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Current Medicinal Chemistry

Volume 28, 42 Issues, 2021
ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)
This journal supports open access

Aims & Scope

Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth/mini reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

Current Medicinal Chemistry


Volume 28


Number 37

Biography   Open Access

Review Article

Mediterranean Diet, Brain and Muscle: Olive Polyphenols and Resveratrol Protection in Neurodegenerative and Neuromuscular Disorders

, 28(37): 7595 - 7613

Carla Petrella*, Maria Grazia Di Certo, Francesca Gabanella, Christian Barbato, Flavio Maria Ceci, Antonio Greco, Massimo Ralli, Antonella Polimeni, Antonio Angeloni, Cinzia Severini, Mario Vitali, Giampiero Ferraguti, Mauro Ceccanti, Marco Lucarelli, Carola Severi and Marco Fiore*

DOI: 10.2174/0929867328666210504113445

Review Article

Protein-Ligand Docking Simulations with AutoDock4 Focused on the Main Protease of SARS-CoV-2

, 28(37): 7614 - 7633

Walter Filgueira de Azevedo Junior*, Gabriela Bitencourt-Ferreira, Joana Retzke Godoy, Hilda Mayela Aran Adriano, Wallyson André dos Santos Bezerra and Alexandra Martins dos Santos Soares

DOI: 10.2174/0929867328666210329094111

Review Article

COVID-19: The Significance of Platelets, Mitochondria, Vitamin D, Serotonin and the Gut Microbiota

, 28(37): 7634 - 7657

István Bókkon*, Gábor Kapócs, András Vucskits, Attila Erdöfi-Szabó, Jan Vagedes , Felix Scholkmann and Henrik Szöke

DOI: 10.2174/0929867328666210526100147

Review Article

Current Non-viral Gene Therapy Strategies for the Treatment of Glioblastoma

, 28(37): 7729 - 7748

Antonela Sofía Asad, Alejandro Javier Nicola Candia, Nazareno González, Camila Florencia Zuccato, Adriana Seilicovich and Marianela Candolfi*

DOI: 10.2174/0929867328666210525141243

Articles Ahead of Print

Machine Learning, Molecular Modeling, and QSAR Studies on Natural Products Against Alzheimer’s Disease

Érika Paiva de Moura, Natan Dias Fernandes, Alex France Messias Monteiro, Herbert Igor Rodrigues de Medeiros, Marcus Tullius Scotti and Luciana Scotti*

DOI: 10.2174/0929867328666210603104749
View Abstract View on PubMed

Recent Trends on the Development of Machine Learning Approaches for the Prediction of Lysine Acetylation Sites

Shaherin Basith, Hye Jin Chang, Saraswathy Nithiyanandam, Tae Hwan Shin, Balachandran Manavalan* and Gwang Lee*

DOI: 10.2174/0929867328999210902125308
View Abstract View on PubMed

LPS/TLR4 Pathways in Breast Cancer: Insights into Cell Signalling

Rizwana Afroz, E M Tanvir, Mousumi Tania, Junjiang Fu, Mohammad Amjad Kamal and Md. Asaduzzaman Khan*

DOI: 10.2174/0929867328666210811145043
View Abstract View on PubMed

Environmental Factors Modifying HDL Functionality

Constantine E. Kosmas, Andreas Sourlas, Eliscer Guzman and Christina E. Kostara*

DOI: 10.2174/0929867328666210714155422
View Abstract View on PubMed

Epigenetics of Triple-negative Breast Cancer via Natural Compounds

Mohammed Kaleem, Maryam Perwaiz, Suza Mohammad Nur, Abdulrasheed O. Abdulrahman, Wasim Ahmad, Fahad A. Al-Abbasi, Vikas Kumar, Mohammad Amjad Kamal and Firoz Anwar*

DOI: 10.2174/0929867328666210707165530
View Abstract View on PubMed

Conformational and Structural Characterization of Carbohydrates and their Interactions Studied by NMR

Francisco Javier Cañada*, Ángeles Canales, Pablo Valverde, Beatriz Fernández de Toro, Mónica Martínez-Orts, Paola Oquist Phillips and Amaia Pereda

DOI: 10.2174/0929867328666210705154046
View Abstract View on PubMed

Abstracts Ahead of Print

Recent Trends in Tubulin-Binding Combretastatin A-4 Analogs for Anticancer Drug Development

