This article by Dr. Guilhem Chaubet et al. is published in Letters in Organic Chemistry, volume 15 , issue 12 , 2018
Researchers from the University of Montpellier have worked on a process for a new ring contraction of fused bis-lactams, which converts them into spirolactams. The team performed a clean conversion of some fused bicycles into spirocycles with good yields, in the presence of a triflate catalyst in various solvents under microwave irradiation. The method involves the use of activated 2,5-diketopiperazines as starting materials and demonstrates the wide range of applications of ring contraction reactions.