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Current Topics in Medicinal Chemistry

Volume 19, 32 Issues, 2019
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

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  • 20th of 61 in

    Chemistry, Medicinal

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Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Current Topics in Medicinal Chemistry

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Volume 19

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Number 9



Editorial   Open Access



Review Article

An Overview on the Potential Antimycobacterial Agents Targeting Serine/Threonine Protein Kinases from Mycobacterium tuberculosis

, 19(9): 646 - 661

Matteo Mori, José Camilla Sammartino, Luca Costantino, Arianna Gelain, Fiorella Meneghetti, Stefania Villa and Laurent Roberto Chiarelli*


DOI: 10.2174/1568026619666190227182701


Research Article

Synthesis, Screening and Docking Analysis of Hispolon Pyrazoles and Isoxazoles as Potential Antitubercular Agents

, 19(9): 662 - 682

Neduri V. Balaji, Bollikolla HariBabu*, Vanga U. Rao, Gottumukkala V. Subbaraju, Kurre P. Nagasree and Muthyala M.K. Kumar*


DOI: 10.2174/1568026619666190305124954


Research Article

Synthesis and Antibacterial Activity of Mefloquine-Based Analogs Against Sensitive and Resistant Mycobacterium tuberculosis Strains

, 19(9): 683 - 689

Adriele da Silva Araújo, Adriana M. Moraes, Maria C.S. Lourenço, Cláudia O. Pessoa, Emerson T. da Silva and Marcus V.N. de Souza*


DOI: 10.2174/1568026619666190304124952


Editorial   Open Access



Review Article



Review Article



Review Article



Articles Ahead of Print

Identification of High-affinity Small Molecules Targeting Gamma Secretase for the Treatment of Alzheimer’s Disease


Meer Asif Ali, Sugunakar Vuree, Himshikha Goud, Tajamul Hussain, Anuraj Nayarisseri* and Sanjeev Kumar Singh*


View Abstract


5-Nitro-Thiophene-Thiosemicarbazone Derivatives Present Antitumor Activity Mediated by Apoptosis and DNA Intercalation


Karla Mirella Roque Marques, Maria Rodrigues do Desterro, Sandrine Maria de Arruda, Luiz Nascimento de-Araújo Neto, Maria do Carmo Alves de Lima, Sinara Mônica Vitalino de Almeida , Edjan Carlos Dantas da Silva, Thiago Mendonça de Aquino, Edeildo Ferreira da Silva Júnior, João Xavier de-Araújo Júnior , Marina de M Silva, Maria Dayanne de A. Dantas, Josué Carinhanha C. Santos, Isis M Figueiredo, Marc Antoine Bazin , Pascal Marchand, Teresinha Gonçalves da Silva and Francisco Jaime Bezerra Mendonça Junior *


View Abstract View on PubMed



Recent Progress on Discovery of Sirt2 Inhibitors for the Treatment of Various Cancers


Ting Wang, Zhuyu Xu, Yongping Lu, Jianyou Shi, Wenbo Liu, Chengchen Zhang, Zhongliang Jiang, Baowen Qi* and Lan Bai*


View Abstract View on PubMed


Higher-Order and Mixed Discrete Derivatives Like a Novel Graph- Theoretical Invariant for Generating New Molecular Descriptors


Oscar Martínez-Santiago, Yovani Marrero-Ponce*, Ricardo Vivas-Reyes, Mauricio E. Orozco Ugarriza, Elízabeth Hurtado-Rodríguez, Yoan Martínez-López, F. Javier Torres, Cesar H. Zambrano and Hai Pham‑The


View Abstract View on PubMed


New Mechanistic Insight on the PIM-1 Kinase Inhibitor AZD1208 Using Multidrug Resistant Human Erythroleukemia Cell Lines and Molecular Docking Simulations


Maiara Bernardes Marques*, Michael González-Durruthy*, Bruna Félix da Silva Nornberg, Bruno Rodrigues Oliveira, Daniela Volcan Almeida, Ana Paula de Souza Votto and Luis Fernando Marins


View Abstract View on PubMed



Recent Study of Dual HDAC/PARP Inhibitor for the Treatment of Tumor


Haiying Lu, Lan Bai, Yanping Zhou, Yongping Lu, Zhongliang Jiang* and Jianyou Shi*


View Abstract View on PubMed


Molecular Targets for Malarial Chemotherapy: A Review


Dharmendra Kumar Yadav*, Surendra Kumar, Mahesh K. Teli, Ravikant Yadav and Sandeep Chaudhary


View Abstract View on PubMed


Griseofulvin Derivatives: Synthesis, Molecular Docking and Biological Evaluation


Victor Kartsev, Athina Geronikaki*, Anthi Petrou, Boris Lichitsky, Marina Kostic, Marija Smiljkovic, Marina Soković and Samvel Sirakanyan


View Abstract View on PubMed


Abstracts Ahead of Print

Vanillin-Related N-Acylhydrazones: Synthesis, Antischistosomal Properties and Target Fishing Studies.


