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Current Pharmaceutical Biotechnology

Volume 22, 15 Issues, 2021
ISSN: 1873-4316 (Online)
ISSN: 1389-2010 (Print)
This journal supports open access

Aims & Scope

Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal includes timely in-depth/mini reviews, original research articles and letters written by leaders in the field, covering a range of current topics in scientific areas of Pharmaceutical Biotechnology. Invited and unsolicited review articles are welcome. The journal encourages contributions describing research at the interface of drug discovery and pharmacological applications, involving in vitro investigations and pre-clinical or clinical studies. Scientific areas within the scope of the journal include pharmaceutical chemistry, biochemistry and genetics, molecular and cellular biology, and polymer and materials sciences as they relate to pharmaceutical science and biotechnology. In addition, the journal also considers comprehensive studies and research advances pertaining food chemistry with pharmaceutical implication. Areas of interest include:

  • DNA/protein engineering and processing
  • Synthetic biotechnology
  • Omics (genomics, proteomics, metabolomics and systems biology)
  • Therapeutic biotechnology (gene therapy, peptide inhibitors, enzymes)
  • Drug delivery and targeting
  • Nanobiotechnology
  • Molecular pharmaceutics and molecular pharmacology
  • Analytical biotechnology (biosensing, advanced technology for detection of bioanalytes)
  • Pharmacokinetics and pharmacodynamics
  • Applied Microbiology
  • Bioinformatics (computational biopharmaceutics and modeling)
  • Environmental biotechnology
  • Regenerative medicine (stem cells, tissue engineering and biomaterials)
  • Translational immunology (cell therapies, antibody engineering, xenotransplantation)
  • Industrial bioprocesses for drug production and development
  • Biosafety
  • Biotech ethics

Special Issues devoted to crucial topics, providing the latest comprehensive information on cutting-edge areas of research and technological advances, are welcome.

Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.

Current Pharmaceutical Biotechnology


Volume 22


Number 15

Editorial   Open Access

Research Article

Research Article

Key Performance Indicators in Claims Management: Definition of a Set of Indicators for the Evaluation of the Medico-Legal Activity

, 22(15): 1971 - 1984

Matteo Scopetti*, Martina Padovano, Federico Manetti, Vittorio Gatto, Stefano D’Errico, Alessandro Santurro, Paola Frati and Vittorio Fineschi

DOI: 10.2174/1389201022666210916124851

Letter Article

Synthesis of Silymarin-Gold Nanoparticle Conjugate and Analysis of its Liver-Protecting Activity

, 22(15): 2001 - 2007

Sergey Staroverov, Sergey Kozlov, Alexander Fomin, Konstantin Gabalov, Alexey Volkov, Ivan Domnitsky, Lev Dykman and Olga Guliy*

DOI: 10.2174/1389201022666210101163734

General Review Article

Current Pharmaceutical Biotechnology, Volume 23 (2022) - Number 2

This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Biotechnology, Volume 23 (2022) - Number 1

This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Diagnostic Accuracy and Validity of Serological and Molecular Tests for Hepatitis B and C

Moein Zangiabadian*, Amir Zamani, Mohammad Javad Nasiri, Elham Behzadi and Abbas Ali Imani Fooladi

DOI: 10.2174/1389201022666210719162802
View Abstract

Bacteriocins: Recent Advances in its Application as an Antimicrobial Alternative

Hadis Fathizadeh, Farzaneh Pakdel, Mahmood Saffari, Davoud Davoud Esmaeili, Mansooreh M. Heravi, Sounkalo Dao, Khudaverdi Ganbarov and Hossein S. Kafil*

DOI: 10.2174/1389201022666210907121254
View Abstract View on PubMed

The Prognostic Value of Long Non-Coding RNA SNHG7 in Human Cancer: A Meta-Analysis

Kexun Yu, Weijie Yuan, Changhao Huang, Lei Xiao, Runsha Xiao, Pengwei Zeng, Lu Chen* and Zihua Chen*

DOI: 10.2174/1389201022666210810100607
View Abstract View on PubMed

A Review of Chemistry and Pharmacology of Piperidine Alkaloids of Pinus and Related Genera

