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Drug Metabolism Letters

Volume 14, 3 Issues, 2021
ISSN: 1874-0758 (Online)
ISSN: 1872-3128 (Print)
This journal supports open access

Aims & Scope

Drug Metabolism Letters publishes letters, original research articles, mini-reviews, thematic issues based on mini-reviews and letters, commentaries, technical notes and drug clinical trial studies on major advances in all areas of drug metabolism and disposition.

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; bioactivation; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.

Drug Metabolism Letters

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Volume 14

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Number 2



Biography   Open Access

















Articles Ahead of Print

There are currently no Articles Ahead of Print available for this journal.

Abstracts Ahead of Print

The catalytic activity of GSTM1 in vitro is independent of MAPK8


Shannon Robin, Khalil Ben-Hassine, Simona Jurkovic Mlakar, Vid Mlakar, Marc Ansari* and Chakradhara Rao S Uppugunduri*


DOI: 10.2174/1872312814666211122164456
View Abstract


Analysis between Linagliptin and Azithromycin: In Vitro and In Vivo Interaction Study


Md. Didaruzzaman Sohel, Faisal Asif*, Tonmoy Kumar Mondal, Md. Helal Uddin Sumon and Md. Hassan Kawsar


DOI: 10.2174/1872312814666210910123056
View Abstract


Editor's Choice











Open Access Articles

Pharmacokinetics of Darolutamide, its Diastereomers and Active Metabolite in the Mouse: Response to Saini NK et al. (2020)

, 2021; 14(1): 9 - 16

Pirjo Nykänen, Timo Korjamo, Hille Gieschen, Christian Zurth and Mikko Koskinen*




Recent Progress in Prediction Systems for Drug-induced Liver Injury Using In vitro Cell Culture

, 2021; 14(1): 25 - 40

Shogo Ozawa*, Toshitaka Miura, Jun Terashima, Wataru Habano and Seiichi Ishida








The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS

, 2019; 13(2): 111 - 122

Dongmei Zhou*, Lifang Sun, Mai Nguyen, Li- Tain Yeh and David M. Wilson




Imatinib Uptake into Cells is Not Mediated by Organic Cation Transporters OCT1, OCT2, or OCT3, But is Influenced by Extracellular pH

, 2019; 13(2): 102 - 110

Jaurès Blanc Mettral, Nicolas Faller, Sandra Cruchon, Loïc Sottas, Thierry Buclin, Laurent Schild, Eva Choong, Aimable Nahimana and Laurent A. Decosterd*





Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS)

, 2019; 13(1): 53 - 63

Yildiz Yilmaz*, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krähenbühl and Gian Camenisch




“Branched Tail” Oxyquinoline Inhibitors of HIF Prolyl Hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip

, 2019; 13(1): 45 - 52

Andrey A. Poloznikov*, Sergey V. Nikulin, Arpenik A. Zakhariants, Anna Y. Khristichenko, Dmitry M. Hushpulian, Ildar N. Gazizov, Vladimir I. Tishkov and Irina G. Gazaryan






Transport of Bupropion and its Metabolites by the Model CHO and HEK293 Cell Lines

, 2019; 13(1): 25 - 36

Lyrialle W. Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao*






Most Cited Articles

Research Article

Comparison of rat and human pulmonary metabolism using precision-cut lung slices (PCLS)

, 2019; 13(1): 53-63.

Yildiz Yilmaz*, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krähenbühl and Gian Camenisch


DOI: 10.2174/1872312812666181022114622


Research Article

Imatinib uptake into cells is not mediated by organic cation transporters OCT1, OCT2, or OCT3, but is influenced by extracellular pH

, 2019; 13(2): 102-110.

Jaurès B. Mettral, Nicolas Faller, Sandra Cruchon, Loïc Sottas, Thierry Buclin, Laurent Schild, Eva Choong, Aimable Nahimana and Laurent A. Decosterd*


DOI: 10.2174/1872312813666190207150207


Research Article

“Branched tail” oxyquinoline inhibitors of HIF prolyl hydroxylase: Early evaluation of toxicity and metabolism using liver-on-a-chip

, 2019; 13(1): 45-52.

