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Endocrine, Metabolic & Immune Disorders - Drug Targets

Formerly: Current Drug Targets - Immune, Endocrine & Metabolic Disorders

Volume 22, 14 Issues, 2022
ISSN: 2212-3873 (Online)
ISSN: 1871-5303 (Print)
This journal supports open access

Aims & Scope

This journal is devoted to full-length/ mini-reviews and original articles based on experimental and clinical studies in the field of endocrine, metabolic, and immune disorders. Specific emphasis is placed on humoral and cellular targets for natural, synthetic, and genetically engineered drugs that enhance or impair endocrine, metabolic, and immune parameters and functions. Moreover, the topics related to the effects of food components and/or nutraceuticals on the endocrine-metabolic-immune axis and on microbiome composition are welcome. The journal’s scope also covers neuroendocrinology, reproductive endocrinology, hormone secretion, and their effects on different organs.

Endocrine, Metabolic & Immune Disorders - Drug Targets

,

Volume 22

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Number 7




Mini-Review Article

The Putative Adverse Effects of Bisphenol A on Autoimmune Diseases

, 22(7): 665 - 676

Kassem Sharif, Adam Kurnick, Louis Coplan, Matthew Alexander, Abdulla Watad, Howard Amital and Yehuda Shoenfeld*


DOI: 10.2174/1871530321666210210154309


Review Article

Endocrine-Disrupting Chemicals: Introduction to the Theme

, 22(7): 677 - 685

Giuseppe Lisco, Vito Angelo Giagulli, Michele Iovino, Edoardo Guastamacchia, Giovanni De Pergola and Vincenzo Triggiani*


DOI: 10.2174/1871530321666210413124425


Review Article

The Male Reproductive System and Endocrine Disruptors

, 22(7): 686 - 703

Mauro Giovanni Schiesaro*, Anna Maria Letizia Amato, Chiara Maneschi, Vincenzo Sciabica, Erika Pigatto and Marta Sanna


DOI: 10.2174/1871530321666211004100633


Review Article

Bone Disruption and Environmental Pollutants

, 22(7): 704 - 715

Raffaele Giannattasio*, Giuseppe Lisco, Vito Angelo Giagulli, Silvio Settembrini, Giovanni De Pergola, Edoardo Guastamacchia, Gaetano Lombardi and Vincenzo Triggiani*


DOI: 10.2174/1871530321666210118163538


Review Article

The Toxic Effects of Endocrine Disrupting Chemicals (EDCs) on Gut Microbiota: Bisphenol A (BPA) A Review

, 22(7): 716 - 727

Ioannis Alexandros Charitos*, Skender Topi, Roberto Gagliano-Candela, Emanuele De Nitto, Lorenzo Polimeno, Monica Montagnani and Luigi Santacroce


DOI: 10.2174/1871530322666220325114045


Review Article




Endocrine, Metabolic & Immune Disorders - Drug Targets, Volume 22 (2022) - Number 10


This issue is in progress but contains articles that are final and fully citable.

Endocrine, Metabolic & Immune Disorders - Drug Targets, Volume 22 (2022) - Number 9


This issue is in progress but contains articles that are final and fully citable.

Endocrine, Metabolic & Immune Disorders - Drug Targets, Volume 22 (2022) - Number 8


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Microbiome and Development of Ovarian Cancer


Aditi Dhingra, Divyani Sharma, Anuj Kumar, Shalini Singh and Pramod Kumar*


DOI: 10.2174/1871530322666220509034847
View Abstract View on PubMed


Splenic Gaucheroma Leading to Incidental Diagnosis of Gaucher Disease in a 46-Year-Old Man with a Rare GBA Mutation: A Case Report


İzzet Erdal*, Yılmaz Yıldız, Gizem Önal, Oktay Halit Aktepe, Selin Ardalı Düzgün, Arzu Sağlam, Serap Dökmeci(Emre) and Hatice Serap Sivri


