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Current Cancer Drug Targets

Volume 20, 11 Issues, 2020
ISSN: 1873-5576 (Online)
ISSN: 1568-0096 (Print)
This journal supports open access

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  • 135th of 229 in

    Oncology

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Aims & Scope

Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes.

Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer.

As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.

Current Cancer Drug Targets

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Volume 19

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Number 11



Biography   Open Access



Review Article

The Role of Shcbp1 in Signaling and Disease

, 19(11): 854 - 862

Geng-Yuan Zhang, Zhi-Jian Ma, Long Wang, Ruo-Fei Sun, Xiang-Yan Jiang, Xu-Juan Yang, Bo Long, Hui-Li Ye, Shu-Ze Zhang, Ze-Yuan Yu, Wen-Gui Shi and Zuo-Yi Jiao*


DOI: 10.2174/1568009619666190620114928


Review Article



Review Article



Research Article



Research Article

Study of Serum Soluble Programmed Death Ligand 1 as a Prognostic Factor in Hepatocellular Carcinoma in Egyptian Patients

, 19(11): 896 - 905

Fatma El-Gebaly , Sabry Abou-saif , Mahmoud Elkadeem, Amal Helmy, Sherief Abd-Elsalam *, Mohamed Yousef, Reham Abdelkader Elkhouly, Ibrahim Fathi Amer and Taher El-Demerdash


DOI: 10.2174/1568009619666190718141647


Research Article



Research Article



Articles Ahead of Print







Anti-tumor Activity of Propofol: A Focus on MicroRNAs


Milad Ashrafizadeh, Hamed Ezzati, Zahra Ahmadi, Tahereh Farkhondeh and Saeed Samarghandian*


DOI: 10.2174/1568009619666191023100046
View Abstract View on PubMed


Resveratrol as an Adjuvant for Normal Tissues Protection and Tumor Sensitization


Keywan Mortezaee, Masoud Najafi*, Bagher Farhood, Amirhossein Ahmadi, Dheyauldeen Shabeeb and Ahmed Eleojo Musa


DOI: 10.2174/1568009619666191019143539
View Abstract View on PubMed


CDK12 Promotes Breast Cancer Progression and Maintains Stemness by Activating c-myc/β -catenin Signaling


Fang Peng, Chuansheng Yang, Yanan Kong, Xiaojia Huang, Yanyu Chen, Yangfan Zhou, Xinhua Xie* and Peng Liu*


DOI: 10.2174/1568009619666191118113220
View Abstract View on PubMed



Abstracts Ahead of Print





Use of small-molecule inhibitory compound of PERK-dependent signaling pathway as a promising target-based therapy for colorectal cancer


Wioletta Rozpędek, Dariusz Pytel, Adam Wawrzynkiewicz, Natalia Siwecka, Adam Dziki, Łukasz Dziki, J. Alan Diehl and Ireneusz Majsterek*


DOI: 10.2174/1568009620666200106114826
View Abstract



Idronoxil as an Anticancer Agent: Activity and Mechanisms


Kate Porter*, W. Douglas Fairlie, Olivier Laczka, Frederic Delebecque and John Wilkinson


DOI: 10.2174/1568009620666200102122830
View Abstract



Old and New Approaches to Target the Hsp90 Chaperone


Jackee Sanchez, Trever R. Carter, Mark S. Cohen* and Brian S. Blagg


DOI: 10.2174/1568009619666191202101330
View Abstract



Published Contents

Editor's Choice






Exploring Proteomic Drug Targets, Therapeutic Strategies and Protein - Protein Interactions in Cancer: Mechanistic View

, 2019; 19(6): 430 - 448

Khalid Bashir Dar, Aashiq Hussain Bhat, Shajrul Amin, Syed Anjum, Bilal Ahmad Reshi, Mohammad Afzal Zargar, Akbar Masood and Showkat Ahmad Ganie*


DOI: 10.2174/1568009618666180803104631







Open Access Articles

Cancer Cell-Derived Secretory Factors in Breast Cancer-Associated Lung Metastasis: their Mechanism and Future Prospects

, 2020; 20: 1 - 19 (E-Pub Ahead of Print)

