Bentham Science Logo

Track Your Manuscript:


Current Medicinal Chemistry

Volume 28, 42 Issues, 2021
ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)
This journal supports open access

Abstracts Ahead of Print

Overview of PROTACs Targeting the Estrogen Receptor: Achievements for Biological and Drug Discovery


Hui Qin, Yiwen Zhang, Yutao Lou, Zongfu Pan, Feifeng Song, Yujia Liu, Tong Xu, Xiaowei Zheng, Xiaoping Hu and Ping Huang*


DOI: 10.2174/0929867328666211110101018
View Abstract


An updated review on the therapeutic, diagnostic, and prognostic value of long non-coding RNAs in gastric cancer


Alemeh Mohammadzadeh, Narges Dastmalchi, Bashdar Mahmud Hussen, Mahdi Abdoli Shadbad and Reza Safaralizadeh*


DOI: 10.2174/0929867328666211115121019
View Abstract



Polyphenols effect on cerebrovascular health


Luis Goya, Ricardo San Román and Sonia de Pascual-Teresa*


DOI: 10.2174/0929867328666211129123459
View Abstract



A2A Adenosine Receptor Antagonists in Neurodegenerative Diseases


Stefania Merighi*, Pier Andrea Borea, Katia Varani, Fabrizio Vincenzi, Kenneth A. Jacobson* and Stefania Gessi*


DOI: 10.2174/0929867328666211129122550
View Abstract





Urinary ethyl glucuronide for the assessment of alcohol consumption during pregnancy: Comparison between biochemical data and screening questionnaires


Flavio Maria Ceci, Marco Fiore*, Enzo Agostinelli, Tomoaki Tahara, Antonio Greco, Massimo Ralli, Antonella Polimeni, Marco Lucarelli, Roberta Colletti, Antonio Angeloni, Paola Tirassa, Mauro Ceccanti, Marisa Patrizia Messina, Mario Vitali, Carla Petrella and Giampiero Ferraguti


DOI: 10.2174/0929867328666211125100329
View Abstract



Millennium Nutrient N,N-Dimethylglycine (DMG) and its Effectiveness in Autism Spectrum Disorders.


Daljeet Singh Dhanjal, Sonali Bhardwaj, Chirag Chopra, Reena Singh*, Jiri Patocka, Bohumir Plucar, Eugenie Nepovimova, Martin Valis and Kamil Kuca*


DOI: 10.2174/0929867328666211125091811
View Abstract



Bioaccessibility of Anthocyanins on in vitro Digestion Mmodels: Factors Implicated and Role in Functional Foods Development


Gabriel Prado, Isidora Pierattini, Guiselle Villarroel, Fernanda Fuentes, Alejandra Silva, Francisca Echeverria, Rodrigo Valenzuela and Andres Bustamante*


DOI: 10.2174/0929867328666211123102536
View Abstract




Prothymosin α and Its C-Terminal Immunoreactive Decapeptide Show no Evidence of Acute Toxicity: A Preliminary in Silico, in Vitro and in Vivo Investigation


Anastasios I. Birmpilis, Panagiotis Vitsos, Ioannis V. Kostopoulos, Lillian Williams, Kyriaki Ioannou, Pinelopi Samara, Chrysoula-Evangelia Karachaliou, Ioannis F. Voutsas, Elena Alyfanti, Nikolaos Angelis, Nikolaos G. Gavalas, Themis Gkraikou, Niki Kappa, Eleftheria Klagkou, Persefoni Klimentzou, Spiridoula Nikou, Nikos E. Papaioannou, Margarita Skopeliti, David Toukli, Meletios-Athanasios Dimopoulos, Aristotelis Bamias, Evangelia Livaniou, Hubert Kalbacher, Ourania E. Tsitsilonis* and Wolfgang Voelter


DOI: 10.2174/0929867328666211117093401
View Abstract


L-carnitine: Searching for New Therapeutic Strategy for Sepsis Management


Adeleh Sahebnasagh, Razieh Avan, Mahila Monajati, Javad Hashemi, Solomon Habtemariam, Sina Negintaji and Fatemeh Saghafi*


DOI: 10.2174/0929867328666211117092345
View Abstract


Interplay Between Endocannabinoid System and Neurodegeneration: Focus on Polypharmacology


Francesca Seghetti, Silvia Gobbi, Federica Belluti, Angela Rampa and Alessandra Bisi*


DOI: 10.2174/0929867328666211115124639
View Abstract


GABA System in Depression: Impact on Pathophysiology and Psychopharmacology


Alessandra Della Vecchia *, Alessandro Arone, Armando Piccinni , Federico Mucci and Donatella Marazziti


DOI: 10.2174/0929867328666211115124149
View Abstract


PCSK9 as a new player in cancer: New opportunity or red herring?


