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Current Drug Targets

Volume 22, 17 Issues, 2021
ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)
This journal supports open access

Aims & Scope

Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes.

Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication full-length/mini review articles and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

Current Drug Targets

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Volume 22

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Number 13



Biography   Open Access



Review Article (Mini-Review)







Review Article





Review Article

The Role of Non-coding Genome in Cancer-associated Fibroblasts; Stateof- the-Art and Perspectives in Cancer Targeted Therapy

, 22(13): 1524 - 1535

Arezoo G. Shabgah, Hamed Mohammadi, Pouya Goleij, Mahdiyeh Hedayati-Moghadam, Arash Salmaninejad and Jamshid G. Navashenaq*


DOI: 10.2174/1389450122666210216091953


Review Article



Current Drug Targets, Volume 22 (2021) - Number 14


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print


Antimycotic Drugs and their Mechanisms of Resistance to Candida Species


Sweety Dahiya, Namita Sharma, Aruna Punia, Pooja Choudhary, Prity Gulia, Virinder S. Parmar and Anil K. Chhillar*


DOI: 10.2174/1389450122666210719124143
View Abstract




Role of ATP-binding Cassette Transporters in Sorafenib Therapy for Hepatocellular Carcinoma: An Overview


Maria Manuela Estevinho*, Carlos Fernandes, João Carlos Silva, Ana Catarina Gomes, Edgar Afecto, João Correia and João Carvalho


DOI: 10.2174/1389450122666210412125018
View Abstract View on PubMed



Research Progress of PARP Inhibitor Monotherapy and Combination Therapy for Endometrial Cancer


Ke Shen, Li Yang, Fei-Yan Li, Feng Zhang, Lei-Lei Ding, Jing Yang, Jie Lu, Nan-Nan Wang and Yan Wang


DOI: 10.2174/1389450122666210617111304
View Abstract View on PubMed


Revealing Insights into Natural Products Against mcr-1-Producing Bacteria


Ana Beatriz Souza Flor dos Santos, Manuele Figueiredo da Silva, João Xavier de Araújo-Júnior and Edeildo Ferreira da Silva-Júnior *


DOI: 10.2174/1389450122666210415102413
View Abstract View on PubMed




Abstracts Ahead of Print

An Updated Review for the Diabetic Wound Healing Systems


Mehmet Evren Okur, Ece Özcan Bülbül, Gökçe Mutlu, Kalliopi Eleftherıadou, Ioannis D. Karantas, Neslihan Üstündağ Okur* and Panoraia I. Sıafaka*


DOI: 10.2174/1389450122666210914104428
View Abstract



Polymer-dendrimer hybrids as carriers of anticancer agents


Guillermo Leobardo Rodríguez-Acosta, Carlos Hernández-Montalbán, María Fernanda Sabrina Vega-Razo, Irving Osiel Castillo-Rodríguez and Marcos Martínez-García*


DOI: 10.2174/1389450122666210906121803
View Abstract


Oral semaglutide in the management of type 2 DM: Clinical status and comparative analysis


Ilora Bandyopadhyay, Sunny Dave, Amita Rai, Madhavan Nampoothiri, Mallikarjuna Rao Chamallamudi and Nitesh Kumar*


DOI: 10.2174/1389450122666210901125420
View Abstract




Lipid metabolism and mitochondria: Cross talk in cancer


Anubhav Srivastava, Pransu Srivastava, Shashank Mathur, Sabiya Abbas*, Neeraj Rai, Swasti Tiwari, Meenakshi Tiwari and Lokendra Sharma*


DOI: 10.2174/1389450122666210824144907
View Abstract



Endemic and indigenous plants from Mascarene Islands with antiviral propensities


Mahomoodally Fawzi*, Jugreet Bibi Sharmeen, Haddad Juliano and El Kalamouni Chaker


DOI: 10.2174/1389450122666210824143910
View Abstract



Published Contents

Editor's Choice



New Framework for the Discovery of PRC2 Inhibitors: Epigenetic Drugs

, 2021; 22(11): 1198 - 1206

Danishuddin, Naidu Subbarao*, Mohd Khan, Sultan Alouffi and Shahper Khan*


DOI: 10.2174/1389450122666210215111744




The Emergence of Immune-checkpoint Inhibitors in Colorectal Cancer Therapy

, 2021; 22(9): 1021 - 1033

Michele Ghidini*, Nicola Fusco, Massimiliano Salati, Shelize Khakoo, Gianluca Tomasello, Fausto Petrelli, Dario Trapani and Angelica Petrillo