Suresh Paidakula, Srinivas Nerella, Shravankumar Kankala* and Ranjith Kumar Kankala*

DOI: 10.2174/0929867328666211202101641
View Abstract

Overview of PROTACs Targeting the Estrogen Receptor: Achievements for Biological and Drug Discovery

Hui Qin, Yiwen Zhang, Yutao Lou, Zongfu Pan, Feifeng Song, Yujia Liu, Tong Xu, Xiaowei Zheng, Xiaoping Hu and Ping Huang*

DOI: 10.2174/0929867328666211110101018
View Abstract

An updated review on the therapeutic, diagnostic, and prognostic value of long non-coding RNAs in gastric cancer

Alemeh Mohammadzadeh, Narges Dastmalchi, Bashdar Mahmud Hussen, Mahdi Abdoli Shadbad and Reza Safaralizadeh*

DOI: 10.2174/0929867328666211115121019
View Abstract

Polyphenols effect on cerebrovascular health

Luis Goya, Ricardo San Román and Sonia de Pascual-Teresa*

DOI: 10.2174/0929867328666211129123459
View Abstract

A2A Adenosine Receptor Antagonists in Neurodegenerative Diseases

Stefania Merighi*, Pier Andrea Borea, Katia Varani, Fabrizio Vincenzi, Kenneth A. Jacobson* and Stefania Gessi*

DOI: 10.2174/0929867328666211129122550
View Abstract

Published Contents

Open Access Articles

Micro Composite Palmitoylethanolamide/Rutin Reduces Vascular Injury through Modulation of the Nrf2/HO−1 and NF-kB Pathways

, 2021; 28(30): 6287 - 6302

Roberta Fusco, Rosalba Siracusa, Enrico Gugliandolo, Alessio Filippo Peritore, Ramona D’Amico, Marika Cordaro, Rosalia Crupi, Daniela Impellizzeri, Chiara Gomiero, Salvatore Cuzzocrea* and Rosanna Di Paola*

Design and Synthesis of Novel Aminoalkanamides Targeting Neurodegeneration and Symptoms of Alzheimer’s Disease

, 2021; 28(29): 6082 - 6094

Agnieszka Jankowska, Grzegorz Satała, Gniewomir Latacz, Anna Partyka, Annamaria Lubelska, Krzysztof Pociecha, Artur Świerczek, Natalia Wilczyńska, Barbara Mordyl, Andrzej J. Bojarski, Elżbieta Wyska and Grażyna Chłoń-Rzepa*

Deep Learning in the Quest for Compound Nomination for Fighting COVID-19

, 2021; 28(28): 5699 - 5732

Maria Mernea, Eliza C. Martin, Andrei-José Petrescu* and Speranta Avram*

Development of Novel Rhodacyanine-Based Heat Shock Protein 70 Inhibitors

, 2021; 28(26): 5431 - 5446

Chih-Shiang Chang, Vathan Kumar, Der-Yen Lee, Yeh Chen, Yu-Chieh Wu, Jing-Yan Gao and Po-Chen Chu*

Design and Synthesis of Quinolizidine Derivatives as Influenza Virus and HIV-1 Inhibitors

, 2021; 28(24): 4995 - 5003

Zhao Dang, Lei Zhu, Lan Xie, Kuo-Hsiung Lee, Faisal Malik, Zhijun Li, Li Huang* and Chin-Ho Chen*

A Novel Dicationic Boron Dipyrromethene-based Photosensitizer for Antimicrobial Photodynamic Therapy against Methicillin-Resistant Staphylococcus aureus

, 2021; 28(21): 4283 - 4294

Priyanga Dharmaratne, Ligang Yu, Roy Chi-Hang Wong, Ben Chun-Lap Chan, Kit-Man Lau, Baiyan Wang, Clara Bik San Lau, Kwok-Pui Fung, Dennis Kee-Pui Ng and Margaret Ip*

Role of Alpha-Fetoprotein in Hepatocellular Carcinoma Drug Resistance

, 2021; 28(6): 1126 - 1142

Wei Li, Kun Liu, Yi Chen, Mingyue Zhu* and Mengsen Li*

miR-30e-5p Regulates Autophagy and Apoptosis by Targeting Beclin1 Involved in Contrast-induced Acute Kidney Injury

