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Current Drug Metabolism

Volume 22, 14 Issues, 2021
ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)
This journal supports open access

Aims & Scope

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism.

More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.

Current Drug Metabolism

,

Volume 22

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Number 9





Review Article

A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview

, 22(9): 672 - 682

Naina Mohamed Pakkir Maideen*, Balasubramanian Rajkapoor, Sudha Muthusamy, Sambathkumar Ramanathan, Subramaniam Ananda Thangadurai and Abdussalam A. Sughir


DOI: 10.2174/1389200222666210614112529










Research Article

Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement

, 22(9): 735 - 745

Jesse Alt , Sadakatali S. Gori, Kathryn M. Lemberg, Arindom Pal , Vijayabhaskar Veeravalli, Ying Wu, Joanna M.H. Aguilar , Ranjeet P. Dash, Lukáš Tenora , Pavel Majer, Qi Sun, Barbara S. Slusher* and Rana Rais*


DOI: 10.2174/1389200222666210831125041


Research Article

Evaluation and Clinical Implication of Zhenwu Decoction on Seven Cytochrome P450 Enzyme in Chronic Heart Failure Rats

, 22(9): 746 - 755

Li-Li Hong, Hong-Song Wang*, Xiao-Yu Cheng*, Sheng Zhang, Yan Zhao, Qian Wang, Ya-TIng Zhao, Lei Wang, Lan Ge, Jun Su and Wei-Dong Chen


DOI: 10.2174/1389200222666210701171047


Articles Ahead of Print


Influence of CYP2C9 Polymorphisms on Plasma Concentration of Warfarin and 7-Hydroxy Warfarin in South Indian Patients


Dhakchinamoorthi Krishna Kumar*, Chakradhara Rao Satyanarayana Uppugunduri, Deepak Gopal Shewade, Sai Chandran BV and Chandrasekaran Adithan


DOI: 10.2174/1389200222666211119104412
View Abstract View on PubMed





Oxypeucedanin is a Mechanism-Based Inactivator of CYP2B6 and CYP2D6


Kehan Zhang, Yilin Li, Yao Fu, Tiantian Cui, Qian Wang, Xu Mao, Ying Peng and Jiang Zheng*


DOI: 10.2174/1389200222666210629114830
View Abstract View on PubMed






Abstracts Ahead of Print

Identification and Quantification of MIDD0301 metabolites


M.S. Rashid Roni, Nicolas M. Zahn, Brandon N. Mikulsky, Daniel A. Webb, Md Yeunus Mian, Daniel E. Knutson, Margaret L. Guthrie, James M. Cook, Douglas C. Stafford and Leggy A. Arnold*


DOI: 10.2174/1389200222666211202093841
View Abstract


Regulatory effects of N-3 PUFAs on pancreatic β-cells and insulin-sensitive tissues


Wen Liu, Qing Zheng, Min Zhu, Xiaohong Liu, Jingping Liu, Yanrong Lu, Jingqiu Cheng and Younan Chen*


DOI: 10.2174/1389200222666211126104002
View Abstract


Recent advances in biotransformation by Cunninghamella species


Manoela Daiele Gonçalves*, Fernanda Tomiotto-Pellissier, Ricardo Luís Nascimento de Matos, João Paulo Assolini, Bruna Taciane da Silva Bortoleti, Virginia Marcia Concato, Taylon Felipe Silva, Janice Aparecida Rafael, Wander Rogério Pavanelli, Ivete Conchon-Costa and Nilton Syogo Arakawa


DOI: 10.2174/1389200222666211126100023
View Abstract



Characterization of Metabolites of α-mangostin in Bio-samples from SD Rats by UHPLC-Q-Exactive Orbitrap MS


Fan Dong, Shaoping Wang, Ailin Yang, Haoran Li, Pingping Dong, Bing Wang, Long Dai, Yongqiang Lin* and Jiayu Zhang*


DOI: 10.2174/1389200222666211126093124
View Abstract


Higher teicoplanin blood level needed in elderly critically ill patients


Ling Wang, Mingguang Chen, Hong Ye, Xiaolan Lin, Yixuan Li, Junshan Ruan*, Fenghui Lin* and Yuxing Lin


