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Current Drug Metabolism

Volume 23, 14 Issues, 2022
ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)
This journal supports open access

Aims & Scope

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism.

More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.

Current Drug Metabolism

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Volume 23

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Number 1




Perspective Article




Review Article

Distribution, Biotransformation, Pharmacological Effects, Metabolic Mechanism and Safety Evaluation of Platycodin D: A Comprehensive Review

, 23(1): 21 - 29

Qianqian Li*, Tan Yang, Shuang Zhao, Qifeng Zheng, Yaxin Li, Zhiyuan Zhang, Xiuyan Sun, Yan Liu, Yanqing Zhang* and Junbo Xie


DOI: 10.2174/1389200223666220202090137



Research Article

Substrate-dependent Inhibition of Hypericin on Human Carboxylesterase 2: Implications for Herb-drug Combination

, 23(1): 38 - 44

Dalong Wang, Tingting Zhao, Shan Zhao, Jing Chen, Tongyi Dou, Guangbo Ge, Changyuan Wang, Huijun Sun, Kexin Liu, Qiang Meng* and Jingjing Wu*


DOI: 10.2174/1389200223666220202093303




Articles Ahead of Print



miRNAs in SARS-CoV-2 Infection: An Update


Asim Azhar*, Wajihul Hasan Khan, Khaled Al-hosaini and Mohammad Amjad Kamal


DOI: 10.2174/1389200223666220321102824
View Abstract View on PubMed





Therapeutic Approaches to Amyotrophic Lateral Sclerosis from the Lab to the Clinic


Vivek Chavda*, Chirag Patel, Dharti Modh, Yavuz Nuri Ertas, Shreya S. Sonak, Nafisa K. Munshi, Krishna Anand*, Arun Soni and Sonal Pandey


DOI: 10.2174/1389200223666220310113110
View Abstract View on PubMed


Simultaneous Method Development and Validation of Anastrozole Along with Piperine: Degradation Studies and Degradants Characterization Using LC-QTOF-ESI-MS Along with In-silico ADMET Predictions


K. Jony Susanna, Rahul Gajbhiye, Bhaskar Sarmah, Sachin Dattram Pawar, Pakhuri Mehta, Upadhyayula Suryanarayana Murty, V. Ravichandiran, Amit Alexander and Pramod Kumar*


DOI: 10.2174/1389200223666220215152606
View Abstract View on PubMed


Orchestration of Obesolytic Activity of Microbiome: Metabiotics at Centre Stage


Bhupinder Kapoor, Apoorva Singh, Monica Gulati*, Sachin Kumar Singh, Pooja Rani, Qushmua Alzahrani, Kamal Dua, Harish Dureja and Leander Corrie


DOI: 10.2174/1389200223666220211095024
View Abstract View on PubMed


Inhibition of Cytochrome P450 Enzyme and Drug-Drug Interaction Potential of Acid Reducing Agents Used in Management of CDK Inhibitors for Breast Cancer Chemotherapy


Prajakta Harish Patil, Puralae Channabasavaiah Jagadish*, Fajeelath Fatima, Sumit Birangal, Gurupur Gautham Shenoy, Mahadev Rao, Junaid Farooqui, Himanshu Rastogi, Tarun Sharma and Jakir Pinjari


DOI: 10.2174/1389200223666220218090948
View Abstract View on PubMed


Abstracts Ahead of Print


Dermatokinetics: Advances and Experimental Models, Focus on Skin Metabolism


Paul Quantin, Mathilde Stricher, Sophie Catoire, Hervé Ficheux and Christophe Egles*


DOI: 10.2174/1389200223666220517114004
View Abstract


Impact of POR*28 Variant on Tacrolimus Pharmacokinetics in Kidney Transplant Patients with Different CYP3A5 Genotypes


Janaina B. F. Everton, Fernando J. B. Patrício, Manuel S. Faria, Teresa C. A. Ferreira, Natalino Salgado Filho, Gyl E. B. Silva, Elen A. Romão and Marcelo Magalhães*


DOI: 10.2174/1389200223666220516094226
View Abstract


Recent Advances in Nanotechnology-Based Targeted Therapeutics for Breast Cancer Management


Abdulsalam Alhalmi, Sarwar Beg, Waleed H. Almalki, Saad Alghamdi and Kanchan Kohli*


DOI: 10.2174/1389200223666220514151110
View Abstract


Structural Modeling of Drosophila melanogaster Gut Cytochrome P450s and Docking Comparison of Fruit Fly Gut and Human Cytochrome P450s


Vijay Nirusimhan, Daniel Andrew Gideon*, Abhinav Parashar, Sangavi Jeyachandran, Jeyakanthan Jeyaraman, Gowthamkumar Subbaraj and Langeswaran Kulanthaivel*


DOI: 10.2174/1389200223666220511162234
View Abstract



Interactions between meropenem and renal drug transporters


Jing Dong, Yanhui Liu, Longxuan Li*, Yunhe Ding, Jun Qian and Zheng Jiao*


DOI: 10.2174/1389200223666220428081109
View Abstract



Elevated Urinary Tissue Inhibitor Of Metalloproteinase-2 And Insulin-Like Growth Factor Binding Protein-7 Predict Drug-Induced Acute Kidney Injury


