Bentham Science Logo

Medicinal Chemistry

Volume 15, 8 Issues, 2019
ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)
This journal supports open access

Ranking and Category

  • 31st of 61 in

    Chemistry, Medicinal

Order Your Article Before Print

Aims & Scope

Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, full-length/mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.

Medicinal Chemistry


Volume 15


Number 5

Biography   Open Access

Editorial   Open Access

Review Article

Review Article

The Multiple Applications and Possible Mechanisms of the Hyperbaric Oxygenation Therapy

, 15(5): 459 - 471

Wan Chen, Xingmei Liang , Zhihuan Nong, Yaoxuan Li, Xiaorong Pan, Chunxia Chen * and Luying Huang*

DOI: 10.2174/1573406415666181219101328

Research Article

Research Article

The Inhibition of Polysialyltranseferase ST8SiaIV Through Heparin Binding to Polysialyltransferase Domain (PSTD)

, 15(5): 486 - 495

Li-Xin Peng, Xue-Hui Liu, Bo Lu, Si-Ming Liao, Feng Zhou, Ji-Min Huang, Dong Chen, Frederic A. Troy II, Guo-Ping Zhou* and Ri-Bo Huang*

DOI: 10.2174/1573406415666181218101623

Research Article

Research Article

Inhibition of α-amylase Activity by Zn2+: Insights from Spectroscopy and Molecular Dynamics Simulations

, 15(5): 510 - 520

Si-Ming Liao, Nai-Kun Shen, Ge Liang, Bo Lu, Zhi-Long Lu, Li-Xin Peng, Feng Zhou, Li-Qin Du, Yu-Tuo Wei, Guo-Ping Zhou* and Ri-Bo Huang*

DOI: 10.2174/1573406415666181217114101

Medicinal Chemistry, Volume 15 (2019) - Number 6

This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Design of Inhibitors for Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Enzyme of Leishmania mexicana

Krisnna Mariana Aranda Alves, Fábio José Bonfim Cardoso, Kathia Maria Honorio and Fábio Alberto de Molfetta*

DOI: 10.2174/1573406415666190712111139
View Abstract View on PubMed

Synthesis of New Cyclic Imides Derived From Safrole, Structure- and Ligand-based Approaches to Evaluate Potential New Multitarget Agents Against Species of Leishmania

José Alixandre de Sousa Luis*, Normando Alexandre da Silva Costa, Cristiane Cosmo Silva Luis, Bruno Freitas Lira, Petrônio Filgueiras Athayde-Filho, Tatjana Keesen de Souza Lima, Juliana da Câmara Rocha, Luciana Scotti and Marcus Tullius Scotti

DOI: 10.2174/1573406415666190430144950
View Abstract View on PubMed

Anti-Mycobacterial Peroxides: A New Class of Agents for Development Against Tuberculosis

Christiaan W. van der Westhuyzen, Richard K. Haynes, Jenny-Lee Panayides, Ian Wiid and Christopher J. Parkinson*

DOI: 10.2174/1573406415666190430143535
View Abstract View on PubMed

First Example of Antiparasitic Activity Influenced by Thermochromism: Leishmanicidal Evaluation of 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine Metal Complexes

José M. Méndez-Arriaga*, Itziar Oyarzabal, Álvaro Martín-Montes, Judith García-Rodríguez, Miguel Quirós and Manuel Sánchez-Moreno

DOI: 10.2174/1573406415666190401120607
View Abstract View on PubMed

Abstracts Ahead of Print

Study of interactions energies between residues of the active site of Hsp90 and the geldanamycin analogues using Quantum Mechanics/Molecular Mechanics (QM/MM) methods

Ricardo Vivas-Reyes, Alejandro Morales-Bayuelo, Carlos Gueto, Juan C. Droso, Johana Márquez, Rosa Baldiris, Maicol Ahumedo, Catalina Vivas-Gomez and Dilia Aparicio

DOI: 10.2174/1573406415666190724142113
View Abstract

Methoxychalcones: Effect of Methoxyl Group toward Antifungal, Antibacterial and Antiproliferative Activities

Beatriz C. Marques, Mariana B. Santos, Daiane B. Anselmo, Diego A. Monteiro, Eleni Gomes, Marilia F. C. Saiki, Paula Rahal, Pedro L. Rosalen, Janaina C. O. Sardi and Luis O. Regasini

DOI: 10.2174/1573406415666190724145158
View Abstract

Novel p-Functionalized Chromen-4-on-3-yl Chalcones Bearing Astonishing Boronic Acid Moiety as MDM2 Inhibitor: Synthesis, Cytotoxic Evaluation and Simulation Studies

Richa Kaur Bhatia*, Lakhwinder Singh, Ruchika Garg, Maninder Kaur, Manmohan Yadav, Jitender Madan, Satyavathi Kancherla, Raghuvir R. S. Pissurlenkar and Evans C. Coutinho