Aldo Bonaventura*, Alessandra Vecchié, Massimiliano Ruscica, Francesco Grossi and Francesco Dentali


DOI: 10.2174/0929867328666211115122324
View Abstract




The Role of Vitamin D in Gastrointestinal Diseases: Inflammation, Gastric Cancer, and Colorectal Cancer


Yao Chen, Jue Hou, Zhangang Xiao, Yueshui Zhao, Fukuan Du, Xu Wu, Mingxing Li, Yu Chen, Lin Zhang, Chi Hin Cho, Qinglian Wen*, Wei Hu* and Jing Shen*


DOI: 10.2174/0929867328666211111163304
View Abstract



Recent Trends in rationally designed molecules as kinase inhibitors


Parteek Prasher, Mousmee Sharma, Yinghan Chan, Sachin Kumar Singh, Krishnan Anand, Harish Dureja, Niraj Kumar Jha, Gaurav Gupta, Flavia Zacconi, Dinesh K. Chellappan and Kamal Dua*


DOI: 10.2174/0929867328666211111161811
View Abstract





Profiling the HCV immune response in patients with chronic liver diseases and hepatocellular carcinoma by peptide microarray analysis


Anna Lucia Tornesello, Ulf Reimer, Pavlo Holenya, Tobias Knaute, Francesca Pezzuto, Francesco Izzo, Luigi Buonaguro, Angelo Salomone Megna, Franco Maria Buonaguro* and Maria Lina Tornesello*


DOI: 10.2174/0929867328666211104093718
View Abstract


Nephrogenesis, Renal Function, and Biomarkers in Preterm Newborns


Luísa Petri Corrêa, Felipe Rodrigues Gatto, Guilherme Yanq Sen Bressani, Katharina Lanza and Ana Cristina Simões e Silva*


DOI: 10.2174/0929867328666211101102227
View Abstract


Effects of polyphenols in aging and neurodegeneration associated with oxidative stress


Francisca Rivas, Carlos Poblete-Aro, María Elsa Pando*, María José Allel, Valentina Fernandez, Angélica Soto, Pablo Nova and Diego Garcia-Diaz


DOI: 10.2174/0929867328666211101100632
View Abstract


Mutual effects of free and nanoencapsulated phenolic compounds on human microbiota


Carina Cassini, Pedro Henrique Zatti, Valéria Weiss Angeli, Catia Santos Branco* and Mirian Salvador


DOI: 10.2174/0929867328666211101095131
View Abstract


PCSK9 inhibition-based therapeutic approaches: an immunotherapy perspective


Amir Abbas Momtazi-Borojeni, Matteo Pirro, Suowen Xu and Amirhossein Sahebkar*


DOI: 10.2174/0929867328666211027125245
View Abstract




Long noncoding RNA GAS5 in age-related diseases


Yaqi Wang, Mengzhen Xue, Fangqi Xia, Leiqi Zhu, Dengke Jia, Yan Gao, Luoying Li, Yue Shi, Yuanyang Li, Silong Chen, Guangfu Xu and Chengfu Yuan*


DOI: 10.2174/0929867328666211027123932
View Abstract


The Role of Endothelial Related Circulating Biomarkers in COVID-19. A Systematic Review and Meta-analysis


Stamatios Lampsas*, Paraskevas Tsaplaris*, Panteleimon Pantelidis*, Evangelos Oikonomou*, Georgios Marinos, Georgios Charalambous, Nektarios Souvaliotis, Vasiliki-Chara Mystakidi, Athina Goliopoulou, Efstratios Katsianos, Gerasimos Siasos, Michael-Andrew Vavuranakis, Costas Tsioufis, Manolis Vavuranakis and Dimitrios Tousoulis


DOI: 10.2174/0929867328666211026124033
View Abstract


Small Molecules as LIM Kinase Inhibitors


Syed Nasir Abbas Bukhari *, Michael Andreas Tandiary, Mohammad M. Al-Sanea, Mohamed A. Abdelgawad, Chin Fei Chee and Muhammad Ajaz Hussain


DOI: 10.2174/0929867328666211026120335
View Abstract



The Syntheses and Medicinal Attributes of Phenanthrenes as Anticancer Agents: A Quinquennial Update