DOI: 10.2174/1389450122666210204204415




MiRNA, a New Treatment Strategy for Pulmonary Fibrosis

, 2021; 22(7): 793 - 802

Yanhong Liu, Hongguang Nie*, Yan Ding, Yapeng Hou, Kejun Mao and Yong Cui


DOI: 10.2174/1874609813666200928141822



Progress in Detection of Insomnia Sleep Disorder: A Comprehensive Review

, 2021; 22(6): 672 - 684

Md Belal Bin Heyat, Faijan Akhtar, M.A. Ansari, Asif Khan, Fahed Alkahtani, Haroon Khan* and Dakun Lai*


DOI: 10.2174/1389450121666201027125828




Anti-platelet Drug-loaded Targeted Technologies for the Effective Treatment of Atherothrombosis

, 2021; 22(4): 399 - 419

Selvakumar Muruganantham, Venkateshwaran Krishnaswami, Shanmugarathinam Alagarsamy and Ruckmani Kandasamy*


DOI: 10.2174/1389450121666201027125303



Open Access Articles

Characteristic of Cyclodextrins: Their Role and Use in the Pharmaceutical Technology

, 2020; 21(14): 1495 - 1510

Malwina Lachowicz*, Andrzej Stańczak and Michał Kołodziejczyk





Recognition of Plasminogen Activator Inhibitor Type 1 as the Primary Regulator of Fibrinolysis

, 2019; 20(16): 1695 - 1701

Tetsumei Urano*, Yuko Suzuki, Takayuki Iwaki, Hideto Sano, Naoki Honkura and Francis J. Castellino




Current Understanding of Group A Streptococcal Biofilms

, 2019; 20(9): 982 - 993

Heema K.N. Vyas, Emma-Jayne Proctor, Jason McArthur, Jody Gorman and Martina Sanderson-Smith*








Opportunities of Bacterial Cellulose to Treat Epithelial Tissues

, 2019; 20(8): 808 - 822

Irene Anton-Sales, Uwe Beekmann, Anna Laromaine*, Anna Roig* and Dana Kralisch





Blood Eosinophils as Biomarkers to Drive Treatment Choices in Asthma and COPD

, 2018; 19(16): 1882 - 1896

Konstantinos Kostikas, Caterina Brindicci and Francesco Patalano*




Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm

, 2018; 19(11): 1265 - 1275

Koichi Yoshimura*, Noriyasu Morikage, Shizuka Nishino-Fujimoto, Akira Furutani, Bungo Shirasawa and Kimikazu Hamano





TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook

, 2017; 18(9): 1095 - 1103

Naif Mohammad Alhawiti, Saeed Al Mahri, Mohammad Azhar Aziz, Shuja Shafi Malik and Sameer Mohammad*






Most Cited Articles



Review Article

Cyclin-dependent kinase 2 in cellular senescence and cancer. A structural and functional review

, 2019; 20(7): 716-726.

Priscylla Andrade Volkart, Gabriela Bitencourt-Ferreira, André Arigony Souto* and Walter Filgueira de Azevedo *


DOI: 10.2174/1389450120666181204165344


Review Article

Celecoxib in cancer therapy and prevention - review

, 2019; 20(3): 302-315.

Natalia Tołoczko-Iwaniuk , Dorota Dziemiańczyk-Pakieła, Beata Klaudia Nowaszewska, Katarzyna Celińska-Janowicz and Wojciech Miltyk*


DOI: 10.2174/1389450119666180803121737



Review Article

High mobility group box-1 (HMGB1): A potential target in therapeutics

, 2019; 20(14): 1474-1485.

Eyaldeva C. Vijayakumar, Lokesh Kumar Bhatt* and Kedar S. Prabhavalkar


DOI: 10.2174/1389450120666190618125100


Review Article

A survey for predicting enzyme family classes using machine learning methods

, 2019; 20(5): 540-550.

Jiu-Xin Tan, Hao Lv, Fang Wang, Fu-Ying Dao, Wei Chen* and Hui Ding*


DOI: 10.2174/1389450119666181002143355


Review Article

Opportunities of bacterial cellulose to treat epithelial tissues

, 2019; 20(8): 808-822.

Irene Anton-Sales, Uwe Beekmann, Anna Laromaine*, Anna Roig* and Dana Kralisch


DOI: 10.2174/1389450120666181129092144



Review Article

CDK9 as an appealing target for therapeutic interventions

, 2019; 20(4): 453-464.