Andrey A. Poloznikov*, Sergey V. Nikulin, Arpenik A. Zakhariants, Anna Y. Khristichenko, Dmitry M. Hushpulian, Ildar N. Gazizov, Vladimir I. Tishkov and Irina G. Gazaryan


DOI: 10.2174/1872312813666181129100950





Research Article

Transport of bupropion and its metabolites by the model CHO and HEK293 cell lines

, 2019; 13(1): 25-36.

Lyrialle W. Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao*


DOI: 10.2174/1872312813666181129101507



Systematic Review Article

Major cyp450 polymorphism among saudi patients

, 2021; 14(1): 17-24.

Ahmad A. Almeman*


DOI: 10.2174/1872312814666200722122232




Letter Article

Pharmacokinetics of darolutamide, its diastereomers and active metabolite in the mouse: Response to saini nk et al. (2020)

, 2021; 14(1): 9-16.

Pirjo Nykänen, Timo Korjamo, Hille Gieschen, Christian Zurth and Mikko Koskinen*


DOI: 10.2174/1872312814666201112121129


Opinion Article

A short exploration of selected sensitive cyp3a4 substrates (Probe drug)

, 2021; 14(1): 2-4.

Sarvesh Sabarathinam and Thangavel M. Vijayakumar*


DOI: 10.2174/1872312814666200811110024


Research Article

Pharmacokinetics of darolutamide in mouse - assessment of the disposition of the diastereomers, key active metabolite and interconversion phenomenon: Implications to cancer patients

, 2021; 14(1): 54-65.

Neeraj K. Saini, Bhavesh B. Gabani, Umesh Todmal, Suresh P. Sulochana, Vinay Kiran, Mohd. Zainuddin, Narayanan Balaji, Sai B. Polina, Nuggehally R. Srinivas and Ramesh Mullangi*


DOI: 10.2174/1872312814666200521091236




Most Accessed Articles




Pharmacokinetics of Darolutamide in Mouse - Assessment of the Disposition of the Diastereomers, Key Active Metabolite and Interconversion Phenomenon: Implications to Cancer Patients

, 2021; 14(1): 54-65.

Neeraj K. Saini, Bhavesh B. Gabani, Umesh Todmal, Suresh P. Sulochana, Vinay Kiran, Mohd. Zainuddin, Narayanan Balaji, Sai B. Polina, Nuggehally R. Srinivas and Ramesh Mullangi*


DOI: 10.2174/1872312814666200521091236


Recent Progress in Prediction Systems for Drug-induced Liver Injury Using In vitro Cell Culture

, 2021; 14(1): 25-40.

Shogo Ozawa*, Toshitaka Miura, Jun Terashima, Wataru Habano and Seiichi Ishida


DOI: 10.2174/1872312814666201202112610






The Effect of Pomegranate Juice on the Expression of Some Murine UDP-Glucuronosyltransferases Genes

, 2021; 14(1): 89-93.

Yacoub M. Irshaid*, Ruba Alani, Razan Al-Rawashdeh, Tuqa Al-Ghazawi, Hiba Hijazi, Dana Amara, Amena Hammad, Zaineh M. Shahrure and Mohammad Al-Shhab


DOI: 10.2174/1872312814999201211203314


Hemodynamic Assessment and In vivo Catabolism of Adenosine 5’-triphosphate in Doxorubicin or Isoproterenol-induced Cardiovascular Toxicity

, 2021; 14(1): 80-88.

Pollen K. Yeung*, Sheyda Mohammadizadeh, Fatemeh Akhoundi, Kelsey Mann, Remigius U. Agu and Thomas Pulinilkunnil


DOI: 10.2174/1872312814666201022103802



Pharmacokinetics Parameters of Diagoxin among Saudi Patients in Qassim Region, Saudi Arabia

, 2021; 14(2): 137-140.

Abdulaziz S. Allihimy, Ahmad A. Almeman*, Nassar A. Alnassar and Jihad Almadhi


DOI: 10.2174/1872312814666210506121637






Editor-in-Chief

graphic
Zhiyang Zhao
Alliance Pharma
Malvern, PA
(USA)
Biography
View Full Editorial Board

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Journal History

Drug Metabolism Letters was launched in 2007. Dr. Zhiyang Zhao serves as the Editor-in-Chief of the journal.

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