Sarthak Jhingran, Kritika Laxmikeshav, Sayali Mone, Venkata Rao K and Nagula Shankaraiah*


DOI: 10.2174/0929867328666211018110223
View Abstract




Multicomponent reactions in the synthesis of antiviral compounds


Lorenzo Botta, Silvia Cesarini, Claudio Zippilli, Bruno Mattia Bizzarri, Angelica Fanelli and Raffaele Saladino*


DOI: 10.2174/0929867328666211007121837
View Abstract


Molecular Link between Circadian Rhythmicity and Mood Disorders


Frank Faltraco, Denise Palm, Andrew Coogan, Frederick Simon, Oliver Tucha and Johannes Thome*


DOI: 10.2174/0929867328666211007113725
View Abstract


The Development of Machine Learning Methods in discriminating Secretory Proteins of Malaria Parasite


Ting Liu, Jiamao Chen, Qian Zhang, Kyle Hippe, Cassandra Hunt, Thu Le, Renzhi Cao and Hua Tang*


DOI: 10.2174/0929867328666211005140625
View Abstract


Celecoxib and dimethylcelecoxib block oxidative phosphorylation, epithelial-mesenchymal transition and invasiveness in breast cancer stem cells


Juan Carlos Gallardo-Pérez, Alhelí Adán-Ladrón de Guevara, Marco Antonio García-Amezcua, Diana Xochiquetzal Robledo-Cadena, Silvia Cecilia Pacheco-Velázquez, Javier Alejandro Belmont-Díaz, Jorge Luis Vargas-Navarro, Rafael Moreno-Sánchez and Sara Rodríguez-Enríquez*


DOI: 10.2174/0929867328666211005124015
View Abstract


The Role of Kallikrein 7 in Tumorigenesis


Fengyi Xiang, Yueqing Wang, Chunyu Cao, Qingyun Li, Hao Deng, Jun Zheng, Xiaowen Liu* and Xiao Tan*


DOI: 10.2174/0929867328666210915104537
View Abstract


Potential Role of Adult Hippocampal Neurogenesis in Traumatic Brain Injury


Lucas Alexandre Santos Marzano, Fabyolla Lúcia Macedo de Castro, Caroline Amaral Machado, João Luís Vieira Monteiro de Barros, Thiago Macedo e Cordeiro, Ana Cristina Simões e Silva, Antônio Lúcio Teixeira and Aline Silva de Miranda*


DOI: 10.2174/0929867328666210923143713
View Abstract


Gut Microbiota and Autoimmune Diseases: a Charming Real World Together with Probiotics


Andrea Piccioni, Sara Cicchinelli*, Federico Valletta, Giulio De Luca, Yaroslava Longhitano, Marcello Candelli, Veronica Ojetti, Francesco Sardeo, Simone Navarra, Marcello Covino and Francesco Franceschi


DOI: 10.2174/0929867328666210922161913
View Abstract


Neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in mood disorders


Donatella Marazziti *, Samuele Torrigiani, Manuel G. Carbone, Federico Mucci , Walter Flamini , Tea Ivaldi and Liliana Dell' Osso


DOI: 10.2174/0929867328666210922160116
View Abstract


Different Sides of Depression in the Elderly: An In-depth View on the Role of Aβ Peptides


Giovann Pagni*, Claudia Tagliarini, Manuel Glauco Carbone, Bruno Pietro Imbimbo, Donatella Marazziti and Nunzio Pomara


DOI: 10.2174/0929867328666210921164816
View Abstract


Inflammation, Oxidative Stress, Vascular Aging And Atherosclerotic Ischemic Stroke


Ioannis K. Koutsaliaris, Iraklis C. Moschonas, Louisa M. Pechlivani, Aikaterini N. Tsouka and Alexandros D. Tselepis*


DOI: 10.2174/0929867328666210921161711
View Abstract


Analysis of the molecular mechanisms by flavonoids with potential use for osteoporosis prevention or therapy


Valeria Rodríguez, María Rivoira, Gabriela Picotto, Gabriela Díaz de Barboza, Alejandro Collin and Nori Tolosa de Talamoni*


DOI: 10.2174/0929867328666210921143644
View Abstract


Therapeutic Targets for Phenolic Compounds from Agro-industrial Byproducts against Obesity


María de la Luz Cádiz-Gurrea*, Álvaro Fernández-Ochoa, María del Carmen Villegas-Aguilar, David Arráez-Román and Antonio Segura-Carretero


