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Drug Metabolism Letters

Volume 14, 3 Issues, 2021
ISSN: 1874-0758 (Online)
ISSN: 1872-3128 (Print)
This journal supports open access

Aims & Scope

Drug Metabolism Letters publishes letters, original research articles, mini-reviews, thematic issues based on mini-reviews and letters, commentaries, technical notes and drug clinical trial studies on major advances in all areas of drug metabolism and disposition.

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; bioactivation; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.

Drug Metabolism Letters


Volume 13


Number 2

Research Article   Open Access

Imatinib Uptake into Cells is Not Mediated by Organic Cation Transporters OCT1, OCT2, or OCT3, But is Influenced by Extracellular pH

, 13(2): 102 - 110

Jaurès B. Mettral, Nicolas Faller, Sandra Cruchon, Loïc Sottas, Thierry Buclin, Laurent Schild, Eva Choong, Aimable Nahimana and Laurent A. Decosterd*

DOI: 10.2174/1872312813666190207150207

Research Article   Open Access

Drug Metabolism Letters, Volume 14 (2021) - Number 1

This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

There are currently no Articles Ahead of Print available for this journal.

Abstracts Ahead of Print

Editor's Choice

Open Access Articles

Pharmacokinetics of Darolutamide, its Diastereomers and Active Metabolite in the Mouse: Response to Saini NK et al. (2020)

, 2021; 14(1): 9 - 16

Pirjo Nykänen, Timo Korjamo, Hille Gieschen, Christian Zurth and Mikko Koskinen*

The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS

, 2019; 13(2): 111 - 122

Dongmei Zhou*, Lifang Sun, Mai Nguyen, Li- Tain Yeh and David M. Wilson

Imatinib Uptake into Cells is Not Mediated by Organic Cation Transporters OCT1, OCT2, or OCT3, But is Influenced by Extracellular pH

, 2019; 13(2): 102 - 110

Jaurès Blanc Mettral, Nicolas Faller, Sandra Cruchon, Loïc Sottas, Thierry Buclin, Laurent Schild, Eva Choong, Aimable Nahimana and Laurent A. Decosterd*

Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS)

, 2019; 13(1): 53 - 63

Yildiz Yilmaz*, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krähenbühl and Gian Camenisch

“Branched Tail” Oxyquinoline Inhibitors of HIF Prolyl Hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip

, 2019; 13(1): 45 - 52

Andrey A. Poloznikov*, Sergey V. Nikulin, Arpenik A. Zakhariants, Anna Y. Khristichenko, Dmitry M. Hushpulian, Ildar N. Gazizov, Vladimir I. Tishkov and Irina G. Gazaryan

Transport of Bupropion and its Metabolites by the Model CHO and HEK293 Cell Lines

, 2019; 13(1): 25 - 36

Lyrialle W. Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao*

Using LC Retention Times in Organic Structure Determination: Drug Metabolite Identification

, 2018; 12(2): 93 - 100

William L. Fitch*, Cyrus Khojasteh, Ignacio Aliagas and Kevin Johnson

Most Cited Articles

Clinical Confirmation that the Selective JAK1 Inhibitor Filgotinib (GLPG0634) has a Low Liability for Drug-drug Interactions

, 2016; 10(1): 38-48.

Florence Namour*, Julie Desrivot, Annegret Van der Aa, Pille Harrison, Chantal Tasset and Gerben van`t Klooster

DOI: 10.2174/1872312810666151223103353

Utility of Pooled Cryopreserved Human Enterocytes as an In vitro Model for Assessing Intestinal Clearance and Drug-Drug Interactions

, 2018; 12(1): 3-13.

Susan Wong, Utkarsh Doshi, Peter Vuong, Ning Liu, Suzanne Tay, Hoa Le, Mika Kosaka, Jane R. Kenny, Albert P. Li and Zhengyin Yan*

DOI: 10.2174/1872312812666171213114422

Non-Clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats

, 2015; 9(2): 119-131.

