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Current Cancer Drug Targets

Volume 22, 11 Issues, 2022
ISSN: 1873-5576 (Online)
ISSN: 1568-0096 (Print)
This journal supports open access

Aims & Scope

Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes.

Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer.

As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.

Current Cancer Drug Targets

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Volume 21

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Number 11



Review Article (Mini-Review)




Review Article

Current Challenges in Targeting Tumor Desmoplasia to Improve the Efficacy of Immunotherapy

, 21(11): 919 - 931

Anna Kasperska*, Jędrzej Borowczak*, Krzysztof Szczerbowski*, Ewa Stec, Navid Ahmadi and Łukasz Szylber


DOI: 10.2174/1568009621666210825101456


Review Article

The Therapeutic Potential of MAPK/ERK Inhibitors in the Treatment of Colorectal Cancer

, 21(11): 932 - 943

Mehran Pashirzad*, Reihaneh Khorasanian*, Maryam Mahmoudi Fard*, Mohammad-Hassan Arjmand , Hadis Langari, Majid Khazaei, Saman Soleimanpour, Majid Rezayi, Gordon A. Ferns, Seyed Mahdi Hassanian and Amir Avan*


DOI: 10.2174/1568009621666211103113339


Systematic Review Article

Spleen Glucose Metabolism on [18F]-FDG PET/CT for Cancer Drug Discovery and Development cannot be Overlooked

, 21(11): 944 - 952

Romain-David Seban, Shwe Synn, Izza Muneer, Laurence Champion, Lawrence H. Schwartz and Laurent Dercle*


DOI: 10.2174/1568009621666210720143826


Research Article

Dextran Sulfate Inhibits Cell Proliferation and Induces Apoptosis by Regulating EZH2 in Gastric Carcinoma

, 21(11): 953 - 964

Yunning Huang *, Wenjun Wang*, Yuan-Yi Xu*, Jiaxin Guo, Longxing Jiao, Honghong Wang, Mengqi Li and Qi Yang


DOI: 10.2174/1568009621666210922112039


Research Article

The Plasticity of Circulating Tumor Cells in Ovarian Cancer During Platinum-containing Chemotherapy

, 21(11): 965 - 974

Snezhanna Olegovna Gening*, Dinara Rishatovna Dolgova, Tatyana Vladimirovna Abakumova, Inna Ivanovna Antoneeva and Tatyana Petrovna Gening


DOI: 10.2174/1568009621666210720141229


Abstracts Ahead of Print





Role of Tumor Microenvironment in Cancer Stem Cells Resistance to Radiotherapy


Shahram Taeb, Milad Ashrafizadeh, Ali Zarrabi, Saeed Rezapoor, Ahmed Eleojo Musa, Bagher Farhood and Masoud Najafi*


DOI: 10.2174/1568009622666211224154952
View Abstract




Pharmacological Targeting of Ferroptosis in Cancer Treatment


Mehdi Rabiee Valashedi, Amirsadegh Nikoo, Nima Najafi-Ghalehlou, Kazuo Tomita, Yoshikazu Kuwahara, Tomoaki Sato, Amaneh Mohammadi Roushandeh* and Mehryar Habibi Roudkenar*


DOI: 10.2174/1568009621666211202091523
View Abstract



State-of-the-Art: Exosomes in Colorectal Cancer


Yan Dang*, Shutian Zhang*, Yongjun Wang, Guiping Zhao, Chuyan Chen and Wei Jiang


DOI: 10.2174/1568009621666211110094442
View Abstract


Published Contents

Editor's Choice

Metastatic Breast Cancer, Organotropism and Therapeutics: A Review

, 2021; 21(10): 813 - 828

Ajaz Ahmad Waza*, Najeebul Tarfeen, Sabhiya Majid, Yasmeena Hassan, Rashid Mir, Mohd Younis Rather and Naseer Ue Din Shah


