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Letters in Drug Design & Discovery

Volume 18, 12 Issues, 2021
ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
This journal supports open access

Aims & Scope

Letters in Drug Design & Discovery publishes letters, full-length/mini-reviews, research articles, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of the latest Internet technology for both the submission and review of manuscripts. The journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Letters in Drug Design & Discovery

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Volume 18

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Number 9













Letters in Drug Design & Discovery, Volume 18 (2021) - Number 12


This issue is in progress but contains articles that are final and fully citable.

Letters in Drug Design & Discovery, Volume 18 (2021) - Number 11


This issue is in progress but contains articles that are final and fully citable.

Letters in Drug Design & Discovery, Volume 18 (2021) - Number 10


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print











Published Contents

Editor's Choice

Synthesis of Chrysin, Quercetin and Naringin Nitroderivatives: Antiproliferative, Anti-inflammatory and Antioxidant Activity

, 2021; 18(8): 795 - 805

Rosario Tavera-Hernández, Manuel Jiménez-Estrada*, Jesús J. Alvarado-Sansininea, Antonio Nieto-Camacho, Hugo López-Muñoz, Luis Sánchez-Sánchez and María L. Escobar


DOI: 10.2174/1570180818666210122162313



Drug Repurposing Using Similarity-based Target Prediction, Docking Studies and Scaffold Hopping of Lefamulin

, 2021; 18(7): 733 - 743

Shikha Sharma, Shweta Sharma, Vaishali Pathak, Parwinder Kaur and Rajesh Kumar Singh*


DOI: 10.2174/1570180817999201201113712




Chitosan: A Promising Protective Component Against SARS-CoV-2 and Influenza Virus

, 2021; 18(5): 418 - 421

Mohammad Reza Rahbar, Hadi Esmaeili Gouvarchin Galeh, Saeed Khalili and Abolfazl Jahangiri*


DOI: 10.2174/1570180817999201110114446




Expanding Opportunities in Treatment of Leukemia by Solid Lipid Nanoparticles

, 2021; 18(3): 212 - 221

Prarthna Yadav, Harshita Mishra, Manju Nagpal and Geeta Aggarwal*


DOI: 10.2174/1570180817999201001155508



Sulfonamides and Sulphonyl Ester of Quinolines as Non-Acidic, Non- Steroidal, Anti-inflammatory Agents

, 2021; 18(2): 112 - 120

Bilquees Bano, Kanwal, Khalid Mohammed Khan*, Almas Jabeen, Aisha Faheem, Muhammad Taha, Syed Moazzam Haider and Shahnaz Perveen


DOI: 10.2174/1570180817999201005201308




Novel Coronavirus 2019 Outbreak: A Global Epidemic

, 2020; 17(12): 1458 - 1464

Sweta Kamboj*, Rohit Kamboj, Shikha Kamboj, Kumar Guarve and Rohit Dutt


DOI: 10.2174/1570180817999200802033916



Evaluation of Kaempferol as AKT Dependent mTOR Regulator via Targeting FKBP-12 in Hepatocellular Carcinoma: An In silico Approach

, 2020; 17(11): 1401 - 1408

Pooja Siniprasad, Bhagyalakshmi Nair, Vaisali Balasubramaniam, Prashanth Sadanandan, Puliyapally Krishnan Namboori* and Lekshmi Reghu Nath*


DOI: 10.2174/1570180817999200623115703



Open Access Articles






Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model

, 2020; 17(6): 787 - 798

Sara Melisa Arciniegas , Sergio Andres Saavedra , Danaé Balderas , Sara del Carmen Caballero, María Josefa Bernad, Julio Cesar Sánchez , María Isabel Gracia, Héctor Ariel Rico and Dinorah Vargas *




Identification of Phosphoinositide-3 Kinases Delta and Gamma Dual Inhibitors Based on the p110δ/γ Crystal Structure

, 2020; 17(6): 772 - 786

Wen-Qing Jia , Xiao-Yan Feng, Ya-Ya Liu , Zhen-Zhen Han , Zhi Jing, Wei-Ren Xu and Xian-Chao Cheng*




Synthesis of Spiro[cycloalkane-pyridazinones] with High Fsp3 Character

, 2020; 17(6): 731 - 744

Csilla Sepsey Für, Gergő Riszter, János Gerencsér, Áron Szigetvári, Miklós Dékány, László Hazai, György Keglevich and Hedvig Bölcskei*




Synthesis, Characterization, and Molecular Docking Studies of N-Acylated Butyro and Valerolactam Derivatives with Antiproliferative and Cytotoxic Activities

, 2020; 17(6): 725 - 730

Mark Tristan J. Quimque, Mark John P. Mandigma, Justin Allen K. Lim, Simon Budde, Hans-Martin Dahse, Oliver B. Villaflores, Arnold V. Hallare and Allan Patrick G. Macabeo*