Shirin Eyvazi, Mohammad Saeid Hejazi, Homan Kahroba, Mozghan Abasi, Reza Eghdam Zamiri and Vahideh Tarhriz*


DOI: 10.2174/1389450119666181026152221


Review Article

Exosomes in therapy: Engineering, pharmacokinetics and future applications

, 2019; 20(1): 87-95.

Claudia Arenaccio, Chiara Chiozzini, Flavia Ferrantelli, Patrizia Leone, Eleonora Olivetta and Maurizio Federico*


DOI: 10.2174/1389450119666180521100409



Review Article

Bioinformatics approaches for anti-cancer drug discovery

, 2020; 21(1): 3-17.

Kening Li, Yuxin Du, Lu Li and Dong-Qing Wei*


DOI: 10.2174/1389450120666190923162203


Review Article

Inhibition of RAGE axis signaling: A pharmacological challenge

, 2019; 20(3): 340-346.

Armando Rojas*, Miguel Morales, Ileana Gonzalez and Paulina Araya


DOI: 10.2174/1389450119666180820105956


Review Article

Molecular aspects of melatonin treatment in tinnitus: A review

, 2019; 20(11): 1112-1128.

Azam Hosseinzadeh, Seyed Kamran Kamrava, Brian C.J. Moore, Russel J. Reiter, Habib Ghaznavi, Mahboobeh Kamali and Saeed Mehrzadi*


DOI: 10.2174/1389450120666190319162147



Most Accessed Articles

GSK-3 Inhibitors in the Regulation and Control of Colon Carcinoma

, 2021; 22(13): 1485-1495.

Sitansu S. Nanda, Md Imran Hossain, Heongkyu Ju and Dong Kee Yi*


DOI: 10.2174/1389450122666210204203950


The Role of Non-coding Genome in Cancer-associated Fibroblasts; Stateof- the-Art and Perspectives in Cancer Targeted Therapy

, 2021; 22(13): 1524-1535.

Arezoo G. Shabgah, Hamed Mohammadi, Pouya Goleij, Mahdiyeh Hedayati-Moghadam, Arash Salmaninejad and Jamshid G. Navashenaq*


DOI: 10.2174/1389450122666210216091953


Remdesivir and Hydroxychloroquine: A Compassionate Use in Covid-19

, 2021; 22(13): 1536-1547.

Amritpal Kaur, Gaurav Chaudhary, Pargat Singh, Sandeep Arora and Rajwinder Kaur*


DOI: 10.2174/1389450121999201228212842



Role of Mitochondrial Heat-shock Proteins and Immunophilins in Neuro Degenerative Diseases

, 2021; 22(14): 1596-1617.

Cristina Daneri-Becerra, Sol M. Ciucci, Gisela Mazaira and Mario D. Galigniana*


DOI: 10.2174/1389450121999201230204320







Aging of Brain Related with Mitochondrial Dysfunctions

, 2021; 22(14): 1668-1687.

Vipin Dhote*, Prem Samundre, Aditya Ganeshpurkar and Aman Upaganlawar


DOI: 10.2174/1389450121999201209202247



GSK-3 Inhibitors as New Leads to Treat Type-II Diabetes

, 2021; 22(13): 1555-1567.

Gowru Srivani, Ramyakrishna Sharvirala, Prabhakar Reddy Veerareddy, Dilipkumar Pal and Gangarapu Kiran*


DOI: 10.2174/1389450122666210120144428


Current Perspectives of Healthy Mitochondrial Function for Healthy Neurons

, 2021; 22(14): 1688-1703.

Arunachalam Muthuraman*, Muthusamy Ramesh*, Venkataratinakumar Thiagarajan, Sumeet K. Singla, Seema Mudhol and Serva P. Muthukumar


DOI: 10.2174/1389450122666210222163528


Review of the Biological Activity of Maslinic Acid

, 2021; 22(13): 1496-1506.

Zhang Jing, Wang Rui, Li Ruihua, Yu Hao* and Fang Hengtong*


DOI: 10.2174/1389450122666210308111159




Editor-in-Chief

graphic
Francis J. Castellino
(14643 citations)
Dean Emeritus, College of Science,
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
(USA)
View Full Editorial Board

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Journal History

Current Drug Targets Journal was launched in 2000. Dr. Francis J. Castellino serves as the Editor-in-Chief of the journal.

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