DOI: 10.2174/1573406415666190531123751
View Abstract

Synthetic Dihydropyridines as Novel Antiacanthamoebic Agents

Ayaz Anwar*, Ruqaiyyah Siddiqui, Abdul Hameed, Muhammad Raza Shah and Naveed Ahmed Khan

DOI: 10.2174/1573406415666190722113412
View Abstract

Published Contents

Open Access Articles

Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity

, 2018; 14(3): 225 - 229

Armando L. Morera-Fumero*, Pedro Abreu-Gonzalez, Manuel Henry-Benitez, Lourdes Fernandez-Lopez, Estefania Diaz-Mesa, Maria del Rosario Cejas-Mendez and Fernando Guillen-Pino

IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages

, 2017; 13(8): 727 - 733

Alfonso Lopez-Vazquez, Jesus J. Garcia-Banuelos*, Angelica S. Gonzalez-Garibay, Pedro E. Urzua-Lozano, Susana Del Toro-Arreola, Miriam R. Bueno-Topete, Sergio Sanchez-Enriquez, Jose F. Munoz-Valle, Luis F. Jave-Suarez, Juan Armendariz-Borunda and Blanca E. Bastidas-Ramirez*

Long Term Stability Evaluation of Prostacyclin Released from Biomedical Device through Turbiscan Lab Expert

, 2015; 11(4): 391 - 399

Christian Celia, Marcello Locatelli, Felisa Cilurzo, Donato Cosco, Emanuela Gentile, Daniela Scalise, Maria Carafa, Cinzia Anna Ventura, Mathias Fleury, Christelle Tisserand, Renato. C Barbacane, Massimo Fresta, Luisa Di Marzio and Donatella Paolino

Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes

, 2015; 11(4): 383 - 390

Huizhen Cai, Fukang Liu, Pingguo Zuo, Guiling Huang, Zhixiu Song, Tingting Wang, Huixia Lu, Fei Guo, Chao Han and Guiju Sun

Synthesis of New Thiazolo[4,5-d]pyrimidines as Corticotropin Releasing Factor Modulators

, 2015; 11(1): 50 - 59

Bhimanna Kuppast, Katerina Spyridaki, Christophina Lynch, Yueshan Hu, George Liapakis, Gareth E. Davies and Hesham Fahmy

Most Cited Articles

Review Article

USP7: Target validation and drug discovery for cancer therapy

, 2018; 14(1): 3-18.

Jin Zhou*, Jinzheng Wang, Chao Chen, Haoliang Yuan, Xiaoan Wen* and Hongbin Sun*

DOI: 10.2174/1573406413666171020115539

Review Article

New perspectives of Alzheimer disease diagnosis - The most popular and future methods

, 11 January 2018; 14(1): 34-43.

Katarzyna Pietrzak, Kamila Czarnecka, Elzbieta Mikiciuk-Olasik and Pawel Szymanski*

DOI: 10.2174/1573406413666171002120847

Research Article

Biology-oriented synthesis (BIOS) of piperine derivatives and their comparative analgesic and antiinflammatory activities

, 1 May 2018; 14(3): 269-280.

Ammar Yasir, Saiqa Ishtiaq, Muhammad Jahangir, Muhammad Ajaib, Uzma Salar and Khalid M. Khan*

DOI: 10.2174/1573406413666170623083810

Research Article

Cell cycle arrest and apoptosis induction activity of nitidine chloride on acute myeloid leukemia cells

, 2018; 14(1): 60-66.

Peng Li, Shuxin Yan, Xin Dong, Zhao Li, Yu Qiu, Chunyan Ji, Jingru Zhang, Min Ji, Wei Li, Hongchun Wang, Zhi Liu, Xing L. Wang, Jingjing Ye* and Daoxin Ma

DOI: 10.2174/1573406413666170620091543

Research Article

Quinolinic carboxylic acid derivatives as potential multi-target compounds for neurodegeneration: Monoamine oxidase and cholinesterase inhibition

, 2018; 14(1): 74-85.

Nehal A. Khan, Imtiaz Khan, Syed M.A. Abid, Sumera Zaib, Aliya Ibrar, Hina Andleeb, Shahid Hameed* and Jamshed Iqbal*

DOI: 10.2174/1573406413666170525125231

Review Article

Is there a link between Vitamin B and multiple sclerosis?

, 1 March 2018; 14(2): 170-180.

Natalie Nemazannikova, Kathleen Mikkelsen, Lily Stojanovska, Gregory L. Blatch and Vasso Apostolopoulos*

DOI: 10.2174/1573406413666170906123857

Research Article

Molecular interaction and computational analytical studies of pinocembrin for its antiangiogenic potential targeting VEGFR-2: A persuader of metastasis

, 2018; 14(6): 626-640.

