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Current Drug Targets

Volume 22, 17 Issues, 2021
ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)
This journal supports open access

Aims & Scope

Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes.

Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication full-length/mini review articles and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

Current Drug Targets

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Volume 22

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Number 8



Biography   Open Access















Review Article



Current Drug Targets, Volume 22 (2021) - Number 9


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print





Triazole-containing Heterocycles: Privileged Scaffolds in Anti-Trypanosoma Cruzi Drug Development


Kamdem Boniface Pone*, Sadou Dalhatou , Hugues Kamdem Paumo, Lebogang Maureen Katata-Seru and Elizabeth Igne Ferreira


DOI: 10.2174/1389450122666210412125643
View Abstract View on PubMed



Current Perspectives of Healthy Mitochondrial Function for Healthy Neurons


Arunachalam Muthuraman*, Muthusamy Ramesh*, Venkataratinakumar Thiagarajan, Sumeet Kumar Singla, Seema Mudhol and Serva Peddha Muthukumar


DOI: 10.2174/1389450122666210222163528
View Abstract View on PubMed





Abstracts Ahead of Print


Thioethers: An Overview


M İhsan Han and Ş. Güniz Küçükgüzel*


DOI: 10.2174/1389450122666210614121237
View Abstract






Revealing Insights into Natural Products Against mcr-1-Producing Bacteria


Ana Beatriz Souza Flor dos Santos, Manuele Figueiredo da Silva, João Xavier de Araújo-Júnior and Edeildo Ferreira da Silva-Júnior *


DOI: 10.2174/1389450122666210415102413
View Abstract



New Trends On Biological Activities And Clinical Studies Of Quinolinic Analogues: A Review


Sandra Elizabeth Barbosa da Silva, José Arion da Silva Moura , Tiago Rafael de Sousa Nunes , Ivan da Rocha Pitta and Marina Galdino da Rocha Pitta*


DOI: 10.2174/1389450122666210415100151
View Abstract


The gut microbiota and traditional Chinese medicine: a new clinical frontier on cancer


Yan-Zhen Chen, Meng-Yun Yuan, Ya Ling Chen, Xingxing Zhang, Xin-Tian Xu, Shen-Lin Liu, Xi Zou, Jia-Lei Tao, Yong-Hu Qiang, Jian Wu* and Qing-Min Sun*


DOI: 10.2174/1389450122666210412141304
View Abstract


Published Contents

Editor's Choice


MiRNA, a New Treatment Strategy for Pulmonary Fibrosis

, 2021; 22(7): 793 - 802

Yanhong Liu, Hongguang Nie*, Yan Ding, Yapeng Hou, Kejun Mao and Yong Cui


DOI: 10.2174/1874609813666200928141822



Progress in Detection of Insomnia Sleep Disorder: A Comprehensive Review

, 2021; 22(6): 672 - 684

Md Belal Bin Heyat, Faijan Akhtar, M.A. Ansari, Asif Khan, Fahed Alkahtani, Haroon Khan* and Dakun Lai*


DOI: 10.2174/1389450121666201027125828




Anti-platelet Drug-loaded Targeted Technologies for the Effective Treatment of Atherothrombosis

, 2021; 22(4): 399 - 419

Selvakumar Muruganantham, Venkateshwaran Krishnaswami, Shanmugarathinam Alagarsamy and Ruckmani Kandasamy*


DOI: 10.2174/1389450121666201027125303



Downregulation of Membrane-bound Angiotensin Converting Enzyme 2 (ACE2) Receptor has a Pivotal Role in COVID-19 Immunopathology

, 2021; 22(3): 254 - 281

Cristina Vieira, Lucas Nery, Ludimila Martins, Luiz Jabour, Raphael Dias and Ana Cristina Simões e Silva*


DOI: 10.2174/1389450121666201020154033



Fibrotic Strictures in Crohn’s Disease: Mechanisms and Predictive Factors

, 2021; 22(2): 241 - 251

Riccardo Mager, Giulia Roda, Mohammad Khaled Shalaby and Stefania Vetrano*


DOI: 10.2174/1389450121666201020160803



Neoadjuvant Chemotherapy Before Radical Cystectomy: Why We Must Adhere?