DOI: 10.2174/1568009621666210806094410






Cholangiocarcinoma Therapeutics: An Update

, 2021; 21(6): 457 - 475

Mai Ly Thi Nguyen, Nguyen Linh Toan, Maria Bozko, Khac Cuong Bui* and Przemyslaw Bozko*


DOI: 10.2174/1568009621666210204152028




PROTACs: Promising Approaches for Epigenetic Strategies to Overcome Drug Resistance

, 2021; 21(4): 306 - 325

Sarah F. Giardina*, Elena Valdambrini, J. David Warren and Francis Barany


DOI: 10.2174/1568009621666210203110857



Novel MicroRNA Binding Site SNPs and the Risk of Clear Cell Renal Cell Carcinoma (ccRCC): A Case-Control Study

, 2021; 21(3): 203 - 212

Irina R. Gilyazova, Narasimha M. Beeraka, Elizaveta A. Klimentova, Kirill V. Bulygin, Vladimir N. Nikolenko, Adel A. Izmailov, Gulshat R. Gilyazova, Valentin N. Pavlov, Elsa K. Khusnutdinova, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1568009620666201120151226



Immunotherapy: A Potential Approach to Targeting Cancer Stem Cells

, 2021; 21(2): 117 - 131

Wenjun Wang, Ling Bai, Dongsheng Xu, Wei Li and Jiuwei Cui*


DOI: 10.2174/1568009620666200504111914



C-Myc Signaling Pathway in Treatment and Prevention of Brain Tumors

, 2021; 21(1): 2 - 20

Milad Ashrafizadeh, Ali Zarabi, Kiavash Hushmandi, Ebrahim Rahmani Moghadam, Farid Hashemi, Salman Daneshi, Fardin Hashemi, Shima Tavakol, Reza Mohammadinejad, Masoud Najafi*, Namrata Dudha and Manoj Garg*


DOI: 10.2174/1568009620666201016121005



Open Access Articles

Re-Sensitizing Tumor Cells to Cancer Drugs with Epigenetic Regulators

, 2021; 21(4): 353 - 359

Stefanie Rauscher, Richard Greil and Roland Geisberger*




Tumor Penetrating Peptide-Functionalized Tenascin-C Antibody for Glioblastoma Targeting

, 2021; 21(1): 70 - 79

Prakash Lingasamy, Anett-Hildegard Laarmann and Tambet Teesalu *




Selinexor (KPT-330), an Oral Selective Inhibitor of Nuclear Export (SINE) Compound, in Combination with FOLFOX in Patients with Metastatic Colorectal Cancer (mCRC) - Final Results of the Phase I Trial SENTINEL

, 2020; 20(10): 811 - 817

Sven Nilsson, Alexander Stein, Christian Rolfo, Anne L. Kranich, Julia Mann, Konstantinos Papadimitriou, Susann Theile, Stefanie Amberg and Carsten Bokemeyer*




The Roles of Alternative Splicing in Tumor-immune Cell Interactions

, 2020; 20(10): 729 - 740

Yue Wang, Honglei Zhang*, Baowei Jiao*, Jianyun Nie*, Xiyin Li, Wenhuan Wang and Hairui Wang




Linc01638 Promotes Tumorigenesis in HER2+ Breast Cancer

, 2019; 19(1): 74 - 80

Peng Liu, Hailin Tang, Jiali Wu, Xingsheng Qiu, Yanan Kong, Lijuan Zhang, Xinhua Xie* and Xiangsheng Xiao*




Role of MicroRNAs in Treatment Response in Prostate Cancer

, 2018; 18(10): 929 - 944

Anshuli Razdan, Paul de Souza* and Tara Laurine Roberts




Noxa: Role in Cancer Pathogenesis and Treatment

, 2018; 18(10): 914 - 928

Rami Z. Morsi, Rouba Hage-Sleiman, Hadile Kobeissy and Ghassan Dbaibo*





Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer

, 2016; 16(4): 346 - 356

Xue-Qing Hu, Yang Sun, Eric Lau, Ming Zhao and Shi-Bing Su





Most Cited Articles

Review Article

Polyploid giant cancer cells (PGCCs): The evil roots of cancer

, 2019; 19(5): 360-367.

