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Medicinal Chemistry

Volume 16, 8 Issues, 2020
ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)
This journal supports open access

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  • 31st of 61 in

    Chemistry, Medicinal

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Aims & Scope

Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, full-length/mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.

Medicinal Chemistry

,

Volume 16

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Number 1



Foreword   Free Content

Foreword

, 16(1): 1

Dimitra Hadjipavlou-Litina


DOI: 10.2174/157340641601191209150546


Biography   Free Content



Review Article   Free Content



Review Article   Free Content



Research Article   Free Content

Synthesis of New Cyclic Imides Derived From Safrole, Structure- and Ligand-based Approaches to Evaluate Potential New Multitarget Agents Against Species of Leishmania

, 16(1): 39 - 51

José A. de Sousa Luis*, Normando A. da Silva Costa, Cristiane C.S. Luis, Bruno F. Lira, Petrônio F. Athayde-Filho, Tatjana K. de Souza Lima, Juliana da Câmara Rocha, Luciana Scotti and Marcus T. Scotti*


DOI: 10.2174/1573406415666190430144950


Research Article   Free Content



Research Article   Free Content



Research Article   Free Content



Medicinal Chemistry, Volume 16 (2020) - Number 2


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print




Fluoroquinolone-3-carboxamide Amino Acid Conjugates: Synthesis, Antibacterial Properties And Molecular Modeling Studies


Riham M. Bokhtia, Siva S. Panda*, Adel S. Girgis, Hitesh H. Honkanadavar, Tarek S. Ibrahim, Amany M. M. Al-Mahmoudy, Riham F. George, Mona T. Kashef, Walid Fayad, Rajeev Sakhuja and Eatedal H. Abdel-Aal


DOI: 10.2174/1573406415666190904143852
View Abstract View on PubMed


Improvement of the Anticancer Activity of Chlorambucil and Ibuprofen via Calix[4]arene Conjugates


Luis D. Pedro-Hernández, Ulises Organista-Mateos, Luis Isaac Allende-Alarcón, Elena Martínez-Klimova*, Teresa Ramírez-Ápan and Marcos Martínez-García


DOI: 10.2174/1573406415666190826162339
View Abstract View on PubMed


Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents


Nikolaos Kollatos, Christos Mitsos, Stella Manta, Niki Tzioumaki, Christos Giannakas, Tania Alexouli, Aggeliki Panagiotopoulou, Dominique Schols, Graciela Andrei and Dimitri Komiotis*


DOI: 10.2174/1573406415666190225112950
View Abstract View on PubMed


Synthetic Dihydropyridines as Novel Antiacanthamoebic Agents


Ayaz Anwar*, Ruqaiyyah Siddiqui, Abdul Hameed, Muhammad Raza Shah and Naveed Ahmed Khan


DOI: 10.2174/1573406415666190722113412
View Abstract View on PubMed


The Antioxidant, Anticarcinogenic and Antimicrobial Properties of Verbascum thapsus L.


Saman Mahdavi*, Morteza Amiradalat, Marzieh Babashpour, Hosein Sheikhlooei and Mohammad Miransari


DOI: 10.2174/1573406415666190828155951
View Abstract View on PubMed


ROS Inhibitory Activity and Cytotoxicity Evaluation of Benzoyl, Acetyl, Alkyl Ester, and Sulfonate Ester Substituted Coumarin Derivatives


Uzma Salar, Khalid Mohammed Khan*, Almas Jabeen, Aisha Faheem, Farwa Naqvi, Shakil Ahmed, Erum Iqbal, Farman Ali, Kanwal and Shahnaz Perveen


DOI: 10.2174/1573406415666190826153001
View Abstract View on PubMed



Abstracts Ahead of Print


Synthesis, antitrypanosomal and antimycobacterial activities of coumarinic N-acylhydrazonic derivatives


