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Current Cancer Drug Targets

Volume 21, 11 Issues, 2021
ISSN: 1873-5576 (Online)
ISSN: 1568-0096 (Print)
This journal supports open access

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes.

Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer.

As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.

Current Cancer Drug Targets

,

Volume 21

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Number 1



Preface   Open Access



Review Article

C-Myc Signaling Pathway in Treatment and Prevention of Brain Tumors

, 21(1): 2 - 20

Milad Ashrafizadeh, Ali Zarabi, Kiavash Hushmandi, Ebrahim Rahmani Moghadam, Farid Hashemi, Salman Daneshi, Fardin Hashemi, Shima Tavakol, Reza Mohammadinejad, Masoud Najafi*, Namrata Dudha and Manoj Garg*


DOI: 10.2174/1568009620666201016121005




Review Article

Tyrosine Kinase Inhibitors (TKIs) in Lung Cancer Treatment: A Comprehensive Analysis

, 21(1): 55 - 69

Sivakumar Murugesan, Jayakumar Murugesan, Seedevi Palaniappan , Sivasankar Palaniappan, Tamilselvi Murugan, Shahid S. Siddiqui and Sivakumar Loganathan*


DOI: 10.2174/1568009620666201009130008






Articles Ahead of Print



Effects of Iron Chelation in Osteosarcoma


Maura Argenziano, Alessandra Di Paola, Chiara Tortora, Daniela Di Pinto, Elvira Pota, Martina Di Martino, Silverio Perrotta, Francesca Rossi* and Francesca Punzo


DOI: 10.2174/1568009620666201230090531
View Abstract View on PubMed





Novel MicroRNA Binding Site SNPs and the Risk of Clear Cell Renal Cell Carcinoma (ccRCC): A Case-Control Study


Irina R. Gilyazova, Narasimha M. Beeraka, Elizaveta A. Klimentova, Kirill V. Bulygin, Vladimir N. Nikolenko, Adel A. Izmailov, Gulshat R. Gilyazova, Valentin N. Pavlov, Elsa K. Khusnutdinova, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1568009620666201120151226
View Abstract View on PubMed





Abstracts Ahead of Print

Association of Polymorphism in Survivin gene and the risk of Liver Cancer resulting from Hepatitis C Virus among Egyptian patients


Amal A. Mohamed, Aymen S. Yassin, Basma S. Gomaa, Hossam Darwish, Rasha S. Mohamed, Sahar Makled, Ahmed Ramdan, Sherief Abd-Elsalam* and Marwa M. Raafat


DOI: 10.2174/1568009621666210302090917
View Abstract




Cross talk between COVID-19 and breast cancer


Hamendra Singh Parmar*, Aakruti Nayak*, Pramod Kumar Gavel, Hemchandra Jha, Shivani Bhagwat and Rajesh Sharma


DOI: 10.2174/1568009621666210216102236
View Abstract


Cholangiocarcinoma therapeutics: an update


Mai Ly Thi Nguyen, Nguyen Linh Toan, Maria Bozko, Khac Cuong Bui and Przemyslaw Bozko*


DOI: 10.2174/1568009621666210204152028
View Abstract





Crosstalk of long non-coding RNAs and EMT: Searching the missing pieces of an incomplete puzzle for lung cancer therapy


Milad Ashrafizadeh, Md Shahinozzaman, Sima Orouei, Vahideh Zarrin, Kiavash Hushmandi, Farid Hashemi, Anuj Kumar, Saeed Samarghandian, Masoud Najafi* and Ali Zarrabi*


DOI: 10.2174/1568009621666210203110305
View Abstract


The Mad2-Binding Protein p31comet as a potential target for human cancer therapy


Ana C. Henriques, Patrícia M. A. Silva, Bruno Sarmento and Hassan Bousbaa*


DOI: 10.2174/1568009621666210129095726
View Abstract


Published Contents

Editor's Choice

C-Myc Signaling Pathway in Treatment and Prevention of Brain Tumors

, 2021; 21(1): 2 - 20

Milad Ashrafizadeh, Ali Zarabi, Kiavash Hushmandi, Ebrahim Rahmani Moghadam, Farid Hashemi, Salman Daneshi, Fardin Hashemi, Shima Tavakol, Reza Mohammadinejad, Masoud Najafi*, Namrata Dudha and Manoj Garg*