DOI: 10.2174/1871530322666220420134935
View Abstract View on PubMed




Nurse-led and Interdisciplinary Secondary Cardiovascular Prevention Programmes: Spanish Cohort of the EUROACTION Project


Cristina Buigues*, Isabel Trapero, Jose Antonio Velasco, Antonio Salvador-Sanz, Catriona Jennings, David Wood and Ana Queralt


DOI: 10.2174/1871530322666220331154354
View Abstract View on PubMed



The Role of Inflammatory and Cytokine Biomarkers in the Pathogenesis of Frailty Syndrome


Rashid Mir*, Chandan K. Jha, Naina Khullar, Mohsin Maqbool, Pradeep K. Dabla, Suruchi Mathur, Amal Moustafa, Uzma A. Faridi, Abdullah Hamadi, Mohammad Muzaffar Mir and Faisel M Abu Duhier


DOI: 10.2174/1871530322666220304220522
View Abstract View on PubMed


Neuroendocrine Modulation of Food Intake and Eating Behavior


Michele Iovino, Tullio Messana, Giuseppe Lisco, Francesco Mariano, Vito Angelo Giagulli, Edoardo Guastamacchia, Giovanni De Pergola and Vincenzo Triggiani*


DOI: 10.2174/1871530322666220127114326
View Abstract View on PubMed


Bilirubin and Epigenetic Modifications in Metabolic and Immunometabolic Disorders


Mostafa Moradi Sarabi, Esmaeel Babaeenezhad, Maral Amini, Mozhgan Kaviani and Fakhraddin Naghibalhossaini*


DOI: 10.2174/1871530321666211125102924
View Abstract View on PubMed



Abstracts Ahead of Print

Tranexamic Acid and Plasminogen/Plasmin Glaring Paradox in COVID-19


Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Nasser A. Hadi Al-Harcan, Athanasios Alexiou* and Gaber El-Saber Batiha*


DOI: 10.2174/1871530322666220801102402
View Abstract


Neuroimmune Dysregulation in Prepubertal and Adolescent Individuals Affected by Klinefelter Syndrome


Luigi T arani, Flavio Maria Ceci, Valentina Carito, Giampiero Ferraguti, Carla Petrella, Antonio Greco, Massimo Ralli, Antonio Minni, Matteo Spaziani, Andrea M. Isidori, Maria Grazia Di Certo, Christian Barbato, Carolina Putotto and Marco Fiore*


DOI: 10.2174/1871530322666220704101310
View Abstract






The Protective Role of Grape Seed in Obesity and Lipid Profile: An Updated Narrative Overview of Preclinical and Clinical Studies


Marjan Talebi, Hadi Esmaeeli, Selen İlgün, Mohsen Talebi, Tahereh Farkhondeh, Gaurav Mishra and Saeed Samarghandian*


DOI: 10.2174/1871530322666220630091859
View Abstract


Subversion of the Oral Microbiota and Induction of Immune-Mediated Systemic Inflammation with Special Reference to Periodontitis. Current Knowledge and Perspectives


Luigi Santacroce*, Eleonora Lo Muzio*, Lucrezia Bottalico, Francesca Spirito, Ioannis Alexandros Charitos, Pier Carmine Passarelli and Emilio Jirillo


DOI: 10.2174/1871530322666220629101357
View Abstract



Correlation between Vitamin B12 Deficiency and Autoimmune Thyroid Diseases


Tinatin Kacharava*, Elene Giorgadze, Shota Janjgava, Nino Lomtadze and Taboridze Iamze


DOI: 10.2174/1871530322666220627145635
View Abstract


Published Contents

Editor's Choice



Can Cytokines be used as an Activation Marker in Rheumatoid Arthritis?

