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Current Cancer Drug Targets

Volume 20, 11 Issues, 2020
ISSN: 1873-5576 (Online)
ISSN: 1568-0096 (Print)
This journal supports open access
Order Your Article Before PrintSubscribe to this Journal

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes.

Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer.

As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.

Current Cancer Drug Targets

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Volume 20

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Number 6



Biography   Open Access



Review Article



Review Article



Review Article



Review Article

Immune Checkpoint Regulators: A New Era Toward Promising Cancer Therapy

, 20(6): 429 - 460

Mohammed Shaaban, Heba Othman, Takwa Ibrahim, Mariam Ali, Mohamed Abdelmoaty, Abdel-Rahman Abdel-Kawi, Ahmed Mostafa, Aya El Nakeeb, Heba Emam and Alaa Refaat*


DOI: 10.2174/1568009620666200422081912


Research Article



Current Cancer Drug Targets, Volume 20 (2020) - Number 8


This issue is in progress but contains articles that are final and fully citable.

Current Cancer Drug Targets, Volume 20 (2020) - Number 7


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print


Regulation of Breast Cancer Progression by Noncoding RNAs


Ravishkumar L Akshaya, Muthukumar Rohini and Nagarajan Selvamurugan*


DOI: 10.2174/1568009620666200712144103
View Abstract


Targeting NUPR1 for Cancer Treatment: A Risky Endeavor


Salma M. A. Mansour, Sahar A. Ali, Shaira Nofal and Sameh H. Soror*


DOI: 10.2174/1568009620666200703152523
View Abstract


The Roles of Alternative Splicing in Tumor-immune Cell Interactions


Yue Wang, Honglei Zhang, Baowei Jiao*, Jianyun Nie, Xiyin Li, Wenhuan Wang and Hairui Wang


DOI: 10.2174/1568009620666200619123725
View Abstract View on PubMed


Targeting MUC15 Protein in Cancer: Molecular Mechanisms and Therapeutic Perspectives


Simei Zhang, Wunai Zhang, Ying Xiao, Tao Qin, Yangyang Yue, Weikun Qian, Xin Shen, Qingyong Ma and Zheng Wang*


DOI: 10.2174/1568009620666200601140639
View Abstract View on PubMed







Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Published Contents

Editor's Choice

COVID-19 Pandemic: Experiences in China and Implications for its Prevention and Treatment Worldwide

, 2020; 20(6): 410 - 416

Ning-Ning Liu*, Jing-Cong Tan, Jingquan Li, Shenghui Li*, Yong Cai* and Hui Wang*


DOI: 10.2174/1568009620666200414151419



CDK9: Therapeutic Perspective in HCC Therapy

, 2020; 20(5): 318 - 324

Jędrzej Borowczak*, Krzysztof Szczerbowski, Ewa Stec, Dariusz Grzanka and Łukasz Szylberg


DOI: 10.2174/1568009620666200212124357











Open Access Articles

Cancer Cell-derived Secretory Factors in Breast Cancer-associated Lung Metastasis: Their Mechanism and Future Prospects

, 2020; 20(3): 168 - 186

Tabinda Urooj*, Bushra Wasim, Shamim Mushtaq, Syed Nudrat Nawaid Shah and Muzna Shah





Linc01638 Promotes Tumorigenesis in HER2+ Breast Cancer

, 2019; 19(1): 74 - 80

Peng Liu, Hailin Tang, Jiali Wu, Xingsheng Qiu, Yanan Kong, Lijuan Zhang, Xinhua Xie* and Xiangsheng Xiao*




Role of MicroRNAs in Treatment Response in Prostate Cancer

, 2018; 18(10): 929 - 944

Anshuli Razdan, Paul de Souza* and Tara Laurine Roberts




Noxa: Role in Cancer Pathogenesis and Treatment

, 2018; 18(10): 914 - 928

Rami Z. Morsi, Rouba Hage-Sleiman, Hadile Kobeissy and Ghassan Dbaibo*








Platycodin D Induces Tumor Growth Arrest by Activating FOXO3a Expression in Prostate Cancer in vitro and in vivo

, 2014; 14(9): 860 - 871

Rui Zhou, Zongliang Lu, Kai Liu, Jing Guo, Jie Liu, Yong Zhou, Jian Yang, Mantian Mi and Hongxia Xu




Pleiotropic Role of HSF1 in Neoplastic Transformation

, 2014; 14(2): 144 - 155

Natalia Vydra, Agnieszka Toma and Wieslawa Widlak






β-Catenin Knockdown in Liver Tumor Cells by a Cell Permeable Gamma Guanidine-based Peptide Nucleic Acid

, 2013; 13(8): 867 - 878

Evan Delgado, Raman Bahal, Jing Yang, Jung M. Lee, Danith H Ly and Satdarshan P. S. Monga




Signal Transduction in Human Cutaneous Melanoma and Target Drugs

, 2013; 13(8): 843 - 866

Anatoly B. Uzdensky, Svetlana V. Demyanenko and Mikhail Y. Bibov





Most Cited Articles

Review Article

Polyploid giant cancer cells (PGCCs): The evil roots of cancer

, 2019; 19(5): 360-367.

Junsong Chen, Na Niu, Jing Zhang, Lisha Qi , Weiwei Shen , Krishna Vanaja Donkena, Zhenqing Feng and Jinsong Liu *


DOI: 10.2174/1568009618666180703154233


Review Article

Epigenetics in metastatic breast cancer: Its regulation and implications in diagnosis, prognosis and therapeutics

, 2019; 19(2): 82-100.