DOI: 10.2174/1389200222666211122124420
View Abstract




Published Contents

Editor's Choice




An Overview of Dietary Supplements on Obesity and Type 2 Diabetes: Efficacy and Mechanisms

, 2021; 22(6): 415 - 440

Xiaohong Liu, Xin Zeng, Wen Liu, Yanrong Lu, Jingqiu Cheng and Younan Chen*


DOI: 10.2174/1389200222666210406110450





Topical Capsaicin for the Treatment of Neuropathic Pain

, 2021; 22(3): 198 - 207

Adiba Sultana, Rajeev K. Singla, Xuefei He, Yan Sun, Md. Shahin Alam and Bairong Shen*


DOI: 10.2174/1389200221999201116143701





Current Treatment Options for HCC: From Pharmacokinetics to Efficacy and Adverse Events in Liver Cirrhosis

, 2020; 21(11): 866 - 884

Giovanni Galati*, Antonio Fabio Massimo Vainieri*, Claudia Angela Maria Fulgenzi, Stefano Di Donato, Marianna Silletta, Paolo Gallo, Angelo Onorato, Umberto Vespasiani-Gentilucci and Antonio Picardi


DOI: 10.2174/1389200221999200918141239



Open Access Articles

Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement

, 2021; 22(9): 735 - 745

Jesse Alt , Sadakatali S. Gori, Kathryn M. Lemberg, Arindom Pal , Vijayabhaskar Veeravalli, Ying Wu, Joanna M.H. Aguilar , Ranjeet P. Dash, Lukáš Tenora , Pavel Majer, Qi Sun, Barbara S. Slusher* and Rana Rais*






Dysregulation of lncRNA and circRNA Expression in Mouse Testes after Exposure to Triptolide

, 2019; 20(8): 665 - 673

Suping Xiong, Yanting Li, Yang Xiang, Na Peng, Chunmiao Shen, Yanqiu Cai, Dandan Song, Peng Zhang, Xiaolong Wang, Xuihui Zeng and Xiaoning Zhang*




Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients

, 2019; 20(7): 592 - 600

Zhiqi Wang, Nan Zhang, Chaoyang Chen, Shuqing Chen, Junyu Xu, Ying Zhou, Xia Zhao* and Yimin Cui*




Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure

, 2019; 20(5): 361 - 376

Ken-ichi Fujita *, Natsumi Matsumoto, Hiroo Ishida, Yutaro Kubota, Shinichi Iwai, Motoko Shibanuma and Yukio Kato




Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*






Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model

, 2019; 20(2): 103 - 113

Shotaro Uehara, Toru Oshio, Kazuyuki Nakanishi, Etsuko Tomioka, Miyu Suzuki, Takashi Inoue, Yasuhiro Uno, Erika Sasaki and Hiroshi Yamazaki*





Thiazide Therapy in Chronic Kidney Disease: Renal and Extra Renal Targets

, 2018; 19(12): 1012 - 1020

Negiin Pourafshar*, Saeed Alshahrani, Ashkan Karimi and Manoocher Soleimani*




Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

, 2018; 19(10): 830 - 838

Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*







Most Cited Articles

Review Article

Survey of machine learning techniques in drug discovery

, 2019; 20(3): 185-193.

Natalie Stephenson, Emily Shane, Jessica Chase, Jason Rowland, David Ries, Nicola Justice, Jie Zhang, Leong Chan and Renzhi Cao*


DOI: 10.2174/1389200219666180820112457


Review Article

Recent advances in machine learning methods for predicting heat shock proteins

, 2019; 20(3): 224-228.

Wei Chen*, Pengmian Feng, Tao Liu and Dianchuan Jin


DOI: 10.2174/1389200219666181031105916




Review Article

Cancer nanotechnology: A new revolution for cancer diagnosis and therapy

, 2019; 20(6): 416-429.

Vivek K Chaturvedi, Anshuman Singh, Vinay K. Singh and Mohan P. Singh*


DOI: 10.2174/1389200219666180918111528


Review Article

Magnetic nanoparticles: Current trends and future aspects in diagnostics and nanomedicine

, 2019; 20(6): 457-472.

