Current Cancer Drug Targets
Volume 21, 11 Issues, 2021
ISSN: 1873-5576 (Online)
ISSN: 1568-0096 (Print)
This journal supports open access
ISSN: 1873-5576 (Online)
ISSN: 1568-0096 (Print)
This journal supports open access
Editor's Choice
C-Myc Signaling Pathway in Treatment and Prevention of Brain Tumors
, 2021; 21(1): 2 - 20Milad Ashrafizadeh, Ali Zarabi, Kiavash Hushmandi, Ebrahim Rahmani Moghadam, Farid Hashemi, Salman Daneshi, Fardin Hashemi, Shima Tavakol, Reza Mohammadinejad, Masoud Najafi*, Namrata Dudha and Manoj Garg*
DOI: 10.2174/1568009620666201016121005
Clinical Outcomes and Safety of Patients Treated with NAb-Paclitaxel Plus Gemcitabine in Metastatic Pancreatic Cancer: The NAPA Study
, 2020; 20(11): 887 - 895Martina Catalano, Giandomenico Roviello*, Raffaele Conca, Alberto D’Angelo, Valeria Emma Palmieri, Benedetta Panella, Roberto Petrioli, Anna Ianza, Stefania Nobili, Enrico Mini and Monica Ramello
DOI: 10.2174/1568009620999200918122426
Selinexor (KPT-330), an Oral Selective Inhibitor of Nuclear Export (SINE) Compound, in Combination with FOLFOX in Patients with Metastatic Colorectal Cancer (mCRC) - Final Results of the Phase I Trial SENTINEL
, 2020; 20(10): 811 - 817Sven Nilsson, Alexander Stein, Christian Rolfo, Anne L. Kranich, Julia Mann, Konstantinos Papadimitriou, Susann Theile, Stefanie Amberg and Carsten Bokemeyer*
DOI: 10.2174/1568009620666200628105727
Cancer Stem Cells with Overexpression of Neuronal Markers Enhance Chemoresistance and Invasion in Retinoblastoma
, 2020; 20(9): 710 - 719Sekaran Balaji, Radhakrishnan Santhi, Usha Kim, Veerappan Muthukkaruppan, Chidambaranathan G. Priya and Ayyasamy Vanniarajan*
DOI: 10.2174/1568009620666200504112711
Strategic Combination Therapies for Ovarian Cancer
, 2020; 20(8): 573 - 585Xinran Li, Angel S.N. Ng, Victor C.Y. Mak, Karen K.L. Chan, Annie N.Y. Cheung and Lydia W.T. Cheung*
DOI: 10.2174/1568009620666200511084007
Autophagy Driven Extracellular Vesicles in the Leukaemic Microenvironment
, 2020; 20(7): 501 - 512Rebecca H. Horton, Tom Wileman and Stuart A. Rushworth*
DOI: 10.2174/1568009620666200428111051
COVID-19 Pandemic: Experiences in China and Implications for its Prevention and Treatment Worldwide
, 2020; 20(6): 410 - 416Ning-Ning Liu*, Jing-Cong Tan, Jingquan Li, Shenghui Li*, Yong Cai* and Hui Wang*
DOI: 10.2174/1568009620666200414151419
CDK9: Therapeutic Perspective in HCC Therapy
, 2020; 20(5): 318 - 324Jędrzej Borowczak*, Krzysztof Szczerbowski, Ewa Stec, Dariusz Grzanka and Łukasz Szylberg
DOI: 10.2174/1568009620666200212124357
PPARγ Agonists in Combination Cancer Therapies
, 2020; 20(3): 197 - 215Piotr Mrowka and Eliza Glodkowska-Mrowka*
DOI: 10.2174/1568009619666191209102015
Novel Mechanistic Insights into the Anti-cancer Mode of Arsenic Trioxide