Lav Singh, Atul K. Upadhyay, Pooja Dixit, Arpit Singh, Divyanshu yadav, Apurv Chhavi, Suraj Konar, Ravi Prakash Srivastava, Shivaraman Pandey, Hari Prasad Devkota, Praveen C. Verma and Gauri Saxena*

DOI: 10.2174/1389201022666210812123815
View Abstract View on PubMed

Abstracts Ahead of Print

Angelica archangelica and Ginkgo biloba Extracts Recover Functional Blood Hemoglobin Derivatives in Rabbits Exposed to High Altitude

Bassem M. Raafat, Amira M. Gamal-Eldeen*, Mazen M Almehmadi, Sherien M. El-Daly, Nahla L. Faizo and Fayez Althobaiti

DOI: 10.2174/1389201022666211118112356
View Abstract

Xiaoyao Pill improves the Affective Dysregulation of Sleep-deprived Female Mice by inhibiting Brain Injury and regulating the Content of Monoamine Neurotransmitter

Yujie Li, Dandan Wei, Minghao Zhang, Tiantian Yue, Huimin Du, Qi Liu, Shihu Gan, Hanbin Liu, Yijie Dong, Xinyue Qiao, Yichi Zhang and Liping Yang*

DOI: 10.2174/1389201022666211012102501
View Abstract

Polymer-Based Nanotherapeutics for Burn Wounds

Rewati Raman Ujjwal, Awesh Yadav*, Shourya Tripathi and S.T.V. Sai Krishna

DOI: 10.2174/1389201022666210927103755
View Abstract

Protective effects of curcumin against iron-induced toxicity

Nastaran Moinipour, Mahdi Barati, Amirhosein Sahebkar*, Milad Iranshahy and Abolfazl Shakeri

DOI: 10.2174/1389201022666210914122846
View Abstract

Escherichia coli and colorectal cancer: Unfolding the enigmatic relationship

Rogayeh Nouri, Alka Hasani, Kourosh Masnadi Shirazi, Mohammad Reza Aliand, Bita Sepehri, Simin Sotoodeh, Fatemeh Hemmati and Mohammad Ahangarzadeh Rezaee*

DOI: 10.2174/1389201022666210910094827
View Abstract

Bacterial proteomics and its application for pathogenesis studies

Mahdi Asghari Ozma, Ehsaneh Khodadadi, Mohammad Ahangarzadeh Rezaee, Mohammad Asgharzadeh, Mohammad Aghazadeh, Elham Zeinalzadeh, Khudaverdi Ganbarov and Hossein Kafil*

DOI: 10.2174/1389201022666210908153234
View Abstract

Published Contents

Drs. Eric Betzig, Stefan W. Hell and William E. Moerner share the 2014 chemistry Nobel for the development of super-resolved fluorescence microscopy.

“The Royal Swedish Academy of Sciences has decided to award the 2014 Nobel Prize in Chemistry to Dr. Eric Betzig at Howard Hughes Medical Institute, Ashburn, U.S.A.; Professor Stefan Hell at Max Planck Institute for Biophysical Chemistry, Göttingen, and the German Cancer Research Center, Heidelberg, Germany; and Professor William Moerner at Stanford University, Stanford, U.S.A., for the development of super-resolved fluorescence microscopy.”

Much research effort was needed to realize that single-cell and single-molecule based approaches directly affect improvements in human health. However, many of these laboratory technologies are not available in a cheap and easy version. Single-molecule based fluorescence imaging and detection have the advantages of a small volume platform, digital analysis, elimination of processing steps, real-time measurements and automation of sample preparation. In 2015, Current Pharmaceutical Biotechnology will continue in this direction with quality papers that can be expected to trigger further investigations.