Junsong Chen, Na Niu, Jing Zhang, Lisha Qi , Weiwei Shen , Krishna Vanaja Donkena, Zhenqing Feng and Jinsong Liu *


DOI: 10.2174/1568009618666180703154233


Review Article

Old and new approaches to target the hsp90 chaperone

, 2020; 20(4): 253-270.

Jackee Sanchez, Trever R. Carter, Mark S. Cohen* and Brian S.J. Blagg


DOI: 10.2174/1568009619666191202101330


Review Article

Resveratrol as an adjuvant for normal tissues protection and tumor sensitization

, 2020; 20(2): 130-145.

Keywan Mortezaee, Masoud Najafi*, Bagher Farhood*, Amirhossein Ahmadi*, Dheyauldeen Shabeeb and Ahmed E. Musa


DOI: 10.2174/1568009619666191019143539


Review Article

HSF1 as a cancer biomarker and therapeutic target

, 2019; 19(7): 515-524.

Richard L. Carpenter* and Yesim Gokmen-Polar


DOI: 10.2174/1568009618666181018162117


Review Article

Glycolysis inhibition as a strategy for hepatocellular carcinoma treatment?

, 2019; 19(1): 26-40.

A.P. Alves, A.C. Mamede, M.G. Alves, P.F. Oliveira, S.M. Rocha, M.F. Botelho and C.J. Maia*


DOI: 10.2174/1568009618666180430144441


Review Article

The RNA binding protein hur: A promising drug target for anticancer therapy

, 2019; 19(5): 382-399.

Mingxia Wu, Christy W.S. Tong, Wei Yan, Kenneth K.W. To* and William C.S. Cho*


DOI: 10.2174/1568009618666181031145953


Review Article

Mesoporous silica nanoparticles as a prospective and promising approach for drug delivery and biomedical applications

, 2019; 19(4): 285-295.

Xiaohui Pu, Jia Li, Peng Qiao, Mengmeng Li, Haiyan Wang, Lanlan Zong*, Qi Yuan and Shaofeng Duan*


DOI: 10.2174/1568009619666181206114904




Research Article

Interactions of vascular endothelial growth factor and p53 with mir-195 in thyroid carcinoma: Possible therapeutic targets in aggressive thyroid cancers

, 2019; 19(7): 561-570.

Hamidreza Maroof , Soussan Irani , Armin Arianna, Jelena Vider, Vinod Gopalan and Alfred King-yin Lam *


DOI: 10.2174/1568009618666180628154727


Research Article

c-Myc inhibitor 10074-G5 induces murine and human hematopoietic stem and progenitor cell expansion and HDR modulator Rad51 expression

, 2019; 19(6): 479-494.

Merve Aksoz, Esra Albayrak, Galip Servet Aslan, Raife Dilek Turan, Lamia Yazgi Alyazici, Pınar Siyah, Emre Can Tuysuz, Serli Canikyan, Dogacan Yucel, Neslihan Meric, Zafer Gulbas, Fikrettin Sahin and Fatih Kocabas*


DOI: 10.2174/1568009618666180905100608


Review Article

Ursolic acid in cancer treatment and metastatic chemoprevention: From synthesized derivatives to nanoformulations in preclinical studies

, 2019; 19(4): 245-256.

Junjie Zou, Juanfang Lin, Chao Li, Ruirui Zhao, Lulu Fan, Jesse Yu and Jingwei Shao*


DOI: 10.2174/1568009618666181016145940


Review Article

Focal adhesion kinase in ovarian cancer: A potential therapeutic target for platinum and taxane-resistant tumors

, 2019; 19(3): 179-188.