, 2021; 21(8): 1459 - 1465

Fatih Öner Kaya, Yeşim Ceylan, Belkız Öngen İpek, Zeynep Güneş Özünal, Gülbüz Sezgin and Selim Nalbant*


DOI: 10.2174/1871530320666201019115030



Benfotiamine Reduces Dendritic Cell Inflammatory Potency

, 2021; 21(7): 1344 - 1351

Neda Djedovic, Iva Božić, Đorđe Miljković* and Irena Lavrnja


DOI: 10.2174/1871530320999200905114135



Acute Versus Chronic Administration of Calcineurin-Inhibitors Differentially Affect T-Cell Function

, 2021; 21(6): 1083 - 1089

Julia Kirchhof, Benjamin Wilde*, Justine Schmidt, Nils Mülling, Liubov Petrakova, Alexandra Brinkhoff, Manfred Schedlowski and Oliver Witzke


DOI: 10.2174/1871530320999200831161710



The Effects of Pemafibrate in Japanese Patients with Type 2 Diabetes Receiving HMG-CoA Reductase Inhibitors

, 2021; 21(5): 919 - 924

Masataka Kusunoki*, Takahiko Sakazaki, Kazuhiko Tsutsumi, Tetsuro Miyata and Yoshiharu Oshida


DOI: 10.2174/1871530320999200818135553



Downregulation of miR-140 is Correlated with Poor Prognosis and Progression of Thyroid Cancer

, 2021; 21(4): 749 - 755

Qianqian Yu, Wenhai Sun, Hui Hua, Yulian Chi, Xiaomin Liu, Anbing Dong, Yinghe Sun, Jianhua Zhang and Ge Guan*


DOI: 10.2174/1871530320666200724180742



T Cell Proliferative Responses and IgG Antibodies to β2GPI in Patients with Diabetes and Atherosclerosis

, 2021; 21(3): 495 - 503

Mohammad R. Monjezi, Hamed Fouladseresht, Shirin Farjadian, Behrouz Gharesi-Fard, Shahdad Khosropanah and Mehrnoosh Doroudchi*


DOI: 10.2174/1871530320666200505115850



Positive Correlation between Circulating Fetuin-A and Severity of Coronary Artery Disease in Men

, 2021; 21(2): 338 - 344

Reza Afrisham, Maliheh Paknejad, Davod Ilbeigi, Sahar Sadegh-Nejadi, Sattar Gorgani-Firuzjaee* and Mahmoud Vahidi*


DOI: 10.2174/1871530320666200601164253




Open Access Articles

The Skeletal Effects of Gonadotropin-Releasing Hormone Antagonists: A Concise Review

, 2021; 21(10): 1713 - 1720

Nur-Vaizura Mohamad, Soelaiman Ima-Nirwana and Kok-Yong Chin*




How Much Vitamin D is Too Much? A Case Report and Review of the Literature

, 2021; 21(9): 1653 - 1659

Sara De Vincentis*, Antonino Russo, Marta Milazzo, Amedeo Lonardo, Maria C. De Santis, Vincenzo Rochira, Manuela Simoni and Bruno Madeo




False Positive of <sup>68</sup>Ga-DOTATATE PET-CT in a Paraganglioma

, 2021; 21(7): 1352 - 1355

Benedetta Zampetti, Roberto Attanasio*, Marco Boniardi and Renato Cozzi




Effects of a Low Carb Diet and Whey Proteins on Anthropometric, Hematochemical, and Cardiovascular Parameters in Subjects with Obesity

, 2020; 20(10): 1719 - 1725

Giovanni De Pergola*, Roberta Zupo, Luisa Lampignano, Silvia Paradiso, Isanna Murro, Annagrazia Cecere, Nicola Bartolomeo, Marco M. Ciccone, Gianluigi Giannelli and Vincenzo Triggiani





The Association between Peripheral Blood Cells and the Frailty Syndrome in Patients with Cardiovascular Diseases

, 2020; 20(9): 1419 - 1433

Constantin Bodolea, Elisabeta I. Hiriscau*, Elena-Cristina Buzdugan, Alin I. Grosu, Laurențiu Stoicescu, Ștefan Vesa and Omar Cauli




Italian Association of Clinical Endocrinologists (AME) and Italian AACE Chapter Position Statement for Clinical Practice: Acromegaly - Part 2: Therapeutic Issues

