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Current Cancer Drug Targets

Volume 20, 11 Issues, 2020
ISSN: 1873-5576 (Online)
ISSN: 1568-0096 (Print)
This journal supports open access

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes.

Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer.

As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.

Current Cancer Drug Targets

,

Volume 20

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Number 9



Review Article (Mini-Review)

Targeting MUC15 Protein in Cancer: Molecular Mechanisms and Therapeutic Perspectives

, 20(9): 647 - 653

Simei Zhang, Wunai Zhang, Ying Xiao, Tao Qin, Yangyang Yue, Weikun Qian, Xin Shen, Qingyong Ma and Zheng Wang*


DOI: 10.2174/1568009620666200601140639


Review Article (Mini-Review)



Research Article

Synthesis and Cytotoxic Activity of Azine Derivatives of 6-Hydroxyxanthanodiene

, 20(9): 666 - 674

Margarita E. Neganova, Sergey G. Klochkov, Sergey A. Pukhov, Svetlana V. Afanasieva, Yulia R. Aleksandrova, Ekaterina Y. Yandulova, Marco F. Avila-Rodriguez, Liudmila M. Mikhaleva, Vladimir N. Nikolenko, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1568009620999200421200338


Research Article



Research Article

Neoadjuvant Chemotherapy Induces the Appearance of New Copy Number Aberrations in Breast Tumor and is Associated with Metastasis

, 20(9): 681 - 688

Nikolai V. Litviakov*, Marina K. Ibragimova, Matvey M. Tsyganov, Artem V. Doroshenko, Eugeniy Y. Garbukov and Elena M. Slonimskaya


DOI: 10.2174/1568009620666200506104523


Research Article



Research Article



Research Article

Cancer Stem Cells with Overexpression of Neuronal Markers Enhance Chemoresistance and Invasion in Retinoblastoma

, 20(9): 710 - 719

Sekaran Balaji, Radhakrishnan Santhi, Usha Kim, Veerappan Muthukkaruppan, Chidambaranathan G. Priya and Ayyasamy Vanniarajan*


DOI: 10.2174/1568009620666200504112711


Current Cancer Drug Targets, Volume 20 (2020) - Number 10


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Management of Prostate Cancer with Systemic Therapy. A Prostate Cancer Unit Perspective


Fabio Campodonico*, Marco Ennas, Silvia Zanardi , Ekaterini Zigoura, Arnoldo Piccardo, Luca Foppiani, Concetta Schiavone, Lino Squillace, Andrea Benelli, Andrea De Censi , Filippo Grillo-Ruggieri and Carlo Introini


DOI: 10.2174/1568009620666201021163919
View Abstract


C-Myc signaling pathway in treatment and prevention of brain tumors


Milad Ashrafizadeh, Ali Zarabi, Kiavash Hushmandi, Ebrahim Rahmani Moghadam, Farid Hashemi, Salman Daneshi, Fardin Hashemi, Shima Tavakol, Reza Mohammadinejad, Masoud Najafi*, Namrata Dudha and Manoj Garg


DOI: 10.2174/1568009620666201016121005
View Abstract





Clinical Outcomes and Safety of Patients Treated with NAb-Paclitaxel Plus Gemcitabine in Metastatic Pancreatic Cancer: the NAPA Study


Martina Catalano, Giandomenico Roviello*, Raffaele Conca, Alberto D’Angelo, Valeria Emma Palmieri, Benedetta Panella, Roberto Petrioli, Anna Ianza, Stefania Nobili, Enrico Mini and Monica Ramello


DOI: 10.2174/1568009620999200918122426
View Abstract View on PubMed


Tyrosine Kinase Inhibitors (TKIs) in Lung Cancer Treatment: a Comprehensive Analysis


Sivakumar Murugesan, Jayakumar Murugesan, Seedevi Palaniappan , Sivasankar Palaniappan, Tamilselvi Murugan, Shahid S. Siddiqui and Sivakumar Loganathan*


DOI: 10.2174/1568009620666201009130008
View Abstract




Identification of WDFY3 Neoantigens as Prognostic Markers in Longterm Survivors of Extrahepatic Cholangiocarcinoma


Yingyi Wang, Bao Jin, Na Zhou, Zhao Sun, Jiayi Li, Qiao Chen, Xiangan Wu, Yi Zhou, Yue Shi, Xin Lu, Xinting Sang, Yilei Mao, Shunda Du*, Wenze Wang* and Chunmei Bai*


DOI: 10.2174/1568009620999200918121456
View Abstract View on PubMed


Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Published Contents

Editor's Choice

Cancer Stem Cells with Overexpression of Neuronal Markers Enhance Chemoresistance and Invasion in Retinoblastoma

, 2020; 20(9): 710 - 719

Sekaran Balaji, Radhakrishnan Santhi, Usha Kim, Veerappan Muthukkaruppan, Chidambaranathan G. Priya and Ayyasamy Vanniarajan*


