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Current Topics in Medicinal Chemistry

Volume 19, 32 Issues, 2019
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

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  • 18th of 59 in

    Chemistry, Medicinal

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Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Current Topics in Medicinal Chemistry

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Volume 19

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Number 5



Editorial   Open Access



Review Article

Prediction of Drug-Drug Interactions Related to Inhibition or Induction of Drug-Metabolizing Enzymes

, 19(5): 319 - 336

Alexander V. Dmitriev*, Alexey A. Lagunin, Dmitry А. Karasev, Anastasia V. Rudik, Pavel V. Pogodin, Dmitry A. Filimonov and Vladimir V. Poroikov


DOI: 10.2174/1568026619666190123160406


Review Article



Research Article

Design, Synthesis, Evaluation of Antimicrobial Activity and Docking Studies of New Thiazole-based Chalcones

, 19(5): 356 - 375

Christophe Tratrat*, Michelyne Haroun, Iakovos Xenikakis, Konstantinos Liaras, Evangelia Tsolaki, Phaedra Eleftheriou, Anthi Petrou, Bandar Aldhubiab, Mahesh Attimarad, Katharigatta N. Venugopala, Sree Harsha, Heba S. Elsewedy, Athina Geronikaki* and Marina Soković


DOI: 10.2174/1568026619666190129121933


Research Article

Synthesis and In Vitro Enzymatic Studies of New 3-Aryldiazenyl Indoles as Promising Helicobacter pylori IMPDH Inhibitors

, 19(5): 376 - 382

Sachin Jangra, Gayathri Purushothaman , Kapil Juvale , Srimadhavi Ravi , Aishwarya Menon , Vijay Thiruvenkatam and Sivapriya Kirubakaran*


DOI: 10.2174/1568026619666190227212334


Research Article



Articles Ahead of Print




Synthesis and Antibacterial Activity of Mefloquine-Based Analogs Against Sensitive and Resistant Mycobacterium tuberculosis Strains


Adriele da Silva Araújo , Adriana Marques Moraes, Maria Cristina S. Lourenço, Cláudia O. Pessoa, Emerson Teixeira da Silva and Marcus Vinícius Nora de Souza*


View Abstract View on PubMed



Tryptanthrin Analogues as Inhibitors of Enoyl-acyl Carrier Protein Reductase: Activity against Mycobacterium tuberculosis, Toxicity, Modeling of Enzyme Binding


Gheorghe H Duca, Serghei Pogrebnoi, Veaceslav Boldescu, Fatma Aksakal, Andrei Uncu, Vladimir Valica, Livia Uncu, Simona Negreș, Florica Nicolescu and Fliur Macaev*


View Abstract View on PubMed


Targeting DNA Gyrase to Combat Mycobacterium tuberculosis: An Update


Swetarka Das, Tanu Garg, Nanduri Srinivas, Arunava Dasgupta and Sidharth Chopra*


View Abstract View on PubMed


Synthesis, Screening and Docking Analysis of Hispolon Pyrazoles and Isoxazoles as Potential Antitubercular Agents


Neduri V. Balaji, Bollikolla HariBabu*, Vanga Umamaheswara Rao, Gottumukkala V. Subbaraju, Kurre Purna Nagasree and Muthyala Murali Krishna Kumar*


View Abstract View on PubMed


An Overview on the Potential Antimycobacterial Agents Targeting Serine/Threonine Protein Kinases from Mycobacterium tuberculosis


Matteo Mori, José Camilla Sammartino, Luca Costantino, Arianna Gelain, Fiorella Meneghetti, Stefania Villa and Laurent Roberto Chiarelli


View Abstract View on PubMed


Protein-Protein Interaction and Aggregation Inhibitors in Alzheimer’s Disease


Ankit Ganeshpurkar, Rayala Swetha, Devendra Kumar, Gore Pravin Gangaram, Ravi Singh, Gopichand Gutti, Srabanti Jana, Dileep Kumar, Ashok Kumar and Sushil Kumar Singh*


View Abstract View on PubMed


Abstracts Ahead of Print



Comparative drug resistance reversal potential of natural glycosides Synergy potential of niaziridin&niazirin


Gaurav Raj Dwivedi, Anupam Maurya, Dharmendra Kumar Yadav, Feroz Khan, Mahendra Kumar Gupta, Prashant Gupta, Mahendra P. Darokar* and Santosh Kumar Srivastava*


View Abstract





Therapeutic Potential of Endophytic Compounds: A Special Reference to Drug Transporter Inhibitors


Khusbu Singh, Gaurav Raj Dwivedi*, A. Swaroop Sanket and Sanghamitra Pati


View Abstract


Pharmaceutical Interfering of Neddylation as Promising Treatments for Various Cancers