DOI: 10.2174/1568009620666201016121005



Clinical Outcomes and Safety of Patients Treated with NAb-Paclitaxel Plus Gemcitabine in Metastatic Pancreatic Cancer: The NAPA Study

, 2020; 20(11): 887 - 895

Martina Catalano, Giandomenico Roviello*, Raffaele Conca, Alberto D’Angelo, Valeria Emma Palmieri, Benedetta Panella, Roberto Petrioli, Anna Ianza, Stefania Nobili, Enrico Mini and Monica Ramello


DOI: 10.2174/1568009620999200918122426



Selinexor (KPT-330), an Oral Selective Inhibitor of Nuclear Export (SINE) Compound, in Combination with FOLFOX in Patients with Metastatic Colorectal Cancer (mCRC) - Final Results of the Phase I Trial SENTINEL

, 2020; 20(10): 811 - 817

Sven Nilsson, Alexander Stein, Christian Rolfo, Anne L. Kranich, Julia Mann, Konstantinos Papadimitriou, Susann Theile, Stefanie Amberg and Carsten Bokemeyer*


DOI: 10.2174/1568009620666200628105727



Cancer Stem Cells with Overexpression of Neuronal Markers Enhance Chemoresistance and Invasion in Retinoblastoma

, 2020; 20(9): 710 - 719

Sekaran Balaji, Radhakrishnan Santhi, Usha Kim, Veerappan Muthukkaruppan, Chidambaranathan G. Priya and Ayyasamy Vanniarajan*


DOI: 10.2174/1568009620666200504112711



Strategic Combination Therapies for Ovarian Cancer

, 2020; 20(8): 573 - 585

Xinran Li, Angel S.N. Ng, Victor C.Y. Mak, Karen K.L. Chan, Annie N.Y. Cheung and Lydia W.T. Cheung*


DOI: 10.2174/1568009620666200511084007




COVID-19 Pandemic: Experiences in China and Implications for its Prevention and Treatment Worldwide

, 2020; 20(6): 410 - 416

Ning-Ning Liu*, Jing-Cong Tan, Jingquan Li, Shenghui Li*, Yong Cai* and Hui Wang*


DOI: 10.2174/1568009620666200414151419



CDK9: Therapeutic Perspective in HCC Therapy

, 2020; 20(5): 318 - 324

Jędrzej Borowczak*, Krzysztof Szczerbowski, Ewa Stec, Dariusz Grzanka and Łukasz Szylberg


DOI: 10.2174/1568009620666200212124357





Open Access Articles

The Roles of Alternative Splicing in Tumor-immune Cell Interactions

, 2020; 20(10): 729 - 740

Yue Wang, Honglei Zhang*, Baowei Jiao*, Jianyun Nie*, Xiyin Li, Wenhuan Wang and Hairui Wang




Cancer Cell-derived Secretory Factors in Breast Cancer-associated Lung Metastasis: Their Mechanism and Future Prospects

, 2020; 20(3): 168 - 186

Tabinda Urooj*, Bushra Wasim, Shamim Mushtaq, Syed Nudrat Nawaid Shah and Muzna Shah





Linc01638 Promotes Tumorigenesis in HER2+ Breast Cancer

, 2019; 19(1): 74 - 80

Peng Liu, Hailin Tang, Jiali Wu, Xingsheng Qiu, Yanan Kong, Lijuan Zhang, Xinhua Xie* and Xiangsheng Xiao*




Role of MicroRNAs in Treatment Response in Prostate Cancer

, 2018; 18(10): 929 - 944

Anshuli Razdan, Paul de Souza* and Tara Laurine Roberts




Noxa: Role in Cancer Pathogenesis and Treatment

, 2018; 18(10): 914 - 928

Rami Z. Morsi, Rouba Hage-Sleiman, Hadile Kobeissy and Ghassan Dbaibo*








Platycodin D Induces Tumor Growth Arrest by Activating FOXO3a Expression in Prostate Cancer in vitro and in vivo

, 2014; 14(9): 860 - 871

Rui Zhou, Zongliang Lu, Kai Liu, Jing Guo, Jie Liu, Yong Zhou, Jian Yang, Mantian Mi and Hongxia Xu




Pleiotropic Role of HSF1 in Neoplastic Transformation

, 2014; 14(2): 144 - 155

Natalia Vydra, Agnieszka Toma and Wieslawa Widlak






β-Catenin Knockdown in Liver Tumor Cells by a Cell Permeable Gamma Guanidine-based Peptide Nucleic Acid

, 2013; 13(8): 867 - 878

Evan Delgado, Raman Bahal, Jing Yang, Jung M. Lee, Danith H Ly and Satdarshan P. S. Monga





Most Cited Articles

Review Article

Resveratrol as an adjuvant for normal tissues protection and tumor sensitization

, 2020; 20(2): 130-145.