Tabinda Urooj*, Bushra Wasim, Shamim Mushtaq, Syed Nudrat Nawaid Shah and Muzna Shah





Linc01638 Promotes Tumorigenesis in HER2+ Breast Cancer

, 2019; 19(1): 74 - 80

Peng Liu, Hailin Tang, Jiali Wu, Xingsheng Qiu, Yanan Kong, Lijuan Zhang, Xinhua Xie* and Xiangsheng Xiao*




Role of MicroRNAs in Treatment Response in Prostate Cancer

, 2018; 18(10): 929 - 944

Anshuli Razdan, Paul de Souza* and Tara Laurine Roberts




Noxa: Role in Cancer Pathogenesis and Treatment

, 2018; 18(10): 914 - 928

Rami Z. Morsi, Rouba Hage-Sleiman, Hadile Kobeissy and Ghassan Dbaibo*








Platycodin D Induces Tumor Growth Arrest by Activating FOXO3a Expression in Prostate Cancer in vitro and in vivo

, 2014; 14(9): 860 - 871

Rui Zhou, Zongliang Lu, Kai Liu, Jing Guo, Jie Liu, Yong Zhou, Jian Yang, Mantian Mi and Hongxia Xu




Pleiotropic Role of HSF1 in Neoplastic Transformation

, 2014; 14(2): 144 - 155

Natalia Vydra, Agnieszka Toma and Wieslawa Widlak






β-Catenin Knockdown in Liver Tumor Cells by a Cell Permeable Gamma Guanidine-based Peptide Nucleic Acid

, 2013; 13(8): 867 - 878

Evan Delgado, Raman Bahal, Jing Yang, Jung M. Lee, Danith H Ly and Satdarshan P. S. Monga




Signal Transduction in Human Cutaneous Melanoma and Target Drugs

, 2013; 13(8): 843 - 866

Anatoly B. Uzdensky, Svetlana V. Demyanenko and Mikhail Y. Bibov





Most Cited Articles

Review Article

Epigenetics in metastatic breast cancer: Its regulation and implications in diagnosis, prognosis and therapeutics

, 2019; 19(2): 82-100.

Yuan Seng Wu, Zhong Yang Lee , Lay-Hong Chuah, Chun Wai Mai and Siew Ching Ngai*


DOI: 10.2174/1568009618666180430130248


Review Article

Polyploid giant cancer cells (PGCCs): The evil roots of cancer

, 2019; 19(5): 360-367.

Junsong Chen, Na Niu, Jing Zhang, Lisha Qi , Weiwei Shen , Krishna Vanaja Donkena, Zhenqing Feng and Jinsong Liu *


DOI: 10.2174/1568009618666180703154233




Review Article

Challenges and opportunities from basic cancer biology for nanomedicine for targeted drug delivery

, 2019; 19(4): 257-276.

Xiaodong Xie, Yingying Zhang, Fengqiao Li, Tingting Lv, Ziying Li, Haijun Chen, Lee Jia* and Yu Gao*


DOI: 10.2174/1568009618666180628160211


Review Article

Ursolic acid in cancer treatment and metastatic chemoprevention: From synthesized derivatives to nanoformulations in preclinical studies

, 2019; 19(4): 245-256.

Junjie Zou, Juanfang Lin, Chao Li, Ruirui Zhao, Lulu Fan, Jesse Yu and Jingwei Shao*


DOI: 10.2174/1568009618666181016145940


Letter

Cathepsin l induces proangiogenic changes in human omental microvascular endothelial cells via activation of the ERK1/2 pathway

, 2019; 19(3): 231-242.

Md Zahidul I. Pranjol, Nicholas J. Gutowski, Michael Hannemann and Jacqueline L. Whatmore*


DOI: 10.2174/1568009618666180831123951


Review Article

Focal adhesion kinase in ovarian cancer: A potential therapeutic target for platinum and taxane-resistant tumors

, 2019; 19(3): 179-188.

Arkene Levy*, Khalid Alhazzani, Priya Dondapati, Ali Alaseem, Khadijah Cheema, Keerthi Thallapureddy, Paramjot Kaur, Saad Alobid and Appu Rathinavelu


DOI: 10.2174/1568009618666180706165222


Review Article

Glycolysis inhibition as a strategy for hepatocellular carcinoma treatment?