, 2021; 28: 1 - 11 (E-Pub Ahead of Print)

Xiaoqin Liu, Qingzhao Li , Lixin Sun, Limei Chen, Yue Li, Beibei Huang, Yunshuang Liu and Chunyang Jiang *

Trends in Deep Learning for Property-driven Drug Design

, 2021; 28: 1 - 25 (E-Pub Ahead of Print)

Jannis Born* and Matteo Manica

Feruloyl Sucrose Esters: Potent and Selective Inhibitors of α-glucosidase and α-amylase

, 2021; 28: 1 - 16 (E-Pub Ahead of Print)

Surabhi Devaraj, Yew Mun Yip, Parthasarathi Panda, Li Lin Ong, Pooi Wen Kathy Wong, Dawei Zhang, Yusuf Ali* and Zaher Judeh*

Tumor in 3D: In Vitro Complex Cellular Models to Improve Nanodrugs Cancer Therapy

, 2020; 27(42): 7234 - 7255

Soraia Fernandes*, Marco Cassani, Stefania Pagliari, Petr Filipensky, Francesca Cavalieri and Giancarlo Forte*

Most Cited Articles

Review Article

Role of ox-LDL and LOX-1 in atherogenesis

, 2019; 26(9): 1693-1700.

Ajoe John Kattoor, Sri Harsha Kanuri and Jawahar L. Mehta*

DOI: 10.2174/0929867325666180508100950

Review Article

Targeting cxcl12/cxcr4 axis in tumor immunotherapy

, 2019; 26(17): 3026-3041.

Weiqiang Zhou, Shanchun Guo*, Mingli Liu, Matthew E. Burow and Guangdi Wang*

DOI: 10.2174/0929867324666170830111531

Review Article

Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases

, 2019; 26(18): 3225-3241.

Miguel D. Ferrer, Carla Busquets-Cortés, Xavier Capó, Silvia Tejada, Josep A. Tur, Antoni Pons and Antoni Sureda*

DOI: 10.2174/0929867325666180514112124

Review Article

Immune checkpoint inhibitors: Basics and challenges

, 2019; 26(17): 3009-3025.

Bin Li*, Ho Lam Chan and Pingping Chen*

DOI: 10.2174/0929867324666170804143706

Review Article

Plant-derived products as antibacterial and antifungal agents in human health care

, 2019; 26(29): 5501-5541.

Ladislav Kokoska*, Pavel Kloucek , Olga Leuner* and Pavel Novy

DOI: 10.2174/0929867325666180831144344

Review Article

Role of autophagy in Parkinson’s disease

, 2019; 26(20): 3702-3718.

Silvia Cerri and Fabio Blandini*

DOI: 10.2174/0929867325666180226094351

General Review Article

Homocysteine and hyperhomocysteinaemia

, 2019; 26(16): 2948-2961.

Bozidarka L. Zaric*, Milan Obradovic, Vladan Bajic , Mohamed A. Haidara , Milos Jovanovic and Esma R. Isenovic*

DOI: 10.2174/0929867325666180313105949

Review Article

Applications of cellulose-based materials in sustained drug delivery systems

, 2019; 26(14): 2485-2501.

Bo Sun, Min Zhang, Jing Shen, Zhibin He, Pedram Fatehi* and Yonghao Ni

DOI: 10.2174/0929867324666170705143308

Review Article

Metal-organic framework (Mof)-based drug delivery

, 2020; 27(35): 5949-5969.

Jian Cao, Xuejiao Li and Hongqi Tian*

DOI: 10.2174/0929867326666190618152518

General Review Article

Aptamer-based targeted drug delivery systems: Current potential and challenges

, 2020; 27(13): 2189-2219.

Fen He, Nachuan Wen, Daipeng Xiao, Jianhua Yan, Hongjie Xiong, Shundong Cai, Zhenbao Liu* and Yanfei Liu*

DOI: 10.2174/0929867325666181008142831

General Review Article

Metal–organic framework (MoF)-based nanomaterials for biomedical applications

, 2019; 26(18): 3341-3369.