Neha Sharma, Mala Sharma, Eram Shakeel, Qazi M.S. Jamal, Mohammad A. Kamal, Usman Sayeed, Mohammad K.A. Khan, Mohammad H. Siddiqui, Jamal M. Arif and Salman Akhtar*

DOI: 10.2174/1573406414666180416125121

Research Article

In vitro and in silico evaluation of non-quaternary reactivators of AChE as antidotes of organophosphorus poisoning - A new hope or a blind alley?

, 1 May 2018; 14(3): 281-292.

Ondrej Soukup, Jan Korabecny, David Malinak, Eugenie Nepovimova, Ngoc L. Pham, Kamil Musilek, Martina Hrabinova, Vendula Hepnarova, Rafael Dolezal, Petr Pavek, Petr Jost, Tereza Kobrlova , Jana Jankockova, Lukas Gorecki, Miroslav Psotka, Thuy D. Nguyen, Karl Box, Breeze Outhwaite, Martina Ceckova, Ales Sorf, Daniel Jun* and Kamil Kuca*

DOI: 10.2174/1573406414666180112105657

Research Article

Synthesis, characterization and biological activities of new symmetric bis-1,2,3-triazoles with click chemistry

, 1 May 2018; 14(3): 230-241.

Fatih Celik*, Yasemin Unver, Burak Barut, Arzu Ozel and Kemal Sancak

DOI: 10.2174/1573406413666171120165226

Most Accessed Articles

Predicting the Activity of Antimicrobial Peptides with Amino Acid Topological Information

, 2013; 9(1): 32-44.

Mao Shu, Rui Yu, Yunru Zhang, Juan Wang, Li Yang, Li Wang and Zhihua Lin

DOI: 10.2174/1573406411309010032

USP7: Target Validation and Drug Discovery for Cancer Therapy

, 2018; 14(1): 3-18.

Jin Zhou*, Jinzheng Wang, Chao Chen, Haoliang Yuan, Xiaoan Wen* and Hongbin Sun*

DOI: 10.2174/1573406413666171020115539

Phenolic Imidazole Derivatives with Dual Antioxidant/Antifungal Activity: Synthesis and Structure-Activity Relationship

, 2019; 15(4): 341-351.

Ana P. Bettencourt, Marián Castro, João P. Silva, Francisco Fernandes, Olga P. Coutinho, Maria J. Sousa, Maria Fernanda Proença* and Filipe M. Areias*

DOI: 10.2174/1573406414666181005143431

Rational Design of Colchicine Derivatives as anti-HIV Agents via QSAR and Molecular Docking

, 2019; 15(4): 328-340.

Apilak Worachartcheewan*, Napat Songtawee, Suphakit Siriwong, Supaluk Prachayasittikul*, Chanin Nantasenamat and Virapong Prachayasittikul

DOI: 10.2174/1573406414666180924163756

New N,C-Diaryl-1,2,4-triazol-3-ones: Synthesis and Evaluation as Anticancer Agents

, 2019; 15(4): 360-372.

Dolores Santa María*, Rosa M. Claramunt, José Elguero, Miguel Carda*, Eva Falomir and Celia Martín-Beltrán

DOI: 10.2174/1573406414666180821103604

Cystic Fibrosis Revisited – a Review Study

, 2017; 13(2): 102-109.

Blanka Klimova, Kamil Kuca, Michal Novotny and Petra Maresova

DOI: 10.2174/1573406412666160608113235

Synthesis and Evaluation of Antifungal and Antitrypanosomastid Activities of Symmetrical 1,4-Disubstituted-1,2,3-Bistriazoles Obtained by CuAAC Conditions

, 2019; 15(4): 400-408.

Mauricio M. Victor*, Ravir R. Farias, Danielle L. da Silva, Paulo H.F. do Carmo, Maria A. de Resende-Stoianoff, Cláudio Viegas, Patrícia F. Espuri and Marcos J. Marques

DOI: 10.2174/1573406414666181024111522

Ligand-Based Drug Design: Synthesis and Biological Evaluation of Substituted Benzoin Derivatives as Potential Antitumor Agents

, 2019; 15(4): 417-429.

Dima A. Sabbah*, Ameerah H. Ibrahim, Wamidh H. Talib, Khalid M. Alqaisi, Kamal Sweidan, Sanaa K. Bardaweel, Ghassan A. Sheikha, Haizhen A. Zhong, Eveen Al-Shalabi, Reema A. Khalaf and Mohammad S. Mubarak

DOI: 10.2174/1573406414666180912111846


Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki

Biography View Full Editorial Board

Journal History

Medicinal Chemistry Journal was launched in 2005. Dr. Dimitra Hadjipavlou-Litina serves as the Editor-in-Chief of the journal.
Track Your Manuscript:

Related Journals

Related eBooks

eBooks Catalog