, 2019; 19(1): 26-40.

A.P. Alves, A.C. Mamede, M.G. Alves, P.F. Oliveira, S.M. Rocha, M.F. Botelho and C.J. Maia*


DOI: 10.2174/1568009618666180430144441


Research Article

Interactions of vascular endothelial growth factor and p53 with mir-195 in thyroid carcinoma: Possible therapeutic targets in aggressive thyroid cancers

, 2019; 19(7): 561-570.

Hamidreza Maroof , Soussan Irani , Armin Arianna, Jelena Vider, Vinod Gopalan and Alfred King-yin Lam *


DOI: 10.2174/1568009618666180628154727


Research Article

Characterization of YY1 OPB peptide for its anticancer activity

, 2019; 19(6): 504-511.

Yige Qi, Ting Yan, Lu Chen, Qiang Zhang, Weishu Wang, Xu Han, Dangdang Li, Jinming Shi and Guangchao Sui*


DOI: 10.2174/1568009618666181031153151


Research Article

c-Myc inhibitor 10074-G5 induces murine and human hematopoietic stem and progenitor cell expansion and HDR modulator Rad51 expression

, 2019; 19(6): 479-494.

Merve Aksoz, Esra Albayrak, Galip Servet Aslan, Raife Dilek Turan, Lamia Yazgi Alyazici, Pınar Siyah, Emre Can Tuysuz, Serli Canikyan, Dogacan Yucel, Neslihan Meric, Zafer Gulbas, Fikrettin Sahin and Fatih Kocabas*


DOI: 10.2174/1568009618666180905100608


Research Article

Formulation, pharmacokinetic evaluation and cytotoxicity of an enhanced-penetration paclitaxel nanosuspension

, 2019; 19(4): 338-347.

Yanping Cao, Zhihao Wei, Mengmeng Li, Haiyan Wang, Li Yin, Dongxiao Chen, Yanfei Wang, Yongchao Chen, Qi Yuan, Xiaohui Pu*, Lanlan Zong* and Shaofeng Duan*


DOI: 10.2174/1568009618666180629150927





Most Accessed Articles



CT-707 Overcomes Resistance of Crizotinib through Activating PDPK1- AKT1 Pathway by Targeting FAK

, 2019; 19(8): 655-665.

Caixia Liang, Ningning Zhang, Qiaoyun Tan, Shuxia Liu, Rongrong Luo, Yanrong Wang, Yuankai Shi* and Xiaohong Han*


DOI: 10.2174/1568009618666181031152140



Overexpression of Nemo-like Kinase Promotes the Proliferation and Invasion of Lung Cancer Cells and Indicates Poor Prognosis

, 2019; 19(8): 674-680.

Lei Lei, Yuan Wang, Yi-Wen Zheng, Liang-Ru Fei, Hao-Yue Shen, Zhi-Han Li, Wen-Jing Huang, Juan-Han Yu and Hong-Tao Xu*


DOI: 10.2174/1568009618666181119150521




Bone Invasive Properties of Oral Squamous Cell Carcinoma and its Interactions with Alveolar Bone Cells: An In Vitro Study

, 2019; 19(8): 631-640.

Omel Baneen Qallandar, Faeza Ebrahimi, Farhadul Islam, Riajul Wahab, Bin Qiao, Peter Reher, Vinod Gopalan* and Alfred King-yin Lam*


DOI: 10.2174/1568009618666181102144317


Gender Differences in the Antioxidant Response to Oxidative Stress in Experimental Brain Tumors

, 2019; 19(8): 641-654.

María Jesús Ramírez-Expósito, María Dolores Mayas, María Pilar Carrera-González and José Manuel Martínez-Martos*


DOI: 10.2174/1568009618666181018162549


Xiao-Chai-Hu-Tang (XCHT) Intervening Irinotecan’s Disposition: The Potential of XCHT in Alleviating Irinotecan-Induced Diarrhea

, 2019; 19(7): 551-560.

Rongjin Sun, Sumit Basu, Min Zeng, Robin Sunsong, Li Li, Romi Ghose, Wei Wang, Zhongqiu Liu, Ming Hu* and Song Gao*


DOI: 10.2174/1568009618666181029153255



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