Camila Capelini, Vitória R. F. Câmara, José D. Figueroa Villar, Juliana M. C. Barbosa, Kelly Salomão, Solange L. de Castro, Policarpo A. Sales Junior, Silvane M. F. Murta, Thais B. Couto, Maria Cristina S. Lourenço, James L. Wardell, John N. Low, Edson F. da Silva and Samir A. Carvalho*


DOI: 10.2174/1573406416666200121105215
View Abstract


A COMPREHENSION INTO TARGET BINDING AND SPATIAL FINGERPRINTS OF NOSCAPINOID ANALOGUES AS INHIBITORS OF TUBULIN


Seema Mandavi, Renu Bhatt, Sant Kumar Verma, Laxmi Banjare, Amit Dubey, Suresh Thareja and Akhlesh Kumar Jain*


DOI: 10.2174/1573406416666200117120348
View Abstract


Antidiabetic Activity of Dihydropyrimidine Scaffolds and Structural Insight by Single Crystal X-ray Studies


Keshab M. Bairagi, Nancy Safwat Younis, Promise Madu Emeka, Ekta Sangtani, Rajesh G. Gonnade, Katharigatta N. Venugopala, Osama I. Alwassil, Hany Ezzat Khalil and Susanta K. Nayak*


DOI: 10.2174/1573406416666191227123048
View Abstract






Synthesis and evaluation of 5-imino-4-thioxoimidazolidin-2-one derivatives as antibacterial and antifungal agents


Samir Y. Abbas*, Marwa A. M. Sh. El-Sharief, Reem A. K. Al-Harbi, Eman W. El-Gammal and Ahmed M. Sh. El-Sharief


DOI: 10.2174/1573406416666191227112648
View Abstract



Published Contents

Open Access Articles

Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity

, 2018; 14(3): 225 - 229

Armando L. Morera-Fumero*, Pedro Abreu-Gonzalez, Manuel Henry-Benitez, Lourdes Fernandez-Lopez, Estefania Diaz-Mesa, Maria del Rosario Cejas-Mendez and Fernando Guillen-Pino




IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages

, 2017; 13(8): 727 - 733

Alfonso Lopez-Vazquez, Jesus J. Garcia-Banuelos*, Angelica S. Gonzalez-Garibay, Pedro E. Urzua-Lozano, Susana Del Toro-Arreola, Miriam R. Bueno-Topete, Sergio Sanchez-Enriquez, Jose F. Munoz-Valle, Luis F. Jave-Suarez, Juan Armendariz-Borunda and Blanca E. Bastidas-Ramirez*




Long Term Stability Evaluation of Prostacyclin Released from Biomedical Device through Turbiscan Lab Expert

, 2015; 11(4): 391 - 399

Christian Celia, Marcello Locatelli, Felisa Cilurzo, Donato Cosco, Emanuela Gentile, Daniela Scalise, Maria Carafa, Cinzia Anna Ventura, Mathias Fleury, Christelle Tisserand, Renato. C Barbacane, Massimo Fresta, Luisa Di Marzio and Donatella Paolino




Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes

, 2015; 11(4): 383 - 390

Huizhen Cai, Fukang Liu, Pingguo Zuo, Guiling Huang, Zhixiu Song, Tingting Wang, Huixia Lu, Fei Guo, Chao Han and Guiju Sun





Synthesis of New Thiazolo[4,5-d]pyrimidines as Corticotropin Releasing Factor Modulators

, 2015; 11(1): 50 - 59

Bhimanna Kuppast, Katerina Spyridaki, Christophina Lynch, Yueshan Hu, George Liapakis, Gareth E. Davies and Hesham Fahmy





Most Cited Articles



Research Article

Synthesis, molecular modelling and biological studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one derivatives as HIV-1 integrase inhibitors

, 2019; 15(7): 755-770.

Hajar Sirous, Afshin Fassihi*, Simone Brogi*, Giuseppe Campiani, Frauke Christ, Zeger Debyser, Sandra Gemma, Stefania Butini, Giulia Chemi, Alessandro Grillo, Rezvan Zabihollahi, Mohammad R. Aghasadeghi, Lotfollah Saghaie and Hamid R. Memarian


DOI: 10.2174/1573406415666181219113225


Research Article

ZnO nanoparticles catalyst in the synthesis of bioactive fused pyrimidines as anti-breast cancer agents targeting VEGFR-2

, 2019; 15(3): 277-286.