, 2020; 20(8): 1144 - 1155

Renato Cozzi*, Maria R. Ambrosio, Roberto Attanasio, Alessandro Bozzao, Laura De Marinis, Ernesto De Menis, Edoardo Guastamacchia, Andrea Lania, Giovanni Lasio, Francesco Logoluso, Pietro Maffei, Maurizio Poggi, Vincenzo Toscano, Michele Zini, Philippe Chanson and Laurence Katznelson




Italian Association of Clinical Endocrinologists (AME) and Italian AACE Chapter Position Statement for Clinical Practice: Acromegaly - Part 1: Diagnostic and Clinical Issues

, 2020; 20(8): 1133 - 1143

Renato Cozzi*, Maria R. Ambrosio, Roberto Attanasio, Alessandro Bozzao, Laura De Marinis, Ernesto De Menis, Edoardo Guastamacchia, Andrea Lania, Giovanni Lasio, Francesco Logoluso, Pietro Maffei, Maurizio Poggi, Vincenzo Toscano, Michele Zini, Philippe Chanson and Laurence Katznelson




Exercise and Stevia Rebaudiana (R) Extracts Attenuate Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms

, 2020; 20(7): 1117 - 1132

Abdelaziz M. Hussein*, Elsayed A. Eid, Ismaeel Bin-Jaliah, Medhat Taha and Lashin S. Lashin




Insulin Resistance in Apolipoprotein M Knockout Mice is Mediated by the Protein Kinase Akt Signaling Pathway

, 2020; 20(5): 771 - 780

Shuang Yao, Jun Zhang, Yuxia Zhan, Yuanping Shi, Yang Yu, Lu Zheng, Ning Xu* and Guanghua Luo*




Future Perspective of Diabetic Animal Models

, 2020; 20(1): 25 - 38

Shashank Pandey and Magdalena C. Dvorakova*




Pioglitazone Therapy and Fractures: Systematic Review and Meta- Analysis

, 2018; 18(5): 502 - 507

Velichka Pavlova*, Elena Filipova, Katya Uzunova, Krassimir Kalinov and Toni Vekov




Italian Association of Clinical Endocrinologists (AME) and Italian AACE Chapter Position Statement for Clinical Practice: Assessment of Response to Treatment and Follow-Up in Gastroenteropancreatic Neuroendocrine Neoplasms

, 2018; 18(5): 419 - 449

Franco Grimaldi*, Nicola Fazio*, Roberto Attanasio, Andrea Frasoldati, Enrico Papini, Nadia Cremonini, Maria V. Davi, Luigi Funicelli, Sara Massironi, Francesca Spada, Vincenzo Toscano, Annibale Versari, Michele Zini, Massimo Falconi and Kjell Oberg




Shift from Levothyroxine Tablets to Liquid Formulation at Breakfast Improves Quality of Life of Hypothyroid Patients

, 2018; 18(3): 235 - 240

Rinaldo Guglielmi, Franco Grimaldi, Roberto Negro, Andrea Frasoldati, Irene Misischi, Filomena Graziano, Claudia Cipri, Edoardo Guastamacchia, Vincenzo Triggiani* and Enrico Papini




GH Supplementation Effects on Cardiovascular Risk in GH Deficient Adult Patients: A Systematic Review and Meta-analysis

, 2017; 17(4): 285 - 296

Vito A. Giagulli*, Marco Castellana, Raffaella Perrone, Edoardo Guastamacchia, Massimo Iacoviello and Vincenzo Triggiani





Most Cited Articles


Research Article

Probiotics efficacy on oxidative stress values in inflammatory bowel disease: A randomized double-blinded placebo-controlled pilot study

, 2019; 19(3): 373-381.

Andrea Ballini, Luigi Santacroce*, Stefania Cantore, Lucrezia Bottalico, Gianna Dipalma, Skender Topi, Rajiv Saini, Danila De Vito and Francesco Inchingolo


DOI: 10.2174/1871530319666181221150352



Research Article

Hypoglycemic and hypolipemic effects of a new lecithin formulation of bergamot polyphenolic fraction: A double blind, randomized, placebo- controlled study

, 2019; 19(2): 136-143.

