer Drug Encapsulated within CPMV Virus-Like Particles

, 24(10): 1557 - 1571

Alaa A.A. Aljabali*, Lorca Alzoubi, Yassmen Hamzat, Alaa Alqudah, Mohammad A. Obeid, Mazhar S. Al Zoubi, Raed M. Ennab, Walhan Alshaer, Khaled Albatayneh, Bahaa Al-Trad, Dana A. Alqudah, Dinesh Kumar Chellappan, Gaurav Gupta, Murtaza M. Tambuwala, Dua Kamal and David J. Evans


DOI: 10.2174/1386207323666200914110012




Review Article

Herbal Medicine: Clinical Perspective and Regulatory Status

, 24(10): 1573 - 1582

Md. Abul Barkat*, Anjali Goyal, Harshita A. Barkat, Mohammad Salauddin, Faheem H. Pottoo and Esra T. Anwer


DOI: 10.2174/1386207323999201110192942


Review Article

Nutraceuticals for Sleep Disorders

, 24(10): 1583 - 1592

Ruhi Ali*, Sana Tariq, Ozaifa Kareem, Faizana Fayaz, Tahira Aziz, Meenu, Faheem Hyder Pottoo and Nadeem Siddiqui


DOI: 10.2174/1386207324666210121111446


Research Article



Combinatorial Chemistry & High Throughput Screening, Volume 25 (2022) - Number 1


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Current Perspective of COVID-19 on Neurology: A Mechanistic Insight


Rajesh Kumar, Seetha Harilal, Sabitha M., Leena K. Pappachan, Roshni P.R. and Bijo Mathew*


DOI: 10.2174/1386207324666210805121828
View Abstract View on PubMed


Systematic Optimisation of Microtiter Plate Lectin Assay to Improve Sialic Acid Linkage Detection


Nur Hanina Izzati Khairol Mokhtar, Ainulkhir Hussin, Aidil Abdul Hamid, Shahrul Hisham Zainal Ariffin and Muhammad Ashraf Shahidan*


DOI: 10.2174/1386207324666210802122538
View Abstract View on PubMed







Xanthine Oxidase Inhibitory Activity of Euphorbia peplus L. Phenolics


Emadeldin M. Kamel, Noha A. Ahmed, Ashraf A. El-Bassuony, Omnia E. Hussein, Barakat Alrashdi, Sayed A. Ahmed, Al Mokhtar Lamsabhi, Hany H. Arab and Ayman M. Mahmoud*


DOI: 10.2174/1386207324666210609104456
View Abstract View on PubMed


Combinatorial Synthesis of Novel 1-sulfonyloxy/acyloxyeugenol Derivatives as Fungicidal Agents


Genqiang Chen, Lina Zhu, Jiaxuan He, Song Zhang, Yuanhao Li, Xiaolong Guo, Di Sun, Yuee Tian, Shengming Liu, Xiaobo Huang and Zhiping Che*


DOI: 10.2174/1386207324666210813114829
View Abstract View on PubMed



Abstracts Ahead of Print








Development of 2D, 3D-QSAR and Pharmacophore Modeling of Chalcones for the Inhibition of Monoamine Oxidase B


Bijo Mathew*, Chonny Herrera-Acevedo, Sanal Dev, T. M. Rangarajan, Mohamed Saheer Kuruniyan, Naseef Punnoth Poonkuzhi, Luciana Scotti and Marcus Tullius Scotti*


DOI: 10.2174/1386207324666210816125738
View Abstract




Published Contents

Editor's Choice

A Potential MRI Agent and an Anticancer Drug Encapsulated within CPMV Virus-Like Particles

, 2021; 24(10): 1557 - 1571

Alaa A.A. Aljabali*, Lorca Alzoubi, Yassmen Hamzat, Alaa Alqudah, Mohammad A. Obeid, Mazhar S. Al Zoubi, Raed M. Ennab, Walhan Alshaer, Khaled Albatayneh, Bahaa Al-Trad, Dana A. Alqudah, Dinesh Kumar Chellappan, Gaurav Gupta, Murtaza M. Tambuwala, Dua Kamal and David J. Evans


DOI: 10.2174/1386207323666200914110012








Cervical Cancer Diagnosis: Insights into Biochemical Biomarkers and Imaging Techniques

, 2021; 24(5): 605 - 623

Fatemeh Tavakoli, Sara Sadat Khatami, Fatemeh Momeni, Javid Azadbakht* and Faezeh Ghasemi*