, 2020; 20(2): 115 - 129Md Wahiduzzaman, Akinobu Ota* and Yoshitaka Hosokawa
DOI: 10.2174/1568009619666191021122006
Anti-VEGF/VEGFR2 Monoclonal Antibodies and their Combinations with PD-1/PD-L1 Inhibitors in Clinic
, 2020; 20(1): 3 - 18Feng Gao* and Chun Yang
DOI: 10.2174/1568009619666191114110359
Cancer Stem Cells Equipped with Powerful Hedgehog Signaling and Better Epigenetic Memory: Avenues to Look for Cancer Therapeutics
, 2019; 19(11): 877 - 884Ishita Tandon, Asawari Waghmode and Nilesh Kumar Sharma*
DOI: 10.2174/1568009619666190808155432
Inhibition of PI3K/mTOR Pathways with GDC-0980 in Pediatric Leukemia: Impact on Abnormal FLT-3 Activity and Cooperation with Intracellular Signaling Targets
, 2019; 19(10): 828 - 837Abdulhameed Al-Ghabkari*, Maneka A. Perinpanayagam and Aru Narendran
DOI: 10.2174/1568009619666190326120833
Autophagy and Apoptosis Specific Knowledgebases-guided Systems Pharmacology Drug Research
, 2019; 19(9): 716 - 728Peihao Fan, Nanyi Wang, Lirong Wang * and Xiang-Qun Xie *
DOI: 10.2174/1568009619666190206122149
Molecular Mechanisms and Targeted Therapies Including Immunotherapy for Non-Small Cell Lung Cancer
, 2019; 19(8): 595 - 630Tatsuya Nagano*, Motoko Tachihara and Yoshihiro Nishimura
DOI: 10.2174/1568009619666181210114559
EH-42: A Novel Small Molecule Induces Apoptosis and Inhibits Migration and Invasion of Human Hepatoma Cells through Suppressing STAT3 Signaling Pathway
, 2019; 19(7): 583 - 593Qi-Zhe Gong, Di Xiao, Gui-Yi Gong, Jian Xu, Xiao-Dong Wen*, Feng Feng* and Wei Qu*
DOI: 10.2174/1568009619666181226094814
Exploring Proteomic Drug Targets, Therapeutic Strategies and Protein - Protein Interactions in Cancer: Mechanistic View
, 2019; 19(6): 430 - 448Khalid Bashir Dar, Aashiq Hussain Bhat, Shajrul Amin, Syed Anjum, Bilal Ahmad Reshi, Mohammad Afzal Zargar, Akbar Masood and Showkat Ahmad Ganie*
DOI: 10.2174/1568009618666180803104631
Targeting Glycosylation Aberrations to Improve the Efficiency of Cancer Phototherapy
, 2019; 19(5): 349 - 359Guillaume Poiroux, Annick Barre, Pierre Rougé and Hervé Benoist*
DOI: 10.2174/1568009618666180628101059
The Evaluation of Animal Models in the Development of Anticancer Agents: From Preclinical to Clinical Tests
, 2019; 19(4): 277 - 284Jie Wang, Haiyan Dong, Jian Liu, Ning Zheng, Xiaodong Xie and Lee Jia*
DOI: 10.2174/1568009618666180817095331
Efficacy and Safety of Antigen-specific Immunotherapy in the Treatment of Patients with Non-small-cell Lung Cancer: A Systematic Review and Meta-analysis
, 2019; 19(3): 199 - 209Bing-Di Yan, Xiao-Feng Cong, Sha-Sha Zhao, Meng Ren, Zi-Ling Liu, Zhi Li, Chen Chen and Lei Yang*
DOI: 10.2174/1568009618666180430124738
Epigenetics in Metastatic Breast Cancer: Its Regulation and Implications in Diagnosis, Prognosis and Therapeutics