Keywan Mortezaee, Masoud Najafi*, Bagher Farhood*, Amirhossein Ahmadi*, Dheyauldeen Shabeeb and Ahmed E. Musa


DOI: 10.2174/1568009619666191019143539



Review Article

Old and new approaches to target the hsp90 chaperone

, 2020; 20(4): 253-270.

Jackee Sanchez, Trever R. Carter, Mark S. Cohen* and Brian S.J. Blagg


DOI: 10.2174/1568009619666191202101330


Review Article

COVID-19 pandemic: Experiences in China and implications for its prevention and treatment worldwide

, 2020; 20(6): 410-416.

Ning-Ning Liu*, Jing-Cong Tan, Jingquan Li, Shenghui Li*, Yong Cai* and Hui Wang*


DOI: 10.2174/1568009620666200414151419


Research Article

CDK12 promotes breast cancer progression and maintains stemness by activating c-myc/β-catenin signaling

, 2020; 20(2): 156-165.

Fang Peng, Chuansheng Yang, Yanan Kong, Xiaojia Huang, Yanyu Chen, Yangfan Zhou, Xinhua Xie* and Peng Liu*


DOI: 10.2174/1568009619666191118113220



Research Article

Circepsti1 acts as a cerna to regulate the progression of osteosarcoma

, 2020; 20(4): 288-294.

Xinyu Tan, Duxun Tan, Haomiao Li, Ye Lin, Zhishen Wen and Canjun Zeng*


DOI: 10.2174/1568009619666191107140948


Review Article

Cancer cell-derived secretory factors in breast cancer-associated lung metastasis: Their mechanism and future prospects

, 2020; 20(3): 168-186.

Tabinda Urooj*, Bushra Wasim, Shamim Mushtaq, Syed Nudrat Nawaid Shah and Muzna Shah


DOI: 10.2174/1568009620666191220151856


Research Article

Effects of intermittent hypoxia on expression of glucose metabolism genes in MCF7 breast cancer cell line

, 2020; 20(3): 216-222.

Yazun Jarrar, Malek Zihlif*, Abdel Qader Al Bawab and Ahmad Sharab


DOI: 10.2174/1568009619666191116095847


Research Article

HOTAIR competitively binds mirna330 as a molecular sponge to increase the resistance of gastric cancer to trastuzumab

, 2020; 20(9): 700-709.

Liangyu Bie, Suxia Luo*, Dan Li, Yan Wei, Yu Mu, Xiaobing Chen, Saiqi Wang, Ping Guo and Xiaoyu Lu


DOI: 10.2174/1568009620666200504114000


Research Article

Overexpression of p62 induces autophagy and promotes proliferation, migration and invasion of nasopharyngeal carcinoma cells through promoting ERK signaling pathway

, 2020; 20(8): 624-637.

Qiong Wu, Manlin Xiang, Kun Wang, Zhen Chen, Lu Long, Ya Tao, Yunlai Liang, Yahui Yan, Zhiqiang Xiao, Shiyang Qiu and Bin Yi*


DOI: 10.2174/1568009620666200424145122


Review Article

Novel homeodomain transcription factor Nkx2.2 in the brain tumor development

, 2020; 20(5): 335-340.

Mubeena P.M. Mariyath, Mehdi H. Shahi*, Shirin Farheen, Mohd Tayyab, Nabeela Khanam and Asif Ali


DOI: 10.2174/1568009618666180102111539


Research Article

C/ebpα regulates foxc1 to modulate tumor growth by interacting with pparγ in hepatocellular carcinoma

, 2020; 20(1): 59-66.

Zhuo Xu, Shao-Hua Meng, Jian-Guo Bai, Chao Sun*, Li-Li Zhao*, Rui-Feng Tang, Zhao-Lin Yin, Jun-Wei Ji, Wei Yang and Guang-Jun Ma


DOI: 10.2174/1568009619666190912161003


Review Article

Exosome as a natural gene delivery vector for cancer treatment

, 2020; 20(11): 821-830.