Yuan Seng Wu, Zhong Yang Lee , Lay-Hong Chuah, Chun Wai Mai and Siew Ching Ngai*


DOI: 10.2174/1568009618666180430130248



Research Article

c-Myc inhibitor 10074-G5 induces murine and human hematopoietic stem and progenitor cell expansion and HDR modulator Rad51 expression

, 2019; 19(6): 479-494.

Merve Aksoz, Esra Albayrak, Galip Servet Aslan, Raife Dilek Turan, Lamia Yazgi Alyazici, Pınar Siyah, Emre Can Tuysuz, Serli Canikyan, Dogacan Yucel, Neslihan Meric, Zafer Gulbas, Fikrettin Sahin and Fatih Kocabas*


DOI: 10.2174/1568009618666180905100608


Review Article

Challenges and opportunities from basic cancer biology for nanomedicine for targeted drug delivery

, 2019; 19(4): 257-276.

Xiaodong Xie, Yingying Zhang, Fengqiao Li, Tingting Lv, Ziying Li, Haijun Chen, Lee Jia* and Yu Gao*


DOI: 10.2174/1568009618666180628160211




Review Article

Glycolysis inhibition as a strategy for hepatocellular carcinoma treatment?

, 2019; 19(1): 26-40.

A.P. Alves, A.C. Mamede, M.G. Alves, P.F. Oliveira, S.M. Rocha, M.F. Botelho and C.J. Maia*


DOI: 10.2174/1568009618666180430144441


Review Article

Resveratrol as an adjuvant for normal tissues protection and tumor sensitization

, 2020; 20(2): 130-145.

Keywan Mortezaee, Masoud Najafi*, Bagher Farhood*, Amirhossein Ahmadi*, Dheyauldeen Shabeeb and Ahmed E. Musa


DOI: 10.2174/1568009619666191019143539


Research Article

Study of serum soluble programmed death ligand 1 as a prognostic factor in hepatocellular carcinoma in Egyptian patients

, 2019; 19(11): 896-905.

Fatma El-Gebaly , Sabry Abou-saif , Mahmoud Elkadeem, Amal Helmy, Sherief Abd-Elsalam *, Mohamed Yousef, Reham Abdelkader Elkhouly, Ibrahim Fathi Amer and Taher El-Demerdash


DOI: 10.2174/1568009619666190718141647



Review Article

Ursolic acid in cancer treatment and metastatic chemoprevention: From synthesized derivatives to nanoformulations in preclinical studies

, 2019; 19(4): 245-256.

Junjie Zou, Juanfang Lin, Chao Li, Ruirui Zhao, Lulu Fan, Jesse Yu and Jingwei Shao*


DOI: 10.2174/1568009618666181016145940



Review Article

Focal adhesion kinase in ovarian cancer: A potential therapeutic target for platinum and taxane-resistant tumors

, 2019; 19(3): 179-188.

Arkene Levy*, Khalid Alhazzani, Priya Dondapati, Ali Alaseem, Khadijah Cheema, Keerthi Thallapureddy, Paramjot Kaur, Saad Alobid and Appu Rathinavelu


DOI: 10.2174/1568009618666180706165222




Most Accessed Articles


Antibody Based EpCAM Targeted Therapy of Cancer, Review and Update

, 2018; 18(9): 857-868.

Shirin Eyvazi, Safar Farajnia*, Siavoush Dastmalchi, Farzad Kanipour, Habib Zarredar and Mojghan Bandehpour


DOI: 10.2174/1568009618666180102102311


C/EBPα Regulates FOXC1 to Modulate Tumor Growth by Interacting with PPARγ in Hepatocellular Carcinoma

, 2020; 20(1): 59-66.

Zhuo Xu, Shao-Hua Meng, Jian-Guo Bai, Chao Sun*, Li-Li Zhao*, Rui-Feng Tang, Zhao-Lin Yin, Jun-Wei Ji, Wei Yang and Guang-Jun Ma


DOI: 10.2174/1568009619666190912161003



Old and New Approaches to Target the Hsp90 Chaperone

, 2020; 20(4): 253-270.

Jackee Sanchez, Trever R. Carter, Mark S. Cohen* and Brian S.J. Blagg


DOI: 10.2174/1568009619666191202101330


Multiple Myeloma and the Immune Microenvironment

, 2017; 17(9): 806-818.

Yawara Kawano, Aldo. M. Roccaro, Irene M. Ghobrial* and Jamil Azzi*


DOI: 10.2174/1568009617666170214102301


Immunomodulatory Drugs (IMiDs) in Multiple Myeloma

, 2017; 17(9): 846-857.

Shahzad Raza, Rachael A. Safyan and Suzanne Lentzsch*


DOI: 10.2174/1568009617666170214104426



Well-defined Graphene Oxide as a Potential Component in Lung Cancer Therapy

, 2020; 20(1): 47-58.

Agnieszka Zuchowska, Elzbieta Jastrzebska, Marta Mazurkiewicz-Pawlicka, Artur Malolepszy, Leszek Stobinski, Maciej Trzaskowski and Zbigniew Brzozka*


DOI: 10.2174/1568009619666191021113807


A Pan-Cancer Review of ALK Mutations: Implications for Carcinogenesis and Therapy

, 2015; 15(4): 327-336.

Nick Ka Ming Yau, Andrew Yuon Fong, Hiu Fung Leung, Krista Roberta Verhoeft, Qin Ying Lim, Wai Yip Lam, Ian Chi Kei Wong and Vivian Wai Yan Lui


DOI: 10.2174/1568009615666150225123712



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