, 2019; 19(2): 82 - 100Yuan Seng Wu, Zhong Yang Lee, Lay-Hong Chuah, Chun Wai Mai and Siew Ching Ngai*
DOI: 10.2174/1568009618666180430130248
Specific Targeting of HER2-Positive Head and Neck Squamous Cell Carcinoma Line HN5 by Idarubicin-ZHER2 Affibody Conjugate
, 2019; 19(1): 65 - 73Marzieh Ghanemi, Aminollah Pourshohod, Mohammad Ali Ghaffari, Alireza kheirollah, Mansour Amin, Majid Zeinali* and Mostafa Jamalan*
DOI: 10.2174/1568009617666170427105417
The Anti-malarial Drug Artesunate Blocks Wnt/β-catenin Pathway and Inhibits Growth, Migration and Invasion of Uveal Melanoma Cells
, 2018; 18(10): 988 - 998Lei Zheng and Jingxuan Pan*
DOI: 10.2174/1568009618666180425142653
Aldose Reductase Inhibitor, Fidarestat Prevents High-fat Diet-induced Intestinal Polyps in ApcMin/+ Mice
, 2018; 18(9): 905 - 911Ashish Saxena, Ravinder Tammali, Kota V. Ramana and Satish K. Srivastava*
DOI: 10.2174/1568009617666170808105633
p53-Mdm2 Interaction Inhibitors as Novel Nongenotoxic Anticancer Agents
, 2018; 18(8): 749 - 772Surendra Kumar Nayak*, Gopal L. Khatik, Rakesh Narang, Vikramdeep Monga and Harish Kumar Chopra
DOI: 10.2174/1568009617666170623111953
Regulation of MicroRNAs by Phytochemicals: A Promising Strategy for Cancer Chemoprevention
, 2018; 18(7): 640 - 651Sadegh Babashah*, Babak Bakhshinejad, Maryam Tahmasebi Birgani, Katayoon Pakravan and William C. Cho*
DOI: 10.2174/1568009617666170623124710
Oncolytic Tanapoxvirus Expressing Interleukin-2 is Capable of Inducing the Regression of Human Melanoma Tumors in the Absence of T Cells
, 2018; 18(6): 577 - 591Tiantian Zhang, Dennis H. Kordish, Yogesh R. Suryawanshi, Rob R. Eversole, Steven Kohler, Charles D. Mackenzie and Karim Essani*
DOI: 10.2174/1568009617666170630143931
The Real Impact of Target Therapy in Breast Cancer Patients: Between Hope and Reality
, 2018; 18(5): 480 - 498Sebastiano Bordonaro, Massimiliano Berretta, Antonino Carmelo Tralongo, Silvia Clementi, Brigida Stanzione and Paolo Tralongo*
DOI: 10.2174/1568009617666170209100322
Cell-derived Exosomes as Promising Carriers for Drug Delivery and Targeted Therapy
, 2018; 18(4): 347 - 354Xinyi Wang, Haiyang Zhang, Haiou Yang, Ming Bai, Tao Ning, Shuang Li, Jialu Li, Ting Deng, Guoguang Ying* and Yi Ba*
DOI: 10.2174/1568009617666170710120311
Autophagy Inhibition in Childhood Nephroblastoma and the Therapeutic Significance
, 2018; 18(3): 295 - 303Lin-Jie Li , Yi-Long Wang, Lin-Qing Yuan, Wei-Zhong Gu, Kun Zhu, Min Yang, Duo Zhou, Yao Lv, Min-Ju Li, Zheng-Yan Zhao, Jin-Hu Wang* and Xi Chen*
DOI: 10.2174/1568009617666170330105433
Oncolytic Viruses: The Best is Yet to Come
, 2018; 18(2): 109 - 123Chantal G. Lemay, Brian A. Keller, Robert E. Edge, Masato Abei and John C. Bell*
DOI: 10.2174/1568009617666170206111609