Ben-Quan Shen, Daniela Bumbaca, Qin Yue, Ola Saad, Jay Tibbitts, S. Cyrus Khojasteh and Sandhya Girish

DOI: 10.2174/1872312809666150602151922

In Vitro Evaluation of Reversible and Time-Dependent Inhibitory Effects of Kalanchoe crenata on CYP2C19 and CYP3A4 Activities

, 2015; 9(1): 48-62.

Charles Awortwe, Vamshi K. Manda, Cristina Avonto, Shabana I. Khan, Ikhlas A. Khan, Larry A. Walker, Patrick J. Bouic and Bernd Rosenkranz

DOI: 10.2174/1872312809666150119110200

Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

, 2016; 10(2): 83-90.

Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni and Mehran F. Moghaddam

DOI: 10.2174/1872312810666160223121836

Genistein Affects Expression of Cytochrome P450 (CYP450) Genes in Hepatocellular Carcinoma (HEPG2/C3A) Cell Line

, 2018; 12(2): 138-144.

Sandra R. Lepri, Daniele Sartori, Simone C. Semprebon*, Adrivanio Baranoski, Giuliana C. Coatti and Mario S. Mantovani

DOI: 10.2174/1872312812666180709150440

Evaluation of Herb-Drug Interaction of Synacinn™ and Individual Biomarker through Cytochrome 450 Inhibition Assay

, 2018; 12(1): 62-67.

Nur Syukriah Ab Rahman, Fadzilah Adibah Abd Majid*, Mohd Effendy Abd Wahid, Ain Nabihah Zainudin, Siti Nurazwa Zainol, Hassan Fahmi Ismail, Tet Soon Wong, Nirbhay Kumar Tiwari, Sanjeev Giri and Vijaya Bhargava

DOI: 10.2174/1872312812666180314112457

Most Accessed Articles

Pharmacokinetics of Darolutamide in Mouse - Assessment of the Disposition of the Diastereomers, Key Active Metabolite and Interconversion Phenomenon: Implications to Cancer Patients

, 2021; 14(1): 54-65.

Neeraj K. Saini, Bhavesh B. Gabani, Umesh Todmal, Suresh P. Sulochana, Vinay Kiran, Mohd. Zainuddin, Narayanan Balaji, Sai B. Polina, Nuggehally R. Srinivas and Ramesh Mullangi*

DOI: 10.2174/1872312814666200521091236

Recent Progress in Prediction Systems for Drug-induced Liver Injury Using In Vitro Cell Culture

, 2021; 14(1): 25-40.

Shogo Ozawa*, Toshitaka Miura, Jun Terashima, Wataru Habano and Seiichi Ishida

DOI: 10.2174/1872312814666201202112610

Hemodynamic Assessment and in vivo Catabolism of Adenosine 5’-triphosphate in Doxorubicin or Isoproterenol-induced Cardiovascular Toxicity

, 2021; 14(1): 80-88.

Pollen K. Yeung*, Sheyda Mohammadizadeh, Fatemeh Akhoundi, Kelsey Mann, Remigius U. Agu and Thomas Pulinilkunnil

DOI: 10.2174/1872312814666201022103802

The Effect of Pomegranate Juice on the Expression of Some Murine UDP-Glucuronosyltransferases Genes

, 2021; 14(1): 89-93.

Yacoub M. Irshaid*, Ruba Alani, Razan Al-Rawashdeh, Tuqa Al-Ghazawi, Hiba Hijazi, Dana Amara, Amena Hammad, Zaineh M. Shahrure and Mohammad Al-Shhab

DOI: 10.2174/1872312814999201211203314


Zhiyang Zhao
Alliance Pharma
Malvern, PA
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Journal History

Drug Metabolism Letters was launched in 2007. Dr. Zhiyang Zhao serves as the Editor-in-Chief of the journal.

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