Drs. Eric Betzig and William E. Moerner also developed methods and biotechniques which have enabled the study of single molecules in ongoing chemical reactions in living cells. Because now it is possible to see individual macromolecules moving about in a living cell, we can study chemistry at a single-molecule level and in real life. And this is very important to chemistry because chemistry has traditionally been about studying a large number of molecules and the effect that they have. The journal Current Pharmaceutical Biotechnology has published on this research and has been at the forefront for over more than one decade. Curr. Pharm. Biotechnol. has published thematic issues, original research and review articles about the entirely new possibilities for chemistry and for biochemistry by eminent scientists from around the world, some examples:

Editor's Choice

Green Synthesis and Applications of Nanomaterials

, 2021; 22(13): 1705 - 1747

N.B. Singh*, Preeti Jain, Anindita De and Richa Tomar

DOI: 10.2174/1389201022666210412142734

Recent Advances in Clinical Utility of Probiotics in Gastrointestinal Tract Disorders

, 2021; 22(12): 1559 - 1573

Prativa Biswasroy, Deepak Pradhan, Dipak K. Sahu, Amita Sahu, Goutam Ghosh and Goutam Rath*

DOI: 10.2174/1389201021666201029154239

Is Biotechnological Next-Generation Therapeutics Promising Enough in Clinical Development to Treat Advanced Colon Cancer?

, 2021; 22(10): 1287 - 1301

Sarubala Malayaperumal, Sushmitha Sriramulu, Antara Banerjee, M.K. Makalakshmi and Surajit Pathak*

DOI: 10.2174/1389201021666201126142716

Targeted Delivery of CRISPR/Cas13 as a Promising Therapeutic Approach to Treat SARS-CoV-2

, 2021; 22(9): 1149 - 1155

Kazem Abbaszadeh-Goudarzi, Mohammad H. Nematollahi, Hashem Khanbabaei, Hossein H. Nave, Hamid R. Mirzaei, Hossein Pourghadamyari* and Amirhossein Sahebkar *

DOI: 10.2174/1389201021666201009154517

Growing Preferences towards Analog-based Drug Discovery

, 2021; 22(8): 1030 - 1045

Mehak Dangi, Alka Khichi, Ritu Jakhar and Anil K. Chhillar*

DOI: 10.2174/1389201021666200908121409

Recent Advances in the Scaffold Engineering of Protein Binders

, 2021; 22(7): 878 - 891

Mohammad K.B. Ahmadi, Seyed A. Mohammadi, Manoochehr Makvandi, Morteza Mamouei, Mohammad Rahmati*, Hesam Dehghani and David W. Wood

DOI: 10.2174/1389201021999200824101035

Biogenesis and Application of Nickel Nanoparticles: A Review

, 2021; 22(6): 808 - 822

Siva S. Sana, Raghvendra P. Singh*, Minaxi Sharma, Atul K. Srivastava, Geetanjali Manchanda, Alok R. Rai and Zhi-Jun Zhang*

DOI: 10.2174/1389201022999210101235233

Open Access Articles

Investigation on the Antibacterial Activity of Electronic Cigarette Liquids (ECLs): A Proof of Concept Study

, 2021; 22(7): 983 - 994

Virginia Fuochi, Massimo Caruso , Rosalia Emma, Aldo Stivala, Riccardo Polosa, Alfio Distefano and Pio M. Furneri *

Analysis of the Differences in the Expression of mRNAs and miRNAs Associated with Drug Resistance in Endometrial Cancer Cells Treated with Salinomycin

, 2021; 22(4): 541 - 548

Piotr Januszyk*, Krzysztof Januszyk, Magdalena Wierzbik-Strońska, Dariusz Boroń and Beniamin Grabarek

Leaf and Fruit Methanolic Extracts of Azadirachta indica Exhibit Antifertility Activity on Rats’ Sperm Quality and Testicular Histology

, 2021; 22(3): 400 - 407

Castillo-Maldonado Irais, Borjón-Ríos Claudia, Pedroza-Escobar David*, Sharma Ashutosh, García-Garza Rubén, Ramírez-Moreno Agustina, Vega-Menchaca M. del Carmen, Rivera-Guillén Mario-Alberto and Serrano-Gallardo Luis-Benjamín*

Salinomycin Modulates the Expression of mRNAs and miRNAs Related to Stemness in Endometrial Cancer