DOI: 10.2174/1386207323666200901101955






Open Access Articles





Exploring miRNA-related Molecular Targets of Erchen Decoction Against Lipid Metabolism Disorder using A Network Pharmacologic Approach

, 2021; 24: 1 - 12 (E-Pub Ahead of Print)

Shanshan Ding, Qiliang Chen, Yiqing Huang, Xiaomei Li, Yujuan Chai, Candong Li and Tetsuya Asakawa*




GCSF as a Potential Molecular Target for Overall Survival of Hepatocellular Carcinoma

, 2021; 24: 1 - 19 (E-Pub Ahead of Print)

Heng Cao, Peng Guo, Xiaohui Wu, Jiankun Li, Chenlong Ge and Shunxiang Wang*




3-T MRI in Patients who Received Anterior Cervical Discectomy and Fusion Surgery with MAVRIC SL IR Sequence: A Feasibility Study

, 2021; 24: 1 - 7 (E-Pub Ahead of Print)

Renjie Yang, Changsheng Liu, Liang Li, Liang Chen, Weiyin Vivian Liu and Yunfei Zha*




FEN1 Status and Its Correlation with Clinicopathologic Characteristic in Colorectal Cancer

, 2021; 24: 1 - 7 (E-Pub Ahead of Print)

Yundi Guo*, Zixuan Du *, Yuanshuai Zhou, Haijun Sun, Rui Liang, Min-Xuan Sun, Zaixiang Tang and Song-Bai Liu






RNA Sequencing Reveals the Wound Repair Mechanism of Cuyuxunxi Prescription in Surgical Patients with Anal Fistulas

, 2021; 24: 1 - 11 (E-Pub Ahead of Print)

Yin Qu, Zhijun Zhang, Yafeng Lu, De Zheng and Wei Yang*




Weighted Gene Co-expression Network Analysis Identifies Five Hub Genes Associated with Metastasis in Synovial Sarcoma

, 2021; 24: 1 - 11 (E-Pub Ahead of Print)

Hongzeng Wu, Benzheng Zhang, Jiazheng Zhao, Yi Zhao, Xiaowei Ma and Helin Feng*




Exploring Dual Agonists for PPARα/γ Receptors using Pharmacophore Modeling, Docking Analysis and Molecule Dynamics Simulation

, 2021; 24: 1 - 12 (E-Pub Ahead of Print)

Ting-Ting Ding, Ya-Ya Liu, Li-Ming Zhang, Jia-Rui Shi, Wei-Ren Xu, Shao-Yong Li* and Xian-Chao Cheng*




Evaluation of Stabilized Chlorine Dioxide in Terms of Antimicrobial Activity and Dentin Bond Strength

, 2021; 24: 1 - 10 (E-Pub Ahead of Print)

Tugba Serin Kalay*, Yakup Kara, Sengul alpay Karaoglu and Sevgi Kolaylı






Most Cited Articles


Research Article

Drug target group prediction with multiple drug networks

, 2020; 23(4): 274-284.

Jingang Che, Lei Chen*, Zi-Han Guo, Shuaiqun Wang and Aorigele


DOI: 10.2174/1386207322666190702103927


Review Article

Progress in molecularly imprinted polymers for biomedical applications

, 2019; 22(2): 78-88.

Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie


DOI: 10.2174/1386207322666190325115526



Research Article

Identification of the active constituents and significant pathways of guizhi-shaoyao-zhimu decoction for the treatment of diabetes mellitus based on molecular docking and network pharmacology

, 2019; 22(9): 584-598.

Qing Zhang, Ruolan Li, Wei Peng, Mengmeng Zhang, Jia Liu, Shujun Wei, Jiaolong Wang, Chunjie Wu, Yongxiang Gao* and Xufeng Pu*


DOI: 10.2174/1386207322666191022101613


General Research Article

Lead finding from selected flavonoids with antiviral (Sars-cov-2) potentials against covid-19: An in-silico evaluation

, 2021; 24(6): 879-890.

Uma Sankar Gorla*, Koteswara Rao, Uma Sankar Kulandaivelu, Rajasekhar Reddy Alavala and Siva Prasad Panda


DOI: 10.2174/1386207323999200818162706






Research Article

Green route for the removal of pb from aquatic environment

, 2020; 23(7): 587-598.

Ahmed Refaat*, Hanan Elhaes, Nabila S. Ammar, Hanan S. Ibrahim and Medhat Ibrahim


DOI: 10.2174/1386207323666200127123349



General Research Article

Discovery of potent sars-cov-2 inhibitors from approved antiviral drugs via docking and virtual screening

, 2021; 24(3): 441-454.