Mechanisms for the Inhibition of Colon Cancer Cells by Sulforaphane through Epigenetic Modulation of MicroRNA-21 and Human Telomerase Reverse Transcriptase (hTERT) Down-regulation
, 2018; 18(1): 97 - 106Samantha L. Martin, Rishabh Kala and Trygve O. Tollefsbol*
DOI: 10.2174/1568009617666170206104032
Coinhibitory Molecule PD-1 as a Therapeutic Target in the Microenvironment of Multiple Myeloma
, 2017; 17(9): 839 - 845Djordje Atanackovic, Tim Luetkens, Sabari Radhakrishnan and Nicolaus Kroger*
DOI: 10.2174/1568009617666170906170348
Potential Therapeutic Targets in Energy Metabolism Pathways of Breast Cancer
, 2017; 17(8): 707 - 721Rowshan Ara Islam, Sazzad Hossain and Ezharul Hoque Chowdhury*
DOI: 10.2174/1568009617666170330150458
Insight into Discovery of Next Generation Reversible TMLR Inhibitors Targeting EGFR Activating and Drug Resistant T790M Mutants
, 2017; 17(7): 617 - 636Subhash Mohan Agarwal*, Divyani Pal, Mansi Gupta and Ravi Saini
DOI: 10.2174/1568009617666170330112842
Epstein-Barr Virus-associated Gastric Cancer and Potential Mechanisms of Oncogenesis
, 2017; 17(6): 534 - 554Abigail Morales-Sanchez and Ezequiel M. Fuentes-Panana*
DOI: 10.2174/1568009616666160926124923
Identification of Novel Agents for the Treatment of Brain Metastases of Breast Cancer
, 2017; 17(5): 479 - 485Vinay K. Venishetty, Werner J. Geldenhuys, Tori B. Terell-Hall, Jessica I.G. Griffith, Gregory R. Sondag, Fayez F. Safadi and Paul R. Lockman*
DOI: 10.2174/1568009617666161121123948
Hitting a Moving Target: Glioma Stem Cells Demand New Approaches in Glioblastoma Therapy
, 2017; 17(3): 236 - 254Drew A. Spencer, Brenda M. Auffinger, Jason P. Murphy, Megan E. Muroski, Jian Qiao, Yureve Gorind and Maciej S. Lesniak
DOI: 10.2174/1568009616666161215161924
Targeting Key Metabolic Enzymes Involved in Lipid and Protein Biosyntheses for Breast Anticancer Therapies
, 2017; 17(2): 158 - 168Mounia Guerram, Aida Mejda Hamdi, Lu-Yong Zhang and Zhenzhou Jiang
DOI: 10.2174/1568009616666160603123014
Does Hypoxic Response Mediate Primary Resistance to Sunitinib in Untreated Locally Advanced Breast Cancer?
, 2017; 17(1): 62 - 73Sofia Braga, Joana Cardoso, Saudade Andre, Margarida Brito, Pedro Sanchez, Lurdes Orvalho, Lucilia Salgado, Sergio Dias, Jose B. Pereira-Leal and Jose Luis Passos-Coelho
DOI: 10.2174/1568009616666161025114914
Pyrimethamine as a Potent and Selective Inhibitor of Acute Myeloid Leukemia Identified by High-throughput Drug Screening
, 2016; 16(9): 818 - 828Amit Sharma, Nidhi Jyotsana, Courteney K. Lai, Anuhar Chaturvedi, Razif Gabdoulline, Kerstin Görlich, Cecilia Murphy, Jan E. Blanchard, Arnold Ganser, Eric Brown, John A. Hassell, R. Keith Humphries, Michael Morgan and Michael Heuser
DOI: 10.2174/1568009616666160617103301
Deregulation of Apoptosis - Is it Still an Important Issue in Pathogenesis of Chronic Lymphocytic Leukemia?