Vincenzo Mollace*, Miriam Scicchitano, Sara Paone, Francesca Casale, Carla Calandruccio, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Jessica Maiuolo, Saverio Nucera, Antonella Riva, Pietro Allegrini, Massimo Ronchi, Giovanna Petrangolini and Ezio Bombardelli


DOI: 10.2174/1871530319666181203151513


Review Article

BPA and nutraceuticals, simultaneous effects on endocrine functions

, 2019; 19(5): 594-604.

Stefania D'Angelo, Marika Scafuro and Rosaria Meccariello*


DOI: 10.2174/1871530319666190101120119


Clinical Trial

The neuromodulatory effects of ω-3 fatty acids and nano-curcumin on the COX-2/ iNOS network in migraines: A clinical trial study from gene expression to clinical symptoms

, 2019; 19(6): 874-884.

Mina Abdolahi, Arash Jafarieh, Payam Sarraf, Mohsen Sedighiyan, Abolghasem Yousefi, Abbas Tafakhori, Hamed Abdollahi, Farahnaz Salehinia and Mahmoud Djalali*


DOI: 10.2174/1871530319666190212170140


Research Article

Evaluation of TG-HDL ratio instead of HOMA ratio as insulin resistance marker in overweight and children with obesity

, 2019; 19(5): 676-682.

Eman G. Behiry*, Nazih Mohamed El Nady, Omima M. AbdEl Haie, May Kamel Mattar and Amira Magdy


DOI: 10.2174/1871530319666190121123535


Research Article

Predictors for fibrosis regression in chronic HCV patients after the treatment with DAAS: Results of a real-world cohort study

, 2020; 20(1): 104-111.

Hanan Soliman, Dina Ziada, Marwa Salama, Manal Hamisa, Rehab Badawi, Nehad Hawash, Amal Selim and Sherief Abd-Elsalam*


DOI: 10.2174/1871530319666190826150344


General Research Article

25 hydroxyvitamin D levels are negatively and independently associated with fat mass in a cohort of healthy overweight and obese subjects

, 2019; 19(6): 838-844.

Giovanni De Pergola*, Tommaso Martino, Roberta Zupo, Domenico Caccavo, Claudio Pecorella, Silvia Paradiso, Franco Silvestris and Vincenzo Triggiani


DOI: 10.2174/1871530319666190122094039


Research Article

Anti-cancerous effect of rutin against HPV-C33A cervical cancer cells via g0/g1 cell cycle arrest and apoptotic induction

, 2020; 20(3): 409-418.

Fahad Khan, Pratibha Pandey*, Tarun K. Upadhyay, Asif Jafri, Niraj K. Jha, Rashmi Mishra and Vineeta Singh


DOI: 10.2174/1871530319666190806122257


General Research Article

Elucidation of the chemopreventive role of stigmasterol against Jab1 in gall bladder carcinoma

, 2019; 19(6): 826-837.

Pratibha Pandey, Preeti Bajpai*, Mohammad H. Siddiqui, Uzma Sayyed, Rohit Tiwari, Rafia Shekh, Kumudesh Mishra and V.K. Kapoor


DOI: 10.2174/1871530319666190206124120


Review Article (Mini-Review)

Quality of life in individuals with diabetic foot syndrome

, 2020; 20(9): 1365-1372.

Emmanuel Navarro-Flores and Omar Cauli*


DOI: 10.2174/1871530320666200128154036



Research Article

Overexpression of hepassocin in diabetic patients with nonalcoholic fatty liver disease may facilitate increased hepatic lipid accumulation

, 2019; 19(2): 185-188.

Ghada Abdelmoemen, Samy Abdelkader Khodeir, Ahmed Nabil Zaki, Maha Kassab, Sabry Abou-Saif and Sherief Abd-Elsalam*


DOI: 10.2174/1871530318666180716100543


Research Article

Sex-specific association between serum uric acid and elevated alanine aminotransferase in a military cohort: The chief study

, 2019; 19(3): 333-340.