Naga Veera Srikanth Vallabani, Sanjay Singh* and Ajay Singh Karakoti*


DOI: 10.2174/1389200220666181122124458


Review Article

Herb-drug interactions and hepatotoxicity

, 2019; 20(4): 275-282.

Mohammad K. Parvez* and Vikas Rishi


DOI: 10.2174/1389200220666190325141422




Review Article

Recent advances in the machine learning-based drug-target interaction prediction

, 2019; 20(3): 194-202.

Wen Zhang*, Weiran Lin, Ding Zhang, Siman Wang, Jingwen Shi and Yanqing Niu


DOI: 10.2174/1389200219666180821094047




Review Article

Survey of machine learning techniques for prediction of the isoform specificity of cytochrome P450 substrates

, 2019; 20(3): 229-235.

Yi Xiong, Yanhua Qiao, Daisuke Kihara, Hui-Yuan Zhang, Xiaolei Zhu* and Dong-Qing Wei*


DOI: 10.2174/1389200219666181019094526


General Review Article

Advanced glycation end products (AGEs), glutathione and breast cancer: Factors, mechanism and therapeutic interventions

, 2019; 20(1): 65-71.

Anil K. Sharma, Var R. Sharma, Girish K. Gupta, Ghulam Md. Ashraf and Mohammad A. Kamal*


DOI: 10.2174/1389200219666180912104342




Most Accessed Articles




A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview

, 2021; 22(9): 672-682.

Naina Mohamed Pakkir Maideen*, Balasubramanian Rajkapoor, Sudha Muthusamy, Sambathkumar Ramanathan, Subramaniam Ananda Thangadurai and Abdussalam A. Sughir


DOI: 10.2174/1389200222666210614112529



Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement

, 2021; 22(9): 735-745.

Jesse Alt , Sadakatali S. Gori, Kathryn M. Lemberg, Arindom Pal , Vijayabhaskar Veeravalli, Ying Wu, Joanna M.H. Aguilar , Ranjeet P. Dash, Lukáš Tenora , Pavel Majer, Qi Sun, Barbara S. Slusher* and Rana Rais*


DOI: 10.2174/1389200222666210831125041


Evaluation and Clinical Implication of Zhenwu Decoction on Seven Cytochrome P450 Enzyme in Chronic Heart Failure Rats

, 2021; 22(9): 746-755.

Li-Li Hong, Hong-Song Wang*, Xiao-Yu Cheng*, Sheng Zhang, Yan Zhao, Qian Wang, Ya-TIng Zhao, Lei Wang, Lan Ge, Jun Su and Wei-Dong Chen


DOI: 10.2174/1389200222666210701171047


The Role of Biotransformation in the Activity of Endocrine Disruptors

, 2021; 22(8): 628-644.

Elif I. Erguc, Alev Tascioglu-Aliyev, Bita Entezari and Hande Gurer-Orhan *


DOI: 10.2174/1389200222666210603114617






Anticancer Activity and In Silico ADMET Properties of 2,4,5-Trisubstitutedthiazole Derivatives

, 2021; 22(7): 532-536.

Bilal A. Al-Jaidi*, Soha T. Telfah, Sanaa K. Bardaweel, Pran K. Deb*, Pobitra Borah, Katharigatta N. Venugopala, Yazan A. Bataineh and Qutaiba A. Al Khames Aga


DOI: 10.2174/1389200221666201217094602


Deciphering the Role of Nanoparticle-based Treatment for Parkinson’s Disease

, 2021; 22(7): 550-560.

Md. Marufur Rahman Moni, Mst. Marium Begum, Md. Sahab Uddin* and Ghulam Md Ashraf*


DOI: 10.2174/1389200222666210202110129


Safe and Effective Kinase Inhibitors for the Treatment of Gynecological Cancers: In Silico Approach

, 2021; 22(7): 537-549.

Vaishali M. Patil*, Abhishek Kumar, Vaishali Anand, Priya Bansal and Neeraj Masand


DOI: 10.2174/1389200222666210331125421




Editor-in-Chief

graphic
Ming Hu
College of Pharmacy
University of Houston
Houston, TX
(United States)
Biography
View Full Editorial Board

COPE Compliant

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Journal History

Current Drug Metabolism was launched in 2000. Dr. Ming Hu serves as the Editor-in-Chief of the journal.

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