DOI: 10.2174/1568009620666200504112711



Strategic Combination Therapies for Ovarian Cancer

, 2020; 20(8): 573 - 585

Xinran Li, Angel S.N. Ng, Victor C.Y. Mak, Karen K.L. Chan, Annie N.Y. Cheung and Lydia W.T. Cheung*


DOI: 10.2174/1568009620666200511084007




COVID-19 Pandemic: Experiences in China and Implications for its Prevention and Treatment Worldwide

, 2020; 20(6): 410 - 416

Ning-Ning Liu*, Jing-Cong Tan, Jingquan Li, Shenghui Li*, Yong Cai* and Hui Wang*


DOI: 10.2174/1568009620666200414151419



CDK9: Therapeutic Perspective in HCC Therapy

, 2020; 20(5): 318 - 324

Jędrzej Borowczak*, Krzysztof Szczerbowski, Ewa Stec, Dariusz Grzanka and Łukasz Szylberg


DOI: 10.2174/1568009620666200212124357








Open Access Articles

Cancer Cell-derived Secretory Factors in Breast Cancer-associated Lung Metastasis: Their Mechanism and Future Prospects

, 2020; 20(3): 168 - 186

Tabinda Urooj*, Bushra Wasim, Shamim Mushtaq, Syed Nudrat Nawaid Shah and Muzna Shah





Linc01638 Promotes Tumorigenesis in HER2+ Breast Cancer

, 2019; 19(1): 74 - 80

Peng Liu, Hailin Tang, Jiali Wu, Xingsheng Qiu, Yanan Kong, Lijuan Zhang, Xinhua Xie* and Xiangsheng Xiao*




Role of MicroRNAs in Treatment Response in Prostate Cancer

, 2018; 18(10): 929 - 944

Anshuli Razdan, Paul de Souza* and Tara Laurine Roberts




Noxa: Role in Cancer Pathogenesis and Treatment

, 2018; 18(10): 914 - 928

Rami Z. Morsi, Rouba Hage-Sleiman, Hadile Kobeissy and Ghassan Dbaibo*








Platycodin D Induces Tumor Growth Arrest by Activating FOXO3a Expression in Prostate Cancer in vitro and in vivo

, 2014; 14(9): 860 - 871

Rui Zhou, Zongliang Lu, Kai Liu, Jing Guo, Jie Liu, Yong Zhou, Jian Yang, Mantian Mi and Hongxia Xu




Pleiotropic Role of HSF1 in Neoplastic Transformation

, 2014; 14(2): 144 - 155

Natalia Vydra, Agnieszka Toma and Wieslawa Widlak






β-Catenin Knockdown in Liver Tumor Cells by a Cell Permeable Gamma Guanidine-based Peptide Nucleic Acid

, 2013; 13(8): 867 - 878

Evan Delgado, Raman Bahal, Jing Yang, Jung M. Lee, Danith H Ly and Satdarshan P. S. Monga




Signal Transduction in Human Cutaneous Melanoma and Target Drugs

, 2013; 13(8): 843 - 866

Anatoly B. Uzdensky, Svetlana V. Demyanenko and Mikhail Y. Bibov





Most Cited Articles

Review Article

Polyploid giant cancer cells (PGCCs): The evil roots of cancer

, 2019; 19(5): 360-367.

Junsong Chen, Na Niu, Jing Zhang, Lisha Qi , Weiwei Shen , Krishna Vanaja Donkena, Zhenqing Feng and Jinsong Liu *


DOI: 10.2174/1568009618666180703154233


Review Article

Epigenetics in metastatic breast cancer: Its regulation and implications in diagnosis, prognosis and therapeutics

, 2019; 19(2): 82-100.

Yuan Seng Wu, Zhong Yang Lee , Lay-Hong Chuah, Chun Wai Mai and Siew Ching Ngai*


DOI: 10.2174/1568009618666180430130248


Review Article

Ursolic acid in cancer treatment and metastatic chemoprevention: From synthesized derivatives to nanoformulations in preclinical studies

, 2019; 19(4): 245-256.

Junjie Zou, Juanfang Lin, Chao Li, Ruirui Zhao, Lulu Fan, Jesse Yu and Jingwei Shao*


DOI: 10.2174/1568009618666181016145940



Research Article

c-Myc inhibitor 10074-G5 induces murine and human hematopoietic stem and progenitor cell expansion and HDR modulator Rad51 expression

, 2019; 19(6): 479-494.

Merve Aksoz, Esra Albayrak, Galip Servet Aslan, Raife Dilek Turan, Lamia Yazgi Alyazici, Pınar Siyah, Emre Can Tuysuz, Serli Canikyan, Dogacan Yucel, Neslihan Meric, Zafer Gulbas, Fikrettin Sahin and Fatih Kocabas*


DOI: 10.2174/1568009618666180905100608


Review Article

Focal adhesion kinase in ovarian cancer: A potential therapeutic target for platinum and taxane-resistant tumors

, 2019; 19(3): 179-188.