Samir Chtita *, Assia Belhassan, Adnane Aouidate, Salah Belaidi, Mohammed Bouachrine and Tahar Lakhlifi


DOI: 10.2174/1386207323999200730205447





Most Accessed Articles

Phyto-chlorophyllin Prevents Food Additive Induced Genotoxicity and Mitochondrial Dysfunction via Cytochrome c Mediated Pathway in Mice Model

, 2021; 24(10): 1618-1627.

Asmita Samadder*, Sudatta Dey, Priyanka Sow, Ruchira Das, Sisir Nandi, Jayeeta Das*, Banani Bhattacharjee, Arnob Chakrovorty, Maharaj Biswas and Pradeepta Guptaroy


DOI: 10.2174/1386207323666201230093510


Identification of an MiRNA-mRNA Regulatory Network in Colorectal Cancer

, 2021; 24(10): 1736-1745.

Ming-fu Cui, Yuan-yu Wu, Ming-yan Chen, Yang Zhao, Song-yun Han, Rui-jie Wang, Haiyan Zhang* and Xue-dong Fang*


DOI: 10.2174/1386207323666201110154142


Nutraceuticals for Sleep Disorders

, 2021; 24(10): 1583-1592.

Ruhi Ali*, Sana Tariq, Ozaifa Kareem, Faizana Fayaz, Tahira Aziz, Meenu, Faheem Hyder Pottoo and Nadeem Siddiqui


DOI: 10.2174/1386207324666210121111446



Herbal Medicine: Clinical Perspective & Regulatory Status

, 2021; 24(10): 1573-1582.

Md. Abul Barkat*, Anjali Goyal, Harshita A. Barkat, Mohammad Salauddin, Faheem H. Pottoo and Esra T. Anwer


DOI: 10.2174/1386207323999201110192942


Curcumin-containing Silver Nanoparticles Prevent Carbon Tetrachloride-Induced Hepatotoxicity in Mice

, 2021; 24(10): 1609-1617.

Hossam Ebaid*, Mohamed Habila, Iftekhar Hassan, Jameel Al-Tamimi, Mohamed S. Omar , Ahmed Rady and Ibrahim M Alhazza


DOI: 10.2174/1386207323666201211100830


Molecular Mechanisms of Thymoquinone as Anticancer Agent

, 2021; 24(10): 1644-1653.

Fatma Alhmied, Ali Alammar, Bayan Alsultan, Muruj Alshehri and Faheem Hyder Pottoo*


DOI: 10.2174/1386207323999201027225305



Envisioning the Future of Nanomedicines in Management and Treatment of Neurological Disorders

, 2021; 24(10): 1544-1556.

Shobhit Kumar*, Priyanka Singh, Shrestha Sharma, Faheem H. Pottoo, Javed Ali and Sanjula Baboota


DOI: 10.2174/1386207323666201217151132



The Cosmetic Potential of The Medicinal Halophyte Tamarix Gallica L. (Tamaricaceae) Growing in The Eastern Part of Algeria: Photoprotective and Antioxidant Activities

, 2021; 24(10): 1671-1678.

Mostefa Lefahal, El-Hani Makhloufi, Warda Trifa, Radia Ayad, Mohamed El Hattab, Merzoug Benahmed, Merve Keskin* and Salah Akkal


DOI: 10.2174/1386207323666201204141541



Protective Role of Morus nigra Leaf Extracts against Murine Infection with Eimeria papillata

, 2021; 24(10): 1603-1608.

Felwa A. Thagfan*, Wafa A. Al-Megrin, Esam M. Al-Shaebi, Saleh Al-Quraishy and Mohamed A. Dkhil


DOI: 10.2174/1386207323666200903152811



Anti-Cancer and Anti-Bacterial Effects of Terfezia boudieri-Derived Silver Nanoparticles

, 2021; 24(10): 1714-1726.

Hashem Yaghoubi*, Amin Izadpanah*, Shahla Nedaei, Hossein Akbari, Elmira Mikaeiliagah, Ricardo Mostany, Bysani Chandrasekar, Eckhard Alt and Reza Izadpanah


DOI: 10.2174/1386207323999201117113401




Editor-in-Chief

graphic
Gerald H. Lushington
LiS Consulting
Lawrence, KS
(USA)
Biography
View Full Editorial Board

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Journal History

Combinatorial Chemistry & High Throughput Screening Journal was launched in 1998. Dr. Gerald H. Lushington serves as the Editor-in-Chief of the journal.

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