K Akalya, Tanusya Murali Murali, Anantharaman Vathsala, Boon-Wee Teo, Sanmay Low, Dharmini Dharmasegaran, Liang-Piu Koh, Glenn Kunnath Bonney, Wei-Zhen Hong, Yi Da and Horng-Ruey Chua*


DOI: 10.2174/1389200223666220425111931
View Abstract



Published Contents

Editor's Choice

Metabolite Identification in the Preclinical and Clinical Phase of Drug Development

, 2021; 22(11): 838 - 857

Yali Wu, Lulu Pan, Zhendong Chen, Yuandong Zheng, Xingxing Diao* and Dafang Zhong*


DOI: 10.2174/1389200222666211006104502



In vitro Measurement and In vivo Prediction of Time-Dependent Inhibitory Effects of Three Tyrosine Kinase Inhibitors on CYP3A Activity

, 2021; 22(10): 802 - 810

Liyan Wang, Tingting Zhao, Yunxiang Wang, Banglian Hu, Jianfei Tao, Jinshan Ke, Tingfei Wei, Guangbo Ge, Qiang Meng, Changyuan Wang, Qi Liu, Huijun Sun, Jingjing Wu* and Yanwei Chen*


DOI: 10.2174/1389200222666210902130319






An Overview of Dietary Supplements on Obesity and Type 2 Diabetes: Efficacy and Mechanisms

, 2021; 22(6): 415 - 440

Xiaohong Liu, Xin Zeng, Wen Liu, Yanrong Lu, Jingqiu Cheng and Younan Chen*


DOI: 10.2174/1389200222666210406110450





Topical Capsaicin for the Treatment of Neuropathic Pain

, 2021; 22(3): 198 - 207

Adiba Sultana, Rajeev K. Singla, Xuefei He, Yan Sun, Md. Shahin Alam and Bairong Shen*


DOI: 10.2174/1389200221999201116143701




Open Access Articles

Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement

, 2021; 22(9): 735 - 745

Jesse Alt , Sadakatali S. Gori, Kathryn M. Lemberg, Arindom Pal , Vijayabhaskar Veeravalli, Ying Wu, Joanna M.H. Aguilar , Ranjeet P. Dash, Lukáš Tenora , Pavel Majer, Qi Sun, Barbara S. Slusher* and Rana Rais*






Dysregulation of lncRNA and circRNA Expression in Mouse Testes after Exposure to Triptolide

, 2019; 20(8): 665 - 673

Suping Xiong, Yanting Li, Yang Xiang, Na Peng, Chunmiao Shen, Yanqiu Cai, Dandan Song, Peng Zhang, Xiaolong Wang, Xuihui Zeng and Xiaoning Zhang*




Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients

, 2019; 20(7): 592 - 600

Zhiqi Wang, Nan Zhang, Chaoyang Chen, Shuqing Chen, Junyu Xu, Ying Zhou, Xia Zhao* and Yimin Cui*




Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*






Thiazide Therapy in Chronic Kidney Disease: Renal and Extra Renal Targets

, 2018; 19(12): 1012 - 1020

Negiin Pourafshar*, Saeed Alshahrani, Ashkan Karimi and Manoocher Soleimani*




Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

, 2018; 19(10): 830 - 838

Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*






Digestive Enzyme Supplementation in Gastrointestinal Diseases

, 2016; 17(2): 187 - 193

Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota




Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines

, 2015; 16(6): 412 - 426

Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti





Most Cited Articles

Review Article

Survey of machine learning techniques in drug discovery

, 2019; 20(3): 185-193.

Natalie Stephenson, Emily Shane, Jessica Chase, Jason Rowland, David Ries, Nicola Justice, Jie Zhang, Leong Chan and Renzhi Cao*


DOI: 10.2174/1389200219666180820112457


Review Article

Recent advances in machine learning methods for predicting heat shock proteins

, 2019; 20(3): 224-228.

Wei Chen*, Pengmian Feng, Tao Liu and Dianchuan Jin


DOI: 10.2174/1389200219666181031105916



Review Article

Cancer nanotechnology: A new revolution for cancer diagnosis and therapy

, 2019; 20(6): 416-429.

Vivek K Chaturvedi, Anshuman Singh, Vinay K. Singh and Mohan P. Singh*


DOI: 10.2174/1389200219666180918111528



Review Article

Magnetic nanoparticles: Current trends and future aspects in diagnostics and nanomedicine

, 2019; 20(6): 457-472.

Naga Veera Srikanth Vallabani, Sanjay Singh* and Ajay Singh Karakoti*


DOI: 10.2174/1389200220666181122124458


Review Article

Herb-drug interactions and hepatotoxicity

, 2019; 20(4): 275-282.

Mohammad K. Parvez* and Vikas Rishi


DOI: 10.2174/1389200220666190325141422




Review Article

Recent advances in the machine learning-based drug-target interaction prediction

, 2019; 20(3): 194-202.