, 2021; 22(1): 14 - 21

Beppe Calò*, Michele Marchioni, Francesca Sanguedolce, Ugo Giovanni Falagario, Marco Chirico, Giuseppe Carrieri and Luigi Cormio


DOI: 10.2174/1389450121666200802022150



The Activating Receptors of Natural Killer Cells and Their Inter-Switching Potentials

, 2020; 21(16): 1733 - 1751

Adekunle Babajide Rowaiye, Titilayo Asala, Angus Nnamdi Oli*, Ikemefuna Chijioke Uzochukwu, Alex Akpa and Charles Okechukwu Esimone


DOI: 10.2174/1389450121666200910160929




Open Access Articles


Recognition of Plasminogen Activator Inhibitor Type 1 as the Primary Regulator of Fibrinolysis

, 2019; 20(16): 1695 - 1701

Tetsumei Urano*, Yuko Suzuki, Takayuki Iwaki, Hideto Sano, Naoki Honkura and Francis J. Castellino




Current Understanding of Group A Streptococcal Biofilms

, 2019; 20(9): 982 - 993

Heema K.N. Vyas, Emma-Jayne Proctor, Jason McArthur, Jody Gorman and Martina Sanderson-Smith*








Opportunities of Bacterial Cellulose to Treat Epithelial Tissues

, 2019; 20(8): 808 - 822

Irene Anton-Sales, Uwe Beekmann, Anna Laromaine*, Anna Roig* and Dana Kralisch





Blood Eosinophils as Biomarkers to Drive Treatment Choices in Asthma and COPD

, 2018; 19(16): 1882 - 1896

Konstantinos Kostikas, Caterina Brindicci and Francesco Patalano*




Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm

, 2018; 19(11): 1265 - 1275

Koichi Yoshimura*, Noriyasu Morikage, Shizuka Nishino-Fujimoto, Akira Furutani, Bungo Shirasawa and Kimikazu Hamano





TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook

, 2017; 18(9): 1095 - 1103

Naif Mohammad Alhawiti, Saeed Al Mahri, Mohammad Azhar Aziz, Shuja Shafi Malik and Sameer Mohammad*







Most Cited Articles


Review Article

Cyclin-dependent kinase 2 in cellular senescence and cancer. A structural and functional review

, 2019; 20(7): 716-726.

Priscylla Andrade Volkart, Gabriela Bitencourt-Ferreira, André Arigony Souto* and Walter Filgueira de Azevedo *


DOI: 10.2174/1389450120666181204165344



Review Article

Celecoxib in cancer therapy and prevention - review

, 2019; 20(3): 302-315.

Natalia Tołoczko-Iwaniuk , Dorota Dziemiańczyk-Pakieła, Beata Klaudia Nowaszewska, Katarzyna Celińska-Janowicz and Wojciech Miltyk*


DOI: 10.2174/1389450119666180803121737



Review Article

High mobility group box-1 (HMGB1): A potential target in therapeutics

, 2019; 20(14): 1474-1485.

Eyaldeva C. Vijayakumar, Lokesh Kumar Bhatt* and Kedar S. Prabhavalkar


DOI: 10.2174/1389450120666190618125100



Review Article

A survey for predicting enzyme family classes using machine learning methods

, 2019; 20(5): 540-550.

Jiu-Xin Tan, Hao Lv, Fang Wang, Fu-Ying Dao, Wei Chen* and Hui Ding*


DOI: 10.2174/1389450119666181002143355


Review Article

Opportunities of bacterial cellulose to treat epithelial tissues

, 2019; 20(8): 808-822.

Irene Anton-Sales, Uwe Beekmann, Anna Laromaine*, Anna Roig* and Dana Kralisch


DOI: 10.2174/1389450120666181129092144


Review Article

CDK9 as an appealing target for therapeutic interventions

, 2019; 20(4): 453-464.

Shirin Eyvazi, Mohammad Saeid Hejazi, Homan Kahroba, Mozghan Abasi, Reza Eghdam Zamiri and Vahideh Tarhriz*


DOI: 10.2174/1389450119666181026152221


Review Article

Exosomes in therapy: Engineering, pharmacokinetics and future applications

, 2019; 20(1): 87-95.

Claudia Arenaccio, Chiara Chiozzini, Flavia Ferrantelli, Patrizia Leone, Eleonora Olivetta and Maurizio Federico*


DOI: 10.2174/1389450119666180521100409


Review Article

Molecular aspects of melatonin treatment in tinnitus: A review

, 2019; 20(11): 1112-1128.