DOI: 10.2174/0929867328666210920103815
View Abstract






Microbiome in Critical illness: An Unconventional and Unknown Ally


Christian Zanza*, Tatsiana Romenskaya, Duraiyah Thangathurai, Veronica Ojetti, Angela Saviano, Ludovico Abenavoli, Chiara Robba, Gianmaria Cammarota, Francesco Franceschi, Andrea Piccioni and Yaroslava Longhitano


DOI: 10.2174/0929867328666210915115056
View Abstract




Histone Deacetylases and their Inhibitors in Colorectal Cancer Therapy: Current Evidence and Future Considerations


Nikolaos Garmpis*, Christos Damaskos*, Anna Garmpi, Afroditi Nonni, Vasiliki E. Georgakopoulou, Efstathios Antoniou, Dimitrios Schizas, Panagiotis Sarantis, Alexandros Patsouras, Athanasios Syllaios, Christos Vallilas, Evangelos Koustas, Konstantinos Kontzoglou, Nikolaos Trakas and Dimitrios Dimitroulis


DOI: 10.2174/0929867328666210915105929
View Abstract



Virtual Screening and Molecular Docking: Discovering Novel c-KIT Inhibitors


Fernanda Mello Tavares, Angela Cristina Gomes, Edson Mareco Assunção, João Luiz Sobral de Medeiros, Marcus T. Scotti, Luciana Scotti* and Hamilton Mitsugu Ishiki


DOI: 10.2174/0929867328666210915102920
View Abstract




The roles of signaling pathways in cardiac regeneration


Amir Valizadeh, Samira Asghari, Parinaz Mansouri, Forough Alemi, Maryam Majidinia, Ata Mahmoodpoor and Bahman Yousefi*


DOI: 10.2174/0929867328666210914115411
View Abstract


Recent Advances in the Development of Triose Phosphate Isomerase Inhibitors as Antiprotozoal Agents


Lenci K. Vázquez-Jiménez, Antonio Moreno-Herrera, Alfredo Juárez-Saldivar, Alonzo González-González, Eyra Ortiz-Pérez, Alma D. Paz-González, Isidro Palos-Pizarro, Esther Ramírez-Moreno and Gildardo Rivera*


DOI: 10.2174/0929867328666210913090928
View Abstract


Anti-proliferative potential of fluorinated curcumin analogues: experimental and computational analysis and review of the literature


Mahdi Hatamipour, Farzin Hadizadeh, Mahmoud Reza Jaafari, Zahra Khashyarmanesh, Thozhukat Sathyapalan and Amirhossein Sahebkar*


DOI: 10.2174/0929867328666210910141316
View Abstract


A Survey for Predicting ATP Binding Residues of Proteins Using Machine Learning Methods


Yu-He Yang, Jia-Shu Wang, Shi-Shi Yuan, Meng-Lu Liu, Wei Su, Hao Lin* and Zhao-Yue Zhang*


DOI: 10.2174/0929867328666210910125802
View Abstract


The role of celecoxib as a potential inhibitor in the treatment of inflammatory diseases - a review


Josiane Viana Cruz, Joaquín María Campos Rosa*, Njogu Mark Kimani, Silvana Giuliatti and Cleydson Breno Rodrigues dos Santos


DOI: 10.2174/0929867328666210910125229
View Abstract




Recent advances in lung cancer therapy based on nanomaterials: a review


Leila Gholami, Jalil Rouhani Ivari, Niloofar Khandan Nasab, Reza Kazemi Oskuee, Thozhukat Sathyapalan* and Amirhossein Sahebkar*


DOI: 10.2174/0929867328666210810160901
View Abstract


Dual Targeting Strategies On Histone Deacetylase 6 (HDAC6) And Heat Shock Protein 90 (Hsp90)


Davide Bonanni, Andrea Citarella, Davide Moi, Luca Pinzi, Elisa Bergamini and Giulio Rastelli*


DOI: 10.2174/0929867328666210902145102
View Abstract



Prevention and management of type II diabetes chronic complications: the role of polyphenols (Mini-Review)


Arianna Pani, Francesco Baratta, Daniele Pastori, Mattia Coronati, Francesco Scaglione and Maria del Ben*


DOI: 10.2174/0929867328666210902131021
View Abstract




Molecular Effects of Pteryxin and Scopoletin in the 5xFAD Alzheimer’s Disease Mouse Model


Irem Kiris, Krystyna Skalicka-Wozniak, Merve Karayel Basar, Betul Sahin, Busra Gurel and Ahmet Tarik Baykal*


DOI: 10.2174/0929867328666210827152914
View Abstract


Pulmonary surfactant: a unique biomaterial with life-saving therapeutic applications.