Jia-Wei Lin, Kun-Zhe Tsai, Kai-Wen Chen, Fang-Ying Su, Yi-Hwei Li, Yen-Po Lin, Chih-Lu Han, Felicia Lin, Yu-Kai Lin, Chung-Bao Hsieh and Gen-Min Lin*


DOI: 10.2174/1871530319666181129163802



Most Accessed Articles

Rebalancing the Oral Microbiota as an Efficient Tool in Endocrine, Metabolic and Immune Disorders

, 2021; 21(5): 777-784.

Isacco, Ciro Gargiulo; Ballini, Andrea; De Vito, Danila; Kieu Cao Diem Nguyen; Cantore, Stefania; Bottalico, Lucrezia; Quagliuolo, Lucio; Boccellino, Mariarosaria; Di Domenico, Marina; Santacroce, Luigi; Arrigoni, Roberto; Dipalma, Gianna; Inchingolo, Francesco


DOI: 10.2174/1871530320666200729142504



A Review of AEG-1 Oncogene Regulating MicroRNA Expression in Colon Cancer Progression

, 2021; 21(1): 27-34.

Malayaperumal, Sarubala; Sriramulu, Sushmitha; Jothimani, Ganesan; Banerjee, Antara; Pathak, Surajit


DOI: 10.2174/1871530320666200618104116


Tanta Protocol for Management of COVID-19: Perspectives from a Devel- oping Country

, 2021; 21(10): 1775-1780.

Abd-Elsalam, Sherief; Esmail, Eslam Saber; Khalaf, Mai; El-Sarnagawy, Ghada N.; Shalaby, Shahinaz M.; Ghafar, Mohamed Samir Abd El; Elbahnasawy, Mohamed; Elfert, Asem; Soliman, Hanan; El-kalla, Ferial; Ghoneim, Ahmed


DOI: 10.2174/1871530320999201117142305






Clinical, Immunologic and Molecular Spectrum of Patients with Immunodeficiency, Centromeric Instability, and Facial Anomalies (ICF) Syndrome: A Systematic Review

, 2021; 21(4): 664-672.

Kiaee, Fatemeh; Zaki-Dizaji, Majid; Hafezi, Nasim; Almasi-Hashiani, Amir; Hamedifar, Haleh; Sabzevari, Araz; Shirkani, Afshin; Zian, Zeineb; Jadidi-Niaragh, Farhad; Aghamahdi, Fatemeh; Goudarzvand, Mahdi; Yazdani, Reza; Abolhassani, Hassan; Aghamohammadi, Asghar; Azizi, Gholamreza


DOI: 10.2174/1871530320666200613204426



Coronaviruses and Endocrine System: A Systematic Review on Evidence and Shadows

, 2021; 21(7): 1242-1251.

Parolin, Matteo; Parisotto, Matteo; Zanchetta, Francesca; Sartorato, Paola; De Menis, Ernesto


DOI: 10.2174/1871530320666200905123332



The Cannabis Spread throughout the Continents and its Therapeutic Use in History

, 2021; 21(3): 407-417.

Charitos, Ioannis A.; Gagliano-Candela, Roberto; Santacroce, Luigi; Bottalico, Lucrezia


DOI: 10.2174/1871530320666200520095900


Historical Anecdotes and Breakthroughs of Histamine: From Discovery to Date

, 2021; 21(5): 801-814.

Charitos, Ioannis A.; Castellaneta, Francesca; Santacroce, Luigi; Bottalico, Lucrezia


DOI: 10.2174/1871530320666200729150124


Theranostic Nanoparticles for Pancreatic Cancer Treatment

, 2021; 21(2): 203-214.

Jaidev, Leela R.; Chede, Laxmi S.; Kandikattu, Hemanth K.


DOI: 10.2174/1871530320666200516164911




Editor-in-Chief

graphic
Emilio Jirillo
Department of Basic Medical Sciences Neuroscience and Sensory Organs
University of Bari “Aldo Moro”
Bari
(Italy)
Biography
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