, 2021; 22(2): 317 - 326

Karol Talkowski*, Kamil Kiełbasiński, Wojciech Peszek, Beniamin O. Grabarek, Dariusz Boroń and Marcin Oplawski

Scutellaria baicalensis Extract-Phospholipid Complex: Preparation and Initial Pharmacodynamics Research in Rats

, 2021; 22: 1 - 14 (E-Pub Ahead of Print)

Shibin Chen*, Qiujie Xie, Ming Yang, Yajun Shi, Junhui Shi and Xiaobin Zeng*

Cisplatin Changes Expression of SEMA3B in Endometrial Cancer

, 2020; 21(13): 1368 - 1376

Wojciech Peszek*, Piotr Kras, Beniamin O. Grabarek, Dariusz Boroń and Marcin Oplawski

Effect of Salinomycin on Expression Pattern of Genes Associated with Apoptosis in Endometrial Cancer Cell Line

, 2020; 21(12): 1269 - 1277

Kamil Kiełbasiński*, Wojciech Peszek, Beniamin O. Grabarek, Dariusz Boroń, Magdalena Wierzbik-Strońska and Marcin Oplawski

Differences in the Expression Pattern of mRNA Protein SEMA3F in Endometrial Cancer in vitro under Cisplatin Treatment

, 2020; 21(11): 1119 - 1128

Przemysław Kieszkowski*, Dariusz Dąbruś, Beniamin O. Grabarek and Dariusz Boroń

Analysis of the Clinical Diagnostic Value of GMFB in Cerebral Infarction

, 2020; 21(10): 955 - 963

Zhaohu Yuan*, Zhiwu Yu, Yiyu Zhang and Huikuan Yang

Plant Phenolics as Pathogen-Carrier Immunogenicity Modulator Haptens

, 2020; 21(10): 897 - 905

Castillo-Maldonado Irais, Sevilla-González María-de-la-Luz, Delgadillo-Guzmán Dealmy, Ramírez-Moreno Agustina, Cabral-Hipólito Nidia, Rivera-Guillén Mario-Alberto, Serrano-Gallardo Luis-Benjamín*, Vega-Menchaca María-del-Carmen and Pedroza-Escobar David*

Most Cited Articles

Review Article

Current prospects of nutraceuticals: A review

, 2020; 21(10): 884-896.

Vedant Sachdeva, Arpita Roy and Navneeta Bharadvaja*

DOI: 10.2174/1389201021666200130113441

Research Article

Healthcare-associated infections due to multidrug-resistant organisms: A surveillance study on extra hospital stay and direct costs

, 2019; 20(8): 643-652.

Guglielmo Giraldi, Marzietta Montesano, Christian Napoli, Paola Frati, Raffaele La Russa, Alessandro Santurro, Matteo Scopetti and Giovanni B. Orsi*

DOI: 10.2174/1389201020666190408095811

Review Article

Ginger: A novel strategy to battle cancer through modulating cell signalling pathways: A review

, 2019; 20(1): 5-16.

Ahmad Almatroudi, Mohammed A. Alsahli, Faris Alrumaihi, Khaled S. Allemailem and Arshad H. Rahmani*

DOI: 10.2174/1389201020666190119142331

Research Article

New rules on patient’s safety and professional liability for the Italian health service

, 2019; 20(8): 615-624.

Sara Albolino, Tommaso Bellandi, Simone Cappelletti, Marco Di Paolo, Vittorio Fineschi*, Paola Frati, Caterina Offidani, Michela Tanzini, Riccardo Tartaglia and Emanuela Turillazzi

DOI: 10.2174/1389201020666190408094016

Review Article

Functional biomolecule delivery systems and bioengineering in cartilage regeneration

, 2019; 20(1): 32-46.

Marta A. Szychlinska, Ugo D'Amora, Silvia Ravalli, Luigi Ambrosio, Michelino Di Rosa and Giuseppe Musumeci*

DOI: 10.2174/1389201020666190206202048

Research Article

Antibacterial and potential antidiabetic activities of flavone C-glycosides isolated from beta vulgaris subspecies cicla L. Var. flavescens (amaranthaceae) cultivated in Egypt

, 2019; 20(7): 595-604.