, 2016; 16(8): 652 - 658Monika Podhorecka, Arkadiusz Macheta, Maria Bozko, Andrzej Bozko, Nisar P. Malek and Przemyslaw Bozko
DOI: 10.2174/1568009616666160427103930
MT1-MMP Activation of TGF-β Signaling Enables Intercellular Activation of an Epithelial-mesenchymal Transition Program in Cancer
, 2016; 16(7): 618 - 630Hoang-Lan Nguyen, Pournima Kadam, Alex Helkin, Kevin Cao, Song Wu, Ghassan J. Samara, Qian Zhang, Stanley Zucker and Jian Cao
DOI: 10.2174/1568009616666160216125634
Recent Advances in Site Specific Conjugations of Antibody Drug Conjugates (ADCs)
, 2016; 16(6): 469 - 479Wenlong Gao, Jingxin Zhang, Jun Xiang, Lei Zhang, Chengbin Wu, Pradeep K. Dhal and Bo Chen
DOI: 10.2174/1568009616666160512144715
Mechanisms and Therapeutic Targets of microRNA-associated Chemoresistance in Epithelial Ovarian Cancer
, 2016; 16(5): 429 - 441Lingyun Zhang, Lubna Nadeem, Kristin Connor and Guoxiong Xu
DOI: 10.2174/1568009616666160404121105
Targeted Inhibition of Rictor/mTORC2 in Cancer Treatment: A New Era after Rapamycin
, 2016; 16(4): 288 - 304Zhipeng Zou, Juan Chen, Jun Yang and Xiaochun Bai
DOI: 10.2174/1568009616666151113120830
Targeting ABCB1 and ABCC1 with their Specific Inhibitor CBT-1® can Overcome Drug Resistance in Osteosarcoma
, 2016; 16(3): 261 - 274Marilù Fanelli, Claudia Maria Hattinger, Serena Vella, Elisa Tavanti, Francesca Michelacci, Beth Gudeman, Daryl Barnett, Piero Picci and Massimo Serra
DOI: 10.2174/1568009616666151106120434
RING-, HECT-, and RBR-type E3 Ubiquitin Ligases: Involvement in Human Cancer
, 2016; 16(2): 157 - 174Chiharu Uchida and Masatoshi Kitagawa
DOI: 10.2174/1568009616666151112122801
Molecular Genetics and Targeted Therapy in Hepatocellular Carcinoma
, 2016; 16(1): 53 - 70Eric I. Marks and Nelson S. Yee
DOI: 10.2174/1568009615666150916092903
Chemotherapy Delivery Strategies to the Central Nervous System: neither Optional nor Superfluous
, 2015; 15(9): 752 - 768Annie Drapeau and David Fortin
DOI: 10.2174/1568009615666150616123548
Prognostic and Predictive Biomarkers in Colorectal Cancer. From the Preclinical Setting to Clinical Practice
, 2015; 15(8): 703 - 715Joan Maurel and Antonio Postigo
DOI: 10.2174/156800961508151001102822
Nanobiotechnological Approaches to Overcome Drug Resistance in Breast Cancer
, 2015; 15(7): 544 - 562Peyman Ranji, Zahra Heydari and Ali Mohammad Alizadeh
DOI: 10.2174/1568009615666150706102842
Bone Metastasis: Molecular Mechanisms Implicated in Tumour Cell Dormancy in Breast and Prostate Cancer
, 2015; 15(6): 469 - 480Lewis Quayle, Penelope D. Ottewell and Ingunn Holen
DOI: 10.2174/1568009615666150506092443
Target Acquired: Progress and Promise of Targeted Therapeutics in the Treatment of Prostate Cancer
, 2015; 15(5): 394 - 405Ryan Stuchbery, Natalie J. Kurganovs, Patrick J. McCoy, Colleen C. Nelson, Vanessa M. Hayes, Niall M. Corcoran and Christopher M. Hovens
DOI: 10.2174/1568009615666150416113453
A Pan-Cancer Review of ALK Mutations: Implications for Carcinogenesis and Therapy
, 2015; 15(4): 327 - 336Nick Ka Ming Yau, Andrew Yuon Fong, Hiu Fung Leung, Krista Roberta Verhoeft, Qin Ying Lim, Wai Yip Lam, Ian Chi Kei Wong and Vivian Wai Yan Lui
DOI: 10.2174/1568009615666150225123712
Present, Emerging and Possible Future Biomarkers in Castration Resistant Prostate Cancer (CRPC)