Synthesis and Evaluation of Anticonvulsant Activities of 4-Phenylpiperidin- 2-one Derivatives

, 2020; 17(6): 713 - 724

Shi-Ben Wang*, Hui Liu, Guang-Yong Li, Kang Lei, Xiao-Jing Li, Zhe-Shan Quan and Xue-Kun Wang*




Mannitol Reduces Spinal Cord Edema in Rats with Acute Traumatic Spinal Cord Injury

, 2020; 17(6): 676 - 683

Chao Zhang, Anming Hu, Yingli Jing, Degang Yang* and Jianjun Li*




Azacyanines as Novel Topoisomerase II Alpha Inhibitors

, 2020; 17(5): 666 - 671

Sercan Guloglu, Fahriye Nur Kirmaci, Özgül Persil Çetinkol*, Mehrdad Forough and Aybuke Gulkaya




Microwave-assisted Synthesis and Docking Studies of Phenylureas as Candidates for the Drug Design Against the Biological Warfare Agent Yersinia Pestis

, 2020; 17(5): 633 - 639

Tanos Celmar Costa França*, Leonardo da Costa Bastos, Teobaldo Cuya, Mehdi Sirouspour, Franklin Chacón-Huete, David Bendahan and Pat Forgione*





Synthesis and Cytotoxicity of New Mannich Bases of 6-[3-(3,4,5-Trimetoxyphenyl)-2- propenoyl]-2(3H)-Benzoxazolone

, 2020; 17(4): 512 - 517

Ognyan Ivanov Petrov, Yordanka Borisova Ivanova*, Mariana Stefanova Gerova and Georgi Tsvetanov Momekov





Most Cited Articles

Research Article

Novel trifluoromethylpyrazole acyl thiourea derivatives: Synthesis, antifungal activity and docking study

, 2019; 16(7): 785-791.

Han Wang, Zhi-Wen Zhai, Yan-Xia Shi, Cheng-Xia Tan, Jian-Quan Weng, Liang Han, Bao-Ju Li and Xing-Hai Liu*


DOI: 10.2174/1570180815666180704103047


Research Article

Novel 1,3,4-oxadiazole fused thiadiazole derivatives: Synthesis and study of anticancer activities

, 2019; 16(6): 656-662.

Zanjam Spandana, Reddymasu Sreenivasulu, Tadigiri MalathiRekha and Mandava Venkata Basaveswara Rao*


DOI: 10.2174/1570180816666181031125946



Research Article

Design, synthesis and anti-tuberculosis activity of hydrazones and N-acylhydrazones containing vitamin B<inf>6</inf> and different heteroaromatic nucleus

, 2019; 16(7): 792-798.

Thais Cristina Mendonça Nogueira, Lucas dos Santos Cruz, Maria Cristina Lourenço and Marcus Vinicius Nora de Souza*


DOI: 10.2174/1570180815666180627122055


Research Article

Design, synthesis and cytotoxicity of novel coumarin-1,2,3-triazole-1,2,4-oxadiazole hybrids as potent anti-breast cancer agents

, 2019; 16(7): 818-824.

Maryam Mohammadi-Khanaposhtani, Kiana Fahimi, Elahe Karimpour-Razkenari, Maliheh Safavi, Mohammad Mahdavi, Mina Saeedi and Tahmineh Akbarzadeh*


DOI: 10.2174/1570180815666180627121006


Research Article

Synthesis, anti-proliferative evaluation, and molecular docking studies of 3-(Alkylthio)-5,6-diaryl-1,2,4-triazines as tubulin polymerization inhibitors

, 2019; 16(11): 1194-1201.

Farhad Saravani, Ebrahim Saeedian Moghadam, Hafezeh Salehabadi, Seyednasser Ostad, Morteza Pirali Hamedani, Massoud Amanlou, Mohammad Ali Faramarzi and Mohsen Amini*


DOI: 10.2174/1570180815666180727114216



Research Article

Antimicrobial activity, antioxidant properties and phytochemical screening of aesculus hippocastanum mother tincture against food-borne bacteria

, 2020; 17(1): 48-56.

Maria Grazia Bonomo*, Caterina Cafaro, Daniela Russo, Luana Calabrone, Luigi Milella, Carmela Saturnino, Anna Capasso and Giovanni Salzano


DOI: 10.2174/1570180816666181108114115


Research Article

Synthesis, characterization, free-radical scavenging capacity and antioxidant activity of novel series of hydrazone, 1,3,4-oxadiazole and 1,2,4-triazole derived from 3,5-dimethyl-1H-pyrazole

, 2019; 16(7): 712-720.