Lina Yin, Yuanyuan Xue, Qiannan Shang, Haichao Zhu, Meihua Liu, Yingxiang Liu and Qingzhong Hu*


View Abstract


Acid Ceramidase; A Novel Therapeutic Target in Cancer


Yadu Vijayan, Manendra Babu Lankadasari and Kuzhuvelil B. Harikumar*


View Abstract


An Overview of HDAC Inhibitors and their Synthetic Routes


Xiaopeng Peng, Guochao Liao, Pinghua Sun, Zhiqiang Yu and Jianjun Chen*


View Abstract


Editor's Choice

Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*


DOI: 10.2174/1568026618666180821145215




A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*


DOI: 10.2174/1568026618666180516123229




Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610






Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao


DOI: 10.2174/1568026618666180410151518



Aurora Kinase Inhibitors in Head and Neck Cancer

, 2018; 18(3): 199 - 213

Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang* and Yasusei Kudo*


DOI: 10.2174/1568026618666180112163741



Open Access Articles



Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*




Mechanical Properties of Composite Hydrogels for Tissue Engineering

, 2018; 18(14): 1214 - 1223

Ramon Rial, J.F. Armando Soltero, Pedro V. Verdes, Zhen Liu and Juan M. Ruso*





Analyzing of Molecular Networks for Human Diseases and Drug Discovery

, 2018; 18(12): 1007 - 1014

Tong Hao, Qian Wang, Lingxuan Zhao, Dan Wu, Edwin Wang* and Jinsheng Sun*




Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development

, 2018; 18(11): 883 - 895

Thomas Gross, Mark Mapstone, Ricardo Miramontes, Robert Padilla, Amrita K. Cheema, Fabio Macciardi, Howard J. Federoff* and Massimo S. Fiandaca*





Ubiquitin Proteasome System as a Potential Drug Target for Malaria

, 2018; 18(5): 315 - 320

Pedro H. Scarpelli Pereira, Chiara Curra and Celia R.S. Garcia*




Metabolomics Applications in Precision Medicine: An Oncological Perspective

, 2017; 17(24): 2740 - 2751

Leonor Puchades-Carrasco and Antonio Pineda- Lucena*




InsP3 Signaling in Apicomplexan Parasites

, 2017; 17(19): 2158 - 2165

Celia R.S. Garcia*, Eduardo Alves, Pedro H. S. Pereira, Paula J. Bartlett, Andrew P. Thomas, Katsuhiko Mikoshiba, Helmut Plattner and L. David Sibley









Most Cited Articles







Electronic Nose and Exhaled Breath NMR-based Metabolomics Applications in Airways Disease

, 2016; 16(14): 1610-1630.

Giuseppe Santini, Nadia Mores, Andreu Penas, Rosamaria Capuano, Chiara Mondino, Andrea Trové, Francesco Macagno, Gina Zini, Paola Cattani, Eugenio Martinelli, Andrea Motta, Giuseppe Macis, Giovanni Ciabattoni and Paolo Montuschi


DOI: 10.2174/1568026616666151223113540


Targeting Insulin Signaling for the Treatment of Alzheimer's Disease

, 2016; 16(5): 485-492.

Yanxing Chen, Jianfang Zhang, Baorong Zhang and Cheng-Xin Gong


DOI: 10.2174/1568026615666150813142423






Most Accessed Articles



Paracoccidioides spp. and Histoplasma capsulatum: Current and New Perspectives for Diagnosis and Treatment

, 2018; 18(15): 1333-1348.

C.P. Taborda*, R. Buccheri, G. Benard, A.N. Duarte-Neto, J.D. Nosanchuk and L.R. Travassos


DOI: 10.2174/1568026618666181002112231


3D-QSAR in Drug Design - A Review

, 2010; 10(1): 95-115.

Jitender Verma, Vijay M. Khedkar and Evans C. Coutinho


DOI: 10.2174/156802610790232260




Genetic Mechanisms of Antibiotic Resistance and the Role of Antibiotic Adjuvants

, 2018; 18(1): 42-74.

Daniela Santos Pontes, Rodrigo Santos Aquino de Araujo, Natalina Dantas, Luciana Scotti , Marcus Tullius Scotti, Ricardo Olimpio de Moura and Francisco Jaime Bezerra Mendonca-Junior *


DOI: 10.2174/1568026618666180206095224







Editor-in-Chief

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
USA

Journal History

Current Topics in Medicinal Chemistry was introduced in 2001 with the assistance of Dr. Allen B. Reitz, who is the current acting Editor-in-Chief since 2001.
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Scopus CiteScore Metrics: 2.97


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