Arkene Levy*, Khalid Alhazzani, Priya Dondapati, Ali Alaseem, Khadijah Cheema, Keerthi Thallapureddy, Paramjot Kaur, Saad Alobid and Appu Rathinavelu


DOI: 10.2174/1568009618666180706165222


Review Article

COVID-19 pandemic: Experiences in China and implications for its prevention and treatment worldwide

, 2020; 20(6): 410-416.

Ning-Ning Liu*, Jing-Cong Tan, Jingquan Li, Shenghui Li*, Yong Cai* and Hui Wang*


DOI: 10.2174/1568009620666200414151419




Most Accessed Articles




CDK-associated Cullin 1 Promotes Cell Proliferation and Inhibits Cell Apoptosis in Human Glioblastoma

, 2021; 21(10): 870-880.

Xiaohua Zhang, Tianying Zhang, Xiaojuan Han, Zhongying Qiu, Jianghong Cheng, Xingchun Gao and Xingchun Gou*


DOI: 10.2174/1568009621666210602164225




Role of ZEB Family Members in Proliferation, Metastasis, and Chemoresistance of Prostate Cancer Cells: Revealing Signaling Networks

, 2021; 21(9): 749-767.

Leyla soleymani, Ali Zarrabi, Farid Hashemi, Fardin Hashemi, Amirhossein Zabolian, Seyed Mohammad Banihashemi, Shirin Sabouhi Moghadam, Kiavash Hushmandi, Saeed Samarghandian, Milad Ashrafizadeh* and Haroon Khan*


DOI: 10.2174/1568009621666210601114631



Role of Exosomes in Breast Cancer Management: Evidence-Based Review

, 2021; 21(8): 666-675.

Razan B. Al-Humaidi, Bahgat Fayed, Suleiman I. Sharif, Ayman Noreddin and Sameh S.M. Soliman*


DOI: 10.2174/1568009621666210601115707


The Clinical Application of Circulating Tumor Cells and DNAs as Prognostic and Predictive Biomarkers in Gastrointestinal Cancer

, 2021; 21(8): 676-688.

Sara Memarpour*, Ghazaleh Khalili-Tanha*, Awa Alizadeh Ghannad, Masoud Sharifian Razavi, Mona Joudi, Marjan Joodi, Gordon A. Ferns, Seyed Mahdi Hassanian, Majid Khazaei and Amir Avan*


DOI: 10.2174/1568009621666210311090531




DDX39B Predicts Poor Survival and Associated with Clinical Benefit of Anti-PD-L1 Therapy in ccRCC

, 2021; 21(10): 849-859.

Jinhuan Wei, Jun Lu, Yun Cao, Gaosheng Yao, Yong Huang, Hongwei Zhao, Yihui Pan, Zihao Feng, Zhenhua Chen, Wei Chen, Junhang Luo* and Jiazheng Cao*


DOI: 10.2174/1568009621666210811115054


Crosstalk of Long Non-coding RNAs and EMT: Searching the Missing Pieces of an Incomplete Puzzle for Lung Cancer Therapy

, 2021; 21(8): 640-665.

Milad Ashrafizadeh, Md Shahinozzaman, Sima Orouei, Vahideh Zarrin, Kiavash Hushmandi, Farid Hashemi, Anuj Kumar, Saeed Samarghandian, Masoud Najafi* and Ali Zarrabi*


DOI: 10.2174/1568009621666210203110305


MiR-129-5p Promotes Radio-sensitivity of NSCLC Cells by Targeting SOX4 and RUNX1

, 2021; 21(8): 702-712.

Tongqing Xue, Gang Yin, Weixuan Yang, Xiaoyu Chen, Cheng Liu, Weixi Yang* and Jun Zhu*


DOI: 10.2174/1568009621666210415094350




Editor-in-Chief

graphic
Ruiwen Zhang
Center for Drug Discovery
University of Houston
3455 Cullen Blvd.
Houston, TX 77204
(USA)
View Full Editorial Board

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Journal History

Current Cancer Drug Targets was launched in 2001. Dr. Ruiwen Zhang serves as the Editor-in-Chief of the journal.

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