Azam Hosseinzadeh, Seyed Kamran Kamrava, Brian C.J. Moore, Russel J. Reiter, Habib Ghaznavi, Mahboobeh Kamali and Saeed Mehrzadi*


DOI: 10.2174/1389450120666190319162147



Review Article

Bioinformatics approaches for anti-cancer drug discovery

, 2020; 21(1): 3-17.

Kening Li, Yuxin Du, Lu Li and Dong-Qing Wei*


DOI: 10.2174/1389450120666190923162203




Most Accessed Articles

Targeting Cancer Stem Cells Pathways for the Effective Treatment of Cancer

, 2020; 21(3): 258-278.

Ashish Ranjan Dwivedi, Amandeep Thakur, Vijay Kumar, Ira Skvortsova and Vinod Kumar*


DOI: 10.2174/1389450120666190821160730






TL1A: A New Potential Target in the Treatment of Inflammatory Bowel Disease

, 2021; 22(7): 760-769.

Federica Furfaro*, Ludovico Alfarone, Daniela Gilardi, Carmen Correale, Mariangela Allocca, Gionata Fiorino, Marjorie Argollo, Alessandra Zilli, Eirini Zacharopoulou, Laura Loy, Giulia Roda and Silvio Danese


DOI: 10.2174/1389450122999210120205607


Artificial Intelligence, Big Data and Machine Learning Approaches in Precision Medicine & Drug Discovery

, 2021; 22(6): 631-655.

Anuraj Nayarisseri*, Ravina Khandelwal, Poonam Tanwar, Maddala Madhavi, Diksha Sharma, Garima Thakur, Alejandro Speck-Planche and Sanjeev Kumar Singh*


DOI: 10.2174/1389450122999210104205732



COVID-19 and Renal Diseases: An Update

, 2021; 22(1): 52-67.

Letícia Bitencourt, Ana Luisa Pedrosa, Stephanie Bruna Camilo Soares de Brito, Ana Cláudia Fontoura Fróes, Sarah Tayná de Carvalho, Giulio Gori Fonseca, Guilherme Costa Ferreira, Pollyanna Faria Fradico and Ana Cristina Simões e Silva*


DOI: 10.2174/1389450121999201013151300



Downregulation of Membrane-bound Angiotensin Converting Enzyme 2 (ACE2) Receptor has a Pivotal Role in COVID-19 Immunopathology

, 2021; 22(3): 254-281.

Cristina Vieira, Lucas Nery, Ludimila Martins, Luiz Jabour, Raphael Dias and Ana Cristina Simões e Silva*


DOI: 10.2174/1389450121666201020154033


Thrombosis in IBD in the Era of JAK Inhibition

, 2021; 22(1): 126-136.

Virginia Solitano, Gionata Fiorino, Ferdinando D’Amico, Laurent Peyrin-Biroulet and Silvio Danese*


DOI: 10.2174/1389450121666200902164240


Curcumin and its Multi-target Function Against Pain and Inflammation: An Update of Pre-clinical Data

, 2021; 22(6): 656-671.

Shaikh Jamal Uddin*, Md. Fahim Hasan, Mohasana Afroz, Dipto Kumer Sarker, Razina Rouf, Muhammad Torequl Islam, Jamil A. Shilpi and Mohammad S. Mubarak*


DOI: 10.2174/1389450121666200925150022


Colorectal Cancer Epidemiology: Recent Trends and Impact on Outcomes

, 2021; 22(9): 998-1009.

Firas Baidoun, Kholoud Elshiwy, Yasmine Elkeraie, Zahi Merjaneh, George Khoudari, Muhammad Talal Sarmini, Mohamed Gad, Muneer Al-Husseini and Anas Saad*


DOI: 10.2174/1389450121999201117115717


Targeting Drugs Against Fibroblast Growth Factor(s)-Induced Cell Signaling

, 2021; 22(2): 214-240.

Shilpi Agrawal, Sanhita Maity, Zeina AlRaawi, Musaab Al-Ameer and Thallapuranam Krishnaswamy Suresh Kumar*


DOI: 10.2174/1389450121999201012201926




Editor-in-Chief

graphic
Francis J. Castellino
(14643 citations)
Dean Emeritus, College of Science,
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
(USA)
View Full Editorial Board

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Journal History

Current Drug Targets Journal was launched in 2000. Dr. Francis J. Castellino serves as the Editor-in-Chief of the journal.

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