Dina H. Dawood, Eman M.H. Abbas, Thoraya A. Farghaly*, Mamdouh M. Ali and Mohammed F. Ibrahim


DOI: 10.2174/1573406414666180912113226


Research Article

Synthesis and structural elucidation of novel benzothiazole derivatives as anti-tubercular agents: In-silico screening for possible target identification

, 2019; 15(3): 311-326.

Katharigatta N. Venugopala*, Sandeep Chandrashekharappa, Melendhran Pillay, Subhrajyoti Bhandary, Mahmoud Kandeel, Fawzi M. Mahomoodally , Mohamed A. Morsy, Deepak Chopra , Bandar E. Aldhubiab, Mahesh Attimarad, Osama I. Alwassil , Sree Harsha, Koleka Mlisana and Bharti Odhav


DOI: 10.2174/1573406414666180703121815


Research Article

New hybrid scaffolds based on hydrazinyl thiazole substituted coumarin; as novel leads of dual potential; In Vitro α-amylase inhibitory and antioxidant (DPPH and ABTS radical scavenging) activities

, 2019; 15(1): 87-101.

Uzma Salar, Khalid M. Khan*, Sridevi Chigurupati, Shazia Syed, Shantini Vijayabalan, Abdul Wadood, Muhammad Riaz, Mehreen Ghufran and Shahnaz Perveen


DOI: 10.2174/1573406414666180903162243


Research Article

Inhibition of α-amylase activity by Zn<sup>2+</sup>: Insights from spectroscopy and molecular dynamics simulations

, 2019; 15(5): 510-520.

Si-Ming Liao, Nai-Kun Shen, Ge Liang, Bo Lu, Zhi-Long Lu, Li-Xin Peng, Feng Zhou, Li-Qin Du, Yu-Tuo Wei, Guo-Ping Zhou* and Ri-Bo Huang*


DOI: 10.2174/1573406415666181217114101


Review Article

The multiple applications and possible mechanisms of the hyperbaric oxygenation therapy

, 2019; 15(5): 459-471.

Wan Chen, Xingmei Liang , Zhihuan Nong, Yaoxuan Li, Xiaorong Pan, Chunxia Chen * and Luying Huang*


DOI: 10.2174/1573406415666181219101328



Research Article

Pyrano[3,2-c]quinoline derivatives as new class of α-glucosidase inhibitors to treat type 2 diabetes: Synthesis, in vitro biological evaluation and kinetic study

, 2019; 15(1): 8-16.

Zahra Heydari, Maryam Mohammadi-Khanaposhtani, Somaye Imanparast, Mohammad A. Faramarzi, Mohammad Mahdavi *, Parviz R. Ranjbar* and Bagher Larijani


DOI: 10.2174/1573406414666180528110104


Research Article

Helminthicidal and larvicidal potentials of biogenic silver nanoparticles synthesized from medicinal plant momordica charantia

, 2019; 15(7): 781-789.

Amruta Shelar, Jaiprakash Sangshetti, Shampa Chakraborti*, Ajay Vikram Singh*, Rajendra Patil* and Suresh Gosavi*


DOI: 10.2174/1573406415666190430142637



Research Article

4-hydroxy-2-pyridone derivatives and the δ-pyrone isostere as novel agents against Mycobacterium smegmatis biofilm inhibitors

, 2019; 15(1): 28-37.

Maheshkumar R. Borkar, Santosh Nandan*, Harish K.M. Nagaraj, Jayashree Puttur, Jisha Manniyodath, Dipankar Chatterji and Evans C. Coutinho *


DOI: 10.2174/1573406414666180525075755


Research Article

Novel amide derivatives as potent tyrosinase inhibitors; in-vitro, in-vivo antimelanogenic activity and computational studies

, 2019; 15(7): 715-728.