Wen Zhang*, Weiran Lin, Ding Zhang, Siman Wang, Jingwen Shi and Yanqing Niu


DOI: 10.2174/1389200219666180821094047





Review Article

Survey of machine learning techniques for prediction of the isoform specificity of cytochrome P450 substrates

, 2019; 20(3): 229-235.

Yi Xiong, Yanhua Qiao, Daisuke Kihara, Hui-Yuan Zhang, Xiaolei Zhu* and Dong-Qing Wei*


DOI: 10.2174/1389200219666181019094526


General Review Article

Advanced glycation end products (AGEs), glutathione and breast cancer: Factors, mechanism and therapeutic interventions

, 2019; 20(1): 65-71.

Anil K. Sharma, Var R. Sharma, Girish K. Gupta, Ghulam Md. Ashraf and Mohammad A. Kamal*


DOI: 10.2174/1389200219666180912104342



Most Accessed Articles


Modulation of Drug Resistance by Limonene: Inhibition of Efflux Pumps in Staphylococcus aureus Strains RN-4220 and IS-58

, 2021; 22(2): 110-113.

de Araujo, Ana C. J.; Freitas, Priscilla R.; dos Santos Barbosa, Cristina R.; Muniz, Debora F.; Ribeiro-Filho, Jaime; Tintino, Saulo R.; Junior, Jose P. S.; Filho, Jose M. B.; de Sousa, Gabriela R.; Coutinho, Henrique D. M.


DOI: 10.2174/1389200221999210104204718


Modulation of the Drug Resistance by Platonia insignis Mart. Extract, Ethyl Acetate Fraction and Morelloflavone/Volkensiflavone (Biflavonoids) in Staphylococcus aureus Strains Overexpressing Efflux Pump Genes

, 2021; 22(2): 114-122.

Silva, Andressa K. F. E.; dos Reis, Antonielly C.; Pinheiro, Emanuelly E. A.; de Sousa, Jonas N.; de Alcantara Oliveira, Felipe A.; Moura, Arkellau K. S.; Neto, Jose de Souza L.; Cito, Antonia M. das Gracas L.; Siqueira-Junior, Jose P.; Kaatz, Glenn W.; Barreto, Humberto M.


DOI: 10.2174/1389200221666200523155617


Metabolism and Mechanism of Human Cytochrome P450 Enzyme 1A2

, 2021; 22(1): 40-49.

Guo, Jingchao; Zhu, Xiaohui; Badawy, Sara; Ihsan, Awais; Liu, Zhenli; Xie, Changqing; Wang, Xu


DOI: 10.2174/1389200221999210101233135


Topical Capsaicin for the Treatment of Neuropathic Pain

, 2021; 22(3): 198-207.

Sultana, Adiba; Singla, Rajeev K.; He, Xuefei; Sun, Yan; Alam, Md Shahin; Shen, Bairong


DOI: 10.2174/1389200221999201116143701


A Novel Nanoformulation of Ellagic Acid is Promising in Restoring Oxidative Homeostasis in Rat Brains with Alzheimer's Disease

, 2021; 22(4): 299-307.

Harakeh, Steve; Qari, Mohamad H.; Ramadan, Wafaa S.; Al Jaouni, Soad K.; Almuhayawi, Mohammed S.; Al Amri, Turki; Ashraf, Ghulam Md; Bharali, Dhruba J.; Mousa, Shaker A.


DOI: 10.2174/1389200221666201216170851





Effectiveness and Tolerability of Very-low Volume Preparation for Colonoscopy: A Narrative Review

, 2021; 22(2): 85-88.

Sinagra, Emanuele; Sferrazza, Sandro; Vitello, Alessandro; Morreale, Gaetano; Rossi, Francesca; Conoscenti, Giuseppe; Pallio, Socrate; Raimondo, Dario; Maida, Marcello


DOI: 10.2174/1389200221999201208212007





The Emerging Roles of Extracellular Vesicles in Ovarian Cancer

, 2021; 22(2): 139-149.

Wang, Yin-Xue; Wang, Yi-Xiang; Li, Yi-Ke; Tu, Shi-Yan; Wang, Yi-Qing


DOI: 10.2174/1389200221666201110155721


Advances in Understanding the Metabolites and Metabolomics of Polygonum multiflorum Thunb: A Mini-review

, 2021; 22(3): 165-172.

Yang, Jian-Bo; Gao, Hui-Yu; Song, Yun-Fei; Liu, Yue; Wang, Qi; Wang, Ying; Ma, Shuang-Cheng; Cheng, Xian-Long; Wei, Feng


DOI: 10.2174/1389200221666201201091345




Editor-in-Chief

graphic
Ming Hu
College of Pharmacy
University of Houston
Houston, TX
(United States)
Biography
View Full Editorial Board

COPE Compliant

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Journal History

Current Drug Metabolism was launched in 2000. Dr. Ming Hu serves as the Editor-in-Chief of the journal.

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