Prasad Pofali, Adrita Mondal and Vaishali Londhe*


DOI: 10.2174/1568009620666200924154149


Research Article

Vs-5584 inhibits human osteosarcoma cells growth by induction of g1-phase arrest through regulating pi3k/mtor and mapk pathways

, 2020; 20(8): 616-623.

Jing-Yi Sun, Ya-Jun Hou, Hai-Juan Cui, Cheng Zhang, Ming-Feng Yang, Feng-Ze Wang, Zheng Sun, Cun-Dong Fan*, Bao-Liang Sun* and Jin Rok Oh*


DOI: 10.2174/1568009620666200414150353



Most Accessed Articles


Immune Checkpoint Inhibitors in AML-A New Frontier

, 2020; 20(7): 545-557.

Rohit Thummalapalli, Hanna A. Knaus, Ivana Gojo and Joshua F. Zeidner*


DOI: 10.2174/1568009620666200421081455



CDK12 Promotes Breast Cancer Progression and Maintains Stemness by Activating c-myc/β -catenin Signaling

, 2020; 20(2): 156-165.

Fang Peng, Chuansheng Yang, Yanan Kong, Xiaojia Huang, Yanyu Chen, Yangfan Zhou, Xinhua Xie* and Peng Liu*


DOI: 10.2174/1568009619666191118113220


Clinical Outcomes and Safety of Patients Treated with NAb-Paclitaxel Plus Gemcitabine in Metastatic Pancreatic Cancer: The NAPA Study

, 2020; 20(11): 887-895.

Martina Catalano, Giandomenico Roviello*, Raffaele Conca, Alberto D’Angelo, Valeria Emma Palmieri, Benedetta Panella, Roberto Petrioli, Anna Ianza, Stefania Nobili, Enrico Mini and Monica Ramello


DOI: 10.2174/1568009620999200918122426


VS-5584 Inhibits Human Osteosarcoma Cells Growth by Induction of G1- phase Arrest through Regulating PI3K/mTOR and MAPK Pathways

, 2020; 20(8): 616-623.

Jing-Yi Sun, Ya-Jun Hou, Hai-Juan Cui, Cheng Zhang, Ming-Feng Yang, Feng-Ze Wang, Zheng Sun, Cun-Dong Fan*, Bao-Liang Sun* and Jin Rok Oh*


DOI: 10.2174/1568009620666200414150353



Strategic Combination Therapies for Ovarian Cancer

, 2020; 20(8): 573-585.

Xinran Li, Angel S.N. Ng, Victor C.Y. Mak, Karen K.L. Chan, Annie N.Y. Cheung and Lydia W.T. Cheung*


DOI: 10.2174/1568009620666200511084007


Identification of WDFY3 Neoantigens as Prognostic Markers in Longterm Survivors of Extrahepatic Cholangiocarcinoma

, 2020; 20(11): 875-886.

Yingyi Wang, Bao Jin, Na Zhou, Zhao Sun, Jiayi Li, Qiao Chen, Xiangan Wu, Yi Zhou, Yue Shi, Xin Lu, Xinting Sang, Yilei Mao, Shunda Du*, Wenze Wang* and Chunmei Bai*


DOI: 10.2174/1568009620999200918121456


C-Myc Signaling Pathway in Treatment and Prevention of Brain Tumors

, 2021; 21(1): 2-20.

Milad Ashrafizadeh, Ali Zarabi, Kiavash Hushmandi, Ebrahim Rahmani Moghadam, Farid Hashemi, Salman Daneshi, Fardin Hashemi, Shima Tavakol, Reza Mohammadinejad, Masoud Najafi*, Namrata Dudha and Manoj Garg*


DOI: 10.2174/1568009620666201016121005


Targeting Different Pathways Using Novel Combination Therapy in Triple Negative Breast Cancer

, 2020; 20(8): 586-602.

Manzoor A. Mir*, Hina Qayoom, Umar Mehraj, Safura Nisar, Basharat Bhat and Nissar A. Wani*


DOI: 10.2174/1570163817666200518081955





The Evolving AML Genomic Landscape: Therapeutic Implications

, 2020; 20(7): 532-544.

Sachi Horibata*, George Alyateem, Christin B. DeStefano and Michael M. Gottesman*


DOI: 10.2174/1568009620666200424150321



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