Josué de Moraes, Daniela G. G Rando, Marcela O. L. da Costa, Thais F. A. Pavani, Thiago Oliveira, Paloma F dos Santos, Carina R Amorim, Pedro L S Pinto, Mariana G de Brito, Marcos P. N Silva and Daniel B Roquini


View Abstract


Research progress of Axl inhibitors


Zhi Gang Sun*, Jin Mai Zhang and Yong Qian


View Abstract


In Vitro And In Vivo Antifilarial Activity Of Standardized Extract Of Calotropis procera Flowers Against Brugia malayi


Puvvada Kalpana Murthy*, Vikas Kushwaha, Subha Rastogi, Madan Mohan Pandey, Kirti Saxena, Sayyada Khatoon and Ajay Kumar Singh Rawat


View Abstract


Chemical Intuition in Drug Design and Discovery


Julia Galvez B. Pedreira, Lucas S. Franco and Eliezer J. Barreiro*


View Abstract



Epigenetic Modification in Macrophages: A Promising Target for Tumor and Inflammation-associated Disease Therapy


Pei Sun, Shu-Jing Zhang, Semenov Maksim, Yong-Fang Yao*, Hong-Min Liu* and Juan Du*


View Abstract



Molecular Hybridization as a Tool for Designing Multitarget Drug Candidates for Complex Diseases


Viktoriya Ivasiv, Claudia Albertini, Ana Elisa Goncalves, Michele Rossi and Maria Laura Bolognesi*


View Abstract




Published Contents

Editor's Choice

Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*


DOI: 10.2174/1568026618666180821145215




A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*


DOI: 10.2174/1568026618666180516123229




Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610






Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao


DOI: 10.2174/1568026618666180410151518



Aurora Kinase Inhibitors in Head and Neck Cancer

, 2018; 18(3): 199 - 213

Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang* and Yasusei Kudo*


DOI: 10.2174/1568026618666180112163741



Open Access Articles



Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*




Mechanical Properties of Composite Hydrogels for Tissue Engineering

, 2018; 18(14): 1214 - 1223

Ramon Rial, J.F. Armando Soltero, Pedro V. Verdes, Zhen Liu and Juan M. Ruso*





Analyzing of Molecular Networks for Human Diseases and Drug Discovery

, 2018; 18(12): 1007 - 1014

Tong Hao, Qian Wang, Lingxuan Zhao, Dan Wu, Edwin Wang* and Jinsheng Sun*




Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development

, 2018; 18(11): 883 - 895

Thomas Gross, Mark Mapstone, Ricardo Miramontes, Robert Padilla, Amrita K. Cheema, Fabio Macciardi, Howard J. Federoff* and Massimo S. Fiandaca*





Ubiquitin Proteasome System as a Potential Drug Target for Malaria

, 2018; 18(5): 315 - 320

Pedro H. Scarpelli Pereira, Chiara Curra and Celia R.S. Garcia*




Metabolomics Applications in Precision Medicine: An Oncological Perspective

, 2017; 17(24): 2740 - 2751

Leonor Puchades-Carrasco and Antonio Pineda- Lucena*




InsP3 Signaling in Apicomplexan Parasites

, 2017; 17(19): 2158 - 2165

Celia R.S. Garcia*, Eduardo Alves, Pedro H. S. Pereira, Paula J. Bartlett, Andrew P. Thomas, Katsuhiko Mikoshiba, Helmut Plattner and L. David Sibley









Most Cited Articles

Review Article

Bis-coumarin derivatives and their biological activities

, 2018; 18(2): 101-113.

Qing-Cheng Ren, Chuan Gao , Zhi Xu , Lian-Shun Feng, Ming-liang Liu*, Xiang Wu* and Feng Zhao*


DOI: 10.2174/1568026618666180221114515


Review Article

Coumarin compounds in medicinal chemistry: Some important examples from the last years

, 2018; 18(2): 124-148.

Thiago Moreira Pereira, Daiana Portella Franco, Felipe Vitorio and Arthur Eugen Kummerle*


DOI: 10.2174/1568026618666180329115523



Review Article

Recent development of small molecule glutaminase inhibitors

, 2018; 18(6): 432-443.

Minsoo Song*, Soong-Hyun Kim, Chun Young Im and Hee-Jong Hwang


DOI: 10.2174/1568026618666180525100830


Review Article

Prediction and targeting of interaction interfaces in G-protein coupled receptor oligomers

, 2018; 18(8): 714-746.

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610


Review Article

Recent development of coumarin derivatives as potential antiplasmodial and antimalarial agents

, 2018; 18(2): 114-123.