Hala S. Mohammed, Marwa M. Abdel-Aziz, Marwa S. Abu-Baker, Amal M. Saad, Mona A. Mohamed and Mosad A. Ghareeb*

DOI: 10.2174/1389201020666190613161212

Review Article

Potential pharmaceutical and food applications of postbiotics: A review

, 2020; 21(15): 1576-1587.

Aziz H. Rad, Amin Abbasi*, Hossein S. Kafil* and Khudaverdi Ganbarov

DOI: 10.2174/1389201021666200516154833

Review Article

Blood brain barrier permeability prediction using machine learning techniques: An update

, 2019; 20(14): 1163-1171.

Deeksha Saxena, Anju Sharma, Mohammed H. Siddiqui and Rajnish Kumar*

DOI: 10.2174/1389201020666190821145346

Most Accessed Articles

Targeting Macrophages in Atherosclerosis

, 2021; 22(15): 2008-2018.

Dan Hu, Zengyan Wang, Yuzhong Wang* and Caihong Liang*

DOI: 10.2174/1389201022666210122142233

Is Hospital Autopsy Auditing Suitable for Clinical Risk Manage ment? Actualities and Perspectives of Auditing in the Autopsy Room Following Italian Law 24/2017 on Patient Safety

, 2021; 22(15): 1964-1970.

Martina Zanon, Eleonora Valentinuz, Martina Montanaro, Davide Radaelli, Alessandro Manfredi, Diana Bonuccelli, Massimo Martelloni and Stefano D’Errico*

DOI: 10.2174/1389201021666201208115525

Synthesis of Silymarin-Gold Nanoparticle Conjugate and Analysis of its Liver-Protecting Activity

, 2021; 22(15): 2001-2007.

Sergey Staroverov, Sergey Kozlov, Alexander Fomin, Konstantin Gabalov, Alexey Volkov, Ivan Domnitsky, Lev Dykman and Olga Guliy*

DOI: 10.2174/1389201022666210101163734

The Role of Hypoxia in Endometrial Cancer

, 2022; 23(2): 230-243.

Yarely M. Salinas-Vera, Dolores Gallardo-Rincón, Erika Ruíz-García, Macrina B. Silva-Cázares, Carmen Sol de la Peña-Cruz and César López-Camarillo*

DOI: 10.2174/1389201022666210224130022

Gut Microbiota and Human Body Interactions; Its Impact on Health: A Review

, 2022; 23(1): 4-14.

Mahdyeh Neghabi Hajiagha, Sepehr Taghizadeh, Mohammad Asgharzadeh, Sounkalo Dao, Khudaverdi Ganbarov, Şükran Köse and Hossein Samadi Kafil*

DOI: 10.2174/1389201022666210104115836

Resveratrol and Cardiac Fibrosis Prevention and Treatment

, 2022; 23(2): 199-209.

Parinaz Zivarpour, Željko Reiner, Jamal Hallajzadeh* and Liaosadat Mirsafaei

DOI: 10.2174/1389201022666210212125003

Engineered Probiotic and Prebiotic Nutraceutical Supplementations in Combating Non-communicable Disorders: A Review

, 2022; 23(1): 72-97.

Rout George Kerry, Gitishree Das, Upendarrao Golla, Maria del Pilar Rodriguez-Torres, HanSeung Shin and Jayanta Kumar Patra*

DOI: 10.2174/1389201021666201013153142

Unravelling the Immune Modulatory Effect of Indian Spices to Impede the Transmission of COVID-19: A Promising Approach

, 2022; 23(2): 210-229.

Aswathy R. Devan, Bhagyalakshmi Nair, Ayana R Kumar, Jaggaiah N. Gorantla, Aishwarya T. S. and Lekshmi R. Nath*

DOI: 10.2174/1389201022666210216144917


Nikolaos Labrou
School of Food, Biotechnology and Development
Department of Biotechnology
Agricultural University of Athens
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Journal History

Current Pharmaceutical Biotechnology was launched in 2000. Dr. Nikolaos Labrou serves as the Editor-in-Chief of the journal.

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