Anser Ali, Zaman Ashraf, Muhammad Rafiq, Ajeet Kumar, Farukh Jabeen, Goon Joon Lee, Fahad Nazir, Mushtaq Ahmed, Myungchull Rhee and Eun Ha Choi*


DOI: 10.2174/1573406415666190319101329


Research Article

Efficacy of novel schiff base derivatives as antifungal compounds in combination with approved drugs against candida albicans

, 2019; 15(6): 648-658.

Manzoor Ahmad Malik, Shabir Ahmad Lone, Parveez Gull, Ovas Ahmad Dar, Mohmmad Younus Wani, Aijaz Ahmad* and Athar Adil Hashmi*


DOI: 10.2174/1573406415666181203115957



Most Accessed Articles

Cystic Fibrosis Revisited – a Review Study

, 2017; 13(2): 102-109.

Blanka Klimova, Kamil Kuca, Michal Novotny and Petra Maresova


DOI: 10.2174/1573406412666160608113235



Discovery and Optimization of a Series of Sulfonamide Inverse Agonists for the Retinoic Acid Receptor-Related Orphan Receptor-α

, 2019; 15(6): 676-684.

Christelle Doebelin, Yuanjun He, Sean Campbell, Philippe Nuhant, Naresh Kumar, Marcel Koenig, Ruben Garcia-Ordonez, Mi Ra Chang, William R. Roush, Li Lin, Susan Kahn, Michael D. Cameron, Patrick R. Griffin, Laura A. Solt* and Theodore M. Kamenecka*


DOI: 10.2174/1573406415666190222124745


Discovery of N-Phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine Derivatives as Potent Mnk2 Inhibitors: Design, Synthesis, SAR Analysis, and Evaluation of in vitro Anti-leukaemic Activity

, 2019; 15(6): 602-623.

Ahmed M. Abdelaziz, Sarah Diab, Saiful Islam, Sunita K.C. Basnet, Benjamin Noll, Peng Li, Laychiluh B. Mekonnen, Jingfeng Lu, Hugo Albrecht, Robert W. Milne, Cobus Gerber, Mingfeng Yu * and Shudong Wang*


DOI: 10.2174/1573406415666181219111511



New Quinazoline-Sulfonylurea Conjugates: Design, Synthesis and Hypoglycemic Activity

, 2019; 15(6): 634-647.

Sahar M. Abou-Seri, AlShaimaa M. Taha, Mona A. Mohamed* and Nour M. Abdelkader


DOI: 10.2174/1573406415666181208104543



USP7: Target Validation and Drug Discovery for Cancer Therapy

, 2018; 14(1): 3-18.

Jin Zhou*, Jinzheng Wang, Chao Chen, Haoliang Yuan, Xiaoan Wen* and Hongbin Sun*


DOI: 10.2174/1573406413666171020115539


Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents

, 2019; 15(7): 729-737.

Monika Gensicka-Kowalewska, Mirosława Cichorek, Anna Ronowska, Milena Deptuła, Ilona Klejbor and Krystyna Dzierzbicka*


DOI: 10.2174/1573406414666181015145120


Novel Amide Derivatives as Potent Tyrosinase Inhibitors; In-vitro, In-vivo Antimelanogenic Activity and Computational Studies

, 2019; 15(7): 715-728.

Anser Ali, Zaman Ashraf, Muhammad Rafiq, Ajeet Kumar, Farukh Jabeen, Goon Joon Lee, Fahad Nazir, Mushtaq Ahmed, Myungchull Rhee and Eun Ha Choi*


DOI: 10.2174/1573406415666190319101329




Editor-in-Chief

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece

Biography View Full Editorial Board

Journal History

Medicinal Chemistry Journal was launched in 2005. Dr. Dimitra Hadjipavlou-Litina serves as the Editor-in-Chief of the journal.
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Scopus CiteScore Metrics: 1.84

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