Barbara Pioselli*, Fabrizio Salomone, Giuseppe Mazzola, Davide Amidani, Elisa Sgarbi, Francesco Amadei, Xabi Murgia, Silvia Catinella, Gino Villetti, Daniele De Luca, Virgilio Carnielli and Maurizio Civelli


DOI: 10.2174/0929867328666210825110421
View Abstract



Research Progress on Natural Compounds Exerting an Antidepressant Effect through Anti-inflammatory


Caixia Yuan, Yucen Yao, Tao Liu, Ying Jin*, Chunrong Yang*, Xian Jun Loh and Zibiao Li*


DOI: 10.2174/0929867328666210820115259
View Abstract



Mucoadhesive Nanosystems for Nose-to-Brain Drug Delivery in the Treatment of Central Nervous System Diseases


Leonardo Delello Di Filippo, Jonatas Duarte, Bruno Fonseca-Santos, Alberto Gomes Tavares Júnior, Victor Araújo, Cesar Augusto Roque Borda, Eduardo Festozo Vicente and Marlus Chorilli*


DOI: 10.2174/0929867328666210813154019
View Abstract


Another look at dietary polyphenols: challenges in cancer prevention and treatment


Roberto Arrigoni, Andrea Ballini*, Luigi Santacroce , Stefania Cantore, Angelo Inchingolo, Francesco Inchingolo , Marina Di Domenico , Lucio Quagliuolo and Mariarosaria Boccellino


DOI: 10.2174/0929867328666210810154732
View Abstract





Metabolomic profiling of exhaled breath condensate and plasma/serum in chronic obstructive pulmonary disease


Salvatore Fuschillo, Debora Paris, Annabella Tramice, Pasquale Ambrosino, Letizia Palomba, Mauro Maniscalco* and Andrea Motta*


DOI: 10.2174/0929867328666210810122350
View Abstract



Flavonoids and PI3K/Akt/mTOR signaling cascade: A potential crosstalk in anticancer treatment


Badar Islam, Mohd Suhail, Mohd Khan, Ajmal Ahmad, Torki Zughaibi, Fohad Husain, Md Tabish Rehman and Shams Tabrez*


DOI: 10.2174/0929867328666210804091548
View Abstract




Recent development of bioinformatics tools for microRNA target prediction


Mst Shamima Khatun, Md Ashad Alam, Watshara Shoombuatong, Md Nurul Haque Mollah, Hiroyuki Kurata* and Md Mehedi Hasan*


DOI: 10.2174/0929867328666210804090224
View Abstract




Natural Products with tandem Anti-inflammatory, Immunomodulatory and Anti-SARS-CoV/2 effects: A Drug Discovery Perspective against SARS-CoV-2


Luana N. O. Leal da Cunha, Tiago Tizziani, Gabriella B. Souza, Monalisa A. Moreira, José S. S. Neto, Carlos V. D. dos Santos, Maryelle G. de Carvalho, Eduardo M. Dalmarco, Leonardo B. Turqueti, Marcus Tullius Scotti, Luciana Scotti, Francisco F. de Assis, Antonio Braga and Louis Pergaud Sandjo*


DOI: 10.2174/0929867328666210726094955
View Abstract





Dietary Phytochemicals in Cancer Signalling Pathways: Role of miRNA targeting


Ambreen Shoaib, Mohammad Tabish, Shafat Ali, Azher Arafah, Muneeb U Rehman*, Shadma Wahab, Feras M. Al-Marshadh and Summya Rashid


DOI: 10.2174/0929867328666210420101605
View Abstract



Editor-in-Chief

Atta-ur-Rahman, FRS
(32052 citations)
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
(UK)
Biography
View Full Editorial Board

Nobel Laureates on Editorial Board

Prof. John Gurdon
(UK)

Prof. Jean-Marie Lehn
(France)

Prof. Ferid Murad
(USA)

COPE Compliant

Cope Logo

Journal History

Current Medicinal Chemistry was introduced in 1994 with the assistance of Dr. Atta-ur-Rahman, who is the current Editor-in-Chief serving since 1994.

Related Journals

Related eBooks

eBooks Catalog