Zhidong Luo, Shuran Fan, Chuying Gu, Weicong Liu, Jinxiang Chen, Baohong Li* and Jianqiang Liu*

DOI: 10.2174/0929867325666180214123500

Review Article

ABC transporters: Regulation and association with multidrug resistance in hepatocellular carcinoma and colorectal carcinoma

, 2019; 26(7): 1224-1250.

María Paula Ceballos, Juan Pablo Rigalli, Lucila Inés Ceré, Mariana Semeniuk, Viviana Alicia Catania and María Laura Ruiz*

DOI: 10.2174/0929867325666180105103637

Most Accessed Articles

The Therapeutic use of the Zonulin Inhibitor AT-1001 (Larazotide) for a Variety of Acute and Chronic Inflammatory Diseases

, 2021; 28(28): 5788-5807.

Jacopo Troisi*, Giorgia Venutolo, Concetta Terracciano, Matteo Delli Carri, Simone Di Micco, Annamaria Landolfi and Alessio Fasano

DOI: 10.2174/0929867328666210104110053

Design and Synthesis of Quinolizidine Derivatives as Influenza Virus and HIV-1 Inhibitors

, 2021; 28(24): 4995-5003.

Zhao Dang, Lei Zhu, Lan Xie, Kuo-Hsiung Lee, Faisal Malik, Zhijun Li, Li Huang* and Chin-Ho Chen*

DOI: 10.2174/0929867328666201229121802

Convolutional Neural Network-based Virtual Screening

, 2021; 28(10): 2033-2047.

Wenying Shan, Xuanyi Li, Hequan Yao and Kejiang Lin*

DOI: 10.2174/0929867327666200526142958

The Correlation between Lipid Metabolism Disorders and Prostate Cancer

, 2021; 28(10): 2048-2061.

Justyna Dłubek, Jacek Rysz, Zbigniew Jabłonowski, Anna Gluba-Brzózka* and Beata Franczyk

DOI: 10.2174/0929867327666200806103744

New Perspectives in the Pharmacological Potential of Naringin in Medicine

, 2021; 28(10): 1987-2007.

María Angélica Rivoira, Valeria Rodriguez, Germán Talamoni and Nori Tolosa de Talamoni*

DOI: 10.2174/0929867327666200604171351

Astroglial Connexins in Neurological and Neuropsychological Disorders and Radiation Exposure

, 2021; 28(10): 1970-1986.

Yuan Duo Liu, Ge Tang, Feng Qian, Lian Liu*, Jiang Rong Huang* and Feng Ru Tang*

DOI: 10.2174/0929867327666200610175037

Lipid-Lowering Therapies for Atherosclerosis: Statins, Fibrates, Ezetimibe and PCSK9 Monoclonal Antibodies

, 2021; 28(36): 7427-7445.

Adel Hajj Ali, Nour Younis, Rola Abdallah, Farah Shaer, Ali Dakroub, Mohammed Akli Ayoub, Rabah Iratni, Hadi Mohamad Yassine, Kazem Zibara, Alexander Orekhov, Ahmed Fawzy El-Yazbi and Ali H. Eid *

DOI: 10.2174/0929867328666210222092628

Advances in Sickle Cell Disease Treatments

, 2021; 28(10): 2008-2032.

Aline Renata Pavan and Jean Leandro dos Santos*

DOI: 10.2174/0929867327666200610175400

MicroRNAs as Biomarkers in Hypertrophic Cardiomyopathy: Current State of the Art

, 2021; 28(36): 7400-7412.

Andreas Angelopoulos, Evangelos Oikonomou*, Georgia Vogiatzi, Alexios Antonopoulos, Sotirios Tsalamandris, Christos Georgakopoulos, Paraskevi Papanikolaou, George Lazaros, Georgios Charalambous, Gerasimos Siasos, Charalambos Vlachopoulos and Dimitris Tousoulis

DOI: 10.2174/0929867328666210405122703


Atta-ur-Rahman, FRS
(32052 citations)
Kings College
University of Cambridge
View Full Editorial Board

Nobel Laureates on Editorial Board

Prof. John Gurdon

Prof. Jean-Marie Lehn

Prof. Ferid Murad

COPE Compliant

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Journal History

Current Medicinal Chemistry was introduced in 1994 with the assistance of Dr. Atta-ur-Rahman, who is the current Editor-in-Chief serving since 1994.

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