Xin-Liang Hu, Chuan Gao, Zhi Xu, Ming-Liang Liu, Lian-Shun Feng and Guang-De Zhang*


DOI: 10.2174/1568026618666171215101158


Research Article

Structure-based virtual screening for the identification of high affinity compounds as potent VEGFR2 inhibitors for the treatment of renal cell carcinoma

, 2018; 18(25): 2174-2185.

Khushboo Sharma, Khushboo Patidar, Meer Asif Ali, Pravin Patil, Himshikha Goud, Tajamul Hussain, Anuraj Nayarisseri* and Sanjeev Kumar Singh*


DOI: 10.2174/1568026619666181130142237


Review Article

Learning from nature: Bioinspired strategies towards antimicrobial nanostructured systems

, 2018; 18(1): 22-41.

Giuseppe Vitiello, Brigida Silvestri and Giuseppina Luciani*


DOI: 10.2174/1568026618666180206101129


Review Article

Current status and future prospects of small–molecule protein–protein interaction (PPI) inhibitors of tumor necrosis factor (TNF) and receptor activator of NF-κB ligand (RANKL)

, 2018; 18(8): 661-673.

Georgia Melagraki, Georgios Leonis, Evangelos Ntougkos, Vagelis Rinotas, Christos Papaneophytou, Thomas Mavromoustakos, George Kontopidis, Eleni Douni, George Kollias* and Antreas Afantitis*


DOI: 10.2174/1568026618666180607084430


Review Article

Cyclic peptides that govern signal transduction pathways: From prokaryotes to multi-cellular organisms

, 2018; 18(7): 625-644.

Ryan W. Mull , Anthony Harrington, Lucia A. Sanchez and Yftah Tal-Gan*


DOI: 10.2174/1568026618666180518090705


Review Article

Targeting sugar uptake and metabolism for cancer identification and therapy: An overview

, 2018; 18(6): 467-483.

Marina Tanasova*, Vagarshak V. Begoyan and Lukasz J. Weselinski


DOI: 10.2174/1568026618666180523110837



Research Article

New benzothiazole-based thiazolidinones as potent antimicrobial agents. Design, synthesis and biological evaluation

, 2018; 18(1): 75-87.

Michelyne Haroun*, Christophe Tratrat, Katerina Kositzi, Evangelia Tsolaki, Anthi Petrou, Bandar Aldhubiab, Mahesh Attimarad, Sree Harsha, Athina Geronikaki*, Katharigatta N. Venugopala, Heba S. Elsewedy, Marina Sokovic, Jasna Glamoclija and Ana Ciric


DOI: 10.2174/1568026618666180206101814


Research Article

Structure-based virtual screening for the identification of high-affinity small molecule towards STAT3 for the clinical treatment of osteosarcoma

, 2018; 18(29): 2511-2526.

Ravina Khandelwal, Aashish Pratap Singh Chauhan, Swarnima Bilawat, Aishwarya Gandhe, Tajamul Hussain, Elizabeth Anne Hood, Anuraj Nayarisseri* and Sanjeev Kumar Singh*


DOI: 10.2174/1568026618666181115092001


Review Article

Tetramethoxyluteolin for the treatment of neurodegenerative diseases

, 2018; 18(21): 1872-1882.

Theoharis C. Theoharides* and Irene Tsilioni


DOI: 10.2174/1568026617666181119154247



Most Accessed Articles




Paracoccidioides spp. and Histoplasma capsulatum: Current and New Perspectives for Diagnosis and Treatment

, 2018; 18(15): 1333-1348.

C.P. Taborda*, R. Buccheri, G. Benard, A.N. Duarte-Neto, J.D. Nosanchuk and L.R. Travassos


DOI: 10.2174/1568026618666181002112231


3D-QSAR in Drug Design - A Review

, 2010; 10(1): 95-115.

Jitender Verma, Vijay M. Khedkar and Evans C. Coutinho


DOI: 10.2174/156802610790232260



Genetic Mechanisms of Antibiotic Resistance and the Role of Antibiotic Adjuvants

, 2018; 18(1): 42-74.

Daniela Santos Pontes, Rodrigo Santos Aquino de Araujo, Natalina Dantas, Luciana Scotti , Marcus Tullius Scotti, Ricardo Olimpio de Moura and Francisco Jaime Bezerra Mendonca-Junior *


DOI: 10.2174/1568026618666180206095224




Recent Advances in Prostate-Specific Membrane Antigen-Based Radiopharmaceuticals

, 2019; 19(1): 33-56.

Wei Diao, Huawei Cai, Lihong Chen, Xi Jin, Xinyang Liao and Zhiyun Jia*


DOI: 10.2174/1568026619666190201100739




Editor-in-Chief

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
USA

Biography View Full Editorial Board

Journal History

Current Topics in Medicinal Chemistry was introduced in 2001 with the assistance of Dr. Allen B. Reitz, who is the current Editor-in-Chief serving since 2001.
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Scopus CiteScore Metrics: 1.24


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