, 2015; 15(3): 243 - 255Martin Boegemann, Andres-Jan Schrader, Laura-Maria Krabbe and Edwin Herrmann
DOI: 10.2174/1568009615666150204145803
Involvement of Mesenchymal Stem Cells in Cancer Progression and Metastases
, 2015; 15(2): 88 - 98Astra I. Chang, Aaron H. Schwertschkow, Jan A. Nolta and Jian Wu
DOI: 10.2174/1568009615666150126154151
Potential Anti-cancer Drugs Commonly Used for Other Indications
, 2015; 15(1): 35 - 52Veronika Hanusova, Lenka Skalova, Vera Kralova and Petra Matouskova
DOI: 10.2174/1568009615666141229152812
Looking out for Cancer Stem Cells’ Properties: The Value-Driving Role of CD44 for Personalized Medicines
, 2014; 14(9): 832 - 849Sara Horta, Ana L. Agostinho, Rita Mateus, Lucilia Pereira, Carolina Pereira, Liliana Capinha, Slavomira Doktorovova, Alexandra Brito and Mafalda Videira
DOI: 10.2174/1568009614666141111154713
Heat Shock Proteins as Prognostic Markers of Cancer
, 2014; 14(8): 713 - 726Evgeniya V. Kaigorodova and Mariya V. Bogatyuk
DOI: 10.2174/1568009614666140926122846
Targeting Oncogenes and Tumor Suppressors genes to Mitigate Chemoresistance
, 2014; 14(7): 599 - 609Tahereh Fatemian and Ezharul Hoque Chowdhury
DOI: 10.2174/156800961407140926104458
Overview of Proteasome Inhibitor-Based Anti-cancer Therapies: Perspective on Bortezomib and Second Generation Proteasome Inhibitors versus Future Generation Inhibitors of Ubiquitin-Proteasome System
, 2014; 14(6): 517 - 536Q. Ping Dou and Jeffrey A. Zonder
DOI: 10.2174/1568009614666140804154511
The Activation of β1-integrin by Type I Collagen Coupling with the Hedgehog Pathway Promotes the Epithelial-Mesenchymal Transition in Pancreatic Cancer
, 2014; 14(5): 446 - 457Wanxing Duan, Jiguang Ma, Qingyong Ma, Qinhong Xu, Jianjun Lei, Liang Han, Xuqi Li, Zheng Wang, Zheng Wu, Shifang Lv, Zhenhua Ma, Mouzhu Liu, Fengfei Wang and Erxi Wu
DOI: 10.2174/1568009614666140402105101
Metabolic Features of Melanoma: A Gold Mine of New Therapeutic Targets?
, 2014; 14(4): 357 - 370Philippe Marchetti, Pierre Guerreschi, Jerome Kluza and Laurent Mortier
DOI: 10.2174/1568009614666140407113124
Targeting BMP9-Promoted Human Osteosarcoma Growth by Inactivation of Notch Signaling
, 2014; 14(3): 274 - 285Ruidong Li, Wenwen Zhang, Jing Cui, Wei Shui, Liangjun Yin, Yang Wang, Hongyu Zhang, Ning Wang, Ningning Wu, Guoxin Nan, Xian Chen, Sheng Wen, Fang Deng, Hongmei Zhang, Guolin Zhou, Zhan Liao, Junhui Zhang, Qian Zhang, Zhengjian Yan, Wei Liu, Zhonglin Zhang, Jixing Ye, Youlin Deng, Hue H. Luu, Rex C. Haydon, Tong-Chuan He and Zhong-Liang Deng
DOI: 10.2174/1568009614666140305105805
PIM1 Kinase as a Target in Prostate Cancer: Roles in Tumorigenesis, Castration Resistance, and Docetaxel Resistance
, 2014; 14(2): 105 - 114Sheldon L. Holder and Sarki A. Abdulkadir
DOI: 10.2174/1568009613666131126113854
Editor-in-Chief
Ruiwen Zhang
Center for Drug Discovery
University of Houston
3455 Cullen Blvd.
Houston, TX 77204
(USA)
Center for Drug Discovery
University of Houston
3455 Cullen Blvd.
Houston, TX 77204
COPE Compliant
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Journal History
Current Cancer Drug Targets was launched in 2001. Dr. Ruiwen Zhang serves as the Editor-in-Chief of the journal.
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