Arkene Levy*, Khalid Alhazzani, Priya Dondapati, Ali Alaseem, Khadijah Cheema, Keerthi Thallapureddy, Paramjot Kaur, Saad Alobid and Appu Rathinavelu


DOI: 10.2174/1568009618666180706165222



Review Article

Glycolysis inhibition as a strategy for hepatocellular carcinoma treatment?

, 2019; 19(1): 26-40.

A.P. Alves, A.C. Mamede, M.G. Alves, P.F. Oliveira, S.M. Rocha, M.F. Botelho and C.J. Maia*


DOI: 10.2174/1568009618666180430144441


Review Article

Resveratrol as an adjuvant for normal tissues protection and tumor sensitization

, 2020; 20(2): 130-145.

Keywan Mortezaee, Masoud Najafi*, Bagher Farhood*, Amirhossein Ahmadi*, Dheyauldeen Shabeeb and Ahmed E. Musa


DOI: 10.2174/1568009619666191019143539



Review Article

HSF1 as a cancer biomarker and therapeutic target

, 2019; 19(7): 515-524.

Richard L. Carpenter* and Yesim Gokmen-Polar


DOI: 10.2174/1568009618666181018162117


Review Article

Challenges and opportunities from basic cancer biology for nanomedicine for targeted drug delivery

, 2019; 19(4): 257-276.

Xiaodong Xie, Yingying Zhang, Fengqiao Li, Tingting Lv, Ziying Li, Haijun Chen, Lee Jia* and Yu Gao*


DOI: 10.2174/1568009618666180628160211


Research Article

Formulation, pharmacokinetic evaluation and cytotoxicity of an enhanced-penetration paclitaxel nanosuspension

, 2019; 19(4): 338-347.

Yanping Cao, Zhihao Wei, Mengmeng Li, Haiyan Wang, Li Yin, Dongxiao Chen, Yanfei Wang, Yongchao Chen, Qi Yuan, Xiaohui Pu*, Lanlan Zong* and Shaofeng Duan*


DOI: 10.2174/1568009618666180629150927


Research Article

Study of serum soluble programmed death ligand 1 as a prognostic factor in hepatocellular carcinoma in Egyptian patients

, 2019; 19(11): 896-905.

Fatma El-Gebaly , Sabry Abou-saif , Mahmoud Elkadeem, Amal Helmy, Sherief Abd-Elsalam *, Mohamed Yousef, Reham Abdelkader Elkhouly, Ibrahim Fathi Amer and Taher El-Demerdash


DOI: 10.2174/1568009619666190718141647


Research Article

The clinical prognostic value of LRG1 in esophageal squamous cell carcinoma

, 2019; 19(9): 756-763.

Yuanyuan Wang, Qian Xing, Xue Chen, Jianbo Wang, Shanghui Guan, Xuan Chen, Peng Sun, Mingxia Wang and Yufeng Cheng*


DOI: 10.2174/1568009619666190204095942



Most Accessed Articles

Cancer Stem Cells in Prostate Cancer Chemoresistance

, 2014; 14(3): 225-240.

Jie Ni, Paul Cozzi, Jingli Hao, Wei Duan, Peter Graham, John Kearsley and Yong Li


DOI: 10.2174/1568009614666140328152459


Dexamethasone Synergizes with Lenalidomide to Inhibit Multiple Myeloma Tumor Growth, But Reduces Lenalidomide-Induced Immunomodulation of T and NK Cell Function

, 2010; 10(2): 155-167.

A. K. Gandhi, J. Kang, L. Capone, A. Parton, L. Wu, L. H. Zhang, D. Mendy, A. Lopez-Girona, T. Tran, L. Sapinoso, W. Fang, S. Xu, G. Hampton, J. B. Bartlett and P. Schafer


DOI: 10.2174/156800910791054239







Deregulation of the Akt Pathway in Human Cancer

, 2008; 8(1): 27-36.

Eriko Tokunaga, Eiji Oki, Akinori Egashira, Noriaki Sadanaga, Masaru Morita, Yoshihiro Kakeji and Yoshihiko Maehara


DOI: 10.2174/156800908783497140


Immune Checkpoint Inhibitors in AML-A New Frontier

, 2020; 20(7): 545-557.

Rohit Thummalapalli, Hanna A. Knaus, Ivana Gojo and Joshua F. Zeidner*


DOI: 10.2174/1568009620666200421081455


The Critical Role of Vascular Endothelial Growth Factor in Tumor Angiogenesis

, 2012; 12(1): 23-43.

A. Amini, S. Masoumi Moghaddam, D. L. Morris and M. H. Pourgholami


DOI: 10.2174/156800912798888956



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