Khalid Karrouchi*, Saad Fettach, Smaail Radi*, El bekkaye Yousfi, Jamal Taoufik, Yahia Nasser Mabkhot, Seham Alterary, My El Abbes Faouzi and Muhammed Ansar


DOI: 10.2174/1570180815666180516103050


Research Article

(Substituted)-benzo[b]thiophene-4-carboxamide synthesis and antiproliferative activity study

, 2020; 17(5): 563-573.

Chandrakant Dhondiram Pawar, Dattatraya Navnath Pansare and Devanand Baburao Shinde*


DOI: 10.2174/1570180815666181004114125


Research Article

New 2-oxopyridine/2-thiopyridine derivatives tethered to a benzotriazole with cytotoxicity on MCF7 cell lines and with antiviral activities

, 2020; 17(2): 124-137.

Adel Mahmoud Attia, Ahmed Ibrahin Khodair*, Eman Abdelnasser Gendy, Mohammed Abu El-Magd and Yaseen Ali Mosa Mohamed Elshaier*


DOI: 10.2174/1570180816666190220123547



General Research Article

The development of tyrosyl-DNA phosphodyesterase 1 (TDP1) inhibitors based on the amines combining aromatic/heteroaromatic and monoterpenoid moieties

, 2019; 16(5): 597-605.

Evgenii Mozhaitsev, Evgenii Suslov*, Yuliya Demidova, Dina Korchagina, Konstantin Volcho, Alexandra Zakharenko, Inna Vasil'eva, Maksim Kupryushkin, Arina Chepanova, Daniel Moscoh Ayine-Tora, Jóhannes Reynisson, Nariman Salakhutdinov and Olga Lavrik


DOI: 10.2174/1570180816666181220121042


Review Article

Potential of nanoparticles in combating Candida infections

, 2019; 16(5): 478-491.

Faizan Abul Qais, Mohd Sajjad Ahmad Khan, Iqbal Ahmad* and Abdullah Safar Althubiani


DOI: 10.2174/1570180815666181015145224


General Research Article

Novel tri-substituted thiazoles bearing piperazine ring: Synthesis and evaluation of their anticancer activity

, 2019; 16(5): 547-555.

Asaf Evrim Evren*, Leyla Yurttaş , Busra Eksellı and Gulsen Akalın-Cıftcı


DOI: 10.2174/1570180815666180731122118



Most Accessed Articles


Rationale Design, Synthesis, and Pharmacological Evaluation of Isatin Analogues as Antiseizure Agents

, 2021; 18(12): 1146-1164.

Sandip Firke, Rameshwar Cheke , Vinod Ugale*, Saurabh Khadse , Manish Gagarani, Sanjay Bari and Sanjay Surana


DOI: 10.2174/1570180818666210804145014





Investigating the Mechanism of Action of Frankincense against Drug- Induced Liver Injury Using Network Pharmacology and Molecular Docking

, 2021; 18(10): 976-986.

Yu-cheng Liao, Jing-wen Wang, Qian Yang, Wen-jun Wanga, Chao Zhao, Lian Sun, Ai-dong Wen*, Rui-li Li* and Yi Ding*


DOI: 10.2174/1570180818666210319160217





Prediction of Inhibition Activity of BET Bromodomain Inhibitors using Grid Search-Based Extreme Learning Machine and Molecular Docking

, 2021; 18(11): 1039-1049.

Oluwatoba Emmanuel Oyeneyin*, Babatunde Samuel Obadawo, Segun Michael Orimoloye, Eric Oluwafisayo Akintemi, Nureni Ipinloju, Adeola M. Asere and Taoreed O. Owolabi


DOI: 10.2174/1570180818666210521215433


Computational Modeling of Aldose Reductase Inhibitory Activity of Flavonoids Derivatives for Diabetic Complications Treatment

, 2021; 18(11): 1094-1105.

Roberto Díaz-Amador, Yudith Cañizares-Carmenate, Alberto Taboada-Crispi and Juan A. Castillo-Garit*


DOI: 10.2174/1570180818666210604113206



3D-QSAR, Docking, and Molecular Dynamics Simulations Studies on Quinazoline Derivatives as PAK4 Inhibitors

, 2021; 18(11): 1025-1038.

Xiao-Zhong Chen, Chen Dai , Yan Shen, Juan Wang, Yong Hu, Yuan-Qiang Wang* and Zhi-Hua Lin*


DOI: 10.2174/1570180818666210602155310






Editor-in-Chief

graphic
Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo
(Italy)
Biography
View Full Editorial Board

Journal History

Letters in Drug Design & Discovery was introduced in 2004. Dr. Ivana Cacciatore serves as the Editor-in-Chief of the journal.

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